U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Small Intestinal High Grade Intraepithelial Neoplasia

MedGen UID:
234791
Concept ID:
C1335997
Neoplastic Process
Synonym: Small Intestinal High-Grade Dysplasia

Definition

A precancerous neoplastic process that affects the small intestine. It is characterized by moderate or severe epithelial dysplasia and complex architectural alterations of the mucosal epithelium. There is no evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal High Grade Intraepithelial Neoplasia

Professional guidelines

PubMed

Messmann H, Bisschops R, Antonelli G, Libânio D, Sinonquel P, Abdelrahim M, Ahmad OF, Areia M, Bergman JJGHM, Bhandari P, Boskoski I, Dekker E, Domagk D, Ebigbo A, Eelbode T, Eliakim R, Häfner M, Haidry RJ, Jover R, Kaminski MF, Kuvaev R, Mori Y, Palazzo M, Repici A, Rondonotti E, Rutter MD, Saito Y, Sharma P, Spada C, Spadaccini M, Veitch A, Gralnek IM, Hassan C, Dinis-Ribeiro M
Endoscopy 2022 Dec;54(12):1211-1231. Epub 2022 Oct 21 doi: 10.1055/a-1950-5694. PMID: 36270318
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Desjonqueres E, Campani C, Marra F, Zucman-Rossi J, Nault JC
Liver Int 2022 Mar;42(3):492-506. Epub 2022 Jan 17 doi: 10.1111/liv.15152. PMID: 34982503
Min EK, Hong SS, Kim JS, Choi M, Hwang HS, Kang CM, Lee WJ, Yoon DS, Hwang HK
Ann Surg Oncol 2022 Apr;29(4):2429-2440. Epub 2021 Dec 20 doi: 10.1245/s10434-021-11190-9. PMID: 34931288Free PMC Article
R S J
Front Cell Infect Microbiol 2021;11:649815. Epub 2021 Apr 30 doi: 10.3389/fcimb.2021.649815. PMID: 33996630Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Yamamoto Y, Nemoto T, Okubo Y, Nihonyanagi Y, Ishiwatari T, Takuma K, Tochigi N, Okano N, Wakayama M, Igarashi Y, Shibuya K
Hum Pathol 2014 Sep;45(9):1910-7. Epub 2014 Jun 12 doi: 10.1016/j.humpath.2014.05.013. PMID: 25081540

Diagnosis

Messmann H, Bisschops R, Antonelli G, Libânio D, Sinonquel P, Abdelrahim M, Ahmad OF, Areia M, Bergman JJGHM, Bhandari P, Boskoski I, Dekker E, Domagk D, Ebigbo A, Eelbode T, Eliakim R, Häfner M, Haidry RJ, Jover R, Kaminski MF, Kuvaev R, Mori Y, Palazzo M, Repici A, Rondonotti E, Rutter MD, Saito Y, Sharma P, Spada C, Spadaccini M, Veitch A, Gralnek IM, Hassan C, Dinis-Ribeiro M
Endoscopy 2022 Dec;54(12):1211-1231. Epub 2022 Oct 21 doi: 10.1055/a-1950-5694. PMID: 36270318
Desjonqueres E, Campani C, Marra F, Zucman-Rossi J, Nault JC
Liver Int 2022 Mar;42(3):492-506. Epub 2022 Jan 17 doi: 10.1111/liv.15152. PMID: 34982503
Li S, Wang Z, Cai F, Linghu E, Sun G, Wang X, Meng J, Du H, Yang Y, Li W
Surg Endosc 2019 Feb;33(2):612-619. Epub 2018 Nov 12 doi: 10.1007/s00464-018-6577-2. PMID: 30421083
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Moretó M
Endoscopy 2005 Jan;37(1):26-32. doi: 10.1055/s-2004-826095. PMID: 15657854

Therapy

Hara Y, Goda K, Dobashi A, Ohya TR, Kato M, Sumiyama K, Mitsuishi T, Hirooka S, Ikegami M, Tajiri H
World J Gastroenterol 2019 Feb 14;25(6):707-718. doi: 10.3748/wjg.v25.i6.707. PMID: 30783374Free PMC Article
Li S, Wang Z, Cai F, Linghu E, Sun G, Wang X, Meng J, Du H, Yang Y, Li W
Surg Endosc 2019 Feb;33(2):612-619. Epub 2018 Nov 12 doi: 10.1007/s00464-018-6577-2. PMID: 30421083
Nonaka S, Oda I, Tada K, Mori G, Sato Y, Abe S, Suzuki H, Yoshinaga S, Nakajima T, Matsuda T, Taniguchi H, Saito Y, Maetani I
Endoscopy 2015 Feb;47(2):129-35. Epub 2014 Oct 14 doi: 10.1055/s-0034-1390774. PMID: 25314330
Jeanniard-Malet O, Caillol F, Pesenti C, Bories E, Monges G, Giovannini M
Scand J Gastroenterol 2011 Jul;46(7-8):1014-9. Epub 2011 Apr 15 doi: 10.3109/00365521.2011.571711. PMID: 21492053
Lewis JT, Talwalkar JA, Rosen CB, Smyrk TC, Abraham SC
Am J Surg Pathol 2010 Jan;34(1):27-34. doi: 10.1097/PAS.0b013e3181bc96f9. PMID: 19898228

Prognosis

Krishnamurthy K, Sriganeshan V
Pathol Oncol Res 2020 Jul;26(3):1735-1739. Epub 2019 Oct 22 doi: 10.1007/s12253-019-00754-6. PMID: 31642034
Rokutan H, Abe H, Nakamura H, Ushiku T, Arakawa E, Hosoda F, Yachida S, Tsuji Y, Fujishiro M, Koike K, Totoki Y, Fukayama M, Shibata T
J Pathol 2019 Apr;247(4):494-504. Epub 2019 Jan 16 doi: 10.1002/path.5208. PMID: 30474112
Li S, Wang Z, Cai F, Linghu E, Sun G, Wang X, Meng J, Du H, Yang Y, Li W
Surg Endosc 2019 Feb;33(2):612-619. Epub 2018 Nov 12 doi: 10.1007/s00464-018-6577-2. PMID: 30421083
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Moretó M
Endoscopy 2005 Jan;37(1):26-32. doi: 10.1055/s-2004-826095. PMID: 15657854

Clinical prediction guides

Krishnamurthy K, Sriganeshan V
Pathol Oncol Res 2020 Jul;26(3):1735-1739. Epub 2019 Oct 22 doi: 10.1007/s12253-019-00754-6. PMID: 31642034
Rokutan H, Abe H, Nakamura H, Ushiku T, Arakawa E, Hosoda F, Yachida S, Tsuji Y, Fujishiro M, Koike K, Totoki Y, Fukayama M, Shibata T
J Pathol 2019 Apr;247(4):494-504. Epub 2019 Jan 16 doi: 10.1002/path.5208. PMID: 30474112
Li S, Wang Z, Cai F, Linghu E, Sun G, Wang X, Meng J, Du H, Yang Y, Li W
Surg Endosc 2019 Feb;33(2):612-619. Epub 2018 Nov 12 doi: 10.1007/s00464-018-6577-2. PMID: 30421083
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Moretó M
Endoscopy 2005 Jan;37(1):26-32. doi: 10.1055/s-2004-826095. PMID: 15657854

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...