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Non-Neoplastic Gonadal Disorder

MedGen UID:
233774
•Concept ID:
C1335012
•
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the testis or the ovary. Representative examples include gonadal agenesis, dysgenesis, and hypogonadism. [from NCI]

Professional guidelines

PubMed

Non-invasive Resolution of Pathological Ovarian Masses with Homeopathic Treatment-A Case Series.
Ramanan VE, Radhakrishnan R
Homeopathy 2022 Aug;111(3):194-201. Epub 2021 Dec 27 doi: 10.1055/s-0041-1735849. PMID: 34959245
Ovarian spindle cell lesions: a review with emphasis on recent developments and differential diagnosis.
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430
Management of non-neoplastic ovarian cysts with sclerotherapy.
Kafali H, Yurtseven S, Atmaca F, Ozardali I
Int J Gynaecol Obstet 2003 Apr;81(1):41-5. doi: 10.1016/s0020-7292(02)00401-0. PMID: 12676392

Recent clinical studies

Etiology

What Is the Malignant Potential of Small (<2 cm), Nonpalpable Testicular Incidentalomas in Adults? A Systematic Review.
Bertolotto M, Campo I, Pavan N, Buoite Stella A, Cantisani V, Drudi FM, Cova MA, Derchi LE
Eur Urol Focus 2023 Mar;9(2):361-370. Epub 2022 Oct 17 doi: 10.1016/j.euf.2022.10.001. PMID: 36257887
Gonadoblastoma: origin and outcome.
Roth LM, Cheng L
Hum Pathol 2020 Jun;100:47-53. Epub 2019 Dec 2 doi: 10.1016/j.humpath.2019.11.005. PMID: 31805291
Cytokines in peritoneal fluid of ovarian neoplasms.
de Lima CA, Silva Rodrigues IS, Martins-Filho A, Côbo Micheli D, Martins Tavares-Murta B, Candido Murta EF, Simões Nomelini R
J Obstet Gynaecol 2020 Apr;40(3):401-405. Epub 2019 Sep 3 doi: 10.1080/01443615.2019.1633516. PMID: 31476946
Imaging of non-neoplastic intratesticular masses.
Bhatt S, Jafri SZ, Wasserman N, Dogra VS
Diagn Interv Radiol 2011 Mar;17(1):52-63. Epub 2010 Jun 30 doi: 10.4261/1305-3825.DIR.3116-09.0. PMID: 20677130
Pathology of ovarian cancer precursors.
Scully RE
J Cell Biochem Suppl 1995;23:208-18. doi: 10.1002/jcb.240590928. PMID: 8747398

Diagnosis

Imaging of scrotal masses.
Sharbidre KG, Lockhart ME
Abdom Radiol (NY) 2020 Jul;45(7):2087-2108. doi: 10.1007/s00261-019-02395-4. PMID: 31919649
Imaging Features of Paratesticular Masses.
Secil M, Bertolotto M, Rocher L, Pekindil G, Stocca T, Richenberg J, Ramchandani P, Derchi LE; European Society of Urogenital Radiology Scrotal Imaging Subcommittee
J Ultrasound Med 2017 Jul;36(7):1487-1509. Epub 2017 Apr 3 doi: 10.7863/ultra.16.07015. PMID: 28370138
Inflammation and Nitrosative Stress Effects in Ovarian and Prostate Pathology and Carcinogenesis.
Burke AJ, Garrido P, Johnson C, Sullivan FJ, Glynn SA
Antioxid Redox Signal 2017 Jun 20;26(18):1078-1090. Epub 2017 Mar 22 doi: 10.1089/ars.2017.7004. PMID: 28326819
Pathology of the adnexal mass.
Bennett JA, Oliva E
Clin Obstet Gynecol 2015 Mar;58(1):3-27. doi: 10.1097/GRF.0000000000000082. PMID: 25608250
Paratesticular tumor-like lesions.
Oliva E, Young RH
Semin Diagn Pathol 2000 Nov;17(4):340-58. PMID: 11202549

Therapy

Serum cytokines and CXCR2: potential tumour markers in ovarian neoplasms.
Micheli DC, Jammal MP, Martins-Filho A, Côrtes JRXM, Souza CN, Nomelini RS, Murta EFC, Tavares-Murta BM
Biomarkers 2020 Sep;25(6):474-482. Epub 2020 Jun 28 doi: 10.1080/1354750X.2020.1783574. PMID: 32544350
Inflammation and Nitrosative Stress Effects in Ovarian and Prostate Pathology and Carcinogenesis.
Burke AJ, Garrido P, Johnson C, Sullivan FJ, Glynn SA
Antioxid Redox Signal 2017 Jun 20;26(18):1078-1090. Epub 2017 Mar 22 doi: 10.1089/ars.2017.7004. PMID: 28326819
Ovarian-Sparing Surgery in Pediatric Benign Ovarian Tumors.
Abbas PI, Dietrich JE, Francis JA, Brandt ML, Cass DL, Lopez ME
J Pediatr Adolesc Gynecol 2016 Oct;29(5):506-510. Epub 2016 Apr 11 doi: 10.1016/j.jpag.2016.03.009. PMID: 27079914
Recurrence of ovarian cyst after sclerotherapy.
Kafali H, Eser A, Duvan CI, Keskin E, Onaran YA
Minerva Ginecol 2011 Feb;63(1):19-24. PMID: 21311417
Alcohol and epithelial ovarian cancer.
La Vecchia C, Negri E, Franceschi S, Parazzini F, Gentile A, Fasoli M
J Clin Epidemiol 1992 Sep;45(9):1025-30. doi: 10.1016/0895-4356(92)90119-8. PMID: 1432017

Prognosis

What Is the Malignant Potential of Small (<2 cm), Nonpalpable Testicular Incidentalomas in Adults? A Systematic Review.
Bertolotto M, Campo I, Pavan N, Buoite Stella A, Cantisani V, Drudi FM, Cova MA, Derchi LE
Eur Urol Focus 2023 Mar;9(2):361-370. Epub 2022 Oct 17 doi: 10.1016/j.euf.2022.10.001. PMID: 36257887
The value of contrast-enhanced ultrasonography in the diagnosis of primary testicular non-neoplastic and neoplastic lesions in adults.
Xue N, Zhang S, Wang G
BMC Urol 2022 Dec 22;22(1):210. doi: 10.1186/s12894-022-01163-9. PMID: 36550425Free PMC Article
Initiation and elongation factor co-expression correlates with recurrence and survival in epithelial ovarian cancer.
Sobočan M, Brunialti D, Sprung S, Schatz C, Knez J, Kavalar R, Takač I, Haybaeck J
J Ovarian Res 2022 Jun 19;15(1):73. doi: 10.1186/s13048-022-00998-y. PMID: 35718769Free PMC Article
Use of contrast enhanced ultrasound in testicular diseases: A comprehensive review.
Tenuta M, Sesti F, Bonaventura I, Mazzotta P, Pofi R, Gianfrilli D, Pozza C
Andrology 2021 Sep;9(5):1369-1382. Epub 2021 Jun 11 doi: 10.1111/andr.13057. PMID: 34043256Free PMC Article
Massive ovarian oedema: a misleading clinical entity.
Machairiotis N, Stylianaki A, Kouroutou P, Sarli P, Alexiou NK, Efthymiou E, Maras A, Alexiou NG, Nikolaou SE, Courcoutsakis N, Papakonstantinou E, Zarogoulidis P, Barbetakis N, Paliouras D, Gogakos A, Machairiotis C
Diagn Pathol 2016 Feb 3;11:18. doi: 10.1186/s13000-016-0469-3. PMID: 26843454Free PMC Article

Clinical prediction guides

What Is the Malignant Potential of Small (<2 cm), Nonpalpable Testicular Incidentalomas in Adults? A Systematic Review.
Bertolotto M, Campo I, Pavan N, Buoite Stella A, Cantisani V, Drudi FM, Cova MA, Derchi LE
Eur Urol Focus 2023 Mar;9(2):361-370. Epub 2022 Oct 17 doi: 10.1016/j.euf.2022.10.001. PMID: 36257887
Ultrasonographic diagnosis and surgical outcomes of adnexal masses in children and adolescents.
Kang GG, So KA, Hwang JY, Kim NR, Yang EJ, Shim SH, Lee SJ, Kim TJ
Sci Rep 2022 Mar 10;12(1):3949. doi: 10.1038/s41598-022-08015-4. PMID: 35273292Free PMC Article
Comprehensive Analysis of the Expression and Prognosis for Laminin Genes in Ovarian Cancer.
Diao B, Yang P
Pathol Oncol Res 2021;27:1609855. Epub 2021 Aug 25 doi: 10.3389/pore.2021.1609855. PMID: 34512203Free PMC Article
Use of contrast enhanced ultrasound in testicular diseases: A comprehensive review.
Tenuta M, Sesti F, Bonaventura I, Mazzotta P, Pofi R, Gianfrilli D, Pozza C
Andrology 2021 Sep;9(5):1369-1382. Epub 2021 Jun 11 doi: 10.1111/andr.13057. PMID: 34043256Free PMC Article
Pathology of ovarian cancer precursors.
Scully RE
J Cell Biochem Suppl 1995;23:208-18. doi: 10.1002/jcb.240590928. PMID: 8747398

Recent systematic reviews

What Is the Malignant Potential of Small (<2 cm), Nonpalpable Testicular Incidentalomas in Adults? A Systematic Review.
Bertolotto M, Campo I, Pavan N, Buoite Stella A, Cantisani V, Drudi FM, Cova MA, Derchi LE
Eur Urol Focus 2023 Mar;9(2):361-370. Epub 2022 Oct 17 doi: 10.1016/j.euf.2022.10.001. PMID: 36257887
Dexamethasone suppression test versus selective ovarian and adrenal vein catheterization in identifying virilizing tumors in postmenopausal hyperandrogenism - a systematic review and meta-analysis.
Tng EL, Tan JM
Gynecol Endocrinol 2021 Jul;37(7):600-608. Epub 2021 Mar 4 doi: 10.1080/09513590.2021.1897099. PMID: 33660585
A Systematic Review on the Use of Qualitative and Quantitative Contrast-enhanced Ultrasound in Diagnosing Testicular Abnormalities.
Pinto SPS, Huang DY, Dinesh AA, Sidhu PS, Ahmed K
Urology 2021 Aug;154:16-23. Epub 2021 Feb 20 doi: 10.1016/j.urology.2021.02.012. PMID: 33621585

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