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Breast Papillary Neoplasm

MedGen UID:
233308
•Concept ID:
C1335321
•
Neoplastic Process
Synonyms: Papillary Breast Neoplasm; Papillary Breast Tumor; Papillary Neoplasm of Breast; Papillary Neoplasm of the Breast; Papillary Tumor of Breast; Papillary Tumor of the Breast

Definition

A benign or malignant papillary neoplasm that arises from the breast. It is characterized by the presence of epithelial proliferations that are supported by fibrovascular cores. Representative examples are intraductal papilloma and papillary carcinoma. [from NCI]

Professional guidelines

PubMed

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Indications and Strategy for Active Surveillance of Adult Low-Risk Papillary Thyroid Microcarcinoma: Consensus Statements from the Japan Association of Endocrine Surgery Task Force on Management for Papillary Thyroid Microcarcinoma.
Sugitani I, Ito Y, Takeuchi D, Nakayama H, Masaki C, Shindo H, Teshima M, Horiguchi K, Yoshida Y, Kanai T, Hirokawa M, Hames KY, Tabei I, Miyauchi A
Thyroid 2021 Feb;31(2):183-192. Epub 2020 Nov 2 doi: 10.1089/thy.2020.0330. PMID: 33023426Free PMC Article

Recent clinical studies

Etiology

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Intraductal Papillomas.
Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article

Diagnosis

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Intraductal Papillomas.
Tierney SN
Surg Clin North Am 2022 Dec;102(6):965-972. doi: 10.1016/j.suc.2022.08.011. PMID: 36335931
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Benign Breast Disease in Women.
Stachs A, Stubert J, Reimer T, Hartmann S
Dtsch Arztebl Int 2019 Aug 9;116(33-34):565-574. doi: 10.3238/arztebl.2019.0565. PMID: 31554551Free PMC Article

Therapy

A Phase 2 Study of Encorafenib in Combination with Binimetinib in Patients with Metastatic BRAF-Mutated Thyroid Cancer in Japan.
Tahara M, Kiyota N, Imai H, Takahashi S, Nishiyama A, Tamura S, Shimizu Y, Kadowaki S, Ito KI, Toyoshima M, Hirashima Y, Ueno S, Sugitani I
Thyroid 2024 Apr;34(4):467-476. Epub 2024 Mar 14 doi: 10.1089/thy.2023.0547. PMID: 38343359
Systematic characterization of antibody-drug conjugate targets in central nervous system tumors.
Coy S, Lee JS, Chan SJ, Woo T, Jones J, Alexandrescu S, Wen PY, Sorger PK, Ligon KL, Santagata S
Neuro Oncol 2024 Mar 4;26(3):458-472. doi: 10.1093/neuonc/noad205. PMID: 37870091Free PMC Article
METTL3 inhibition induced by M2 macrophage-derived extracellular vesicles drives anti-PD-1 therapy resistance via M6A-CD70-mediated immune suppression in thyroid cancer.
Ning J, Hou X, Hao J, Zhang W, Shi Y, Huang Y, Ruan X, Zheng X, Gao M
Cell Death Differ 2023 Oct;30(10):2265-2279. Epub 2023 Aug 30 doi: 10.1038/s41418-023-01217-x. PMID: 37648786Free PMC Article
RET fusions in solid tumors.
Li AY, McCusker MG, Russo A, Scilla KA, Gittens A, Arensmeyer K, Mehra R, Adamo V, Rolfo C
Cancer Treat Rev 2019 Dec;81:101911. Epub 2019 Oct 30 doi: 10.1016/j.ctrv.2019.101911. PMID: 31715421
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.
Chang S, Yim S, Park H
Exp Mol Med 2019 Jun 20;51(6):1-17. doi: 10.1038/s12276-019-0230-6. PMID: 31221981Free PMC Article

Prognosis

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
The Spectrum of Mucinous Lesions of the Breast.
Joneja U, Palazzo J
Arch Pathol Lab Med 2023 Jan 1;147(1):19-29. doi: 10.5858/arpa.2022-0054-RA. PMID: 36577093
Clinicopathologic Characteristics and Prognosis of Invasive Papillary Carcinoma of the Breast.
Huang K, Appiah L, Mishra A, Bagaria SP, Gabriel ME, Misra S
J Surg Res 2021 May;261:105-112. Epub 2021 Jan 7 doi: 10.1016/j.jss.2020.12.026. PMID: 33422900
Treatment and Prognosis of Rare Breast Cancers.
Terando AM, Agnese DM, Holmes DR
Ann Surg Oncol 2015 Oct;22(10):3225-9. Epub 2015 Aug 11 doi: 10.1245/s10434-015-4748-0. PMID: 26259751
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000

Clinical prediction guides

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Metastatic Neoplasms Involving the Stomach.
Vyas M, Hissong E, Gonzalez RS, Shia J, Jessurun J
Am J Clin Pathol 2022 Jun 7;157(6):863-873. doi: 10.1093/ajcp/aqab202. PMID: 34875001
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
A direct immunohistochemistry (IHC) method improves the intraoperative diagnosis of breast papillary lesions including breast cancer.
Liu M, Zhao SQ, Yang L, Li X, Song X, Zheng Y, Fan J, Shi H
Discov Med 2019 Jul;28(151):29-37. PMID: 31465723
Diagnostic challenges in papillary lesions of the breast.
Rakha EA, Ellis IO
Pathology 2018 Jan;50(1):100-110. Epub 2017 Nov 26 doi: 10.1016/j.pathol.2017.10.005. PMID: 29179906

Recent systematic reviews

Risk of Malignant Neoplasm in Patients with Primary Hyperparathyroidism: A Systematic Review and Meta-analysis.
Charoenngam N, Rittiphairoj T, Wannaphut C, Pangkanon W, Saowapa S
Calcif Tissue Int 2024 Jul;115(1):1-13. Epub 2024 May 21 doi: 10.1007/s00223-024-01219-y. PMID: 38772934Free PMC Article
The role of lncRNA CERS6-AS1 in cancer and its molecular mechanisms: A systematic review and meta-analysis.
Rastad H, Samimisedeh P, Alan MS, Afshar EJ, Ghalami J, Hashemnejad M, Alan MS
Pathol Res Pract 2023 Jan;241:154245. Epub 2022 Dec 14 doi: 10.1016/j.prp.2022.154245. PMID: 36580796
Endometrial Cancer in Germline BRCA Mutation Carriers: A Systematic Review and Meta-analysis.
Matanes E, Volodarsky-Perel A, Eisenberg N, Rottenstreich M, Yasmeen A, Mitric C, Lau S, Salvador S, Gotlieb WH, Kogan L
J Minim Invasive Gynecol 2021 May;28(5):947-956. Epub 2020 Nov 27 doi: 10.1016/j.jmig.2020.11.023. PMID: 33249269
Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis.
Mao J, Zhang Q, Zhang H, Zheng K, Wang R, Wang G
Front Endocrinol (Lausanne) 2020;11:265. Epub 2020 May 15 doi: 10.3389/fendo.2020.00265. PMID: 32477264Free PMC Article
A systematic review and meta-analysis evaluating completeness and outcomes of robotic thyroidectomy.
Lang BH, Wong CK, Tsang JS, Wong KP, Wan KY
Laryngoscope 2015 Feb;125(2):509-18. Epub 2014 Sep 19 doi: 10.1002/lary.24946. PMID: 25236330

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