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Refractory Acute Monoblastic and Monocytic Leukemia

MedGen UID:
1734713
•Concept ID:
C5420824
•
Neoplastic Process

Definition

Acute monoblastic and monocytic leukemia that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Acute Monoblastic and Monocytic Leukemia

Professional guidelines

PubMed

Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009

Recent clinical studies

Etiology

A case of monocytic leukaemia cutis in a patient with myelodysplastic syndrome transforming to acute myeloid leukaemia.
Perez A, Kennedy C, Standen G, Oxley J
Clin Exp Dermatol 2004 Sep;29(5):497-8. doi: 10.1111/j.1365-2230.2004.01578.x. PMID: 15347335

Diagnosis

Refractory acute monoblastic leukaemia with low hypodiploidy.
Lum SH, Chin TF, Lau KH, Yap TY, Rajagopal R, Ariffin H
Int J Hematol 2014 Mar;99(3):215-6. Epub 2014 Jan 28 doi: 10.1007/s12185-014-1515-0. PMID: 24470150
Expression of immune inhibitory receptor ILT3 in acute myeloid leukemia with monocytic differentiation.
Dobrowolska H, Gill KZ, Serban G, Ivan E, Li Q, Qiao P, Suciu-Foca N, Savage D, Alobeid B, Bhagat G, Colovai AI
Cytometry B Clin Cytom 2013 Jan-Feb;84(1):21-9. Epub 2012 Oct 18 doi: 10.1002/cyto.b.21050. PMID: 23027709
Monocytic leukemia cutis diagnosed simultaneously with refractory anemia with monocytosis: a case report.
Yavorkovsky LL, Zain J, Wu CD, Trivelli L, Cook P
Am J Hematol 2001 Feb;66(2):120-2. doi: 10.1002/1096-8652(200102)66:2<120::AID-AJH1027>3.0.CO;2-V. PMID: 11421290
Opposite sensitivity to the antiproliferative action of interferon-alpha and granulocyte-macrophage colony-stimulating factor in monoblastic U937 cells.
Kloke O, Moritz T, Kummer G, Hust H, Ross B, Seeber S, Niederle N
J Interferon Res 1992 Oct;12(5):369-76. doi: 10.1089/jir.1992.12.369. PMID: 1431316
Cardiac tamponade as the initial manifestation of acute leukemia: report of a case and review of the literature.
Batlle M, Ribera JM, Larrousse E, Abella E, Las Heras G, Milla F, Junca J
Haematologica 1991 Nov-Dec;76(6):505-7. PMID: 1820988

Therapy

Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia.
Bunworasate U, Arnouk H, Minderman H, O'Loughlin KL, Sait SN, Barcos M, Stewart CC, Baer MR
Blood 2001 Dec 1;98(12):3492-4. doi: 10.1182/blood.v98.12.3492. PMID: 11719396
IL-2/LAK therapy for refractory acute monoblastic leukemia relapsing after unrelated allogeneic bone marrow transplantation.
Nagayama H, Takahashi S, Takahashi T, Ogami K, Ikebuchi K, Tojo A, Tani K, Asano S
Bone Marrow Transplant 1999 Jan;23(2):183-5. doi: 10.1038/sj.bmt.1701550. PMID: 10197806
Treatment of acute monoblastic leukaemia by combination of recombinant human macrophage colony-stimulating factor and low dose of ara-C.
Kitano K, Kobayashi H, Maeyama H, Miyabayashi H, Furuta S
Br J Haematol 1993 Sep;85(1):176-8. doi: 10.1111/j.1365-2141.1993.tb08663.x. PMID: 8251387
Cardiac tamponade as the initial manifestation of acute leukemia: report of a case and review of the literature.
Batlle M, Ribera JM, Larrousse E, Abella E, Las Heras G, Milla F, Junca J
Haematologica 1991 Nov-Dec;76(6):505-7. PMID: 1820988
Acute monoblastic leukemia in infancy and early childhood: successful treatment with an epipodophyllotoxin.
Odom LF, Gordon EM
Blood 1984 Oct;64(4):875-82. PMID: 6592009

Prognosis

Refractory acute monoblastic leukaemia with low hypodiploidy.
Lum SH, Chin TF, Lau KH, Yap TY, Rajagopal R, Ariffin H
Int J Hematol 2014 Mar;99(3):215-6. Epub 2014 Jan 28 doi: 10.1007/s12185-014-1515-0. PMID: 24470150
Expression of immune inhibitory receptor ILT3 in acute myeloid leukemia with monocytic differentiation.
Dobrowolska H, Gill KZ, Serban G, Ivan E, Li Q, Qiao P, Suciu-Foca N, Savage D, Alobeid B, Bhagat G, Colovai AI
Cytometry B Clin Cytom 2013 Jan-Feb;84(1):21-9. Epub 2012 Oct 18 doi: 10.1002/cyto.b.21050. PMID: 23027709
A case of monocytic leukaemia cutis in a patient with myelodysplastic syndrome transforming to acute myeloid leukaemia.
Perez A, Kennedy C, Standen G, Oxley J
Clin Exp Dermatol 2004 Sep;29(5):497-8. doi: 10.1111/j.1365-2230.2004.01578.x. PMID: 15347335
Monocytic leukemia cutis diagnosed simultaneously with refractory anemia with monocytosis: a case report.
Yavorkovsky LL, Zain J, Wu CD, Trivelli L, Cook P
Am J Hematol 2001 Feb;66(2):120-2. doi: 10.1002/1096-8652(200102)66:2<120::AID-AJH1027>3.0.CO;2-V. PMID: 11421290

Clinical prediction guides

Expression of immune inhibitory receptor ILT3 in acute myeloid leukemia with monocytic differentiation.
Dobrowolska H, Gill KZ, Serban G, Ivan E, Li Q, Qiao P, Suciu-Foca N, Savage D, Alobeid B, Bhagat G, Colovai AI
Cytometry B Clin Cytom 2013 Jan-Feb;84(1):21-9. Epub 2012 Oct 18 doi: 10.1002/cyto.b.21050. PMID: 23027709
Erythropoietin-dependent transformation of myelodysplastic syndrome to acute monoblastic leukemia.
Bunworasate U, Arnouk H, Minderman H, O'Loughlin KL, Sait SN, Barcos M, Stewart CC, Baer MR
Blood 2001 Dec 1;98(12):3492-4. doi: 10.1182/blood.v98.12.3492. PMID: 11719396
Monocytic leukemia cutis diagnosed simultaneously with refractory anemia with monocytosis: a case report.
Yavorkovsky LL, Zain J, Wu CD, Trivelli L, Cook P
Am J Hematol 2001 Feb;66(2):120-2. doi: 10.1002/1096-8652(200102)66:2<120::AID-AJH1027>3.0.CO;2-V. PMID: 11421290
Treatment of acute monoblastic leukaemia by combination of recombinant human macrophage colony-stimulating factor and low dose of ara-C.
Kitano K, Kobayashi H, Maeyama H, Miyabayashi H, Furuta S
Br J Haematol 1993 Sep;85(1):176-8. doi: 10.1111/j.1365-2141.1993.tb08663.x. PMID: 8251387
Cardiac tamponade as the initial manifestation of acute leukemia: report of a case and review of the literature.
Batlle M, Ribera JM, Larrousse E, Abella E, Las Heras G, Milla F, Junca J
Haematologica 1991 Nov-Dec;76(6):505-7. PMID: 1820988

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