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Low Grade Endometrial Endometrioid Adenocarcinoma

MedGen UID:
1792870
•Concept ID:
C5556429
•
Neoplastic Process
Synonyms: Low Grade Endometrial Endometrioid Carcinoma; Low-Grade Endometrial Endometrioid Adenocarcinoma; Low-Grade Endometrial Endometrioid Carcinoma

Definition

Endometrial endometrioid adenocarcinoma exhibiting 50% or less solid non-glandular, non-squamous growth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Endometrial Endometrioid Adenocarcinoma

Professional guidelines

PubMed

Evolving treatment paradigms in metastatic or recurrent low-grade endometrial cancer: When is hormonal-based therapy the preferred option?
Mahdi H, Ray-Coquard I, Lorusso D, Mirza MR, Monk BJ, Slomovitz B
Int J Gynecol Cancer 2023 Nov 6;33(11):1675-1681. doi: 10.1136/ijgc-2023-004454. PMID: 37640446Free PMC Article
The clinical features and management of Lynch syndrome-associated ovarian cancer.
Ran X, Jing H, Li Z
J Obstet Gynaecol Res 2022 Jul;48(7):1538-1545. Epub 2022 Apr 27 doi: 10.1111/jog.15273. PMID: 35478369
Role of the pathologist in assessing response to treatment of ovarian and endometrial cancers.
Williams AT, Ganesan R
Histopathology 2020 Jan;76(1):93-101. doi: 10.1111/his.13994. PMID: 31846531

Recent clinical studies

Etiology

Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas.
Jamieson A, Vermij L, Kramer CJH, Jobsen JJ, Jürgemlienk-Schulz I, Lutgens L, Mens JW, Haverkort MAD, Slot A, Nout RA, Oosting J, Carlson J, Howitt BE, Ip PPC, Lax SF, McCluggage WG, Singh N, McAlpine JN, Creutzberg CL, Horeweg N, Gilks CB, Bosse T
Clin Cancer Res 2023 Dec 1;29(23):4949-4957. doi: 10.1158/1078-0432.CCR-23-1397. PMID: 37773079Free PMC Article
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
Endometrial Carcinoma Diagnosis: Use of FIGO Grading and Genomic Subcategories in Clinical Practice: Recommendations of the International Society of Gynecological Pathologists.
Soslow RA, Tornos C, Park KJ, Malpica A, Matias-Guiu X, Oliva E, Parkash V, Carlson J, McCluggage WG, Gilks CB
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S64-S74. doi: 10.1097/PGP.0000000000000518. PMID: 30550484Free PMC Article

Diagnosis

Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas.
Jamieson A, Vermij L, Kramer CJH, Jobsen JJ, Jürgemlienk-Schulz I, Lutgens L, Mens JW, Haverkort MAD, Slot A, Nout RA, Oosting J, Carlson J, Howitt BE, Ip PPC, Lax SF, McCluggage WG, Singh N, McAlpine JN, Creutzberg CL, Horeweg N, Gilks CB, Bosse T
Clin Cancer Res 2023 Dec 1;29(23):4949-4957. doi: 10.1158/1078-0432.CCR-23-1397. PMID: 37773079Free PMC Article
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
Endometrial Carcinoma Diagnosis: Use of FIGO Grading and Genomic Subcategories in Clinical Practice: Recommendations of the International Society of Gynecological Pathologists.
Soslow RA, Tornos C, Park KJ, Malpica A, Matias-Guiu X, Oliva E, Parkash V, Carlson J, McCluggage WG, Gilks CB
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S64-S74. doi: 10.1097/PGP.0000000000000518. PMID: 30550484Free PMC Article
High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations.
Murali R, Davidson B, Fadare O, Carlson JA, Crum CP, Gilks CB, Irving JA, Malpica A, Matias-Guiu X, McCluggage WG, Mittal K, Oliva E, Parkash V, Rutgers JKL, Staats PN, Stewart CJR, Tornos C, Soslow RA
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S40-S63. doi: 10.1097/PGP.0000000000000491. PMID: 30550483Free PMC Article
Molecular Genetics of Endometrial Carcinoma.
Bell DW, Ellenson LH
Annu Rev Pathol 2019 Jan 24;14:339-367. Epub 2018 Oct 17 doi: 10.1146/annurev-pathol-020117-043609. PMID: 30332563

Therapy

The promise of combining CDK4/6 inhibition with hormonal therapy in the first-line treatment setting for metastatic or recurrent endometrial adenocarcinoma.
Ray-Coquard I, Monk BJ, Lorusso D, Mahdi H, Upadhyay V, Graul R, Husain A, Mirza MR, Slomovitz B
Int J Gynecol Cancer 2023 Dec 4;33(12):1943-1949. doi: 10.1136/ijgc-2023-004739. PMID: 37907262Free PMC Article
Evolving treatment paradigms in metastatic or recurrent low-grade endometrial cancer: When is hormonal-based therapy the preferred option?
Mahdi H, Ray-Coquard I, Lorusso D, Mirza MR, Monk BJ, Slomovitz B
Int J Gynecol Cancer 2023 Nov 6;33(11):1675-1681. doi: 10.1136/ijgc-2023-004454. PMID: 37640446Free PMC Article
The role of HER2 as a therapeutic biomarker in gynaecological malignancy: potential for use beyond uterine serous carcinoma.
Talia KL, Banet N, Buza N
Pathology 2023 Feb;55(1):8-18. Epub 2022 Nov 23 doi: 10.1016/j.pathol.2022.11.004. PMID: 36503635
The Prediction of Recurrence in Low-Risk Endometrial Cancer: Is It Time for a Paradigm Shift in Adjuvant Therapy?
Laban M, El-Swaify ST, Ali SH, Refaat MA, Sabbour M, Farrag N, Hassanin AS
Reprod Sci 2022 Apr;29(4):1068-1085. Epub 2021 Apr 15 doi: 10.1007/s43032-021-00565-8. PMID: 33856667
Pathology and physiopathology of adenomyosis.
Bergeron C, Amant F, Ferenczy A
Best Pract Res Clin Obstet Gynaecol 2006 Aug;20(4):511-21. Epub 2006 Mar 24 doi: 10.1016/j.bpobgyn.2006.01.016. PMID: 16563870

Prognosis

FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
Int J Gynaecol Obstet 2023 Aug;162(2):383-394. Epub 2023 Jun 20 doi: 10.1002/ijgo.14923. PMID: 37337978
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
Endometrial Carcinoma Diagnosis: Use of FIGO Grading and Genomic Subcategories in Clinical Practice: Recommendations of the International Society of Gynecological Pathologists.
Soslow RA, Tornos C, Park KJ, Malpica A, Matias-Guiu X, Oliva E, Parkash V, Carlson J, McCluggage WG, Gilks CB
Int J Gynecol Pathol 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S64-S74. doi: 10.1097/PGP.0000000000000518. PMID: 30550484Free PMC Article
Molecular Genetics of Endometrial Carcinoma.
Bell DW, Ellenson LH
Annu Rev Pathol 2019 Jan 24;14:339-367. Epub 2018 Oct 17 doi: 10.1146/annurev-pathol-020117-043609. PMID: 30332563

Clinical prediction guides

Clinical Behavior and Molecular Landscape of Stage I p53-Abnormal Low-Grade Endometrioid Endometrial Carcinomas.
Jamieson A, Vermij L, Kramer CJH, Jobsen JJ, Jürgemlienk-Schulz I, Lutgens L, Mens JW, Haverkort MAD, Slot A, Nout RA, Oosting J, Carlson J, Howitt BE, Ip PPC, Lax SF, McCluggage WG, Singh N, McAlpine JN, Creutzberg CL, Horeweg N, Gilks CB, Bosse T
Clin Cancer Res 2023 Dec 1;29(23):4949-4957. doi: 10.1158/1078-0432.CCR-23-1397. PMID: 37773079Free PMC Article
High-grade endometrial carcinomas: Morphologic spectrum and molecular classification.
Zhang C, Zheng W
Semin Diagn Pathol 2022 May;39(3):176-186. Epub 2021 Nov 20 doi: 10.1053/j.semdp.2021.11.002. PMID: 34852949
Atypical Endometrial Hyperplasia, Low-grade: "Much ADO About Nothing".
D'Angelo E, Espinosa I, Cipriani V, Szafranska J, Barbareschi M, Prat J
Am J Surg Pathol 2021 Jul 1;45(7):988-996. doi: 10.1097/PAS.0000000000001705. PMID: 34105519
The Many Uses of p53 Immunohistochemistry in Gynecological Pathology: Proceedings of the ISGyP Companion Society Session at the 2020 USCAP Annual9 Meeting.
Köbel M, Kang EY
Int J Gynecol Pathol 2021 Jan;40(1):32-40. doi: 10.1097/PGP.0000000000000725. PMID: 33290354
Molecular Genetics of Endometrial Carcinoma.
Bell DW, Ellenson LH
Annu Rev Pathol 2019 Jan 24;14:339-367. Epub 2018 Oct 17 doi: 10.1146/annurev-pathol-020117-043609. PMID: 30332563

Recent systematic reviews

Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endometrial cancer: Systematic review and meta-analysis.
Casanova J, Duarte GS, da Costa AG, Catarino A, Nave M, Antunes T, Serra SS, Dias SS, Abu-Rustum N, Lima J
Gynecol Oncol 2024 Mar;182:99-107. Epub 2024 Jan 22 doi: 10.1016/j.ygyno.2024.01.018. PMID: 38262245Free PMC Article
Transvaginal ultrasound versus magnetic resonance imaging for preoperative assessment of myometrial infiltration in patients with low-grade endometrioid endometrial cancer: A systematic review and head-to-head meta-analysis.
Tameish S, Florez N, Vidal JRP, Chen H, Vara J, Alcázar JL
J Clin Ultrasound 2023 Sep;51(7):1188-1197. Epub 2023 Jun 15 doi: 10.1002/jcu.23508. PMID: 37318272
Fertility-Sparing Approach in Patients with Endometrioid Endometrial Cancer Grade 2 Stage IA (FIGO): A Qualitative Systematic Review.
Giampaolino P, Cafasso V, Boccia D, Ascione M, Mercorio A, Viciglione F, Palumbo M, Serafino P, Buonfantino C, De Angelis MC, Verrazzo P, Grasso G, Gullo G, Bifulco G, Della Corte L
Biomed Res Int 2022;2022:4070368. Epub 2022 Sep 27 doi: 10.1155/2022/4070368. PMID: 36203482Free PMC Article
Sentinel lymph node biopsy in high-grade endometrial cancer: a systematic review and meta-analysis of performance characteristics.
Marchocki Z, Cusimano MC, Clarfield L, Kim SR, Fazelzad R, Espin-Garcia O, Bouchard-Fortier G, Rossi EC, Stewart KI, Soliman PT, How JA, Gotlieb WH, Holloway RW, Ianieri MM, Cabrera S, Lim YK, Ferguson SE
Am J Obstet Gynecol 2021 Oct;225(4):367.e1-367.e39. Epub 2021 May 29 doi: 10.1016/j.ajog.2021.05.034. PMID: 34058168
TCGA molecular subgroups and FIGO grade in endometrial endometrioid carcinoma.
Travaglino A, Raffone A, Mollo A, Borrelli G, Alfano P, Zannoni GF, Insabato L, Zullo F
Arch Gynecol Obstet 2020 May;301(5):1117-1125. Epub 2020 Apr 6 doi: 10.1007/s00404-020-05531-4. PMID: 32253551

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