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Advanced Oropharyngeal Squamous Cell Carcinoma

MedGen UID:
1661808
•Concept ID:
C4725662
•
Neoplastic Process
Synonym: Advanced Squamous Cell Carcinoma of the Oropharynx

Definition

A squamous cell carcinoma of the oropharynx that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Oropharyngeal Squamous Cell Carcinoma

Professional guidelines

PubMed

Clinical Impact of CYFRA 21-1 a Marker for Treatment Failure in Patients With Oropharyngeal Cancer Treated by Radio(chemo)therapy.
Rudhart SA, Langen P, Thangavelu K, Gehrt F, Stankovic P, Wilhelm T, Stuck BA, Hoch S
Anticancer Res 2022 Jan;42(1):137-146. doi: 10.21873/anticanres.15467. PMID: 34969719
Treatment trends for advanced oropharyngeal squamous cell carcinoma in the era of human papillomavirus.
Mirza FA, Johnson CZ, Byrd JK, Albergotti WG 3rd
Head Neck 2021 Nov;43(11):3476-3492. Epub 2021 Sep 9 doi: 10.1002/hed.26860. PMID: 34499392
De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma.
Masterson L, Moualed D, Masood A, Dwivedi RC, Benson R, Sterling JC, Rhodes KM, Sudhoff H, Jani P, Goon P
Cochrane Database Syst Rev 2014 Feb 15;2014(2):CD010271. doi: 10.1002/14651858.CD010271.pub2. PMID: 24532092Free PMC Article

Recent clinical studies

Etiology

Neo-adjuvant chemotherapy and transoral robotic surgery in locoregionally advanced oropharyngeal cancer.
Costantino A, Sampieri C, De Virgilio A, Kim SH
Eur J Surg Oncol 2023 Dec;49(12):107121. Epub 2023 Oct 18 doi: 10.1016/j.ejso.2023.107121. PMID: 37879162
A predictive model for patients with local-regionally advanced oropharyngeal squamous cell carcinoma treated after cervical lymph node dissection.
Xie X, Kang M, Qu Z, Gu K
J Cancer Res Clin Oncol 2023 Dec;149(19):17241-17251. Epub 2023 Oct 7 doi: 10.1007/s00432-023-05379-6. PMID: 37804427
Catastrophic Hemorrhage After Chemoradiation for Advanced Stage Oropharyngeal Carcinoma: A Case Series.
Chou CT, Rath TJ, Johnson JT, Goyal LK
Laryngoscope 2021 May;131(5):1049-1052. Epub 2020 Oct 17 doi: 10.1002/lary.29167. PMID: 33068291
Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma.
Weiss BG, Anczykowski MZ, Küffer S, Spiegel JL, Bertlich M, Canis M, Ihler F, Kitz J, Jakob M
Eur Arch Otorhinolaryngol 2021 Jun;278(6):1983-2000. Epub 2020 Aug 20 doi: 10.1007/s00405-020-06262-7. PMID: 32814982Free PMC Article
Cetuximab induced aseptic meningitis.
Ulrich A, Weiler S, Weller M, Rordorf T, Tarnutzer AA
J Clin Neurosci 2015 Jun;22(6):1061-3. Epub 2015 Mar 11 doi: 10.1016/j.jocn.2014.11.034. PMID: 25769257

Diagnosis

Treatment trends for advanced oropharyngeal squamous cell carcinoma in the era of human papillomavirus.
Mirza FA, Johnson CZ, Byrd JK, Albergotti WG 3rd
Head Neck 2021 Nov;43(11):3476-3492. Epub 2021 Sep 9 doi: 10.1002/hed.26860. PMID: 34499392
Early MRI Blood Volume Changes in Constrictor Muscles Correlate With Postradiation Dysphagia.
Mierzwa ML, Gharzai LA, Li P, Wilkie JR, Hawkins PG, Aryal MP, Lee C, Rosen B, Lyden T, Blakely A, Chapman CH, Thamarus J, Schonewolf C, Shah J, Eisbruch A, Schipper MJ, Cao Y
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):566-573. Epub 2020 Dec 24 doi: 10.1016/j.ijrobp.2020.12.018. PMID: 33346093
Catastrophic Hemorrhage After Chemoradiation for Advanced Stage Oropharyngeal Carcinoma: A Case Series.
Chou CT, Rath TJ, Johnson JT, Goyal LK
Laryngoscope 2021 May;131(5):1049-1052. Epub 2020 Oct 17 doi: 10.1002/lary.29167. PMID: 33068291
Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma.
Weiss BG, Anczykowski MZ, Küffer S, Spiegel JL, Bertlich M, Canis M, Ihler F, Kitz J, Jakob M
Eur Arch Otorhinolaryngol 2021 Jun;278(6):1983-2000. Epub 2020 Aug 20 doi: 10.1007/s00405-020-06262-7. PMID: 32814982Free PMC Article
Cetuximab induced aseptic meningitis.
Ulrich A, Weiler S, Weller M, Rordorf T, Tarnutzer AA
J Clin Neurosci 2015 Jun;22(6):1061-3. Epub 2015 Mar 11 doi: 10.1016/j.jocn.2014.11.034. PMID: 25769257

Therapy

Neo-adjuvant chemotherapy and transoral robotic surgery in locoregionally advanced oropharyngeal cancer.
Costantino A, Sampieri C, De Virgilio A, Kim SH
Eur J Surg Oncol 2023 Dec;49(12):107121. Epub 2023 Oct 18 doi: 10.1016/j.ejso.2023.107121. PMID: 37879162
Early MRI Blood Volume Changes in Constrictor Muscles Correlate With Postradiation Dysphagia.
Mierzwa ML, Gharzai LA, Li P, Wilkie JR, Hawkins PG, Aryal MP, Lee C, Rosen B, Lyden T, Blakely A, Chapman CH, Thamarus J, Schonewolf C, Shah J, Eisbruch A, Schipper MJ, Cao Y
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):566-573. Epub 2020 Dec 24 doi: 10.1016/j.ijrobp.2020.12.018. PMID: 33346093
Catastrophic Hemorrhage After Chemoradiation for Advanced Stage Oropharyngeal Carcinoma: A Case Series.
Chou CT, Rath TJ, Johnson JT, Goyal LK
Laryngoscope 2021 May;131(5):1049-1052. Epub 2020 Oct 17 doi: 10.1002/lary.29167. PMID: 33068291
Cetuximab induced aseptic meningitis.
Ulrich A, Weiler S, Weller M, Rordorf T, Tarnutzer AA
J Clin Neurosci 2015 Jun;22(6):1061-3. Epub 2015 Mar 11 doi: 10.1016/j.jocn.2014.11.034. PMID: 25769257
Submandibular gland-sparing radiation therapy for locally advanced oropharyngeal squamous cell carcinoma: patterns of failure and xerostomia outcomes.
Gensheimer MF, Liao JJ, Garden AS, Laramore GE, Parvathaneni U
Radiat Oncol 2014 Nov 26;9:255. doi: 10.1186/s13014-014-0255-x. PMID: 25424729Free PMC Article

Prognosis

A predictive model for patients with local-regionally advanced oropharyngeal squamous cell carcinoma treated after cervical lymph node dissection.
Xie X, Kang M, Qu Z, Gu K
J Cancer Res Clin Oncol 2023 Dec;149(19):17241-17251. Epub 2023 Oct 7 doi: 10.1007/s00432-023-05379-6. PMID: 37804427
Prognostic value of FOXP3+ regulatory T cells for patients with locally advanced oropharyngeal squamous cell carcinoma.
Hur JY, Ku BM, Park S, Jung HA, Lee SH, Ahn MJ
PLoS One 2022;17(10):e0274830. Epub 2022 Oct 6 doi: 10.1371/journal.pone.0274830. PMID: 36201479Free PMC Article
Early MRI Blood Volume Changes in Constrictor Muscles Correlate With Postradiation Dysphagia.
Mierzwa ML, Gharzai LA, Li P, Wilkie JR, Hawkins PG, Aryal MP, Lee C, Rosen B, Lyden T, Blakely A, Chapman CH, Thamarus J, Schonewolf C, Shah J, Eisbruch A, Schipper MJ, Cao Y
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):566-573. Epub 2020 Dec 24 doi: 10.1016/j.ijrobp.2020.12.018. PMID: 33346093
Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma.
Weiss BG, Anczykowski MZ, Küffer S, Spiegel JL, Bertlich M, Canis M, Ihler F, Kitz J, Jakob M
Eur Arch Otorhinolaryngol 2021 Jun;278(6):1983-2000. Epub 2020 Aug 20 doi: 10.1007/s00405-020-06262-7. PMID: 32814982Free PMC Article
Long-term results of surgical treatment for advanced oropharyngeal squamous cell carcinoma.
Bastos de Souza TR, Pinto CA, da Cunha Mercante AM, Nishimoto IN, Brasilino de Carvalho M, Kowalski LP
Head Neck 2014 Aug;36(8):1146-54. Epub 2013 Nov 6 doi: 10.1002/hed.23427. PMID: 23897725

Clinical prediction guides

A predictive model for patients with local-regionally advanced oropharyngeal squamous cell carcinoma treated after cervical lymph node dissection.
Xie X, Kang M, Qu Z, Gu K
J Cancer Res Clin Oncol 2023 Dec;149(19):17241-17251. Epub 2023 Oct 7 doi: 10.1007/s00432-023-05379-6. PMID: 37804427
Prognostic value of FOXP3+ regulatory T cells for patients with locally advanced oropharyngeal squamous cell carcinoma.
Hur JY, Ku BM, Park S, Jung HA, Lee SH, Ahn MJ
PLoS One 2022;17(10):e0274830. Epub 2022 Oct 6 doi: 10.1371/journal.pone.0274830. PMID: 36201479Free PMC Article
Early MRI Blood Volume Changes in Constrictor Muscles Correlate With Postradiation Dysphagia.
Mierzwa ML, Gharzai LA, Li P, Wilkie JR, Hawkins PG, Aryal MP, Lee C, Rosen B, Lyden T, Blakely A, Chapman CH, Thamarus J, Schonewolf C, Shah J, Eisbruch A, Schipper MJ, Cao Y
Int J Radiat Oncol Biol Phys 2021 Jun 1;110(2):566-573. Epub 2020 Dec 24 doi: 10.1016/j.ijrobp.2020.12.018. PMID: 33346093
Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma.
Weiss BG, Anczykowski MZ, Küffer S, Spiegel JL, Bertlich M, Canis M, Ihler F, Kitz J, Jakob M
Eur Arch Otorhinolaryngol 2021 Jun;278(6):1983-2000. Epub 2020 Aug 20 doi: 10.1007/s00405-020-06262-7. PMID: 32814982Free PMC Article
Prediction of concurrent chemoradiotherapy outcome in advanced oropharyngeal cancer.
Hasegawa M, Maeda H, Deng Z, Kiyuna A, Ganaha A, Yamashita Y, Matayoshi S, Agena S, Toita T, Uehara T, Suzuki M
Int J Oncol 2014 Sep;45(3):1017-26. Epub 2014 Jun 18 doi: 10.3892/ijo.2014.2504. PMID: 24969413Free PMC Article

Recent systematic reviews

De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis of current clinical trials.
Masterson L, Moualed D, Liu ZW, Howard JE, Dwivedi RC, Tysome JR, Benson R, Sterling JC, Sudhoff H, Jani P, Goon PK
Eur J Cancer 2014 Oct;50(15):2636-48. Epub 2014 Aug 1 doi: 10.1016/j.ejca.2014.07.001. PMID: 25091798

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