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Conventional Chordoma

MedGen UID:
1791577
Concept ID:
C5555136
Neoplastic Process

Definition

A malignant bone tumor arising from the remnants of the fetal notochord. It is characterized by the presence of large epithelioid cells with clear to light eosinophilic cytoplasm. Some of the cells are large with bubbly, vacuolated cytoplasm (physaliphorous cells). The cells form cords and nests that are embedded within an extracellular myxoid matrix. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Nachwalter RN, Rothrock RJ, Katsoulakis E, Gounder MM, Boland PJ, Bilsky MH, Laufer I, Schmitt AM, Yamada Y, Higginson DS
J Neurooncol 2019 Sep;144(2):369-376. Epub 2019 Jul 23 doi: 10.1007/s11060-019-03239-3. PMID: 31338785Free PMC Article
Colia V, Stacchiotti S
Eur J Cancer 2017 Sep;83:220-228. Epub 2017 Jul 25 doi: 10.1016/j.ejca.2017.06.038. PMID: 28750274

Recent clinical studies

Etiology

Park M, Park I, Hong CK, Kim SH, Cha YJ
Sci Rep 2022 Oct 3;12(1):16504. doi: 10.1038/s41598-022-20787-3. PMID: 36192442Free PMC Article
Lin K, Song K, Wang S, Jiang L, Wang H, Dong J
Clin Neurol Neurosurg 2020 Oct;197:106174. Epub 2020 Aug 22 doi: 10.1016/j.clineuro.2020.106174. PMID: 32889324
Nachwalter RN, Rothrock RJ, Katsoulakis E, Gounder MM, Boland PJ, Bilsky MH, Laufer I, Schmitt AM, Yamada Y, Higginson DS
J Neurooncol 2019 Sep;144(2):369-376. Epub 2019 Jul 23 doi: 10.1007/s11060-019-03239-3. PMID: 31338785Free PMC Article
Kayani B, Sewell MD, Hanna SA, Saifuddin A, Aston W, Pollock R, Skinner J, Molloy S, Briggs TW
Neurosurgery 2014 Sep;75(3):269-75; discussion 275. doi: 10.1227/NEU.0000000000000423. PMID: 24867206
Makhdoomi R, Ramzan A, Khursheed N, Bhat S, Baba K, Mohsin R, Basharat M, Yameen B, Ahmad R, Iqbal L, Maqbool M, Ajaz H, Farhat M
Turk Neurosurg 2013;23(6):700-6. doi: 10.5137/1019-5149.JTN.5941-12.3. PMID: 24310451

Diagnosis

Gajdzis P, Klijanienko J, Gajdzis M
Cytopathology 2023 Sep;34(5):503-506. Epub 2023 Mar 13 doi: 10.1111/cyt.13225. PMID: 36840426
Ulici V, Hart J
Arch Pathol Lab Med 2022 Mar 1;146(3):386-395. doi: 10.5858/arpa.2020-0258-RA. PMID: 34319396
Tirabosco R, O'Donnell P, Flanagan AM
Surg Pathol Clin 2021 Dec;14(4):619-643. Epub 2021 Jul 28 doi: 10.1016/j.path.2021.06.006. PMID: 34742484
Hung YP, Diaz-Perez JA, Cote GM, Wejde J, Schwab JH, Nardi V, Chebib IA, Deshpande V, Selig MK, Bredella MA, Rosenberg AE, Nielsen GP
Am J Surg Pathol 2020 Sep;44(9):1213-1223. doi: 10.1097/PAS.0000000000001501. PMID: 32427623
Shih AR, Chebib I, Deshpande V, Dickson BC, Iafrate AJ, Nielsen GP
Genes Chromosomes Cancer 2019 Nov;58(11):804-808. Epub 2019 Jun 13 doi: 10.1002/gcc.22782. PMID: 31135077

Therapy

Wen X, Cimera R, Aryeequaye R, Abhinta M, Athanasian E, Healey J, Fabbri N, Boland P, Zhang Y, Hameed M
Genes Chromosomes Cancer 2021 Dec;60(12):796-807. Epub 2021 Aug 26 doi: 10.1002/gcc.22992. PMID: 34392582Free PMC Article
Lin K, Song K, Wang S, Jiang L, Wang H, Dong J
Clin Neurol Neurosurg 2020 Oct;197:106174. Epub 2020 Aug 22 doi: 10.1016/j.clineuro.2020.106174. PMID: 32889324
Colia V, Stacchiotti S
Eur J Cancer 2017 Sep;83:220-228. Epub 2017 Jul 25 doi: 10.1016/j.ejca.2017.06.038. PMID: 28750274

Prognosis

Lipplaa A, van der Wal RJP, Krol ADG, Peul WC, Bovée JVMG, Gelderblom H
Cancer Epidemiol 2024 Apr;89:102527. Epub 2024 Jan 25 doi: 10.1016/j.canep.2024.102527. PMID: 38277716
Ulici V, Hart J
Arch Pathol Lab Med 2022 Mar 1;146(3):386-395. doi: 10.5858/arpa.2020-0258-RA. PMID: 34319396
Tirabosco R, O'Donnell P, Flanagan AM
Surg Pathol Clin 2021 Dec;14(4):619-643. Epub 2021 Jul 28 doi: 10.1016/j.path.2021.06.006. PMID: 34742484
Lin K, Song K, Wang S, Jiang L, Wang H, Dong J
Clin Neurol Neurosurg 2020 Oct;197:106174. Epub 2020 Aug 22 doi: 10.1016/j.clineuro.2020.106174. PMID: 32889324
Shih AR, Chebib I, Deshpande V, Dickson BC, Iafrate AJ, Nielsen GP
Genes Chromosomes Cancer 2019 Nov;58(11):804-808. Epub 2019 Jun 13 doi: 10.1002/gcc.22782. PMID: 31135077

Clinical prediction guides

Lipplaa A, van der Wal RJP, Krol ADG, Peul WC, Bovée JVMG, Gelderblom H
Cancer Epidemiol 2024 Apr;89:102527. Epub 2024 Jan 25 doi: 10.1016/j.canep.2024.102527. PMID: 38277716
Klubíčková N, Michal M, Kinkor Z, Soukup J, Ryška A, Brtková J, Lutonský M, Hájková V, Ptáková N, Michal M, Farkas M, Švajdler M
Virchows Arch 2024 Apr;484(4):621-627. Epub 2023 Aug 18 doi: 10.1007/s00428-023-03620-8. PMID: 37594643
Gajdzis P, Klijanienko J, Gajdzis M
Cytopathology 2023 Sep;34(5):503-506. Epub 2023 Mar 13 doi: 10.1111/cyt.13225. PMID: 36840426
Lin K, Song K, Wang S, Jiang L, Wang H, Dong J
Clin Neurol Neurosurg 2020 Oct;197:106174. Epub 2020 Aug 22 doi: 10.1016/j.clineuro.2020.106174. PMID: 32889324
Ridenour RV 3rd, Ahrens WA, Folpe AL, Miller DV
Pediatr Dev Pathol 2010 Jan-Feb;13(1):9-17. doi: 10.2350/09-01-0584.1. PMID: 19348512

Recent systematic reviews

Maroufi SF, Fallahi MS, Sabahi M, Maroufi SP, Sheehan JP
Neurosurg Focus 2024 May;56(5):E10. doi: 10.3171/2024.2.FOCUS249. PMID: 38691855

Supplemental Content

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    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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