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Thyroid hyperplasia

MedGen UID:
206817
•Concept ID:
C1112776
•
Finding
Synonym: Large thyroid
 
HPO: HP:0008249

Definition

Hyperplasia of the thyroid gland. [from HPO]

Conditions with this feature

Familial hyperthyroidism due to mutations in TSH receptor
MedGen UID:
373154
•Concept ID:
C1836706
•
Disease or Syndrome
A rare hyperthyroidism characterized by mild to severe hyperthyroidism, presence of goiter, absence of features of autoimmunity, frequent relapses while on treatment and a positive family history.
See: Condition Record
Familial hyperthyroidism due to mutations in TSH receptor

Professional guidelines

PubMed

Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma.
Wang CC, Lu DD, Shen MH, Chen RL, Zhang ZH, Lv JH
Diagn Pathol 2023 Nov 11;18(1):123. doi: 10.1186/s13000-023-01410-z. PMID: 37951919Free PMC Article
Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment.
Read ML, Lewy GD, Fong JC, Sharma N, Seed RI, Smith VE, Gentilin E, Warfield A, Eggo MC, Knauf JA, Leadbeater WE, Watkinson JC, Franklyn JA, Boelaert K, McCabe CJ
Cancer Res 2011 Oct 1;71(19):6153-64. Epub 2011 Aug 15 doi: 10.1158/0008-5472.CAN-11-0720. PMID: 21844185Free PMC Article
Propanolol and 131-I in the treatment of diffuse thyroid hyperplasia with hyperthyroidism.
Franco J, Coppler M, Kovaleski B
J Nucl Med 1970 May;11(5):219-20. PMID: 5444005

Recent clinical studies

Etiology

Regional reference values of thyroid gland volume in Turkish Adults.
Şahin E, Elboğa U, Kalender E
Srp Arh Celok Lek 2015 Mar-Apr;143(3-4):141-5. doi: 10.2298/sarh1504141s. PMID: 26012121
Autoimmune thyrotoxicosis: diagnostic challenges.
Ponto KA, Kahaly GJ
Am J Med 2012 Sep;125(9):S1. doi: 10.1016/j.amjmed.2012.05.011. PMID: 22938935
Molecular pathogenesis of nodular goiter.
Paschke R
Langenbecks Arch Surg 2011 Dec;396(8):1127-36. Epub 2011 Apr 14 doi: 10.1007/s00423-011-0788-5. PMID: 21487943
Evaluation of health aspects of kojic acid in food.
Burdock GA, Soni MG, Carabin IG
Regul Toxicol Pharmacol 2001 Feb;33(1):80-101. doi: 10.1006/rtph.2000.1442. PMID: 11259181
Thyroid nodules in Graves disease and the risk of thyroid carcinoma.
Cantalamessa L, Baldini M, Orsatti A, Meroni L, Amodei V, Castagnone D
Arch Intern Med 1999 Aug 9-23;159(15):1705-8. doi: 10.1001/archinte.159.15.1705. PMID: 10448772

Diagnosis

Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma.
Wang CC, Lu DD, Shen MH, Chen RL, Zhang ZH, Lv JH
Diagn Pathol 2023 Nov 11;18(1):123. doi: 10.1186/s13000-023-01410-z. PMID: 37951919Free PMC Article
Stromal modulation and its role in the diagnosis of papillary patterned thyroid lesions.
Daoud SA, Esmail RS, Hareedy AA, Khalil A
Asian Pac J Cancer Prev 2015;16(8):3307-12. doi: 10.7314/apjcp.2015.16.8.3307. PMID: 25921136
Autoimmune thyrotoxicosis: diagnostic challenges.
Ponto KA, Kahaly GJ
Am J Med 2012 Sep;125(9):S1. doi: 10.1016/j.amjmed.2012.05.011. PMID: 22938935
Molecular pathogenesis of euthyroid and toxic multinodular goiter.
Krohn K, Führer D, Bayer Y, Eszlinger M, Brauer V, Neumann S, Paschke R
Endocr Rev 2005 Jun;26(4):504-24. Epub 2004 Dec 22 doi: 10.1210/er.2004-0005. PMID: 15615818
Optimal laboratory testing for diagnosis and monitoring of thyroid nodules, goiter, and thyroid cancer.
Ladenson PW
Clin Chem 1996 Jan;42(1):183-7. PMID: 8565224

Therapy

When is surgical tracheostomy indicated? Surgical "U-shaped" versus percutaneous tracheostomy.
Kilic D, Fındıkcıoglu A, Akin S, Korun O, Aribogan A, Hatiboglu A
Ann Thorac Cardiovasc Surg 2011;17(1):29-32. doi: 10.5761/atcs.oa.09.01477. PMID: 21587125
Complications of ultrasound guided percutaneous ethanol injection therapy of the thyroid and parathyroid glands.
Mauz PS, Stiegler M, Holderried M, Brosch S
Ultraschall Med 2005 Apr;26(2):142-5. doi: 10.1055/s-2005-857867. PMID: 15852178
Distinction between papillary thyroid hyperplasia and papillary thyroid carcinoma by immunohistochemical staining for cytokeratin 19, galectin-3, and HBME-1.
Casey MB, Lohse CM, Lloyd RV
Endocr Pathol 2003 Spring;14(1):55-60. doi: 10.1385/ep:14:1:55. PMID: 12746563
Fetal thyroid hyperplasia, rhesus isoimmunisation, and amniography.
Becroft DM, Smeeton WM, Stewart JH
Arch Dis Child 1980 Mar;55(3):213-7. doi: 10.1136/adc.55.3.213. PMID: 6247979Free PMC Article
Hypothyroidism and thyroid hyperplasia in patients treated with cobalt.
KRISS JP, CARNES WH, GROSS RT
J Am Med Assoc 1955 Jan 8;157(2):117-21. doi: 10.1001/jama.1955.02950190017004. PMID: 13211322

Prognosis

Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma.
Wang CC, Lu DD, Shen MH, Chen RL, Zhang ZH, Lv JH
Diagn Pathol 2023 Nov 11;18(1):123. doi: 10.1186/s13000-023-01410-z. PMID: 37951919Free PMC Article
ACROSCORE: a new and simple tool for the diagnosis of acromegaly, a rare and underdiagnosed disease.
Prencipe N, Floriani I, Guaraldi F, Di Giacomo SV, Cannavo S, Arnaldi G, Berton A, Torri V, Spinello M, Arvat E, Ghigo E, Grottoli S
Clin Endocrinol (Oxf) 2016 Mar;84(3):380-5. Epub 2015 Oct 21 doi: 10.1111/cen.12959. PMID: 26433136
Molecular pathogenesis of nodular goiter.
Paschke R
Langenbecks Arch Surg 2011 Dec;396(8):1127-36. Epub 2011 Apr 14 doi: 10.1007/s00423-011-0788-5. PMID: 21487943
Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA.
Wu KM, Farrelly JG
Am J Ther 2006 Mar-Apr;13(2):141-4. doi: 10.1097/01.mjt.0000209673.01885.b0. PMID: 16645431
Thyroid nodules in Graves disease and the risk of thyroid carcinoma.
Cantalamessa L, Baldini M, Orsatti A, Meroni L, Amodei V, Castagnone D
Arch Intern Med 1999 Aug 9-23;159(15):1705-8. doi: 10.1001/archinte.159.15.1705. PMID: 10448772

Clinical prediction guides

PARAMETERS OF CENTRAL AND INTRACARDIAC HAEMODYNAMICS IN WOMEN WITH THYROID HYPERPLASIA AND ACALCULOUS CHOLECYSTITIS.
Fuchko OL
Pol Merkur Lekarski 2023;51(6):603-607. doi: 10.36740/Merkur202306104. PMID: 38207060
Clinical value of Cyclin D1 and P21 in the differential diagnosis of papillary thyroid carcinoma.
Wang CC, Lu DD, Shen MH, Chen RL, Zhang ZH, Lv JH
Diagn Pathol 2023 Nov 11;18(1):123. doi: 10.1186/s13000-023-01410-z. PMID: 37951919Free PMC Article
ACROSCORE: a new and simple tool for the diagnosis of acromegaly, a rare and underdiagnosed disease.
Prencipe N, Floriani I, Guaraldi F, Di Giacomo SV, Cannavo S, Arnaldi G, Berton A, Torri V, Spinello M, Arvat E, Ghigo E, Grottoli S
Clin Endocrinol (Oxf) 2016 Mar;84(3):380-5. Epub 2015 Oct 21 doi: 10.1111/cen.12959. PMID: 26433136
Fibroblast growth factor receptor-2 expression in thyroid tumor progression: potential diagnostic application.
Redler A, Di Rocco G, Giannotti D, Frezzotti F, Bernieri MG, Ceccarelli S, D'Amici S, Vescarelli E, Mitterhofer AP, Angeloni A, Marchese C
PLoS One 2013;8(8):e72224. Epub 2013 Aug 19 doi: 10.1371/journal.pone.0072224. PMID: 23977259Free PMC Article
Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA.
Wu KM, Farrelly JG
Am J Ther 2006 Mar-Apr;13(2):141-4. doi: 10.1097/01.mjt.0000209673.01885.b0. PMID: 16645431

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