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Aberrant DNA Methylation of MGMT Gene

MedGen UID:
397127
•Concept ID:
C2699332
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAberrant DNA Methylation of MGMT Gene

Professional guidelines

PubMed

Aberrant epigenetic inactivation of RASSF1A and MGMT gene and genetic mutations of KRAS, cKIT and BRAF in Indian testicular germ cell tumours.
Ahmad F, Surve P, Natarajan S, Patil A, Pol S, Patole K, Das BR
Cancer Genet 2020 Feb;241:42-50. Epub 2019 Oct 13 doi: 10.1016/j.cancergen.2019.10.002. PMID: 31653608
The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis.
Liu D, Peng H, Sun Q, Zhao Z, Yu X, Ge S, Wang H, Fang H, Gao Q, Liu J, Wu L, Song M, Wang Y
Int J Environ Res Public Health 2017 Jun 23;14(7) doi: 10.3390/ijerph14070679. PMID: 28644424Free PMC Article
Aberrant DNA methylation profile in pleural fluid for differential diagnosis of malignant pleural mesothelioma.
Fujii M, Fujimoto N, Hiraki A, Gemba K, Aoe K, Umemura S, Katayama H, Takigawa N, Kiura K, Tanimoto M, Kishimoto T
Cancer Sci 2012 Mar;103(3):510-4. Epub 2012 Jan 13 doi: 10.1111/j.1349-7006.2011.02180.x. PMID: 22146010Free PMC Article

Recent clinical studies

Etiology

Overview of DNA methylation in adult diffuse gliomas.
Aoki K, Natsume A
Brain Tumor Pathol 2019 Apr;36(2):84-91. Epub 2019 Apr 1 doi: 10.1007/s10014-019-00339-w. PMID: 30937703
Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma.
Zhang C, Li J, Huang T, Duan S, Dai D, Jiang D, Sui X, Li D, Chen Y, Ding F, Huang C, Chen G, Wang K
Oncotarget 2016 Dec 6;7(49):81255-81267. doi: 10.18632/oncotarget.13221. PMID: 27835605Free PMC Article
DNA methylation in adult diffuse gliomas.
LeBlanc VG, Marra MA
Brief Funct Genomics 2016 Nov;15(6):491-500. Epub 2016 Jun 10 doi: 10.1093/bfgp/elw019. PMID: 27288434
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P
Clin Chim Acta 2013 Sep 23;424:53-65. Epub 2013 May 10 doi: 10.1016/j.cca.2013.05.002. PMID: 23669186
Comprehensive genomic characterization defines human glioblastoma genes and core pathways.
Cancer Genome Atlas Research Network
Nature 2008 Oct 23;455(7216):1061-8. Epub 2008 Sep 4 doi: 10.1038/nature07385. PMID: 18772890Free PMC Article

Diagnosis

Progress in the study of markers related to glioma prognosis.
Luo Y, Hou WT, Zeng L, Li ZP, Ge W, Yi C, Kang JP, Li WM, Wang F, Wu DB, Wang RY, Qu BL, Li XF, Wang JJ
Eur Rev Med Pharmacol Sci 2020 Jul;24(14):7690-7697. doi: 10.26355/eurrev_202007_22271. PMID: 32744695
Overview of DNA methylation in adult diffuse gliomas.
Aoki K, Natsume A
Brain Tumor Pathol 2019 Apr;36(2):84-91. Epub 2019 Apr 1 doi: 10.1007/s10014-019-00339-w. PMID: 30937703
Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma.
Zhang C, Li J, Huang T, Duan S, Dai D, Jiang D, Sui X, Li D, Chen Y, Ding F, Huang C, Chen G, Wang K
Oncotarget 2016 Dec 6;7(49):81255-81267. doi: 10.18632/oncotarget.13221. PMID: 27835605Free PMC Article
Molecular classification of gliomas.
Masui K, Mischel PS, Reifenberger G
Handb Clin Neurol 2016;134:97-120. doi: 10.1016/B978-0-12-802997-8.00006-2. PMID: 26948350
Gene methylation in gastric cancer.
Qu Y, Dang S, Hou P
Clin Chim Acta 2013 Sep 23;424:53-65. Epub 2013 May 10 doi: 10.1016/j.cca.2013.05.002. PMID: 23669186

Therapy

The prevalence and persistence of aberrant promoter DNA methylation in benzene-exposed Chinese workers.
Ren J, Cui JP, Luo M, Liu H, Hao P, Wang X, Zhang GH
PLoS One 2019;14(8):e0220500. Epub 2019 Aug 5 doi: 10.1371/journal.pone.0220500. PMID: 31381583Free PMC Article
The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer.
Gao D, Herman JG, Guo M
Oncotarget 2016 Jun 14;7(24):37331-37346. doi: 10.18632/oncotarget.7949. PMID: 26967246Free PMC Article
Ras regulation of DNA-methylation and cancer.
Patra SK
Exp Cell Res 2008 Apr 1;314(6):1193-201. Epub 2008 Jan 26 doi: 10.1016/j.yexcr.2008.01.012. PMID: 18282569
MGMT methylation status: the advent of stratified therapy in glioblastoma?
Hau P, Stupp R, Hegi ME
Dis Markers 2007;23(1-2):97-104. doi: 10.1155/2007/159242. PMID: 17325429Free PMC Article
Aberrant DNA methylation as a cancer-inducing mechanism.
Esteller M
Annu Rev Pharmacol Toxicol 2005;45:629-56. doi: 10.1146/annurev.pharmtox.45.120403.095832. PMID: 15822191

Prognosis

Progress in the study of markers related to glioma prognosis.
Luo Y, Hou WT, Zeng L, Li ZP, Ge W, Yi C, Kang JP, Li WM, Wang F, Wu DB, Wang RY, Qu BL, Li XF, Wang JJ
Eur Rev Med Pharmacol Sci 2020 Jul;24(14):7690-7697. doi: 10.26355/eurrev_202007_22271. PMID: 32744695
Overview of DNA methylation in adult diffuse gliomas.
Aoki K, Natsume A
Brain Tumor Pathol 2019 Apr;36(2):84-91. Epub 2019 Apr 1 doi: 10.1007/s10014-019-00339-w. PMID: 30937703
Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma.
Zhang C, Li J, Huang T, Duan S, Dai D, Jiang D, Sui X, Li D, Chen Y, Ding F, Huang C, Chen G, Wang K
Oncotarget 2016 Dec 6;7(49):81255-81267. doi: 10.18632/oncotarget.13221. PMID: 27835605Free PMC Article
Molecular classification of gliomas.
Masui K, Mischel PS, Reifenberger G
Handb Clin Neurol 2016;134:97-120. doi: 10.1016/B978-0-12-802997-8.00006-2. PMID: 26948350
Gene regulation by methylation.
Mueller WC, von Deimling A
Recent Results Cancer Res 2009;171:217-39. doi: 10.1007/978-3-540-31206-2_13. PMID: 19322547

Clinical prediction guides

Progress in the study of markers related to glioma prognosis.
Luo Y, Hou WT, Zeng L, Li ZP, Ge W, Yi C, Kang JP, Li WM, Wang F, Wu DB, Wang RY, Qu BL, Li XF, Wang JJ
Eur Rev Med Pharmacol Sci 2020 Jul;24(14):7690-7697. doi: 10.26355/eurrev_202007_22271. PMID: 32744695
Meta-analysis of DNA methylation biomarkers in hepatocellular carcinoma.
Zhang C, Li J, Huang T, Duan S, Dai D, Jiang D, Sui X, Li D, Chen Y, Ding F, Huang C, Chen G, Wang K
Oncotarget 2016 Dec 6;7(49):81255-81267. doi: 10.18632/oncotarget.13221. PMID: 27835605Free PMC Article
Molecular classification of gliomas.
Masui K, Mischel PS, Reifenberger G
Handb Clin Neurol 2016;134:97-120. doi: 10.1016/B978-0-12-802997-8.00006-2. PMID: 26948350
DNA methylation in cancer: a gene silencing mechanism and the clinical potential of its biomarkers.
Fukushige S, Horii A
Tohoku J Exp Med 2013 Mar;229(3):173-85. doi: 10.1620/tjem.229.173. PMID: 23419314
Comprehensive genomic characterization defines human glioblastoma genes and core pathways.
Cancer Genome Atlas Research Network
Nature 2008 Oct 23;455(7216):1061-8. Epub 2008 Sep 4 doi: 10.1038/nature07385. PMID: 18772890Free PMC Article

Recent systematic reviews

Differential methylation landscape of pancreatic ductal adenocarcinoma and its precancerous lesions.
Bararia A, Dey S, Gulati S, Ghatak S, Ghosh S, Banerjee S, Sikdar N
Hepatobiliary Pancreat Dis Int 2020 Jun;19(3):205-217. Epub 2020 Apr 8 doi: 10.1016/j.hbpd.2020.03.010. PMID: 32312637

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