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Renal interstitial amyloid deposits

MedGen UID:
1719343
Concept ID:
C5397634
Disease or Syndrome
Synonyms: Renal interstitial amyloid; Renal interstitial amyloid deposition; Renal interstitial amyloidosis
 
HPO: HP:0032613

Definition

Deposition of amyloid in the interstitial tissue of the kidney. Amyloid is is made up of 10 nm (on average) fibrils that are most commonly composed of monoclonal light chains (AL), transthyretin (TTR), amd LECT2, or occur in the setting of long standing systemic inflammation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal interstitial amyloid deposits

Recent clinical studies

Etiology

Ozdemir A, Yılmaz M, Ozagari AA, Kocak SY
Int Urol Nephrol 2022 Oct;54(10):2591-2597. Epub 2022 Mar 11 doi: 10.1007/s11255-022-03163-y. PMID: 35275358
Caza TN, Hassen SI, Larsen CP
Kidney360 2020 Jun 25;1(6):491-500. Epub 2020 Apr 21 doi: 10.34067/KID.0000432020. PMID: 35368588Free PMC Article
Fonseca EO, Caldas MLR, Soares Filho PJ, Almeida JR
Braz J Med Biol Res 2020;53(6):e8625. Epub 2020 May 18 doi: 10.1590/1414-431x20208625. PMID: 32428129Free PMC Article
Sethi S, Theis JD
J Nephrol 2018 Jun;31(3):343-350. Epub 2017 Aug 21 doi: 10.1007/s40620-017-0426-6. PMID: 28828707
Comenzo RL
Contrib Nephrol 2007;153:195-210. doi: 10.1159/000096768. PMID: 17075231

Diagnosis

Kmochová T, Kidd KO, Orr A, Hnízda A, Hartmannová H, Hodaňová K, Vyleťal P, Naušová K, Brinsa V, Trešlová H, Sovová J, Barešová V, Svojšová K, Vrbacká A, Stránecký V, Robins VC, Taylor A, Martin L, Rivas-Chavez A, Payne R, Bleyer HA, Williams A, Rennke HG, Weins A, Short PJ, Agrawal V, Storsley LJ, Waikar SS, McPhail ED, Dasari S, Leung N, Hewlett T, Yorke J, Gaston D, Geldenhuys L, Samuels M, Levine AP, West M, Hůlková H, Pompach P, Novák P, Weinberg RB, Bedard K, Živná M, Sikora J, Bleyer AJ Sr, Kmoch S
Kidney Int 2024 Apr;105(4):799-811. Epub 2023 Dec 12 doi: 10.1016/j.kint.2023.11.021. PMID: 38096951
Ozdemir A, Yılmaz M, Ozagari AA, Kocak SY
Int Urol Nephrol 2022 Oct;54(10):2591-2597. Epub 2022 Mar 11 doi: 10.1007/s11255-022-03163-y. PMID: 35275358
Caza TN, Hassen SI, Larsen CP
Kidney360 2020 Jun 25;1(6):491-500. Epub 2020 Apr 21 doi: 10.34067/KID.0000432020. PMID: 35368588Free PMC Article
Sethi S, Theis JD
J Nephrol 2018 Jun;31(3):343-350. Epub 2017 Aug 21 doi: 10.1007/s40620-017-0426-6. PMID: 28828707
Doshi M, Lahoti A, Danesh FR, Batuman V, Sanders PW; American Society of Nephrology Onco-Nephrology Forum
Clin J Am Soc Nephrol 2016 Dec 7;11(12):2288-2294. Epub 2016 Aug 15 doi: 10.2215/CJN.02560316. PMID: 27526707Free PMC Article

Therapy

Pinedo Pichilingue A, Thayyil A, Dai DF, Rastogi P
Histopathology 2023 Nov;83(5):722-732. Epub 2023 Jul 28 doi: 10.1111/his.15014. PMID: 37501637
Stasi A, Franzin R, Divella C, Sallustio F, Curci C, Picerno A, Pontrelli P, Staffieri F, Lacitignola L, Crovace A, Cantaluppi V, Medica D, Ronco C, de Cal M, Lorenzin A, Zanella M, Pertosa GB, Stallone G, Gesualdo L, Castellano G
Front Immunol 2021;12:605212. Epub 2021 Apr 1 doi: 10.3389/fimmu.2021.605212. PMID: 33868226Free PMC Article
Angel-Korman A, Jaberi A, Sanchorawala V, Havasi A
Amyloid 2020 Mar;27(1):17-24. Epub 2019 Oct 9 doi: 10.1080/13506129.2019.1672650. PMID: 31595786Free PMC Article
Lu C, Zuo K, Lu Y, Liang S, Huang X, Zeng C, Zhang J, An Y, Wang J
Medicine (Baltimore) 2017 Sep;96(39):e8148. doi: 10.1097/MD.0000000000008148. PMID: 28953655Free PMC Article
Comenzo RL
Contrib Nephrol 2007;153:195-210. doi: 10.1159/000096768. PMID: 17075231

Prognosis

Kmochová T, Kidd KO, Orr A, Hnízda A, Hartmannová H, Hodaňová K, Vyleťal P, Naušová K, Brinsa V, Trešlová H, Sovová J, Barešová V, Svojšová K, Vrbacká A, Stránecký V, Robins VC, Taylor A, Martin L, Rivas-Chavez A, Payne R, Bleyer HA, Williams A, Rennke HG, Weins A, Short PJ, Agrawal V, Storsley LJ, Waikar SS, McPhail ED, Dasari S, Leung N, Hewlett T, Yorke J, Gaston D, Geldenhuys L, Samuels M, Levine AP, West M, Hůlková H, Pompach P, Novák P, Weinberg RB, Bedard K, Živná M, Sikora J, Bleyer AJ Sr, Kmoch S
Kidney Int 2024 Apr;105(4):799-811. Epub 2023 Dec 12 doi: 10.1016/j.kint.2023.11.021. PMID: 38096951
Ozdemir A, Yılmaz M, Ozagari AA, Kocak SY
Int Urol Nephrol 2022 Oct;54(10):2591-2597. Epub 2022 Mar 11 doi: 10.1007/s11255-022-03163-y. PMID: 35275358
Stasi A, Franzin R, Divella C, Sallustio F, Curci C, Picerno A, Pontrelli P, Staffieri F, Lacitignola L, Crovace A, Cantaluppi V, Medica D, Ronco C, de Cal M, Lorenzin A, Zanella M, Pertosa GB, Stallone G, Gesualdo L, Castellano G
Front Immunol 2021;12:605212. Epub 2021 Apr 1 doi: 10.3389/fimmu.2021.605212. PMID: 33868226Free PMC Article
Fonseca EO, Caldas MLR, Soares Filho PJ, Almeida JR
Braz J Med Biol Res 2020;53(6):e8625. Epub 2020 May 18 doi: 10.1590/1414-431x20208625. PMID: 32428129Free PMC Article
Sethi S, Theis JD
J Nephrol 2018 Jun;31(3):343-350. Epub 2017 Aug 21 doi: 10.1007/s40620-017-0426-6. PMID: 28828707

Clinical prediction guides

Kmochová T, Kidd KO, Orr A, Hnízda A, Hartmannová H, Hodaňová K, Vyleťal P, Naušová K, Brinsa V, Trešlová H, Sovová J, Barešová V, Svojšová K, Vrbacká A, Stránecký V, Robins VC, Taylor A, Martin L, Rivas-Chavez A, Payne R, Bleyer HA, Williams A, Rennke HG, Weins A, Short PJ, Agrawal V, Storsley LJ, Waikar SS, McPhail ED, Dasari S, Leung N, Hewlett T, Yorke J, Gaston D, Geldenhuys L, Samuels M, Levine AP, West M, Hůlková H, Pompach P, Novák P, Weinberg RB, Bedard K, Živná M, Sikora J, Bleyer AJ Sr, Kmoch S
Kidney Int 2024 Apr;105(4):799-811. Epub 2023 Dec 12 doi: 10.1016/j.kint.2023.11.021. PMID: 38096951
Pinedo Pichilingue A, Thayyil A, Dai DF, Rastogi P
Histopathology 2023 Nov;83(5):722-732. Epub 2023 Jul 28 doi: 10.1111/his.15014. PMID: 37501637
Ozdemir A, Yılmaz M, Ozagari AA, Kocak SY
Int Urol Nephrol 2022 Oct;54(10):2591-2597. Epub 2022 Mar 11 doi: 10.1007/s11255-022-03163-y. PMID: 35275358
Fonseca EO, Caldas MLR, Soares Filho PJ, Almeida JR
Braz J Med Biol Res 2020;53(6):e8625. Epub 2020 May 18 doi: 10.1590/1414-431x20208625. PMID: 32428129Free PMC Article
Castano E, Palmer MB, Vigneault C, Luciano R, Wong S, Moeckel G
BMC Nephrol 2015 Apr 29;16:64. doi: 10.1186/s12882-015-0046-0. PMID: 25924613Free PMC Article

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