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Acute Myelomonocytic Leukemia with Abnormal Eosinophils

MedGen UID:
272281
•Concept ID:
C1332156
•
Neoplastic Process
Synonyms: Acute myelomonocytic leukemia with abnormal eosinophils; Acute myelomonocytic leukemia with eosinophils; AMML Eo; FAB M4E; FAB M4Eo
SNOMED CT: Acute myelomonocytic leukemia with eosinophils (103688009); FAB M4E (103688009); Acute myelomonocytic leukemia with abnormal eosinophils (103688009)

Definition

Acute myelomonocytic leukemia characterized by the presence of abnormal bone marrow eosinophils. It is associated with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22). It has a favorable prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Myelomonocytic Leukemia with Abnormal Eosinophils

Recent clinical studies

Etiology

Clinical aspects of acute myeloid leukemias of the FAB types M3 and M4Eo. The AML Cooperative Group.
Haferlach T, Gassmann W, Löffler H, Jürgensen C, Noak J, Ludwig WD, Thiel E, Haase D, Fonatsch C, Becher R
Ann Hematol 1993 Apr;66(4):165-70. doi: 10.1007/BF01703230. PMID: 8485203

Diagnosis

Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up.
Chang ST, Hsieh YC, Lee LP, Tzeng CC, Chuang SS
Chang Gung Med J 2006 Sep-Oct;29(5):532-7. PMID: 17214400
Acute myelomonocytic leukemia with abnormal eosinophils presenting as an ovarian mass: a report of two cases and a review of the literature.
Drinkard LC, Waggoner S, Stein RN, Byrne RA, Larson RA
Gynecol Oncol 1995 Feb;56(2):307-11. doi: 10.1006/gyno.1995.1052. PMID: 7896204
Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv(16).
Russell SJ, Giles FJ, Thompson DS, Scanlon DJ, Walker H, Richards JD
Cancer Genet Cytogenet 1988 Oct 15;35(2):231-5. doi: 10.1016/0165-4608(88)90245-2. PMID: 3180024
Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD
Blood 1986 Dec;68(6):1242-9. PMID: 3465376

Therapy

Clinical aspects of acute myeloid leukemias of the FAB types M3 and M4Eo. The AML Cooperative Group.
Haferlach T, Gassmann W, Löffler H, Jürgensen C, Noak J, Ludwig WD, Thiel E, Haase D, Fonatsch C, Becher R
Ann Hematol 1993 Apr;66(4):165-70. doi: 10.1007/BF01703230. PMID: 8485203
Syndromes of acute nonlymphocytic leukemia.
Koeffler HP
Ann Intern Med 1987 Nov;107(5):748-58. doi: 10.7326/0003-4819-107-5-748. PMID: 3310797

Prognosis

Acute myelomonocytic leukemia with abnormal eosinophils: a case report with multi-modality diagnostic work-up.
Chang ST, Hsieh YC, Lee LP, Tzeng CC, Chuang SS
Chang Gung Med J 2006 Sep-Oct;29(5):532-7. PMID: 17214400
Acute myelomonocytic leukemia with abnormal eosinophils presenting as an ovarian mass: a report of two cases and a review of the literature.
Drinkard LC, Waggoner S, Stein RN, Byrne RA, Larson RA
Gynecol Oncol 1995 Feb;56(2):307-11. doi: 10.1006/gyno.1995.1052. PMID: 7896204
Unbalanced translocation (1;7) and inversion 16 in a patient with acute myelocytic leukemia.
Tasaka T, Nagai M, Bando S, Sayo Y, Murata M, Sasaki K, Ikeda K, Takahara J
Leuk Res 1993 Aug;17(8):699-701. doi: 10.1016/0145-2126(93)90077-x. PMID: 8355514
Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv(16).
Russell SJ, Giles FJ, Thompson DS, Scanlon DJ, Walker H, Richards JD
Cancer Genet Cytogenet 1988 Oct 15;35(2):231-5. doi: 10.1016/0165-4608(88)90245-2. PMID: 3180024
Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD
Blood 1986 Dec;68(6):1242-9. PMID: 3465376

Clinical prediction guides

The abnormal eosinophils are part of the leukemic cell population in acute myelomonocytic leukemia with abnormal eosinophils (AML M4Eo) and carry the pericentric inversion 16: a combination of May-Grünwald-Giemsa staining and fluorescence in situ hybridization.
Haferlach T, Winkemann M, Löffler H, Schoch R, Gassmann W, Fonatsch C, Schoch C, Poetsch M, Weber-Matthiesen K, Schlegelberger B
Blood 1996 Mar 15;87(6):2459-63. PMID: 8630411
Unbalanced translocation (1;7) and inversion 16 in a patient with acute myelocytic leukemia.
Tasaka T, Nagai M, Bando S, Sayo Y, Murata M, Sasaki K, Ikeda K, Takahara J
Leuk Res 1993 Aug;17(8):699-701. doi: 10.1016/0145-2126(93)90077-x. PMID: 8355514
Acute myelomonocytic leukemia with abnormal eosinophils and inv(16) or t(16;16) has a favorable prognosis.
Larson RA, Williams SF, Le Beau MM, Bitter MA, Vardiman JW, Rowley JD
Blood 1986 Dec;68(6):1242-9. PMID: 3465376

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