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Mixed Cell Type Gastrointestinal Stromal Tumor

MedGen UID:
277376
•Concept ID:
C1334781
•
Neoplastic Process
Synonym: Mixed Cell Type GIST

Definition

A gastrointestinal stromal tumor composed of a mixture of neoplastic epithelioid and spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed Cell Type Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

Clinicopathological features, risk profile assessment, and the surgical outcome of gastrointestinal stromal tumors in Lagos, Nigeria.
Balogun OS, Osinowo AO, Abdulkareem FB, Ajayi OO, Atoyebi OA, Rocha-Afodu JTD
Ann Afr Med 2022 Oct-Dec;21(4):432-438. doi: 10.4103/aam.aam_172_21. PMID: 36412347Free PMC Article
"Pediatric-type" gastrointestinal stromal tumors in adults: distinctive histology predicts genotype and clinical behavior.
Rege TA, Wagner AJ, Corless CL, Heinrich MC, Hornick JL
Am J Surg Pathol 2011 Apr;35(4):495-504. doi: 10.1097/PAS.0b013e31820e5f7d. PMID: 21358303
Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Recent clinical studies

Etiology

Gastrointestinal Stromal Tumours.
Sunamak O, Gul MO, Subasi IE, Donmez T, Ozkara S
J Coll Physicians Surg Pak 2021 Sep;31(9):1089-1093. doi: 10.29271/jcpsp.2021.09.1089. PMID: 34500527
Clinicopathological characteristics and outcomes of gastrointestinal stromal tumors with high progranulin expression.
Do IG, Jung KU, Koo DH, Lee YG, Oh S, Kim K, Kim DH, Sohn JH, Son BH, Lee SR, Shin JH, Kim HO, Kim H, Chun HK, Serrero G, Yoo CH
PLoS One 2021;16(1):e0245153. Epub 2021 Jan 7 doi: 10.1371/journal.pone.0245153. PMID: 33411849Free PMC Article
Immune Cell Infiltration and the Expression of PD-1 and PD-L1 in Primary PDGFRA-Mutant Gastrointestinal Stromal Tumors.
Sun X, Sun J, Yuan W, Gao X, Fu M, Xue A, Li H, Shu P, Fang Y, Hou Y, Shen K, Sun Y, Qin J, Qin X
J Gastrointest Surg 2021 Aug;25(8):2091-2100. Epub 2020 Nov 9 doi: 10.1007/s11605-020-04860-8. PMID: 33169322
Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis.
Jumniensuk C, Charoenpitakchai M
World J Surg Oncol 2018 Dec 3;16(1):231. doi: 10.1186/s12957-018-1532-1. PMID: 30509310Free PMC Article
Gastrointestinal stromal tumors.
Suster S
Semin Diagn Pathol 1996 Nov;13(4):297-313. PMID: 8946608

Diagnosis

Clinical and Morphological Characteristics of Gastrointestinal Stromal Tumor.
Munteanu A, Patrascu S, Bordu S, Laskou S, Surlin V, Radu P
Chirurgia (Bucur) 2023 Dec;118(6):618-623. doi: 10.21614/chirurgia.2023.v.118.i.6.p.618. PMID: 38228594
Expression of TLE-1 in Gastrointestinal Stromal Tumour and Its Relationship to Clinicopathological Parameters.
Hasbay B, kayaselCuk F
J Coll Physicians Surg Pak 2023 Mar;33(3):286-291. doi: 10.29271/jcpsp.2023.03.286. PMID: 36945158
Gastrointestinal Stromal Tumours.
Sunamak O, Gul MO, Subasi IE, Donmez T, Ozkara S
J Coll Physicians Surg Pak 2021 Sep;31(9):1089-1093. doi: 10.29271/jcpsp.2021.09.1089. PMID: 34500527
Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis.
Jumniensuk C, Charoenpitakchai M
World J Surg Oncol 2018 Dec 3;16(1):231. doi: 10.1186/s12957-018-1532-1. PMID: 30509310Free PMC Article
Clinical and pathological characteristics of gastrointestinal stromal tumor (GIST) metastatic to bone.
Kosemehmetoglu K, Kaygusuz G, Fritchie K, Aydin O, Yapicier O, Coskun O, Karatayli E, Boyacigil S, Guler G, Dervisoglu S, Kuzu I
Virchows Arch 2017 Jul;471(1):77-90. Epub 2017 May 9 doi: 10.1007/s00428-017-2138-7. PMID: 28488171

Therapy

Calcitriol-Mediated Hypercalcemia, Somatostatin Receptors Expression and 25-Hydroxyvitamin D(3)-1α- Hydroxylase in GIST Tumors.
Herrera-Martínez Y, Contreras González MJ, Pedraza-Arévalo S, Guerrero Martínez MDC, Rodrigo Martínez Á, González Menchen A, Blanco Molina MA, Gálvez-Moreno MA, Moreno-Vega AL, Luque RM, Herrera-Martínez AD
Front Endocrinol (Lausanne) 2021;12:812385. Epub 2022 Jan 26 doi: 10.3389/fendo.2021.812385. PMID: 35154010Free PMC Article
Clinicopathological characteristics and outcomes of gastrointestinal stromal tumors with high progranulin expression.
Do IG, Jung KU, Koo DH, Lee YG, Oh S, Kim K, Kim DH, Sohn JH, Son BH, Lee SR, Shin JH, Kim HO, Kim H, Chun HK, Serrero G, Yoo CH
PLoS One 2021;16(1):e0245153. Epub 2021 Jan 7 doi: 10.1371/journal.pone.0245153. PMID: 33411849Free PMC Article
Gastrointestinal stromal tumor after tyrosine kinase inhibition therapy: a review of biopsies of 34 patients with clinically suspected relapse and/or progression of the tumor.
Plank L, Buzalkova V, Szepe P, Lasabova Z, Jasek K, Stanclova A, Minarik G, Sufliarsky J
Neoplasma 2017;64(3):464-473. doi: 10.4149/neo_2017_319. PMID: 28253727
Gastrointestinal stromal tumors: morphological, immunohistochemical and molecular changes associated with kinase inhibitor therapy.
Díaz Delgado M, Hernández Amate A, Pereira Gallardo S, Jaramillo S, Virizuela Echaburu JA, González-Cámpora RJ
Pathol Oncol Res 2011 Sep;17(3):455-61. Epub 2011 Jan 29 doi: 10.1007/s12253-011-9362-2. PMID: 21279555
Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis.
Houk BE, Bello CL, Poland B, Rosen LS, Demetri GD, Motzer RJ
Cancer Chemother Pharmacol 2010 Jul;66(2):357-71. Epub 2009 Dec 5 doi: 10.1007/s00280-009-1170-y. PMID: 19967539

Prognosis

Clinical and Morphological Characteristics of Gastrointestinal Stromal Tumor.
Munteanu A, Patrascu S, Bordu S, Laskou S, Surlin V, Radu P
Chirurgia (Bucur) 2023 Dec;118(6):618-623. doi: 10.21614/chirurgia.2023.v.118.i.6.p.618. PMID: 38228594
Multifocal gastrointestinal stromal tumor with osseous metaplasia: a case report.
Al Saleem MA, Khan NM, ElSharkawy TM
J Med Case Rep 2023 Dec 15;17(1):546. doi: 10.1186/s13256-023-04262-9. PMID: 38098096Free PMC Article
Expression of TLE-1 in Gastrointestinal Stromal Tumour and Its Relationship to Clinicopathological Parameters.
Hasbay B, kayaselCuk F
J Coll Physicians Surg Pak 2023 Mar;33(3):286-291. doi: 10.29271/jcpsp.2023.03.286. PMID: 36945158
Gastrointestinal Stromal Tumours.
Sunamak O, Gul MO, Subasi IE, Donmez T, Ozkara S
J Coll Physicians Surg Pak 2021 Sep;31(9):1089-1093. doi: 10.29271/jcpsp.2021.09.1089. PMID: 34500527
Gastrointestinal stromal tumor: clinicopathological characteristics and pathologic prognostic analysis.
Jumniensuk C, Charoenpitakchai M
World J Surg Oncol 2018 Dec 3;16(1):231. doi: 10.1186/s12957-018-1532-1. PMID: 30509310Free PMC Article

Clinical prediction guides

Expression of TLE-1 in Gastrointestinal Stromal Tumour and Its Relationship to Clinicopathological Parameters.
Hasbay B, kayaselCuk F
J Coll Physicians Surg Pak 2023 Mar;33(3):286-291. doi: 10.29271/jcpsp.2023.03.286. PMID: 36945158
Clinicopathological characteristics and outcomes of gastrointestinal stromal tumors with high progranulin expression.
Do IG, Jung KU, Koo DH, Lee YG, Oh S, Kim K, Kim DH, Sohn JH, Son BH, Lee SR, Shin JH, Kim HO, Kim H, Chun HK, Serrero G, Yoo CH
PLoS One 2021;16(1):e0245153. Epub 2021 Jan 7 doi: 10.1371/journal.pone.0245153. PMID: 33411849Free PMC Article
Immune Cell Infiltration and the Expression of PD-1 and PD-L1 in Primary PDGFRA-Mutant Gastrointestinal Stromal Tumors.
Sun X, Sun J, Yuan W, Gao X, Fu M, Xue A, Li H, Shu P, Fang Y, Hou Y, Shen K, Sun Y, Qin J, Qin X
J Gastrointest Surg 2021 Aug;25(8):2091-2100. Epub 2020 Nov 9 doi: 10.1007/s11605-020-04860-8. PMID: 33169322
The role of DOG1 immunohistochemistry in dermatopathology.
Goto K
J Cutan Pathol 2016 Nov;43(11):974-983. Epub 2016 Sep 5 doi: 10.1111/cup.12787. PMID: 27506854
Gastrointestinal stromal tumors: morphological, immunohistochemical and molecular changes associated with kinase inhibitor therapy.
Díaz Delgado M, Hernández Amate A, Pereira Gallardo S, Jaramillo S, Virizuela Echaburu JA, González-Cámpora RJ
Pathol Oncol Res 2011 Sep;17(3):455-61. Epub 2011 Jan 29 doi: 10.1007/s12253-011-9362-2. PMID: 21279555

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