U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Acrootoocular syndrome

MedGen UID:
337882
Concept ID:
C1849661
Congenital Abnormality; Disease or Syndrome
Synonyms: AOO SYNDROME; Pseudopapilledema, ocular hypotelorism, blepharophimosis, and hand anomalies
SNOMED CT: Acro-oto-ocular syndrome (720410001); Acrootoocular syndrome (720410001); Pseudopapilledema, blepharophimosis and hand anomaly syndrome (720410001); Pseudopapilloedema, blepharophimosis and hand anomaly syndrome (720410001)
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
 
Monarch Initiative: MONDO:0009920
OMIM®: 264475
Orphanet: ORPHA2980

Definition

A very rare disorder associating pseudopapilloedema (optic disc swelling not secondary to increased intracranial pressure) mixed hearing loss, facial dysmorphism and limb extremity anomalies. Only 4 cases have been reported in the literature from 3 inbred sibships. The affected patients have no intellectual deficit. Transmitted as an autosomal recessive trait. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcrootoocular syndrome
Follow this link to review classifications for Acrootoocular syndrome in Orphanet.

Recent clinical studies

Diagnosis

Bertola DR, Wolf LM, Toriello HV, Netzloff ML
Am J Med Genet 1997 Dec 31;73(4):442-6. PMID: 9415472

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...