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Increased circulating precipitin level

MedGen UID:
1754251
•Concept ID:
C5421566
•
Finding
Synonym: Increased level of antigen-precipitating IgG antibodies
 
HPO: HP:0033039

Definition

The presence of high titers of antigen-precipitating IgG in the serum. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating precipitin level

Recent clinical studies

Etiology

Gliadin and tissue transglutaminase complexes in normal and coeliac duodenal mucosa.
Ciccocioppo R, Di Sabatino A, Ara C, Biagi F, Perilli M, Amicosante G, Cifone MG, Corazza GR
Clin Exp Immunol 2003 Dec;134(3):516-24. doi: 10.1111/j.1365-2249.2003.02326.x. PMID: 14632760Free PMC Article
Glycation amplifies lipoprotein(a)-induced alterations in the generation of fibrinolytic regulators from human vascular endothelial cells.
Zhang J, Ren S, Shen GX
Atherosclerosis 2000 Jun;150(2):299-308. doi: 10.1016/s0021-9150(99)00381-0. PMID: 10856522
Changes of circulating immune complexes in the serum and CSF of patients with multiple sclerosis.
Cojocaru M, Cojocaru MI, Steriu O, Băldescu R
Rom J Intern Med 1992 Jan-Mar;30(1):51-6. PMID: 1496259
Circulating immune complexes in myelofibrosis.
Hasselbalch H, Nielsen H, Berild D, Kappelgaard E
Scand J Haematol 1985 Feb;34(2):177-80. doi: 10.1111/j.1600-0609.1985.tb02252.x. PMID: 3871960
Bovine antigens and the formation of circulating immune complexes in selective immunoglobulin A deficiency.
Cunningham-Rundles C, Brandeis WE, Good RA, Day NK
J Clin Invest 1979 Jul;64(1):272-9. doi: 10.1172/JCI109448. PMID: 571875Free PMC Article

Diagnosis

Detection of Fcgamma binding protein antigen in human sera and its relation with autoimmune diseases.
Kobayashi K, Yagasaki M, Harada N, Chichibu K, Hibi T, Yoshida T, Brown WR, Morikawa M
Immunol Lett 2001 Dec 3;79(3):229-35. doi: 10.1016/s0165-2478(01)00288-7. PMID: 11600203
Immunoglobulins in tears and sera in patients with atopic dermatitis.
Somos S, Schneider I, Farkas B
Allergy Asthma Proc 2001 Mar-Apr;22(2):81-6. doi: 10.2500/108854101778250571. PMID: 11332296
Circulating immune complexes in collagen diseases.
Purice S, Serban MG, Negru T
Rom J Intern Med 1991 Jul-Dec;29(3-4):145-9. PMID: 1784942
Circulating immune complexes in myelofibrosis.
Hasselbalch H, Nielsen H, Berild D, Kappelgaard E
Scand J Haematol 1985 Feb;34(2):177-80. doi: 10.1111/j.1600-0609.1985.tb02252.x. PMID: 3871960
Pseudomonas aeruginosa: immune status in patients with cystic fibrosis.
Doggett RG, Harrison GM
Infect Immun 1972 Oct;6(4):628-35. doi: 10.1128/iai.6.4.628-635.1972. PMID: 4628901Free PMC Article

Therapy

Free circulating soluble CD52 as a tumor marker in chronic lymphocytic leukemia and its implication in therapy with anti-CD52 antibodies.
Albitar M, Do KA, Johnson MM, Giles FJ, Jilani I, O'Brien S, Cortes J, Thomas D, Rassenti LZ, Kipps TJ, Kantarjian HM, Keating M
Cancer 2004 Sep 1;101(5):999-1008. doi: 10.1002/cncr.20477. PMID: 15329909
Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha.
Le HT, Ponniah S, Pallen CJ
Biochem Biophys Res Commun 2004 Feb 6;314(2):321-9. doi: 10.1016/j.bbrc.2003.12.087. PMID: 14733908
Immunoglobulins in tears and sera in patients with atopic dermatitis.
Somos S, Schneider I, Farkas B
Allergy Asthma Proc 2001 Mar-Apr;22(2):81-6. doi: 10.2500/108854101778250571. PMID: 11332296
Protection of normal proliferating cells against chemotherapy by staurosporine-mediated, selective, and reversible G(1) arrest.
Chen X, Lowe M, Herliczek T, Hall MJ, Danes C, Lawrence DA, Keyomarsi K
J Natl Cancer Inst 2000 Dec 20;92(24):1999-2008. doi: 10.1093/jnci/92.24.1999. PMID: 11121462
Nature of circulating immune complexes in infective endocarditis.
Burton-Kee J, Morgan-Capner P, Mowbray JF
J Clin Pathol 1980 Jul;33(7):653-9. doi: 10.1136/jcp.33.7.653. PMID: 7430371Free PMC Article

Prognosis

Free circulating soluble CD52 as a tumor marker in chronic lymphocytic leukemia and its implication in therapy with anti-CD52 antibodies.
Albitar M, Do KA, Johnson MM, Giles FJ, Jilani I, O'Brien S, Cortes J, Thomas D, Rassenti LZ, Kipps TJ, Kantarjian HM, Keating M
Cancer 2004 Sep 1;101(5):999-1008. doi: 10.1002/cncr.20477. PMID: 15329909
Candida albicans vertebral osteomyelitis in chronic renal failure.
Neale TJ, Muir JC, Mills H, Horne JG, Jones MR
Postgrad Med J 1987 Aug;63(742):695-8. doi: 10.1136/pgmj.63.742.695. PMID: 3422876Free PMC Article
Bovine antigens and the formation of circulating immune complexes in selective immunoglobulin A deficiency.
Cunningham-Rundles C, Brandeis WE, Good RA, Day NK
J Clin Invest 1979 Jul;64(1):272-9. doi: 10.1172/JCI109448. PMID: 571875Free PMC Article

Clinical prediction guides

Plasminogen activator inhibitor-1 promotes formation of endothelial microparticles with procoagulant potential.
Brodsky SV, Malinowski K, Golightly M, Jesty J, Goligorsky MS
Circulation 2002 Oct 29;106(18):2372-8. doi: 10.1161/01.cir.0000033972.90653.af. PMID: 12403669
Pancreatic bile-salt-dependent lipase activity in serum of diabetic patients: is there a relationship with glycation?
Caillol N, Pasqualini E, Mas E, Guieu R, Valette A, Boyer J, Lombardo D
Clin Sci (Lond) 1998 Feb;94(2):181-8. doi: 10.1042/cs0940181. PMID: 9536927
Insulin-like growth factor binding proteins in sera of pregnant nonhuman primates.
Giudice LC, Dsupin BA, De las Fuentes L, Gargosky SE, Rosenfeld RG, Zelinski-Wooten MB, Stouffer RL, Fazleabas AT
Endocrinology 1993 Apr;132(4):1514-26. doi: 10.1210/endo.132.4.7681762. PMID: 7681762
Changes of circulating immune complexes in the serum and CSF of patients with multiple sclerosis.
Cojocaru M, Cojocaru MI, Steriu O, Băldescu R
Rom J Intern Med 1992 Jan-Mar;30(1):51-6. PMID: 1496259
Circulating immune complexes in pregnancy, preeclampsia, and autoimmune diseases: evaluation of Raji cell enzyme-linked immunosorbent assay and polyethylene glycol precipitation methods.
Rote NS, Caudle MR
Am J Obstet Gynecol 1983 Oct 1;147(3):267-73. doi: 10.1016/0002-9378(83)91109-2. PMID: 6353922

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