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Abnormal enzyme concentration or activity

MedGen UID:
1841674
Concept ID:
C5826586
Finding
HPO: HP:0034684

Definition

Concentration or activity of an enzyme is above or below the limits of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal enzyme concentration or activity

Professional guidelines

PubMed

Cervantes A, Adam R, Roselló S, Arnold D, Normanno N, Taïeb J, Seligmann J, De Baere T, Osterlund P, Yoshino T, Martinelli E; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Jan;34(1):10-32. Epub 2022 Oct 25 doi: 10.1016/j.annonc.2022.10.003. PMID: 36307056
Succoio M, Sacchettini R, Rossi A, Parenti G, Ruoppolo M
Biomolecules 2022 Jul 11;12(7) doi: 10.3390/biom12070968. PMID: 35883524Free PMC Article
Izquierdo M, Merchant RA, Morley JE, Anker SD, Aprahamian I, Arai H, Aubertin-Leheudre M, Bernabei R, Cadore EL, Cesari M, Chen LK, de Souto Barreto P, Duque G, Ferrucci L, Fielding RA, García-Hermoso A, Gutiérrez-Robledo LM, Harridge SDR, Kirk B, Kritchevsky S, Landi F, Lazarus N, Martin FC, Marzetti E, Pahor M, Ramírez-Vélez R, Rodriguez-Mañas L, Rolland Y, Ruiz JG, Theou O, Villareal DT, Waters DL, Won Won C, Woo J, Vellas B, Fiatarone Singh M
J Nutr Health Aging 2021;25(7):824-853. doi: 10.1007/s12603-021-1665-8. PMID: 34409961

Recent clinical studies

Etiology

Montalant A, Carlsen EMM, Perrier JF
Physiol Rep 2021 Sep;9(18):e15029. doi: 10.14814/phy2.15029. PMID: 34558208Free PMC Article
Billinger SA, Arena R, Bernhardt J, Eng JJ, Franklin BA, Johnson CM, MacKay-Lyons M, Macko RF, Mead GE, Roth EJ, Shaughnessy M, Tang A; American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; Council on Lifestyle and Cardiometabolic Health; Council on Epidemiology and Prevention; Council on Clinical Cardiology
Stroke 2014 Aug;45(8):2532-53. Epub 2014 May 20 doi: 10.1161/STR.0000000000000022. PMID: 24846875
Landry BW, Driscoll SW
PM R 2012 Nov;4(11):826-32. doi: 10.1016/j.pmrj.2012.09.585. PMID: 23174545
Perelle IB, Ehrman L
Behav Genet 2005 May;35(3):343-50. doi: 10.1007/s10519-005-3226-z. PMID: 15864449
Pascual-Leone A, Nguyet D, Cohen LG, Brasil-Neto JP, Cammarota A, Hallett M
J Neurophysiol 1995 Sep;74(3):1037-45. doi: 10.1152/jn.1995.74.3.1037. PMID: 7500130

Diagnosis

Wen W
Conscious Cogn 2019 Aug;73:102759. Epub 2019 Jun 4 doi: 10.1016/j.concog.2019.05.007. PMID: 31173998
Caleo M
Neuroscience 2015 Dec 17;311:180-94. Epub 2015 Oct 19 doi: 10.1016/j.neuroscience.2015.10.029. PMID: 26493858
Wolpert DM
Cold Spring Harb Symp Quant Biol 2014;79:93-8. Epub 2015 Apr 7 doi: 10.1101/sqb.2014.79.024919. PMID: 25851507Free PMC Article
Bennell K, Dobson F, Hinman R
Arthritis Care Res (Hoboken) 2011 Nov;63 Suppl 11:S350-70. doi: 10.1002/acr.20538. PMID: 22588756
Bassuk SS, Manson JE
Nutr Metab Cardiovasc Dis 2010 Jul;20(6):467-73. Epub 2010 Apr 15 doi: 10.1016/j.numecd.2009.12.015. PMID: 20399084

Therapy

Poyatos-León R, García-Hermoso A, Sanabria-Martínez G, Álvarez-Bueno C, Cavero-Redondo I, Martínez-Vizcaíno V
Birth 2017 Sep;44(3):200-208. Epub 2017 Jun 6 doi: 10.1111/birt.12294. PMID: 28589648
French B, Thomas LH, Coupe J, McMahon NE, Connell L, Harrison J, Sutton CJ, Tishkovskaya S, Watkins CL
Cochrane Database Syst Rev 2016 Nov 14;11(11):CD006073. doi: 10.1002/14651858.CD006073.pub3. PMID: 27841442Free PMC Article
Benjamin K, Edwards N, Ploeg J, Legault F
J Aging Phys Act 2014 Jan;22(1):154-65. Epub 2013 Feb 20 doi: 10.1123/japa.2012-0139. PMID: 23434919
Reid G, Bouffard M, MacDonald C
Adapt Phys Activ Q 2012 Apr;29(2):115-31. doi: 10.1123/apaq.29.2.115. PMID: 22467832
Taub E, Uswatte G
J Rehabil Med 2003 May;(41 Suppl):34-40. doi: 10.1080/16501960310010124. PMID: 12817655

Prognosis

McTiernan A, Friedenreich CM, Katzmarzyk PT, Powell KE, Macko R, Buchner D, Pescatello LS, Bloodgood B, Tennant B, Vaux-Bjerke A, George SM, Troiano RP, Piercy KL; 2018 PHYSICAL ACTIVITY GUIDELINES ADVISORY COMMITTEE*
Med Sci Sports Exerc 2019 Jun;51(6):1252-1261. doi: 10.1249/MSS.0000000000001937. PMID: 31095082Free PMC Article
Ford ME, Magwood G, Brown ET, Cannady K, Gregoski M, Knight KD, Peterson LL, Kramer R, Evans-Knowell A, Turner DP
Adv Cancer Res 2017;133:23-50. Epub 2016 Oct 31 doi: 10.1016/bs.acr.2016.08.002. PMID: 28052820Free PMC Article
Biswas A, Oh PI, Faulkner GE, Bajaj RR, Silver MA, Mitchell MS, Alter DA
Ann Intern Med 2015 Jan 20;162(2):123-32. doi: 10.7326/M14-1651. PMID: 25599350
Bloomfield SA
Curr Osteoporos Rep 2010 Jun;8(2):91-7. doi: 10.1007/s11914-010-0013-4. PMID: 20425616
Visovsky C
Cancer Invest 2003 Jun;21(3):439-51. doi: 10.1081/cnv-120018236. PMID: 12901290

Clinical prediction guides

Pires CDS, Marba STM, Caldas JPS, Stopiglia MCS
Rev Paul Pediatr 2020;38:e2018286. Epub 2020 May 8 doi: 10.1590/1984-0462/2020/38/2018286. PMID: 32401947Free PMC Article
Jantunen H, Wasenius N, Salonen MK, Perälä MM, Osmond C, Kautiainen H, Simonen M, Pohjolainen P, Kajantie E, Rantanen T, von Bonsdorff MB, Eriksson JG
Age Ageing 2017 Mar 1;46(2):232-237. doi: 10.1093/ageing/afw194. PMID: 27810849Free PMC Article
Stinear CM, Byblow WD
Curr Opin Neurol 2014 Dec;27(6):624-30. doi: 10.1097/WCO.0000000000000153. PMID: 25364953
Adams RA, Shipp S, Friston KJ
Brain Struct Funct 2013 May;218(3):611-43. Epub 2012 Nov 6 doi: 10.1007/s00429-012-0475-5. PMID: 23129312Free PMC Article
Sainsbury A, Seebass G, Bansal A, Young JB
Age Ageing 2005 May;34(3):228-32. doi: 10.1093/ageing/afi063. PMID: 15863408

Recent systematic reviews

Pojednic R, D'Arpino E, Halliday I, Bantham A
Int J Environ Res Public Health 2022 Apr 20;19(9) doi: 10.3390/ijerph19094981. PMID: 35564376Free PMC Article
French B, Thomas LH, Coupe J, McMahon NE, Connell L, Harrison J, Sutton CJ, Tishkovskaya S, Watkins CL
Cochrane Database Syst Rev 2016 Nov 14;11(11):CD006073. doi: 10.1002/14651858.CD006073.pub3. PMID: 27841442Free PMC Article
Aune D, Norat T, Leitzmann M, Tonstad S, Vatten LJ
Eur J Epidemiol 2015 Jul;30(7):529-42. Epub 2015 Jun 20 doi: 10.1007/s10654-015-0056-z. PMID: 26092138
Young MD, Plotnikoff RC, Collins CE, Callister R, Morgan PJ
Obes Rev 2014 Dec;15(12):983-95. Epub 2014 Oct 7 doi: 10.1111/obr.12225. PMID: 25428600
Teixeira PJ, Carraça EV, Markland D, Silva MN, Ryan RM
Int J Behav Nutr Phys Act 2012 Jun 22;9:78. doi: 10.1186/1479-5868-9-78. PMID: 22726453Free PMC Article

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