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Esophageal small cell neuroendocrine carcinoma

MedGen UID:
207270
•Concept ID:
C1112474
•
Neoplastic Process
Synonyms: esophageal Oat cell carcinoma; Esophageal Small Cell Carcinoma; esophageal small cell carcinoma; Esophageal Small Cell NEC; esophageal small cell NEC; Esophageal Small Cell Neuroendocrine Carcinoma; esophageal small cell neuroendocrine carcinoma; esophagus Oat cell carcinoma; Esophagus Small Cell Carcinoma; esophagus small cell carcinoma; Oat cell carcinoma of esophagus; Oat cell carcinoma of oesophagus; Oat cell carcinoma of the esophagus; Oat cell carcinoma of the oesophagus; oesophagus Oat cell carcinoma; oesophagus small cell carcinoma; Small Cell Carcinoma of Esophagus; small cell carcinoma of esophagus; small cell carcinoma of oesophagus; Small Cell Carcinoma of the Esophagus; small cell carcinoma of the esophagus; small cell carcinoma of the oesophagus; Small Cell Carcinoma, Esophagus; small cell carcinoma, esophagus; small cell carcinoma, oesophagus
 
Monarch Initiative: MONDO:0004116

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEsophageal small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Research Progress on Mechanism and Management of Adverse Drug Reactions of Anlotinib.
Li S, Wang H
Drug Des Devel Ther 2023;17:3429-3437. Epub 2023 Nov 15 doi: 10.2147/DDDT.S426898. PMID: 38024530Free PMC Article
Revised ESTS guidelines for preoperative mediastinal lymph node staging for non-small-cell lung cancer.
De Leyn P, Dooms C, Kuzdzal J, Lardinois D, Passlick B, Rami-Porta R, Turna A, Van Schil P, Venuta F, Waller D, Weder W, Zielinski M
Eur J Cardiothorac Surg 2014 May;45(5):787-98. Epub 2014 Feb 26 doi: 10.1093/ejcts/ezu028. PMID: 24578407
Management of esophageal adenocarcinoma.
Tougeron D, Richer JP, Silvain C
J Visc Surg 2011 Jun;148(3):e161-70. Epub 2011 Jun 28 doi: 10.1016/j.jviscsurg.2011.05.008. PMID: 21715236

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Effect of an artificial intelligence-assisted system on endoscopic diagnosis of superficial oesophageal squamous cell carcinoma and precancerous lesions: a multicentre, tandem, double-blind, randomised controlled trial.
Yuan XL, Liu W, Lin YX, Deng QY, Gao YP, Wan L, Zhang B, Zhang T, Zhang WH, Bi XG, Yang GD, Zhu BH, Zhang F, Qin XB, Pan F, Zeng XH, Chaudhry H, Pang MY, Yang J, Zhang JY, Hu B
Lancet Gastroenterol Hepatol 2024 Jan;9(1):34-44. Epub 2023 Nov 10 doi: 10.1016/S2468-1253(23)00276-5. PMID: 37952555
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial.
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer: results of the Japan Clinical Oncology Group Study 9104.
Takada M, Fukuoka M, Kawahara M, Sugiura T, Yokoyama A, Yokota S, Nishiwaki Y, Watanabe K, Noda K, Tamura T, Fukuda H, Saijo N
J Clin Oncol 2002 Jul 15;20(14):3054-60. doi: 10.1200/JCO.2002.12.071. PMID: 12118018
Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide.
Turrisi AT 3rd, Kim K, Blum R, Sause WT, Livingston RB, Komaki R, Wagner H, Aisner S, Johnson DH
N Engl J Med 1999 Jan 28;340(4):265-71. doi: 10.1056/NEJM199901283400403. PMID: 9920950

Diagnosis

Effect of an artificial intelligence-assisted system on endoscopic diagnosis of superficial oesophageal squamous cell carcinoma and precancerous lesions: a multicentre, tandem, double-blind, randomised controlled trial.
Yuan XL, Liu W, Lin YX, Deng QY, Gao YP, Wan L, Zhang B, Zhang T, Zhang WH, Bi XG, Yang GD, Zhu BH, Zhang F, Qin XB, Pan F, Zeng XH, Chaudhry H, Pang MY, Yang J, Zhang JY, Hu B
Lancet Gastroenterol Hepatol 2024 Jan;9(1):34-44. Epub 2023 Nov 10 doi: 10.1016/S2468-1253(23)00276-5. PMID: 37952555
MicroRNAs in esophageal squamous cell carcinoma: Application in prognosis, diagnosis, and drug delivery.
Mohammadi E, Aliarab A, Babaei G, Habibi NK, Jafari SM, Mir SM, Memar MY
Pathol Res Pract 2022 Dec;240:154196. Epub 2022 Nov 2 doi: 10.1016/j.prp.2022.154196. PMID: 36356334
A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study.
Li K, Lin Y, Luo Y, Xiong X, Wang L, Durante K, Li J, Zhou F, Guo Y, Chen S, Chen Y, Zhang D, Yeung SJ, Zhang H
Mol Cancer 2022 Jan 18;21(1):21. doi: 10.1186/s12943-022-01499-8. PMID: 35042519Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Oncologic Quality Indicators in Thoracic Surgery.
Hudson J, Semenkovich T, Puri V
Thorac Surg Clin 2017 Aug;27(3):227-244. doi: 10.1016/j.thorsurg.2017.04.001. PMID: 28647069Free PMC Article

Therapy

Effect of an artificial intelligence-assisted system on endoscopic diagnosis of superficial oesophageal squamous cell carcinoma and precancerous lesions: a multicentre, tandem, double-blind, randomised controlled trial.
Yuan XL, Liu W, Lin YX, Deng QY, Gao YP, Wan L, Zhang B, Zhang T, Zhang WH, Bi XG, Yang GD, Zhu BH, Zhang F, Qin XB, Pan F, Zeng XH, Chaudhry H, Pang MY, Yang J, Zhang JY, Hu B
Lancet Gastroenterol Hepatol 2024 Jan;9(1):34-44. Epub 2023 Nov 10 doi: 10.1016/S2468-1253(23)00276-5. PMID: 37952555
Sintilimab: First Global Approval.
Hoy SM
Drugs 2019 Feb;79(3):341-346. doi: 10.1007/s40265-019-1066-z. PMID: 30742278
Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial.
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Phase III study of concurrent versus sequential thoracic radiotherapy in combination with cisplatin and etoposide for limited-stage small-cell lung cancer: results of the Japan Clinical Oncology Group Study 9104.
Takada M, Fukuoka M, Kawahara M, Sugiura T, Yokoyama A, Yokota S, Nishiwaki Y, Watanabe K, Noda K, Tamura T, Fukuda H, Saijo N
J Clin Oncol 2002 Jul 15;20(14):3054-60. doi: 10.1200/JCO.2002.12.071. PMID: 12118018
Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide.
Turrisi AT 3rd, Kim K, Blum R, Sause WT, Livingston RB, Komaki R, Wagner H, Aisner S, Johnson DH
N Engl J Med 1999 Jan 28;340(4):265-71. doi: 10.1056/NEJM199901283400403. PMID: 9920950

Prognosis

Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes.
Li R, Yang Z, Shao F, Cheng H, Wen Y, Sun S, Guo W, Li Z, Zhang F, Xue L, Bi N, Wang J, Sun Y, Li Y, Tan F, Xue Q, Gao S, Shi S, Gao Y, He J
Nat Commun 2021 Jun 18;12(1):3785. doi: 10.1038/s41467-021-24043-6. PMID: 34145257Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
High-dose versus standard-dose twice-daily thoracic radiotherapy for patients with limited stage small-cell lung cancer: an open-label, randomised, phase 2 trial.
Grønberg BH, Killingberg KT, Fløtten Ø, Brustugun OT, Hornslien K, Madebo T, Langer SW, Schytte T, Nyman J, Risum S, Tsakonas G, Engleson J, Halvorsen TO
Lancet Oncol 2021 Mar;22(3):321-331. doi: 10.1016/S1470-2045(20)30742-7. PMID: 33662285
Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial.
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide.
Turrisi AT 3rd, Kim K, Blum R, Sause WT, Livingston RB, Komaki R, Wagner H, Aisner S, Johnson DH
N Engl J Med 1999 Jan 28;340(4):265-71. doi: 10.1056/NEJM199901283400403. PMID: 9920950

Clinical prediction guides

Effect of an artificial intelligence-assisted system on endoscopic diagnosis of superficial oesophageal squamous cell carcinoma and precancerous lesions: a multicentre, tandem, double-blind, randomised controlled trial.
Yuan XL, Liu W, Lin YX, Deng QY, Gao YP, Wan L, Zhang B, Zhang T, Zhang WH, Bi XG, Yang GD, Zhu BH, Zhang F, Qin XB, Pan F, Zeng XH, Chaudhry H, Pang MY, Yang J, Zhang JY, Hu B
Lancet Gastroenterol Hepatol 2024 Jan;9(1):34-44. Epub 2023 Nov 10 doi: 10.1016/S2468-1253(23)00276-5. PMID: 37952555
Biomarkers for immunotherapy in esophageal cancer.
Wang X, Wang P, Huang X, Han Y, Zhang P
Front Immunol 2023;14:1117523. Epub 2023 May 1 doi: 10.3389/fimmu.2023.1117523. PMID: 37197663Free PMC Article
Clinical Benefit of First-Line Programmed Death-1 Antibody Plus Chemotherapy in Low Programmed Cell Death Ligand 1-Expressing Esophageal Squamous Cell Carcinoma: A Post Hoc Analysis of JUPITER-06 and Meta-Analysis.
Wu HX, Pan YQ, He Y, Wang ZX, Guan WL, Chen YX, Yao YC, Shao NY, Xu RH, Wang F
J Clin Oncol 2023 Mar 20;41(9):1735-1746. Epub 2022 Dec 6 doi: 10.1200/JCO.22.01490. PMID: 36473145Free PMC Article
A signature of saliva-derived exosomal small RNAs as predicting biomarker for esophageal carcinoma: a multicenter prospective study.
Li K, Lin Y, Luo Y, Xiong X, Wang L, Durante K, Li J, Zhou F, Guo Y, Chen S, Chen Y, Zhang D, Yeung SJ, Zhang H
Mol Cancer 2022 Jan 18;21(1):21. doi: 10.1186/s12943-022-01499-8. PMID: 35042519Free PMC Article
Neuroendocrine neoplasms of the esophagus and stomach.
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article

Recent systematic reviews

Radiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Efficacy and safety of particle therapy for inoperable stage II-III non-small cell lung cancer: a systematic review and meta-analysis.
Chen Y, Luo H, Liu R, Tan M, Wang Q, Wu X, Du T, Liu Z, Sun S, Zhang Q, Wang X
Radiat Oncol 2023 May 22;18(1):86. doi: 10.1186/s13014-023-02264-x. PMID: 37217970Free PMC Article
Efficacy and safety of EGFR inhibitors and radiotherapy in locally advanced non-small-cell lung cancer: a meta-analysis.
Li X, Wang F, Jia H, Lian Z, Ren K, Yuan Z, Wang P, Zhao L
Future Oncol 2022 Sep;18(27):3055-3065. Epub 2022 Aug 10 doi: 10.2217/fon-2022-0491. PMID: 35947522
Bevacizumab and wound-healing complications: a systematic review and meta-analysis of randomized controlled trials.
Zhang H, Huang Z, Zou X, Liu T
Oncotarget 2016 Dec 13;7(50):82473-82481. doi: 10.18632/oncotarget.12666. PMID: 27756883Free PMC Article
Thoracic Radiotherapy for Extensive Stage Small-Cell Lung Cancer: A Meta-Analysis.
Palma DA, Warner A, Louie AV, Senan S, Slotman B, Rodrigues GB
Clin Lung Cancer 2016 Jul;17(4):239-44. Epub 2015 Oct 1 doi: 10.1016/j.cllc.2015.09.007. PMID: 26498503

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    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

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