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Advanced Bladder Carcinoma

MedGen UID:
1718946
•Concept ID:
C5238474
•
Neoplastic Process

Definition

A bladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Bladder Carcinoma

Professional guidelines

PubMed

The Challenge of Managing Bladder Cancer and Upper Tract Urothelial Carcinoma: A Review with Treatment Recommendations from the Spanish Oncology Genitourinary Group (SOGUG).
Font A, Luque R, Villa JC, Domenech M, Vázquez S, Gallardo E, Virizuela JA, Beato C, Morales-Barrera R, Gelabert A, Maciá S, Puente J, Rubio G, Maldonado X, Perez-Valderrama B, Pinto A, Fernández Calvo O, Grande E, Garde-Noguera J, Fernández-Parra E, Arranz JÁ
Target Oncol 2019 Feb;14(1):15-32. doi: 10.1007/s11523-019-00619-7. PMID: 30694442
Combined treatment approaches in regionally advanced bladder cancer.
Walther PJ
Urol Clin North Am 1992 Nov;19(4):761-74. PMID: 1441030
Treatment of advanced bladder carcinoma with irradiation and concomitant 5-fluorouracil infusion.
Rotman M, Macchia R, Silverstein M, Aziz H, Choi K, Rosenthal J, Braverman A, Laungani GB
Cancer 1987 Feb 15;59(4):710-4. doi: 10.1002/1097-0142(19870215)59:4<710::aid-cncr2820590408>3.0.co;2-u. PMID: 3802030

Recent clinical studies

Etiology

Radiotherapy with concurrent carbogen and nicotinamide in bladder carcinoma.
Hoskin PJ, Rojas AM, Bentzen SM, Saunders MI
J Clin Oncol 2010 Nov 20;28(33):4912-8. Epub 2010 Oct 18 doi: 10.1200/JCO.2010.28.4950. PMID: 20956620
Clinical outcome in patients with locally advanced bladder carcinoma treated with conservative multimodality therapy.
George L, Bladou F, Bardou VJ, Gravis G, Tallet A, Alzieu C, Serment G, Salem N
Urology 2004 Sep;64(3):488-93. doi: 10.1016/j.urology.2004.04.088. PMID: 15351577
Gemcitabine and carboplatin combination as first-line treatment in elderly patients and those unfit for cisplatin-based chemotherapy with advanced bladder carcinoma: Phase II study of the Hellenic Co-operative Oncology Group.
Linardou H, Aravantinos G, Efstathiou E, Kalofonos C, Anagnostopoulos A, Deliveliotis C, Bafaloukos D, Athanasios Dimopoulos M, Bamias A; Phase II study of Hellenic Co-operative Oncology Group
Urology 2004 Sep;64(3):479-84. doi: 10.1016/j.urology.2004.04.024. PMID: 15351574
Symptomatic relief of patients with advanced bladder carcinoma after regional intra-arterial chemotherapy.
Mantadakis E, Panagiotidis C, Delakas D, Samonis G
Anticancer Res 2003 Nov-Dec;23(6D):5143-7. PMID: 14981980
Carboplatin-based versus cisplatin-based chemotherapy in the treatment of surgically incurable advanced bladder carcinoma.
Bellmunt J, Ribas A, Eres N, Albanell J, Almanza C, Bermejo B, Solé LA, Baselga J
Cancer 1997 Nov 15;80(10):1966-72. doi: 10.1002/(sici)1097-0142(19971115)80:10<1966::aid-cncr14>3.0.co;2-w. PMID: 9366300

Diagnosis

Bladder carcinoma during pregnancy.
Spahn M, Bader P, Westermann D, Echtle D, Frohneberg D
Urol Int 2005;74(2):153-9. doi: 10.1159/000083287. PMID: 15756068
Cytostatic sensitivity and MDR in bladder carcinoma cells: implications for tumor therapy.
Schuldes H, Dolderer JH, Schoch C, Bickeböller R, Woodcock BG
Int J Clin Pharmacol Ther 2000 Apr;38(4):204-8. doi: 10.5414/cpp38204. PMID: 10783830
CMV front-line chemotherapy in transitional bladder carcinoma.
Paz-Ares L, Lianes P, Díaz-Puente M, Rivera F, Passas J, Costas P, Mendiola C, Cortés-Funes H
Ann Oncol 1993 Feb;4(2):147-50. doi: 10.1093/oxfordjournals.annonc.a058418. PMID: 8448083
Altered expression of retinoblastoma protein and known prognostic variables in locally advanced bladder cancer.
Logothetis CJ, Xu HJ, Ro JY, Hu SX, Sahin A, Ordonez N, Benedict WF
J Natl Cancer Inst 1992 Aug 19;84(16):1256-61. doi: 10.1093/jnci/84.16.1256. PMID: 1640485
Radical radiation treatment of invasive and locally advanced bladder carcinoma in elderly patients.
Smaaland R, Akslen LA, Tønder B, Mehus A, Lote K, Albrektsen G
Br J Urol 1991 Jan;67(1):61-9. doi: 10.1111/j.1464-410x.1991.tb15071.x. PMID: 1993278

Therapy

Programmed Cell Death Ligand 1 (PD-L1) Immunohistochemical Expression in Advanced Urothelial Bladder Carcinoma: An Updated Review with Clinical and Pathological Implications.
Germanà E, Pepe L, Pizzimenti C, Ballato M, Pierconti F, Tuccari G, Ieni A, Giuffrè G, Fadda G, Fiorentino V, Martini M
Int J Mol Sci 2024 Jun 19;25(12) doi: 10.3390/ijms25126750. PMID: 38928456Free PMC Article
Neoadjuvant and adjuvant chemotherapy for locally advanced bladder carcinoma: development of novel bladder preservation approach, Osaka Medical College regimen.
Azuma H, Inamoto T, Takahara K, Ibuki N, Nomi H, Yamamoto K, Narumi Y, Ubai T
Int J Urol 2012 Jan;19(1):26-38. Epub 2011 Nov 13 doi: 10.1111/j.1442-2042.2011.02856.x. PMID: 22077821
Carbogen and nicotinamide in locally advanced bladder cancer: early results of a phase-III randomized trial.
Hoskin PJ, Rojas AM, Saunders MI, Bentzen SM, Motohashi KJ; BCON investigators
Radiother Oncol 2009 Apr;91(1):120-5. Epub 2008 Nov 5 doi: 10.1016/j.radonc.2008.10.001. PMID: 18992952
Clinical outcome in patients with locally advanced bladder carcinoma treated with conservative multimodality therapy.
George L, Bladou F, Bardou VJ, Gravis G, Tallet A, Alzieu C, Serment G, Salem N
Urology 2004 Sep;64(3):488-93. doi: 10.1016/j.urology.2004.04.088. PMID: 15351577
Chemotherapy for advanced bladder carcinoma: new molecules and regimens.
Abi-Aad AS
Acta Urol Belg 1996 May;64(2):43-5. PMID: 8701810

Prognosis

Programmed Cell Death Ligand 1 (PD-L1) Immunohistochemical Expression in Advanced Urothelial Bladder Carcinoma: An Updated Review with Clinical and Pathological Implications.
Germanà E, Pepe L, Pizzimenti C, Ballato M, Pierconti F, Tuccari G, Ieni A, Giuffrè G, Fadda G, Fiorentino V, Martini M
Int J Mol Sci 2024 Jun 19;25(12) doi: 10.3390/ijms25126750. PMID: 38928456Free PMC Article
Sunitinib malate and sorafenib may be beneficial at the treatment of advanced bladder cancer due to their anti-angiogenic effects.
Silay MS, Miroglu C
Med Hypotheses 2007;69(4):892-5. Epub 2007 Mar 26 doi: 10.1016/j.mehy.2007.01.065. PMID: 17368754
Acute and late morbidity in the treatment of advanced bladder carcinoma with accelerated radiotherapy, carbogen, and nicotinamide.
Hoskin PJ, Rojas AM, Phillips H, Saunders MI
Cancer 2005 Jun 1;103(11):2287-97. doi: 10.1002/cncr.21048. PMID: 15834926
Bladder carcinoma during pregnancy.
Spahn M, Bader P, Westermann D, Echtle D, Frohneberg D
Urol Int 2005;74(2):153-9. doi: 10.1159/000083287. PMID: 15756068
Clinical outcome in patients with locally advanced bladder carcinoma treated with conservative multimodality therapy.
George L, Bladou F, Bardou VJ, Gravis G, Tallet A, Alzieu C, Serment G, Salem N
Urology 2004 Sep;64(3):488-93. doi: 10.1016/j.urology.2004.04.088. PMID: 15351577

Clinical prediction guides

Programmed Cell Death Ligand 1 (PD-L1) Immunohistochemical Expression in Advanced Urothelial Bladder Carcinoma: An Updated Review with Clinical and Pathological Implications.
Germanà E, Pepe L, Pizzimenti C, Ballato M, Pierconti F, Tuccari G, Ieni A, Giuffrè G, Fadda G, Fiorentino V, Martini M
Int J Mol Sci 2024 Jun 19;25(12) doi: 10.3390/ijms25126750. PMID: 38928456Free PMC Article
Accelerated radiotherapy, carbogen, and nicotinamide (ARCON) in the treatment of advanced bladder cancer: mature results of a Phase II nonrandomized study.
Hoskin P, Rojas A, Saunders M
Int J Radiat Oncol Biol Phys 2009 Apr 1;73(5):1425-31. Epub 2008 Nov 25 doi: 10.1016/j.ijrobp.2008.06.1950. PMID: 19036531
Gemcitabine plus vinorelbine chemotherapy in patients with advanced bladder carcinoma who are medically unsuitable for or who have failed cisplatin-based chemotherapy.
Türkölmez K, Bedük Y, Baltaci S, Göğüş C, Göğüş O
Eur Urol 2003 Dec;44(6):682-6. doi: 10.1016/s0302-2838(03)00385-3. PMID: 14644120
Carboplatin-based versus cisplatin-based chemotherapy in the treatment of surgically incurable advanced bladder carcinoma.
Bellmunt J, Ribas A, Eres N, Albanell J, Almanza C, Bermejo B, Solé LA, Baselga J
Cancer 1997 Nov 15;80(10):1966-72. doi: 10.1002/(sici)1097-0142(19971115)80:10<1966::aid-cncr14>3.0.co;2-w. PMID: 9366300
CMV front-line chemotherapy in transitional bladder carcinoma.
Paz-Ares L, Lianes P, Díaz-Puente M, Rivera F, Passas J, Costas P, Mendiola C, Cortés-Funes H
Ann Oncol 1993 Feb;4(2):147-50. doi: 10.1093/oxfordjournals.annonc.a058418. PMID: 8448083

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