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Spinal chordoma

MedGen UID:
347800
•Concept ID:
C1859101
•
Neoplastic Process
Synonym: Vertebral chordoma
 
Monarch Initiative: MONDO:0002894

Definition

A chordoma that arises from the spine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpinal chordoma

Professional guidelines

PubMed

Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Surgical Management of Spinal Chordoma: A Systematic Review and Single-Center Experience.
Baig Mirza A, Bartram J, Okasha M, Al Banna Q, Vastani A, Maratos E, Gullan R, Thomas N
World Neurosurg 2021 Dec;156:e111-e129. Epub 2021 Sep 22 doi: 10.1016/j.wneu.2021.09.001. PMID: 34506978
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article

Recent clinical studies

Etiology

Immunohistochemical markers predicting long-term recurrence following clival and spinal chordoma resection: a multicenter study.
Ghaith AK, Akinduro OO, Alexander AY, Goyal A, Bon-Nieves A, de Macedo Filho L, Otamendi-Lopez A, Nathani KR, Abode-Iyamah K, Jentoft ME, Bendok BR, Clarke MJ, Link MJ, Van Gompel JJ, Quiñones-Hinojosa A, Bydon M
Neurosurg Focus 2023 Jun;54(6):E15. doi: 10.3171/2023.3.FOCUS22653. PMID: 37552641
The mutational landscape of skull base and spinal chordomas and the identification of potential prognostic and theranostic biomarkers.
Passeri T, Gutman T, Hamza A, Adle-Biassette H, Girard E, Beaurepere R, Tariq Z, Mariani O, Dahmani A, Bourneix C, Abbritti R, Driouch K, Bohec M, Servant N, Baulande S, Decaudin D, Guichard JP, Calugaru V, Feuvret L, Guinebretière JM, Champion L, Bièche I, Froelich S, Mammar H, Masliah-Planchon J
J Neurosurg 2023 Nov 1;139(5):1270-1280. Epub 2023 Apr 7 doi: 10.3171/2023.1.JNS222180. PMID: 37029667
Survival and treatment of cranial and spinal chordomas: a population-based study.
Zhang GJ, Cui YS, Li H
Neurosurg Rev 2022 Feb;45(1):637-647. Epub 2021 Jun 22 doi: 10.1007/s10143-021-01583-5. PMID: 34156550
Surgical Management of Spinal Chordoma: A Systematic Review and Single-Center Experience.
Baig Mirza A, Bartram J, Okasha M, Al Banna Q, Vastani A, Maratos E, Gullan R, Thomas N
World Neurosurg 2021 Dec;156:e111-e129. Epub 2021 Sep 22 doi: 10.1016/j.wneu.2021.09.001. PMID: 34506978
Prognostic factors in spinal chordoma: A systematic review.
Zou MX, Huang W, Wang XB, Li J, Lv GH, Deng YW
Clin Neurol Neurosurg 2015 Dec;139:110-8. Epub 2015 Sep 25 doi: 10.1016/j.clineuro.2015.09.012. PMID: 26432656

Diagnosis

Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Immunohistochemical markers predicting long-term recurrence following clival and spinal chordoma resection: a multicenter study.
Ghaith AK, Akinduro OO, Alexander AY, Goyal A, Bon-Nieves A, de Macedo Filho L, Otamendi-Lopez A, Nathani KR, Abode-Iyamah K, Jentoft ME, Bendok BR, Clarke MJ, Link MJ, Van Gompel JJ, Quiñones-Hinojosa A, Bydon M
Neurosurg Focus 2023 Jun;54(6):E15. doi: 10.3171/2023.3.FOCUS22653. PMID: 37552641
Imaging of spinal chordoma and benign notochordal cell tumor (BNCT) with radiologic pathologic correlation.
Murphey MD, Minn MJ, Contreras AL, Koeller KK, Shih RY, Inwards CY, Yamaguchi T
Skeletal Radiol 2023 Mar;52(3):349-363. Epub 2022 Sep 5 doi: 10.1007/s00256-022-04158-7. PMID: 36063190
Survival and treatment of cranial and spinal chordomas: a population-based study.
Zhang GJ, Cui YS, Li H
Neurosurg Rev 2022 Feb;45(1):637-647. Epub 2021 Jun 22 doi: 10.1007/s10143-021-01583-5. PMID: 34156550
Prognostic factors in spinal chordoma: A systematic review.
Zou MX, Huang W, Wang XB, Li J, Lv GH, Deng YW
Clin Neurol Neurosurg 2015 Dec;139:110-8. Epub 2015 Sep 25 doi: 10.1016/j.clineuro.2015.09.012. PMID: 26432656

Therapy

Proton versus photon adjuvant radiotherapy: a multicenter comparative evaluation of recurrence following spinal chordoma resection.
Ghaith AK, Nguyen R, El-Hajj VG, Montaser A, De Biase G, Ravindran K, Perez-Vega C, Lee SJ, Dominari A, Battistin U, Suárez-Meade P, Moussalem C, Patel NP, Kalani MA, Clarke MJ, Rose PS, Bydon M, Abode-Iyamah K, Akinduro OO
Neurosurg Focus 2024 May;56(5):E9. doi: 10.3171/2024.2.FOCUS23927. PMID: 38691864
Immunohistochemical markers predicting long-term recurrence following clival and spinal chordoma resection: a multicenter study.
Ghaith AK, Akinduro OO, Alexander AY, Goyal A, Bon-Nieves A, de Macedo Filho L, Otamendi-Lopez A, Nathani KR, Abode-Iyamah K, Jentoft ME, Bendok BR, Clarke MJ, Link MJ, Van Gompel JJ, Quiñones-Hinojosa A, Bydon M
Neurosurg Focus 2023 Jun;54(6):E15. doi: 10.3171/2023.3.FOCUS22653. PMID: 37552641
Periocular Manifestations of Afatinib Therapy.
Joganathan V, Norris JH
Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e12-e13. doi: 10.1097/IOP.0000000000001277. PMID: 30531213
Long-Term Clinical Safety of High-Dose Proton Radiation Therapy Delivered With Pencil Beam Scanning Technique for Extracranial Chordomas and Chondrosarcomas in Adult Patients: Clinical Evidence of Spinal Cord Tolerance.
Stieb S, Snider JW 3rd, Placidi L, Kliebsch U, Lomax AJ, Schneider RA, Weber DC
Int J Radiat Oncol Biol Phys 2018 Jan 1;100(1):218-225. Epub 2017 Sep 4 doi: 10.1016/j.ijrobp.2017.08.037. PMID: 29029887
Effects of primary and recurrent sacral chordoma on the motor and nociceptive function of hindlimbs in rats: an orthotopic spine model.
Sarabia-Estrada R, Ruiz-Valls A, Shah SR, Ahmed AK, Ordonez AA, Rodriguez FJ, Guerrero-Cazares H, Jimenez-Estrada I, Velarde E, Tyler B, Li Y, Phillips NA, Goodwin CR, Petteys RJ, Jain SK, Gallia GL, Gokaslan ZL, Quinones-Hinojosa A, Sciubba DM
J Neurosurg Spine 2017 Aug;27(2):215-226. Epub 2017 Jun 9 doi: 10.3171/2016.12.SPINE16917. PMID: 28598292

Prognosis

Chordoma: Genetics and Contemporary Management.
Desai R, Pelargos PE, Dunn IF
Int J Mol Sci 2024 May 28;25(11) doi: 10.3390/ijms25115877. PMID: 38892063Free PMC Article
Imaging of spinal chordoma and benign notochordal cell tumor (BNCT) with radiologic pathologic correlation.
Murphey MD, Minn MJ, Contreras AL, Koeller KK, Shih RY, Inwards CY, Yamaguchi T
Skeletal Radiol 2023 Mar;52(3):349-363. Epub 2022 Sep 5 doi: 10.1007/s00256-022-04158-7. PMID: 36063190
Survival and treatment of cranial and spinal chordomas: a population-based study.
Zhang GJ, Cui YS, Li H
Neurosurg Rev 2022 Feb;45(1):637-647. Epub 2021 Jun 22 doi: 10.1007/s10143-021-01583-5. PMID: 34156550
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients.
Zhou J, Sun J, Bai HX, Huang X, Zou Y, Tan X, Zhang Z, Tang X, Tao Y, Xiao B, Zhang PJ, Yang L
Neurosurgery 2017 Nov 1;81(5):812-823. doi: 10.1093/neuros/nyx081. PMID: 28368502
Prognostic factors in spinal chordoma: A systematic review.
Zou MX, Huang W, Wang XB, Li J, Lv GH, Deng YW
Clin Neurol Neurosurg 2015 Dec;139:110-8. Epub 2015 Sep 25 doi: 10.1016/j.clineuro.2015.09.012. PMID: 26432656

Clinical prediction guides

Deep-Learning-Based Model for the Prediction of Cancer-Specific Survival in Patients with Spinal Chordoma.
Cheng D, Liu D, Li X, Zhang Z, Mi Z, Tao W, Fu J, Fan H
World Neurosurg 2023 Oct;178:e835-e845. Epub 2023 Aug 14 doi: 10.1016/j.wneu.2023.08.032. PMID: 37586553
Immunohistochemical markers predicting long-term recurrence following clival and spinal chordoma resection: a multicenter study.
Ghaith AK, Akinduro OO, Alexander AY, Goyal A, Bon-Nieves A, de Macedo Filho L, Otamendi-Lopez A, Nathani KR, Abode-Iyamah K, Jentoft ME, Bendok BR, Clarke MJ, Link MJ, Van Gompel JJ, Quiñones-Hinojosa A, Bydon M
Neurosurg Focus 2023 Jun;54(6):E15. doi: 10.3171/2023.3.FOCUS22653. PMID: 37552641
The mutational landscape of skull base and spinal chordomas and the identification of potential prognostic and theranostic biomarkers.
Passeri T, Gutman T, Hamza A, Adle-Biassette H, Girard E, Beaurepere R, Tariq Z, Mariani O, Dahmani A, Bourneix C, Abbritti R, Driouch K, Bohec M, Servant N, Baulande S, Decaudin D, Guichard JP, Calugaru V, Feuvret L, Guinebretière JM, Champion L, Bièche I, Froelich S, Mammar H, Masliah-Planchon J
J Neurosurg 2023 Nov 1;139(5):1270-1280. Epub 2023 Apr 7 doi: 10.3171/2023.1.JNS222180. PMID: 37029667
Prognostic Factors in Patients With Spinal Chordoma: An Integrative Analysis of 682 Patients.
Zhou J, Sun J, Bai HX, Huang X, Zou Y, Tan X, Zhang Z, Tang X, Tao Y, Xiao B, Zhang PJ, Yang L
Neurosurgery 2017 Nov 1;81(5):812-823. doi: 10.1093/neuros/nyx081. PMID: 28368502
Prognostic factors in spinal chordoma: A systematic review.
Zou MX, Huang W, Wang XB, Li J, Lv GH, Deng YW
Clin Neurol Neurosurg 2015 Dec;139:110-8. Epub 2015 Sep 25 doi: 10.1016/j.clineuro.2015.09.012. PMID: 26432656

Recent systematic reviews

Fractionated radiotherapy after gross-total resection of spinal chordoma: a systematic review of survival outcomes using individualized patient data.
Gendreau JL, Gowda K, Kazemi F, Horowitz M, Shalom M, Kuo CC, Mehkri Y, Yan M, Redmond KJ, Lubelski D, Mukherjee D
J Neurosurg Spine 2024 Sep 1;41(3):428-435. Epub 2024 Jun 7 doi: 10.3171/2024.4.SPINE2491. PMID: 38848586
Surgical Management of Spinal Chordoma: A Systematic Review and Single-Center Experience.
Baig Mirza A, Bartram J, Okasha M, Al Banna Q, Vastani A, Maratos E, Gullan R, Thomas N
World Neurosurg 2021 Dec;156:e111-e129. Epub 2021 Sep 22 doi: 10.1016/j.wneu.2021.09.001. PMID: 34506978
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article
Prognostic factors in spinal chordoma: A systematic review.
Zou MX, Huang W, Wang XB, Li J, Lv GH, Deng YW
Clin Neurol Neurosurg 2015 Dec;139:110-8. Epub 2015 Sep 25 doi: 10.1016/j.clineuro.2015.09.012. PMID: 26432656

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