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Human Papillomavirus-Related Cervical Squamous Cell Carcinoma

MedGen UID:
232616
•Concept ID:
C1334052
•
Neoplastic Process
Synonyms: HPV-Associated Cervical Squamous Cell Carcinoma; HPV-Related Cervical Squamous Cell Carcinoma; HPVA Cervical Squamous Cell Carcinoma; Human Papilloma Virus Related Cervical Squamous Cell Carcinoma; Human Papilloma Virus-Related Cervical Squamous Cell Carcinoma; Human Papillomavirus-Associated Cervical Squamous Cell Carcinoma

Definition

A cervical squamous cell carcinoma associated with human papillomavirus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHuman Papillomavirus-Related Cervical Squamous Cell Carcinoma

Professional guidelines

PubMed

De-Escalation Treatment for Human Papillomavirus-Related Oropharyngeal Cancer: Questions for Practical Consideration.
Chen AM
Oncology (Williston Park) 2023 Jul 21;37(7):281-287. doi: 10.46883/2023.25921000. PMID: 37499250
Transoral Robotic Surgery and De-escalation of Cancer Treatment.
Wahle B, Zevallos J
Otolaryngol Clin North Am 2020 Dec;53(6):981-994. Epub 2020 Sep 8 doi: 10.1016/j.otc.2020.07.009. PMID: 32917423Free PMC Article
Clinical management of emerging sinonasal malignancies.
Contrera KJ, Woody NM, Rahman M, Sindwani R, Burkey BB
Head Neck 2020 Aug;42(8):2202-2212. Epub 2020 Mar 25 doi: 10.1002/hed.26150. PMID: 32212360

Recent clinical studies

Etiology

Global epidemiologic patterns of oropharyngeal cancer incidence trends.
Zumsteg ZS, Luu M, Rosenberg PS, Elrod JK, Bray F, Vaccarella S, Gay C, Lu DJ, Chen MM, Chaturvedi AK, Goodman MT
J Natl Cancer Inst 2023 Dec 6;115(12):1544-1554. doi: 10.1093/jnci/djad169. PMID: 37603716Free PMC Article
Human papilomaviru-related oropharyngeal squamous cell carcinoma and radiomics: A new era?
Caprini E, D'Agnese G, Brennan PA, Rahimi S
J Oral Pathol Med 2023 Apr;52(4):300-304. Epub 2023 Mar 13 doi: 10.1111/jop.13419. PMID: 36847112
Human papillomavirus-related neoplasia of the ocular adnexa.
Ramberg IMS
Acta Ophthalmol 2022 Oct;100 Suppl 272(Suppl 272):3-33. doi: 10.1111/aos.15244. PMID: 36203222Free PMC Article
Human papillomavirus-related oropharyngeal cancer.
Taberna M, Mena M, Pavón MA, Alemany L, Gillison ML, Mesía R
Ann Oncol 2017 Oct 1;28(10):2386-2398. doi: 10.1093/annonc/mdx304. PMID: 28633362
Human Papillomavirus-Related Head and Neck Cancer.
Wagner S, Sharma SJ, Wuerdemann N, Knuth J, Reder H, Wittekindt C, Klussmann JP
Oncol Res Treat 2017;40(6):334-340. Epub 2017 May 19 doi: 10.1159/000477252. PMID: 28521311

Diagnosis

Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis.
Fonsêca TC, Jural LA, Marañón-Vásquez GA, Magno MB, Roza ALOC, Ferreira DMTP, Maia LC, Romañach MJ, Agostini M, Abrahão AC
Clin Oral Investig 2023 Dec 30;28(1):62. doi: 10.1007/s00784-023-05425-0. PMID: 38158517
Human papilomaviru-related oropharyngeal squamous cell carcinoma and radiomics: A new era?
Caprini E, D'Agnese G, Brennan PA, Rahimi S
J Oral Pathol Med 2023 Apr;52(4):300-304. Epub 2023 Mar 13 doi: 10.1111/jop.13419. PMID: 36847112
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Human papillomavirus-related oropharyngeal cancer.
Taberna M, Mena M, Pavón MA, Alemany L, Gillison ML, Mesía R
Ann Oncol 2017 Oct 1;28(10):2386-2398. doi: 10.1093/annonc/mdx304. PMID: 28633362
Human Papillomavirus-Related Head and Neck Cancer.
Wagner S, Sharma SJ, Wuerdemann N, Knuth J, Reder H, Wittekindt C, Klussmann JP
Oncol Res Treat 2017;40(6):334-340. Epub 2017 May 19 doi: 10.1159/000477252. PMID: 28521311

Therapy

Human papillomavirus-related oropharyngeal carcinoma.
Saito Y, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Yokota T, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R
Jpn J Clin Oncol 2022 Jul 8;52(7):700-706. doi: 10.1093/jjco/hyac049. PMID: 35383359
Palbociclib and cetuximab in cetuximab-resistant human papillomavirus-related oropharynx squamous-cell carcinoma: A multicenter phase 2 trial.
Oppelt P, Ley JC, Worden F, Palka K, Maggiore R, Liu J, Adkins D
Oral Oncol 2021 Mar;114:105164. Epub 2021 Jan 16 doi: 10.1016/j.oraloncology.2020.105164. PMID: 33465681
Radiation Therapy Alone for Human Papillomavirus-Related Squamous Cell Carcinoma of the Oropharynx: A Single-Arm, Phase 2 Study.
Takemoto N, Seo Y, Nakahara S, Yoshioka Y, Teshima T, Fujii T, Isohashi F, Otani K, Yoshii T, Takenaka Y, Suzuki M, Fukusumi T, Hanamoto A, Yasui T, Michiba T, Yamamoto Y, Shimamoto S, Tanaka H, Tatsumi M, Ogawa K, Inohara H
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):403-411. Epub 2020 Dec 26 doi: 10.1016/j.ijrobp.2020.12.025. PMID: 33373656
Surgical Options for Locally Advanced Oropharyngeal Cancer.
Qureshi HA, Abouyared M, Barber B, Houlton JJ
Curr Treat Options Oncol 2019 Apr 1;20(5):36. doi: 10.1007/s11864-019-0621-x. PMID: 30931485
Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis.
O'Rorke MA, Ellison MV, Murray LJ, Moran M, James J, Anderson LA
Oral Oncol 2012 Dec;48(12):1191-201. Epub 2012 Jul 28 doi: 10.1016/j.oraloncology.2012.06.019. PMID: 22841677

Prognosis

Global epidemiologic patterns of oropharyngeal cancer incidence trends.
Zumsteg ZS, Luu M, Rosenberg PS, Elrod JK, Bray F, Vaccarella S, Gay C, Lu DJ, Chen MM, Chaturvedi AK, Goodman MT
J Natl Cancer Inst 2023 Dec 6;115(12):1544-1554. doi: 10.1093/jnci/djad169. PMID: 37603716Free PMC Article
Human papilomaviru-related oropharyngeal squamous cell carcinoma and radiomics: A new era?
Caprini E, D'Agnese G, Brennan PA, Rahimi S
J Oral Pathol Med 2023 Apr;52(4):300-304. Epub 2023 Mar 13 doi: 10.1111/jop.13419. PMID: 36847112
Human papillomavirus-related oropharyngeal carcinoma.
Saito Y, Homma A, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Yokota T, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Tanaka K, Onoe T, Okano S, Imamura Y, Ariizumi Y, Hayashi R
Jpn J Clin Oncol 2022 Jul 8;52(7):700-706. doi: 10.1093/jjco/hyac049. PMID: 35383359
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Human Papillomavirus-Related Head and Neck Cancer.
Wagner S, Sharma SJ, Wuerdemann N, Knuth J, Reder H, Wittekindt C, Klussmann JP
Oncol Res Treat 2017;40(6):334-340. Epub 2017 May 19 doi: 10.1159/000477252. PMID: 28521311

Clinical prediction guides

Global epidemiologic patterns of oropharyngeal cancer incidence trends.
Zumsteg ZS, Luu M, Rosenberg PS, Elrod JK, Bray F, Vaccarella S, Gay C, Lu DJ, Chen MM, Chaturvedi AK, Goodman MT
J Natl Cancer Inst 2023 Dec 6;115(12):1544-1554. doi: 10.1093/jnci/djad169. PMID: 37603716Free PMC Article
Diverse intratumoral heterogeneity and immune microenvironment of two HPV-related cervical cancer types revealed by single-cell RNA sequencing.
Li C, Liu D, Zhao Y, Ding Y, Hua K
J Med Virol 2023 Jun;95(6):e28857. doi: 10.1002/jmv.28857. PMID: 37287196
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Human papillomavirus-related oropharyngeal cancer.
Taberna M, Mena M, Pavón MA, Alemany L, Gillison ML, Mesía R
Ann Oncol 2017 Oct 1;28(10):2386-2398. doi: 10.1093/annonc/mdx304. PMID: 28633362
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342

Recent systematic reviews

Global prevalence of human papillomavirus-related oral and oropharyngeal squamous cell carcinomas: a systematic review and meta-analysis.
Fonsêca TC, Jural LA, Marañón-Vásquez GA, Magno MB, Roza ALOC, Ferreira DMTP, Maia LC, Romañach MJ, Agostini M, Abrahão AC
Clin Oral Investig 2023 Dec 30;28(1):62. doi: 10.1007/s00784-023-05425-0. PMID: 38158517
Distant metastases in human papillomavirus-related oropharyngeal squamous cell carcinoma: Systematic review and meta-analysis.
Crossley JR, Nelson LL, Chou J, Maxwell JH
Head Neck 2023 Jan;45(1):275-282. Epub 2022 Oct 28 doi: 10.1002/hed.27230. PMID: 36306202
Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma-An Even Broader Tumor Entity?
Zupancic M, Näsman A
Viruses 2021 Sep 17;13(9) doi: 10.3390/v13091861. PMID: 34578442Free PMC Article
High-Risk Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma Among Non-Indigenous and Indigenous Populations: A Systematic Review.
Ju X, Canfell K, Smith M, Sethi S, Garvey G, Hedges J, Logan RM, Antonsson A, Jamieson LM
Otolaryngol Head Neck Surg 2021 Jul;165(1):23-32. Epub 2020 Nov 24 doi: 10.1177/0194599820975042. PMID: 33228443
Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis.
O'Rorke MA, Ellison MV, Murray LJ, Moran M, James J, Anderson LA
Oral Oncol 2012 Dec;48(12):1191-201. Epub 2012 Jul 28 doi: 10.1016/j.oraloncology.2012.06.019. PMID: 22841677

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