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Juvenile type testicular granulosa cell tumor

MedGen UID:
308257
•Concept ID:
C1515285
•
Neoplastic Process
Synonyms: Juvenile Testicular Granulosa Cell Tumor; Juvenile Type Testicular Granulosa Cell Tumor; juvenile type testicular granulosa cell tumor
 
HPO: HP:0034380
Monarch Initiative: MONDO:0003741

Definition

Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVJuvenile type testicular granulosa cell tumor

Professional guidelines

PubMed

DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry.
Schultz KAP, Harris AK, Finch M, Dehner LP, Brown JB, Gershenson DM, Young RH, Field A, Yu W, Turner J, Cost NG, Schneider DT, Stewart DR, Frazier AL, Messinger Y, Hill DA
Gynecol Oncol 2017 Dec;147(3):521-527. Epub 2017 Oct 14 doi: 10.1016/j.ygyno.2017.09.034. PMID: 29037807Free PMC Article

Recent clinical studies

Etiology

Management and outcome of paediatric testicular tumours - A 20 year experience.
O'Shea K, Tong A, Farrelly P, Craigie R, Cheesman E, Shukla R, Losty P
J Pediatr Surg 2021 Nov;56(11):2032-2036. Epub 2021 Mar 5 doi: 10.1016/j.jpedsurg.2021.02.063. PMID: 33789803
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry.
Schultz KAP, Harris AK, Finch M, Dehner LP, Brown JB, Gershenson DM, Young RH, Field A, Yu W, Turner J, Cost NG, Schneider DT, Stewart DR, Frazier AL, Messinger Y, Hill DA
Gynecol Oncol 2017 Dec;147(3):521-527. Epub 2017 Oct 14 doi: 10.1016/j.ygyno.2017.09.034. PMID: 29037807Free PMC Article
Adult-type granulosa cell tumor of the testis: report of a case and review of literature.
Elbachiri M, Taleb A, Derrabi N, Bouchbika Z, Benchakroun N, Jouhadi H, Tawfiq N, Sahraoui S, Benider A
Pan Afr Med J 2017;26:198. Epub 2017 Apr 4 doi: 10.11604/pamj.2017.26.198.11523. PMID: 28674591Free PMC Article
Granulosa cell tumor of testis: clinicopathological correlation of a rare tumor.
Rane SU, Menon S, Desai S, Bakshi G, Joshi A
Indian J Pathol Microbiol 2014 Oct-Dec;57(4):564-73. doi: 10.4103/0377-4929.142665. PMID: 25308008
Prepubertal testicular tumours and efficacy of testicular preserving surgery.
Bujons A, Sfulcini JC, Pascual M, Feu OA, Garat JM, Villavicencio H
BJU Int 2011 Jun;107(11):1812-6. Epub 2010 Oct 29 doi: 10.1111/j.1464-410X.2010.09796.x. PMID: 21040368

Diagnosis

Management and outcome of paediatric testicular tumours - A 20 year experience.
O'Shea K, Tong A, Farrelly P, Craigie R, Cheesman E, Shukla R, Losty P
J Pediatr Surg 2021 Nov;56(11):2032-2036. Epub 2021 Mar 5 doi: 10.1016/j.jpedsurg.2021.02.063. PMID: 33789803
Granulosa cell tumor of testis: clinicopathological correlation of a rare tumor.
Rane SU, Menon S, Desai S, Bakshi G, Joshi A
Indian J Pathol Microbiol 2014 Oct-Dec;57(4):564-73. doi: 10.4103/0377-4929.142665. PMID: 25308008
FOXL2 mutations in granulosa cell tumors occurring in males.
Lima JF, Jin L, de Araujo AR, Erikson-Johnson MR, Oliveira AM, Sebo TJ, Keeney GL, Medeiros F
Arch Pathol Lab Med 2012 Jul;136(7):825-8. doi: 10.5858/arpa.2011-0355-OA. PMID: 22742556
Congenital juvenile granulosa cell tumor of the testis in newborns.
Zugor V, Labanaris AP, Witt J, Seidler A, Weingärtner K, Schott GE
Anticancer Res 2010 May;30(5):1731-4. PMID: 20592370
Juvenile granulosa cell tumor of the testis.
Fagin R, Berbescu E, Landis S, Strumpf K, Patil U
Urology 2003 Aug;62(2):351. doi: 10.1016/s0090-4295(03)00355-8. PMID: 12893354

Therapy

Adult-type granulosa cell tumor of the testis: report of a case and review of literature.
Elbachiri M, Taleb A, Derrabi N, Bouchbika Z, Benchakroun N, Jouhadi H, Tawfiq N, Sahraoui S, Benider A
Pan Afr Med J 2017;26:198. Epub 2017 Apr 4 doi: 10.11604/pamj.2017.26.198.11523. PMID: 28674591Free PMC Article

Prognosis

Adult-type granulosa cell tumor of the testis: report of a case and review of literature.
Elbachiri M, Taleb A, Derrabi N, Bouchbika Z, Benchakroun N, Jouhadi H, Tawfiq N, Sahraoui S, Benider A
Pan Afr Med J 2017;26:198. Epub 2017 Apr 4 doi: 10.11604/pamj.2017.26.198.11523. PMID: 28674591Free PMC Article
Granulosa cell tumor of testis: clinicopathological correlation of a rare tumor.
Rane SU, Menon S, Desai S, Bakshi G, Joshi A
Indian J Pathol Microbiol 2014 Oct-Dec;57(4):564-73. doi: 10.4103/0377-4929.142665. PMID: 25308008
Prepubertal testicular tumours and efficacy of testicular preserving surgery.
Bujons A, Sfulcini JC, Pascual M, Feu OA, Garat JM, Villavicencio H
BJU Int 2011 Jun;107(11):1812-6. Epub 2010 Oct 29 doi: 10.1111/j.1464-410X.2010.09796.x. PMID: 21040368
Congenital juvenile granulosa cell tumor of the testis in newborns.
Zugor V, Labanaris AP, Witt J, Seidler A, Weingärtner K, Schott GE
Anticancer Res 2010 May;30(5):1731-4. PMID: 20592370
Juvenile granulosa cell tumor of the testis.
Fagin R, Berbescu E, Landis S, Strumpf K, Patil U
Urology 2003 Aug;62(2):351. doi: 10.1016/s0090-4295(03)00355-8. PMID: 12893354

Clinical prediction guides

Anti-Müllerian hormone is a specific marker of sertoli- and granulosa-cell origin in gonadal tumors.
Rey R, Sabourin JC, Venara M, Long WQ, Jaubert F, Zeller WP, Duvillard P, Chemes H, Bidart JM
Hum Pathol 2000 Oct;31(10):1202-8. doi: 10.1053/hupa.2000.18498. PMID: 11070112
Use of monoclonal antibody against human inhibin as a marker for sex cord-stromal tumors of the ovary.
Rishi M, Howard LN, Bratthauer GL, Tavassoli FA
Am J Surg Pathol 1997 May;21(5):583-9. doi: 10.1097/00000478-199705000-00012. PMID: 9158684

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