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Pinealoma

MedGen UID:
19315
Concept ID:
C0031941
Neoplastic Process
Synonyms: Neoplasm, Pineal; Neoplasms, Pineal; Pineal Gland Tumor; Pineal Gland Tumors; Pineal Neoplasm; Pineal Neoplasms; Pineal Parenchymal Tumor; Pineal Parenchymal Tumors; Pineal Tumor; Pineal Tumors; Pinealomas; Tumor, Pineal; Tumor, Pineal Gland; Tumor, Pineal Parenchymal; Tumors, Pineal; Tumors, Pineal Gland; Tumors, Pineal Parenchymal
SNOMED CT: Pineal tumor (127026004); Tumor of pineal gland (127026004); Neoplasm of pineal gland (127026004); Pinealoma (359619007)
 
HPO: HP:0010799

Definition

A neoplasm of the pineal gland. [from HPO]

Conditions with this feature

Retinoblastoma
MedGen UID:
20552
Concept ID:
C0035335
Neoplastic Process
Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma develops from cells that have cancer-predisposing variants in both copies of RB1. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is an autosomal dominant susceptibility for retinoblastoma. Individuals with heritable retinoblastoma are also at increased risk of developing non-ocular tumors.

Professional guidelines

PubMed

Bakhshi SK, Mushtaq N, Tariq R, Tariq M, Hafiz A, Gilani A, Aziz HF, Shamim MS, Laghari AA, Siddiqui K, Enam SA; Pakistan Brain Tumour Consortium
J Pak Med Assoc 2024 Mar;74(3 (Supple-3)):S135-S144. doi: 10.47391/JPMA.S3.GNO-16. PMID: 39262074
Tian ZM, Liu ZH, Kang GQ, Zhang Y, Li SY, Chen XH, Chui Y, Feng H
Stereotact Funct Neurosurg 1992;59(1-4):169-73. doi: 10.1159/000098936. PMID: 1295037
Fasano VA, Zeme S, Frego L, Gunetti R
J Neurosurg Sci 1981 Jan-Mar;25(1):35-40. PMID: 7328433

Recent clinical studies

Etiology

Reznicek J, Sharifai N, Jamshidi P, Wadhwani N, Ahrendsen JT
Cytopathology 2024 Sep;35(5):561-571. Epub 2023 Dec 15 doi: 10.1111/cyt.13350. PMID: 38100134
Ogiwara H, Liao YM, Wong TT
Childs Nerv Syst 2023 Oct;39(10):2649-2665. Epub 2023 Oct 13 doi: 10.1007/s00381-023-06081-1. PMID: 37831207
Zaccagna F, Brown FS, Allinson KSJ, Devadass A, Kapadia A, Massoud TF, Matys T
Clin Radiol 2022 Feb;77(2):e107-e119. Epub 2021 Nov 11 doi: 10.1016/j.crad.2021.09.020. PMID: 34774298
Kamihara J, Bourdeaut F, Foulkes WD, Molenaar JJ, Mossé YP, Nakagawara A, Parareda A, Scollon SR, Schneider KW, Skalet AH, States LJ, Walsh MF, Diller LR, Brodeur GM
Clin Cancer Res 2017 Jul 1;23(13):e98-e106. doi: 10.1158/1078-0432.CCR-17-0652. PMID: 28674118Free PMC Article
Dahiya S, Perry A
Adv Anat Pathol 2010 Nov;17(6):419-27. doi: 10.1097/PAP.0b013e3181f895a4. PMID: 20966647

Diagnosis

Reznicek J, Sharifai N, Jamshidi P, Wadhwani N, Ahrendsen JT
Cytopathology 2024 Sep;35(5):561-571. Epub 2023 Dec 15 doi: 10.1111/cyt.13350. PMID: 38100134
Gempt J, Ringel F, Oexle K, Delbridge C, Förschler A, Schlegel J, Meyer B, Schmidt-Graf F
Acta Neurochir (Wien) 2012 Aug;154(8):1413-6. Epub 2012 Jun 15 doi: 10.1007/s00701-012-1402-5. PMID: 22699425
Dahiya S, Perry A
Adv Anat Pathol 2010 Nov;17(6):419-27. doi: 10.1097/PAP.0b013e3181f895a4. PMID: 20966647
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Baumgartner JE, Edwards MS
Neurosurg Clin N Am 1992 Oct;3(4):853-62. PMID: 1392580

Therapy

Rosenberg T, Cooney T
Pediatr Neurosurg 2023;58(5):299-306. Epub 2023 May 26 doi: 10.1159/000531256. PMID: 37245504
Sonabend AM, Bowden S, Bruce JN
J Neurooncol 2016 Nov;130(2):351-366. Epub 2016 May 19 doi: 10.1007/s11060-016-2138-5. PMID: 27193692
Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402
Cuccia V, Rodríguez F, Palma F, Zuccaro G
Childs Nerv Syst 2006 Jun;22(6):577-85. Epub 2006 Mar 23 doi: 10.1007/s00381-006-0095-6. PMID: 16555075
Meadows A
Med Pediatr Oncol 1986;14(6):323-6. doi: 10.1002/mpo.2950140609. PMID: 3784984

Prognosis

Vasiljevic A
Childs Nerv Syst 2023 Sep;39(9):2273-2284. Epub 2022 Aug 16 doi: 10.1007/s00381-022-05637-x. PMID: 35972537
Sonabend AM, Bowden S, Bruce JN
J Neurooncol 2016 Nov;130(2):351-366. Epub 2016 May 19 doi: 10.1007/s11060-016-2138-5. PMID: 27193692
Srinivasan N, Pakala A, Mukkamalla C, Oswal A
South Med J 2010 Oct;103(10):1031-7. doi: 10.1097/SMJ.0b013e3181ebeeff. PMID: 20818311
Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402
Baumgartner JE, Edwards MS
Neurosurg Clin N Am 1992 Oct;3(4):853-62. PMID: 1392580

Clinical prediction guides

Ogiwara H
Childs Nerv Syst 2023 Sep;39(9):2349-2352. Epub 2022 Oct 1 doi: 10.1007/s00381-022-05676-4. PMID: 36181520
Zhu Y, Li Z, Xiong Z, Zhang T, Chen J
Contrast Media Mol Imaging 2022;2022:5702309. Epub 2022 Aug 10 doi: 10.1155/2022/5702309. PMID: 36017015Free PMC Article
Le Reste PJ, Avril T, Quillien V, Morandi X, Chevet E
Brain Res 2016 Jul 1;1642:59-69. Epub 2016 Mar 23 doi: 10.1016/j.brainres.2016.03.015. PMID: 27016056
Sato K, Kubota T
Prog Neurol Surg 2009;23:12-25. Epub 2009 Mar 23 doi: 10.1159/000210050. PMID: 19329858
Blakeley JO, Grossman SA
Curr Treat Options Oncol 2006 Nov;7(6):505-16. doi: 10.1007/s11864-006-0025-6. PMID: 17032562

Recent systematic reviews

Gagliardi F, De Domenico P, Garbin E, Snider S, Mortini P
J Pineal Res 2023 Dec;75(4):e12910. Epub 2023 Sep 13 doi: 10.1111/jpi.12910. PMID: 37705383
Palmisciano P, Ogasawara C, Nwagwu CD, Bin Alamer O, Gupta AD, Giantini-Larsen AM, Scalia G, Yu K, Umana GE, Cohen-Gadol AA, El Ahmadieh TY, Haider AS
World Neurosurg 2022 Mar;159:156-167.e2. Epub 2022 Jan 6 doi: 10.1016/j.wneu.2022.01.005. PMID: 34999267Free PMC Article
Takase H, Tanoshima R, Singla N, Nakamura Y, Yamamoto T
Neurosurg Rev 2022 Apr;45(2):1135-1155. Epub 2021 Oct 20 doi: 10.1007/s10143-021-01674-3. PMID: 34668090
Yamaki VN, Solla DJF, Ribeiro RR, da Silva SA, Teixeira MJ, Figueiredo EG
Neurosurgery 2019 Sep 1;85(3):E420-E429. doi: 10.1093/neuros/nyz062. PMID: 30989225
Clark AJ, Ivan ME, Sughrue ME, Yang I, Aranda D, Han SJ, Kane AJ, Parsa AT
J Neurosurg 2010 Aug;113(2):319-24. doi: 10.3171/2009.12.JNS091683. PMID: 20136388

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