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Aberrant DNA Methylation

MedGen UID:
267626
•Concept ID:
C1510714
•
Cell or Molecular Dysfunction

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAberrant DNA Methylation

Professional guidelines

PubMed

Deciphering the DNA methylome in women with PCOS diagnosed using the new international evidence-based guidelines.
Wang Y, Gao X, Yang Z, Yan X, He X, Guo T, Zhao S, Zhao H, Chen ZJ
Hum Reprod 2023 Nov 20;38(Supplement_2):ii69-ii79. doi: 10.1093/humrep/dead191. PMID: 37982419
Cell-free DNA methylation markers for differential diagnosis of hepatocellular carcinoma.
Luo B, Ma F, Liu H, Hu J, Rao L, Liu C, Jiang Y, Kuangzeng S, Lin X, Wang C, Lei Y, Si Z, Chen G, Zhou N, Liang C, Jiang F, Liu F, Dai W, Liu W, Gao Y, Li Z, Li X, Zhou G, Li B, Zhang Z, Nian W, Luo L, Liu X
BMC Med 2022 Jan 14;20(1):8. doi: 10.1186/s12916-021-02201-3. PMID: 35027051Free PMC Article
Methylation alterations and advance of treatment in lymphoma.
Liu MK, Sun XJ, Gao XD, Qian Y, Wang L, Zhao WL
Front Biosci (Landmark Ed) 2021 Sep 30;26(9):602-613. doi: 10.52586/4970. PMID: 34590470

Recent clinical studies

Etiology

Precancerous nature of intestinal metaplasia with increased chance of conversion and accelerated DNA methylation.
Takeuchi C, Yamashita S, Liu YY, Takeshima H, Sasaki A, Fukuda M, Hashimoto T, Naka T, Ishizu K, Sekine S, Yoshikawa T, Hamada A, Yamamichi N, Fujishiro M, Ushijima T
Gut 2024 Jan 5;73(2):255-267. doi: 10.1136/gutjnl-2023-329492. PMID: 37751933
Prostate Cancer: Genetics, Epigenetics and the Need for Immunological Biomarkers.
Rafikova G, Gilyazova I, Enikeeva K, Pavlov V, Kzhyshkowska J
Int J Mol Sci 2023 Aug 14;24(16) doi: 10.3390/ijms241612797. PMID: 37628978Free PMC Article
DNA Methylation in Solid Tumors: Functions and Methods of Detection.
Martisova A, Holcakova J, Izadi N, Sebuyoya R, Hrstka R, Bartosik M
Int J Mol Sci 2021 Apr 19;22(8) doi: 10.3390/ijms22084247. PMID: 33921911Free PMC Article
Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome.
Mahmoud AM, Ali MM
Nutrients 2019 Mar 13;11(3) doi: 10.3390/nu11030608. PMID: 30871166Free PMC Article
Epigenetics and Precision Oncology.
Werner RJ, Kelly AD, Issa JJ
Cancer J 2017 Sep/Oct;23(5):262-269. doi: 10.1097/PPO.0000000000000281. PMID: 28926426Free PMC Article

Diagnosis

Prostate Cancer: Genetics, Epigenetics and the Need for Immunological Biomarkers.
Rafikova G, Gilyazova I, Enikeeva K, Pavlov V, Kzhyshkowska J
Int J Mol Sci 2023 Aug 14;24(16) doi: 10.3390/ijms241612797. PMID: 37628978Free PMC Article
DNA methylation biomarkers for noninvasive detection of triple-negative breast cancer using liquid biopsy.
Manoochehri M, Borhani N, Gerhäuser C, Assenov Y, Schönung M, Hielscher T, Christensen BC, Lee MK, Gröne HJ, Lipka DB, Brüning T, Brauch H, Ko YD, Hamann U
Int J Cancer 2023 Mar 1;152(5):1025-1035. Epub 2022 Nov 8 doi: 10.1002/ijc.34337. PMID: 36305646
DNA Methylation in Solid Tumors: Functions and Methods of Detection.
Martisova A, Holcakova J, Izadi N, Sebuyoya R, Hrstka R, Bartosik M
Int J Mol Sci 2021 Apr 19;22(8) doi: 10.3390/ijms22084247. PMID: 33921911Free PMC Article
DNA Methylation-Based Testing in Liquid Biopsies as Detection and Prognostic Biomarkers for the Four Major Cancer Types.
Constâncio V, Nunes SP, Henrique R, Jerónimo C
Cells 2020 Mar 5;9(3) doi: 10.3390/cells9030624. PMID: 32150897Free PMC Article
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers.
Okugawa Y, Grady WM, Goel A
Gastroenterology 2015 Oct;149(5):1204-1225.e12. Epub 2015 Jul 26 doi: 10.1053/j.gastro.2015.07.011. PMID: 26216839Free PMC Article

Therapy

Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer.
Yamada Y, Venkadakrishnan VB, Mizuno K, Bakht M, Ku SY, Garcia MM, Beltran H
Sci Transl Med 2023 Nov 15;15(722):eadf6732. doi: 10.1126/scitranslmed.adf6732. PMID: 37967200Free PMC Article
Multicenter phase 2 study of oral azacitidine (CC-486) plus CHOP as initial treatment for PTCL.
Ruan J, Moskowitz A, Mehta-Shah N, Sokol L, Chen Z, Kotlov N, Nos G, Sorokina M, Maksimov V, Sboner A, Sigouros M, van Besien K, Horwitz S, Rutherford SC, Mulvey E, Revuelta MV, Xiang J, Alonso A, Melnick A, Elemento O, Inghirami G, Leonard JP, Cerchietti L, Martin P
Blood 2023 May 4;141(18):2194-2205. doi: 10.1182/blood.2022018254. PMID: 36796016Free PMC Article
Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities.
Micevic G, Theodosakis N, Bosenberg M
Clin Epigenetics 2017;9:34. Epub 2017 Apr 4 doi: 10.1186/s13148-017-0332-8. PMID: 28396701Free PMC Article
DNA Hypomethylating Drugs in Cancer Therapy.
Sato T, Issa JJ, Kropf P
Cold Spring Harb Perspect Med 2017 May 1;7(5) doi: 10.1101/cshperspect.a026948. PMID: 28159832Free PMC Article
Cancer epigenetics.
Momparler RL
Oncogene 2003 Sep 29;22(42):6479-83. doi: 10.1038/sj.onc.1206774. PMID: 14528271

Prognosis

Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer.
Yamada Y, Venkadakrishnan VB, Mizuno K, Bakht M, Ku SY, Garcia MM, Beltran H
Sci Transl Med 2023 Nov 15;15(722):eadf6732. doi: 10.1126/scitranslmed.adf6732. PMID: 37967200Free PMC Article
Prostate Cancer: Genetics, Epigenetics and the Need for Immunological Biomarkers.
Rafikova G, Gilyazova I, Enikeeva K, Pavlov V, Kzhyshkowska J
Int J Mol Sci 2023 Aug 14;24(16) doi: 10.3390/ijms241612797. PMID: 37628978Free PMC Article
DNA Methylation-Based Testing in Liquid Biopsies as Detection and Prognostic Biomarkers for the Four Major Cancer Types.
Constâncio V, Nunes SP, Henrique R, Jerónimo C
Cells 2020 Mar 5;9(3) doi: 10.3390/cells9030624. PMID: 32150897Free PMC Article
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers.
Okugawa Y, Grady WM, Goel A
Gastroenterology 2015 Oct;149(5):1204-1225.e12. Epub 2015 Jul 26 doi: 10.1053/j.gastro.2015.07.011. PMID: 26216839Free PMC Article
Epigenetics and cervical cancer: from pathogenesis to therapy.
Fang J, Zhang H, Jin S
Tumour Biol 2014 Jun;35(6):5083-93. Epub 2014 Feb 20 doi: 10.1007/s13277-014-1737-z. PMID: 24554414

Clinical prediction guides

DNA methylation biomarkers for noninvasive detection of triple-negative breast cancer using liquid biopsy.
Manoochehri M, Borhani N, Gerhäuser C, Assenov Y, Schönung M, Hielscher T, Christensen BC, Lee MK, Gröne HJ, Lipka DB, Brüning T, Brauch H, Ko YD, Hamann U
Int J Cancer 2023 Mar 1;152(5):1025-1035. Epub 2022 Nov 8 doi: 10.1002/ijc.34337. PMID: 36305646
DNA Methylation: From Cancer Biology to Clinical Perspectives.
Chen C, Wang Z, Ding Y, Wang L, Wang S, Wang H, Qin Y
Front Biosci (Landmark Ed) 2022 Dec 20;27(12):326. doi: 10.31083/j.fbl2712326. PMID: 36624943
Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome.
Mahmoud AM, Ali MM
Nutrients 2019 Mar 13;11(3) doi: 10.3390/nu11030608. PMID: 30871166Free PMC Article
Morphology-oriented epigenetic research.
Kitazawa S, Haraguchi R, Kitazawa R
Histochem Cell Biol 2018 Jul;150(1):3-12. Epub 2018 May 2 doi: 10.1007/s00418-018-1675-8. PMID: 29721644
Epigenetics and Precision Oncology.
Werner RJ, Kelly AD, Issa JJ
Cancer J 2017 Sep/Oct;23(5):262-269. doi: 10.1097/PPO.0000000000000281. PMID: 28926426Free PMC Article

Recent systematic reviews

Epigenetics in the diagnosis and prognosis of head and neck cancer: A systematic review.
Lim I, Tan J, Alam A, Idrees M, Brenan PA, Coletta RD, Kujan O
J Oral Pathol Med 2024 Feb;53(2):90-106. Epub 2024 Feb 5 doi: 10.1111/jop.13513. PMID: 38316046
DNA Methylation Biomarkers for Young Children with Idiopathic Autism Spectrum Disorder: A Systematic Review.
Stoccoro A, Conti E, Scaffei E, Calderoni S, Coppedè F, Migliore L, Battini R
Int J Mol Sci 2023 May 23;24(11) doi: 10.3390/ijms24119138. PMID: 37298088Free PMC Article
DNA methylation profiles after ART during human lifespan: a systematic review and meta-analysis.
Barberet J, Ducreux B, Guilleman M, Simon E, Bruno C, Fauque P
Hum Reprod Update 2022 Aug 25;28(5):629-655. doi: 10.1093/humupd/dmac010. PMID: 35259267
Aberrant DNA methylation and miRNAs in coronary artery diseases and stroke: a systematic review.
Sharma AR, Shashikiran U, Uk AR, Shetty R, Satyamoorthy K, Rai PS
Brief Funct Genomics 2020 Jul 29;19(4):259-285. doi: 10.1093/bfgp/elz043. PMID: 31950130
The diagnostic value of DNA methylation in leukemia: a systematic review and meta-analysis.
Jiang D, Hong Q, Shen Y, Xu Y, Zhu H, Li Y, Xu C, Ouyang G, Duan S
PLoS One 2014;9(5):e96822. Epub 2014 May 8 doi: 10.1371/journal.pone.0096822. PMID: 24810788Free PMC Article

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