U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal optic disc morphology

MedGen UID:
1815046
•Concept ID:
C5706140
•
Anatomical Abnormality
Synonym: Abnormality of the optic disc
 
HPO: HP:0012795

Definition

A morphological abnormality of the optic disc, i.e., of the portion of the optic nerve clinically visible on fundoscopic examination. [from HPO]

Professional guidelines

PubMed

Thoughts and Challenges for the Current Treatment of Optic Disc Pit Maculopathy.
Theodossiadis G, Theodossiadis P, Chatziralli I
Semin Ophthalmol 2020 May 18;35(4):232-236. Epub 2020 Aug 18 doi: 10.1080/08820538.2020.1809684. PMID: 32809892
Optic disc pit maculopathy: a review of diagnosis and treatment.
Wan R, Chang A
Clin Exp Optom 2020 Jul;103(4):425-429. Epub 2019 Aug 22 doi: 10.1111/cxo.12957. PMID: 31441129
The swollen optic nerve: an approach to diagnosis and management.
Margolin E
Pract Neurol 2019 Aug;19(4):302-309. Epub 2019 Jun 13 doi: 10.1136/practneurol-2018-002057. PMID: 31196885

Recent clinical studies

Etiology

Optic Nerve Head Abnormalities in Nonpathologic High Myopia and the Relationship With Visual Field.
Jiang J, Song Y, Kong K, Wang P, Lin F, Gao X, Wang Z, Jin L, Chen M, Lam DSC, Weinreb RN, Jonas JB, Ohno-Matsui K, Chen S, Zhang X; Glaucoma Suspects with High Myopia Study Group
Asia Pac J Ophthalmol (Phila) 2023 Sep-Oct 01;12(5):460-467. Epub 2023 Sep 22 doi: 10.1097/APO.0000000000000636. PMID: 37851563
Classification of Visual Field Abnormalities in Highly Myopic Eyes without Pathologic Change.
Lin F, Chen S, Song Y, Li F, Wang W, Zhao Z, Gao X, Wang P, Jin L, Liu Y, Chen M, Liang X, Yang B, Ning G, Cheng CY, Healey PR, Park KH, Zangwill LM, Aung T, Ohno-Matsui K, Jonas JB, Weinreb RN, Zhang X; Glaucoma Suspects with High Myopia Study Group
Ophthalmology 2022 Jul;129(7):803-812. Epub 2022 Mar 12 doi: 10.1016/j.ophtha.2022.03.001. PMID: 35288144Free PMC Article
Superior segmental optic nerve hypoplasia: A review.
Wu JH, Lin CW, Liu CH, Weinreb RN, Welsbie DS
Surv Ophthalmol 2022 Sep-Oct;67(5):1467-1475. Epub 2022 Feb 18 doi: 10.1016/j.survophthal.2022.02.008. PMID: 35189184
Congenital optic nerve anomalies.
Martín-Begué N, Saint-Gerons M
Arch Soc Esp Oftalmol 2016 Dec;91(12):577-588. Epub 2016 Jul 1 doi: 10.1016/j.oftal.2016.05.010. PMID: 27378455
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574

Diagnosis

Topical Review: Optic Disc Pits and Associated Maculopathy.
Anglo M
Optom Vis Sci 2020 Jul;97(7):531-535. doi: 10.1097/OPX.0000000000001536. PMID: 32697561
Optic disc pit maculopathy: a review of diagnosis and treatment.
Wan R, Chang A
Clin Exp Optom 2020 Jul;103(4):425-429. Epub 2019 Aug 22 doi: 10.1111/cxo.12957. PMID: 31441129
Optic Disc Pit Maculopathy: A Review.
Kalogeropoulos D, Ch'ng SW, Lee R, Elaraoud I, Purohit M, Felicida V, Mathew M, Ajith-Kumar N, Sharma A, Mitra A
Asia Pac J Ophthalmol (Phila) 2019 May-Jun;8(3):247-255. doi: 10.22608/APO.2018473. PMID: 31179667
Optic disk pits and optic disk pit maculopathy: A review.
Uzel MM, Karacorlu M
Surv Ophthalmol 2019 Sep-Oct;64(5):595-607. Epub 2019 Feb 22 doi: 10.1016/j.survophthal.2019.02.006. PMID: 30797884
Congenital optic disc anomalies.
Al-Mohtaseb Z, Foroozan R
Int Ophthalmol Clin 2012 Summer;52(3):1-16, xi. doi: 10.1097/IIO.0b013e31825a1166. PMID: 22668536

Therapy

Using ImageJ to evaluate optic disc pallor in traumatic optic neuropathy.
Kang S, Kim US
Korean J Ophthalmol 2014 Apr;28(2):164-9. Epub 2014 Mar 14 doi: 10.3341/kjo.2014.28.2.164. PMID: 24688260Free PMC Article
Drug-induced ocular disorders.
Li J, Tripathi RC, Tripathi BJ
Drug Saf 2008;31(2):127-41. doi: 10.2165/00002018-200831020-00003. PMID: 18217789
Optic disc tuber.
Brodsky MC, Safar AN
Arch Ophthalmol 2007 May;125(5):710-2. doi: 10.1001/archopht.125.5.710. PMID: 17502518
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574
Talc retinopathy.
Tse DT, Ober RR
Am J Ophthalmol 1980 Nov;90(5):624-40. doi: 10.1016/s0002-9394(14)75129-3. PMID: 6160767

Prognosis

Superior segmental optic nerve hypoplasia: A review.
Wu JH, Lin CW, Liu CH, Weinreb RN, Welsbie DS
Surv Ophthalmol 2022 Sep-Oct;67(5):1467-1475. Epub 2022 Feb 18 doi: 10.1016/j.survophthal.2022.02.008. PMID: 35189184
Principles of OCTA and Applications in Clinical Neurology.
Wylęgała A
Curr Neurol Neurosci Rep 2018 Oct 18;18(12):96. doi: 10.1007/s11910-018-0911-x. PMID: 30338429Free PMC Article
Dominant optic atrophy.
Lenaers G, Hamel C, Delettre C, Amati-Bonneau P, Procaccio V, Bonneau D, Reynier P, Milea D
Orphanet J Rare Dis 2012 Jul 9;7:46. doi: 10.1186/1750-1172-7-46. PMID: 22776096Free PMC Article
Tilted optic disks.
Witmer MT, Margo CE, Drucker M
Surv Ophthalmol 2010 Sep-Oct;55(5):403-28. Epub 2010 Jul 10 doi: 10.1016/j.survophthal.2010.01.002. PMID: 20621322
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574

Clinical prediction guides

Optic Nerve Head Abnormalities in Nonpathologic High Myopia and the Relationship With Visual Field.
Jiang J, Song Y, Kong K, Wang P, Lin F, Gao X, Wang Z, Jin L, Chen M, Lam DSC, Weinreb RN, Jonas JB, Ohno-Matsui K, Chen S, Zhang X; Glaucoma Suspects with High Myopia Study Group
Asia Pac J Ophthalmol (Phila) 2023 Sep-Oct 01;12(5):460-467. Epub 2023 Sep 22 doi: 10.1097/APO.0000000000000636. PMID: 37851563
Classification of Visual Field Abnormalities in Highly Myopic Eyes without Pathologic Change.
Lin F, Chen S, Song Y, Li F, Wang W, Zhao Z, Gao X, Wang P, Jin L, Liu Y, Chen M, Liang X, Yang B, Ning G, Cheng CY, Healey PR, Park KH, Zangwill LM, Aung T, Ohno-Matsui K, Jonas JB, Weinreb RN, Zhang X; Glaucoma Suspects with High Myopia Study Group
Ophthalmology 2022 Jul;129(7):803-812. Epub 2022 Mar 12 doi: 10.1016/j.ophtha.2022.03.001. PMID: 35288144Free PMC Article
Superior segmental optic nerve hypoplasia: A review.
Wu JH, Lin CW, Liu CH, Weinreb RN, Welsbie DS
Surv Ophthalmol 2022 Sep-Oct;67(5):1467-1475. Epub 2022 Feb 18 doi: 10.1016/j.survophthal.2022.02.008. PMID: 35189184
Retinal Manifestations of Idiopathic Intracranial Hypertension.
Nichani P, Micieli JA
Ophthalmol Retina 2021 May;5(5):429-437. Epub 2020 Aug 26 doi: 10.1016/j.oret.2020.08.016. PMID: 32860958
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.
Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, Parrish RK 2nd, Wilson MR, Gordon MO
Arch Ophthalmol 2002 Jun;120(6):701-13; discussion 829-30. doi: 10.1001/archopht.120.6.701. PMID: 12049574

Recent systematic reviews

The characteristics of optic disc pit maculopathy and the efficacy of vitrectomy: a systematic review and meta-analysis.
Meng L, Zhao X, Zhang W, Wang D, Chen Y
Acta Ophthalmol 2021 Nov;99(7):e1176-e1189. Epub 2021 Jan 9 doi: 10.1111/aos.14730. PMID: 33421324
Prevalence of Cilioretinal Arteries: A systematic review and a prospective cross-sectional observational study.
Schneider M, Molnar A, Angeli O, Szabo D, Bernath F, Hajdu D, Gombocz E, Mate B, Jiling B, Nagy BV, Nagy ZZ, Peto T, Papp A
Acta Ophthalmol 2021 May;99(3):e310-e318. Epub 2020 Aug 24 doi: 10.1111/aos.14592. PMID: 32833328
Surgical Options and Outcomes in the Treatment of Optic Pit Maculopathy: A Meta-analysis and Systematic Review.
Zheng A, Singh RP, Lavine JA
Ophthalmol Retina 2020 Mar;4(3):289-299. Epub 2019 Nov 21 doi: 10.1016/j.oret.2019.10.011. PMID: 31937471
Choroidal Thickness and Open-Angle Glaucoma: A Meta-Analysis and Systematic Review.
Zhang Z, Yu M, Wang F, Dai Y, Wu Z
J Glaucoma 2016 May;25(5):e446-54. doi: 10.1097/IJG.0000000000000275. PMID: 25943737

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...