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Reduced neutrophil myeloperoxidase activity

MedGen UID:
1053720
•Concept ID:
CN376971
•
Finding
HPO: HP:6000375

Definition

Concentration or activity of myeloperoxidase (EC 1.11.1.7) as measured in neutrophils is below the limits of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced neutrophil myeloperoxidase activity

Conditions with this feature

Myeloperoxidase deficiency
MedGen UID:
96015
•Concept ID:
C0398595
•
Disease or Syndrome
A rare primary immunodeficiency due to a defect in innate immunity characterized by a marked decrease or absence of myeloperoxidase activity in neutrophils and monocytes. Clinically, most patients are asymptomatic. Occasionally, severe infectious complications may occur, particularly recurrent candida infections, being especially severe in the setting of comorbid diabetes mellitus.
See: Condition Record
Myeloperoxidase deficiency

Professional guidelines

PubMed

Systematic literature review informing the 2022 update of the EULAR recommendations for the management of ANCA-associated vasculitis (AAV): Part 2 - Treatment of eosinophilic granulomatosis with polyangiitis and diagnosis and general management of AAV.
Sanchez-Alamo B, Schirmer JH, Hellmich B, Jayne D, Monti S, Tomasson G, Luqmani RA
RMD Open 2023 Jun;9(2) doi: 10.1136/rmdopen-2023-003083. PMID: 37349121Free PMC Article
Antineutrophil cytoplasmic antibody (ANCA) vasculitis: pathophysiology, diagnosis, and the evolving treatment landscape.
Koening CL, von Hennigs I
Am J Manag Care 2021 Sep;27(15 Suppl):S267-S276. doi: 10.37765/ajmc.2021.88746. PMID: 34473462
New strategies for treatment of infectious sepsis.
Ward PA, Fattahi F
J Leukoc Biol 2019 Jul;106(1):187-192. Epub 2019 Mar 1 doi: 10.1002/JLB.4MIR1118-425R. PMID: 30821872

Recent clinical studies

Etiology

Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.
Chen F, Chu C, Wang X, Yang C, Deng Y, Duan Z, Wang K, Liu B, Ji W, Ding W
Food Funct 2023 May 11;14(9):4213-4227. doi: 10.1039/d2fo02707k. PMID: 37067254
Recombinant Myeloperoxidase as a New Class of Antimicrobial Agents.
Cao Z, Cheng G
Microbiol Spectr 2022 Feb 23;10(1):e0052221. Epub 2022 Jan 12 doi: 10.1128/spectrum.00522-21. PMID: 35019674Free PMC Article
Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.
Sarr D, Oliveira LJ, Russ BN, Owino SO, Middii JD, Mwalimu S, Ambasa L, Almutairi F, Vulule J, Rada B, Moore JM
Front Immunol 2021;12:682668. Epub 2021 Oct 19 doi: 10.3389/fimmu.2021.682668. PMID: 34737733Free PMC Article
NETosis as a Pathogenic Factor for Heart Failure.
Ling S, Xu JW
Oxid Med Cell Longev 2021;2021:6687096. Epub 2021 Feb 23 doi: 10.1155/2021/6687096. PMID: 33680285Free PMC Article
Myeloperoxidase - A bridge linking inflammation and oxidative stress with cardiovascular disease.
Ndrepepa G
Clin Chim Acta 2019 Jun;493:36-51. Epub 2019 Feb 21 doi: 10.1016/j.cca.2019.02.022. PMID: 30797769

Diagnosis

Inhibition of myeloperoxidase to treat left ventricular dysfunction in non-ischaemic cardiomyopathy.
Geissen S, Braumann S, Adler J, Nettersheim FS, Mehrkens D, Hof A, Guthoff H, von Stein P, Witkowski S, Gerdes N, Tellkamp F, Krüger M, Isermann L, Trifunovic A, Bunck AC, Mollenhauer M, Winkels H, Adam M, Klinke A, Buch G, Ten Cate V, Hellmich M, Kelm M, Rudolph V, Wild PS, Rosenkranz S, Baldus S
Eur J Heart Fail 2024 Oct;26(10):2269-2281. Epub 2024 Aug 30 doi: 10.1002/ejhf.3435. PMID: 39212229
Systematic literature review informing the 2022 update of the EULAR recommendations for the management of ANCA-associated vasculitis (AAV): Part 2 - Treatment of eosinophilic granulomatosis with polyangiitis and diagnosis and general management of AAV.
Sanchez-Alamo B, Schirmer JH, Hellmich B, Jayne D, Monti S, Tomasson G, Luqmani RA
RMD Open 2023 Jun;9(2) doi: 10.1136/rmdopen-2023-003083. PMID: 37349121Free PMC Article
NETosis induction reflects COVID-19 severity and long COVID: insights from a 2-center patient cohort study in Israel.
Krinsky N, Sizikov S, Nissim S, Dror A, Sas A, Prinz H, Pri-Or E, Perek S, Raz-Pasteur A, Lejbkowicz I, Cohen-Matsliah SI, Almog R, Chen N, Kurd R, Jarjou'i A, Rokach A, Ben-Chetrit E, Schroeder A, Caulin AF, Yost CC, Schiffman JD, Goldfeder M, Martinod K
J Thromb Haemost 2023 Sep;21(9):2569-2584. Epub 2023 Apr 11 doi: 10.1016/j.jtha.2023.02.033. PMID: 37054916Free PMC Article
Neutrophil degranulation and myocardial infarction.
Zhang N, Aiyasiding X, Li WJ, Liao HH, Tang QZ
Cell Commun Signal 2022 Apr 11;20(1):50. doi: 10.1186/s12964-022-00824-4. PMID: 35410418Free PMC Article
Neutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma.
Varricchi G, Modestino L, Poto R, Cristinziano L, Gentile L, Postiglione L, Spadaro G, Galdiero MR
Clin Exp Med 2022 May;22(2):285-300. Epub 2021 Aug 3 doi: 10.1007/s10238-021-00750-8. PMID: 34342773Free PMC Article

Therapy

Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF.
Michaëlsson E, Lund LH, Hage C, Shah SJ, Voors AA, Saraste A, Redfors B, Grove EL, Barasa A, Richards AM, Svedlund S, Lagerström-Fermér M, Gabrielsen A, Garkaviy P, Gan LM, Lam CSP
JACC Heart Fail 2023 Jul;11(7):775-787. Epub 2023 May 3 doi: 10.1016/j.jchf.2023.03.002. PMID: 37140510
Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.
Chen F, Chu C, Wang X, Yang C, Deng Y, Duan Z, Wang K, Liu B, Ji W, Ding W
Food Funct 2023 May 11;14(9):4213-4227. doi: 10.1039/d2fo02707k. PMID: 37067254
Probiotics (Lactobacillus plantarum HNU082) Supplementation Relieves Ulcerative Colitis by Affecting Intestinal Barrier Functions, Immunity-Related Gene Expression, Gut Microbiota, and Metabolic Pathways in Mice.
Wu Y, Jha R, Li A, Liu H, Zhang Z, Zhang C, Zhai Q, Zhang J
Microbiol Spectr 2022 Dec 21;10(6):e0165122. Epub 2022 Nov 2 doi: 10.1128/spectrum.01651-22. PMID: 36321893Free PMC Article
Recombinant Myeloperoxidase as a New Class of Antimicrobial Agents.
Cao Z, Cheng G
Microbiol Spectr 2022 Feb 23;10(1):e0052221. Epub 2022 Jan 12 doi: 10.1128/spectrum.00522-21. PMID: 35019674Free PMC Article
Myeloperoxidase and Other Markers of Neutrophil Activation Associate With Malaria and Malaria/HIV Coinfection in the Human Placenta.
Sarr D, Oliveira LJ, Russ BN, Owino SO, Middii JD, Mwalimu S, Ambasa L, Almutairi F, Vulule J, Rada B, Moore JM
Front Immunol 2021;12:682668. Epub 2021 Oct 19 doi: 10.3389/fimmu.2021.682668. PMID: 34737733Free PMC Article

Prognosis

The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis.
Gutierrez V, Kim-Vasquez D, Shum M, Yang Q, Dikeman D, Louie SG, Shirihai OS, Tsukamoto H, Liesa M
Redox Biol 2024 Apr;70:103052. Epub 2024 Jan 24 doi: 10.1016/j.redox.2024.103052. PMID: 38290384Free PMC Article
Systematic literature review informing the 2022 update of the EULAR recommendations for the management of ANCA-associated vasculitis (AAV): Part 2 - Treatment of eosinophilic granulomatosis with polyangiitis and diagnosis and general management of AAV.
Sanchez-Alamo B, Schirmer JH, Hellmich B, Jayne D, Monti S, Tomasson G, Luqmani RA
RMD Open 2023 Jun;9(2) doi: 10.1136/rmdopen-2023-003083. PMID: 37349121Free PMC Article
Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF.
Michaëlsson E, Lund LH, Hage C, Shah SJ, Voors AA, Saraste A, Redfors B, Grove EL, Barasa A, Richards AM, Svedlund S, Lagerström-Fermér M, Gabrielsen A, Garkaviy P, Gan LM, Lam CSP
JACC Heart Fail 2023 Jul;11(7):775-787. Epub 2023 May 3 doi: 10.1016/j.jchf.2023.03.002. PMID: 37140510
Neutrophil degranulation and myocardial infarction.
Zhang N, Aiyasiding X, Li WJ, Liao HH, Tang QZ
Cell Commun Signal 2022 Apr 11;20(1):50. doi: 10.1186/s12964-022-00824-4. PMID: 35410418Free PMC Article
Myeloperoxidase - A bridge linking inflammation and oxidative stress with cardiovascular disease.
Ndrepepa G
Clin Chim Acta 2019 Jun;493:36-51. Epub 2019 Feb 21 doi: 10.1016/j.cca.2019.02.022. PMID: 30797769

Clinical prediction guides

The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis.
Gutierrez V, Kim-Vasquez D, Shum M, Yang Q, Dikeman D, Louie SG, Shirihai OS, Tsukamoto H, Liesa M
Redox Biol 2024 Apr;70:103052. Epub 2024 Jan 24 doi: 10.1016/j.redox.2024.103052. PMID: 38290384Free PMC Article
Myeloperoxidase Inhibition Reverses Biomarker Profiles Associated With Clinical Outcomes in HFpEF.
Michaëlsson E, Lund LH, Hage C, Shah SJ, Voors AA, Saraste A, Redfors B, Grove EL, Barasa A, Richards AM, Svedlund S, Lagerström-Fermér M, Gabrielsen A, Garkaviy P, Gan LM, Lam CSP
JACC Heart Fail 2023 Jul;11(7):775-787. Epub 2023 May 3 doi: 10.1016/j.jchf.2023.03.002. PMID: 37140510
Probiotics (Lactobacillus plantarum HNU082) Supplementation Relieves Ulcerative Colitis by Affecting Intestinal Barrier Functions, Immunity-Related Gene Expression, Gut Microbiota, and Metabolic Pathways in Mice.
Wu Y, Jha R, Li A, Liu H, Zhang Z, Zhang C, Zhai Q, Zhang J
Microbiol Spectr 2022 Dec 21;10(6):e0165122. Epub 2022 Nov 2 doi: 10.1128/spectrum.01651-22. PMID: 36321893Free PMC Article
Neutrophil degranulation and myocardial infarction.
Zhang N, Aiyasiding X, Li WJ, Liao HH, Tang QZ
Cell Commun Signal 2022 Apr 11;20(1):50. doi: 10.1186/s12964-022-00824-4. PMID: 35410418Free PMC Article
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease.
Lood C, Blanco LP, Purmalek MM, Carmona-Rivera C, De Ravin SS, Smith CK, Malech HL, Ledbetter JA, Elkon KB, Kaplan MJ
Nat Med 2016 Feb;22(2):146-53. Epub 2016 Jan 18 doi: 10.1038/nm.4027. PMID: 26779811Free PMC Article

Recent systematic reviews

Molecular and functional changes in neutrophilic granulocytes induced by nicotine: a systematic review and critical evaluation.
Brembach TC, Sabat R, Witte K, Schwerdtle T, Wolk K
Front Immunol 2023;14:1281685. Epub 2023 Nov 23 doi: 10.3389/fimmu.2023.1281685. PMID: 38077313Free PMC Article
Systematic literature review informing the 2022 update of the EULAR recommendations for the management of ANCA-associated vasculitis (AAV): Part 2 - Treatment of eosinophilic granulomatosis with polyangiitis and diagnosis and general management of AAV.
Sanchez-Alamo B, Schirmer JH, Hellmich B, Jayne D, Monti S, Tomasson G, Luqmani RA
RMD Open 2023 Jun;9(2) doi: 10.1136/rmdopen-2023-003083. PMID: 37349121Free PMC Article
Ischaemic preconditioning for liver transplantation.
Gurusamy KS, Kumar Y, Sharma D, Davidson BR
Cochrane Database Syst Rev 2008 Jan 23;2008(1):CD006315. doi: 10.1002/14651858.CD006315.pub2. PMID: 18254099Free PMC Article

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