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Advanced Oropharyngeal Carcinoma

MedGen UID:
1729598
•Concept ID:
C5418792
•
Neoplastic Process

Definition

Oropharyngeal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Oropharyngeal Carcinoma

Professional guidelines

PubMed

Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma.
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V
Head Neck 2014 Dec;36(12):1689-94. Epub 2014 Jan 13 doi: 10.1002/hed.23512. PMID: 24123603
Functional outcomes after treatment of advanced oropharyngeal carcinoma with radiation or chemoradiation.
Myers C, Kerr P, Cooke A, Bammeke F, Butler J, Lambert P
J Otolaryngol Head Neck Surg 2012 Apr;41(2):108-18. PMID: 22569011
Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma.
Lybak S, Liavaag PG, Monge OR, Olofsson J
Eur Arch Otorhinolaryngol 2011 Mar;268(3):449-56. Epub 2010 Aug 28 doi: 10.1007/s00405-010-1344-6. PMID: 20803151Free PMC Article

Recent clinical studies

Etiology

Response to primary chemoradiotherapy of locally advanced oropharyngeal carcinoma is determined by the degree of cytotoxic T cell infiltration within tumor cell aggregates.
Haist M, Kaufmann J, Kur IM, Zimmer S, Grabbe S, Schmidberger H, Weigert A, Mayer A
Front Immunol 2023;14:1070203. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1070203. PMID: 37187729Free PMC Article
Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma.
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V
Head Neck 2014 Dec;36(12):1689-94. Epub 2014 Jan 13 doi: 10.1002/hed.23512. PMID: 24123603
Functional outcomes after treatment of advanced oropharyngeal carcinoma with radiation or chemoradiation.
Myers C, Kerr P, Cooke A, Bammeke F, Butler J, Lambert P
J Otolaryngol Head Neck Surg 2012 Apr;41(2):108-18. PMID: 22569011
Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma.
Lybak S, Liavaag PG, Monge OR, Olofsson J
Eur Arch Otorhinolaryngol 2011 Mar;268(3):449-56. Epub 2010 Aug 28 doi: 10.1007/s00405-010-1344-6. PMID: 20803151Free PMC Article
Transoral robotic surgery for advanced oropharyngeal carcinoma.
Weinstein GS, O'Malley BW Jr, Cohen MA, Quon H
Arch Otolaryngol Head Neck Surg 2010 Nov;136(11):1079-85. doi: 10.1001/archoto.2010.191. PMID: 21079160

Diagnosis

Prognostic value of radiographically defined extranodal extension in human papillomavirus-associated locally advanced oropharyngeal carcinoma.
Tian S, Ferris MJ, Switchenko JM, Magliocca KR, Cassidy RJ, Jhaveri J, Aiken AH, Baugnon KL, Hudgins PA, Kendi ATK, Patel MR, Saba NF, Curran WJ, Beitler JJ
Head Neck 2019 Sep;41(9):3056-3063. Epub 2019 May 2 doi: 10.1002/hed.25791. PMID: 31046181Free PMC Article
Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma.
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V
Head Neck 2014 Dec;36(12):1689-94. Epub 2014 Jan 13 doi: 10.1002/hed.23512. PMID: 24123603
Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century.
Garden AS, Kies MS, Morrison WH, Weber RS, Frank SJ, Glisson BS, Gunn GB, Beadle BM, Ang KK, Rosenthal DI, Sturgis EM
Radiat Oncol 2013 Jan 29;8:21. doi: 10.1186/1748-717X-8-21. PMID: 23360540Free PMC Article
Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma.
Lybak S, Liavaag PG, Monge OR, Olofsson J
Eur Arch Otorhinolaryngol 2011 Mar;268(3):449-56. Epub 2010 Aug 28 doi: 10.1007/s00405-010-1344-6. PMID: 20803151Free PMC Article
Transoral robotic surgery for advanced oropharyngeal carcinoma.
Weinstein GS, O'Malley BW Jr, Cohen MA, Quon H
Arch Otolaryngol Head Neck Surg 2010 Nov;136(11):1079-85. doi: 10.1001/archoto.2010.191. PMID: 21079160

Therapy

De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma.
Masterson L, Moualed D, Masood A, Dwivedi RC, Benson R, Sterling JC, Rhodes KM, Sudhoff H, Jani P, Goon P
Cochrane Database Syst Rev 2014 Feb 15;2014(2):CD010271. doi: 10.1002/14651858.CD010271.pub2. PMID: 24532092Free PMC Article
Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century.
Garden AS, Kies MS, Morrison WH, Weber RS, Frank SJ, Glisson BS, Gunn GB, Beadle BM, Ang KK, Rosenthal DI, Sturgis EM
Radiat Oncol 2013 Jan 29;8:21. doi: 10.1186/1748-717X-8-21. PMID: 23360540Free PMC Article
Concurrent radiochemotherapy in locally-regionally advanced oropharyngeal squamous cell carcinoma: analysis of treatment results and prognostic factors.
Krstevska V, Stojkovski I, Zafirova-Ivanovska B
Radiat Oncol 2012 May 28;7:78. doi: 10.1186/1748-717X-7-78. PMID: 22640662Free PMC Article
Functional outcomes after treatment of advanced oropharyngeal carcinoma with radiation or chemoradiation.
Myers C, Kerr P, Cooke A, Bammeke F, Butler J, Lambert P
J Otolaryngol Head Neck Surg 2012 Apr;41(2):108-18. PMID: 22569011
Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume.
Chao KS, Ozyigit G, Blanco AI, Thorstad WL, Deasy JO, Haughey BH, Spector GJ, Sessions DG
Int J Radiat Oncol Biol Phys 2004 May 1;59(1):43-50. doi: 10.1016/j.ijrobp.2003.08.004. PMID: 15093897

Prognosis

Response to primary chemoradiotherapy of locally advanced oropharyngeal carcinoma is determined by the degree of cytotoxic T cell infiltration within tumor cell aggregates.
Haist M, Kaufmann J, Kur IM, Zimmer S, Grabbe S, Schmidberger H, Weigert A, Mayer A
Front Immunol 2023;14:1070203. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1070203. PMID: 37187729Free PMC Article
Prognosis of HPV-Positive and -Negative Oropharyngeal Cancers Depends on the Treatment Modality.
Horáková Z, Slavik M, Veselý K, Budíková M, Kostřica R, Binková H
Klin Onkol 2019 Spring;32(3):187-196. PMID: 31216850
Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma.
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V
Head Neck 2014 Dec;36(12):1689-94. Epub 2014 Jan 13 doi: 10.1002/hed.23512. PMID: 24123603
Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma.
Lybak S, Liavaag PG, Monge OR, Olofsson J
Eur Arch Otorhinolaryngol 2011 Mar;268(3):449-56. Epub 2010 Aug 28 doi: 10.1007/s00405-010-1344-6. PMID: 20803151Free PMC Article
Transoral robotic surgery for advanced oropharyngeal carcinoma.
Weinstein GS, O'Malley BW Jr, Cohen MA, Quon H
Arch Otolaryngol Head Neck Surg 2010 Nov;136(11):1079-85. doi: 10.1001/archoto.2010.191. PMID: 21079160

Clinical prediction guides

Response to primary chemoradiotherapy of locally advanced oropharyngeal carcinoma is determined by the degree of cytotoxic T cell infiltration within tumor cell aggregates.
Haist M, Kaufmann J, Kur IM, Zimmer S, Grabbe S, Schmidberger H, Weigert A, Mayer A
Front Immunol 2023;14:1070203. Epub 2023 Apr 28 doi: 10.3389/fimmu.2023.1070203. PMID: 37187729Free PMC Article
Prognosis of HPV-Positive and -Negative Oropharyngeal Cancers Depends on the Treatment Modality.
Horáková Z, Slavik M, Veselý K, Budíková M, Kostřica R, Binková H
Klin Onkol 2019 Spring;32(3):187-196. PMID: 31216850
Predicting two-year longitudinal MD Anderson Dysphagia Inventory outcomes after intensity modulated radiotherapy for locoregionally advanced oropharyngeal carcinoma.
Goepfert RP, Lewin JS, Barrow MP, Fuller CD, Lai SY, Song J, Hobbs BP, Gunn GB, Beadle BM, Rosenthal DI, Garden AS, Kies MS, Papadimitrakopoulou VA, Schwartz DL, Hutcheson KA
Laryngoscope 2017 Apr;127(4):842-848. Epub 2016 Jul 21 doi: 10.1002/lary.26153. PMID: 27440393Free PMC Article
Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma.
Kann BH, Buckstein M, Carpenter TJ, Bakst R, Misiukiewicz K, Genden E, Posner M, Kostakoglu L, Som P, Gupta V
Head Neck 2014 Dec;36(12):1689-94. Epub 2014 Jan 13 doi: 10.1002/hed.23512. PMID: 24123603
Advanced oropharyngeal carcinoma treated with surgery and radiotherapy: oncologic outcome and functional assessment.
Denittis AS, Machtay M, Rosenthal DI, Sanfilippo NJ, Lee JH, Goldfeder S, Chalian AA, Weinstein GS, Weber RS
Am J Otolaryngol 2001 Sep-Oct;22(5):329-35. doi: 10.1053/ajot.2001.26492. PMID: 11562884

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