U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Renal interstitial deposits

MedGen UID:
1709193
•Concept ID:
C5397661
•
Finding
HPO: HP:0032644

Definition

Abnormal accumulation of a metabolite, protein, or protein-derived substance in the interstitial region of the kidney. [from HPO]

Professional guidelines

PubMed

Rituximab for the Treatment of IgG4-Related Tubulointerstitial Nephritis: Case Report and Review of the Literature.
McMahon BA, Novick T, Scheel PJ, Bagnasco S, Atta MG
Medicine (Baltimore) 2015 Aug;94(32):e1366. doi: 10.1097/MD.0000000000001366. PMID: 26266393Free PMC Article
Diagnosis and management of gout.
Pittman JR, Bross MH
Am Fam Physician 1999 Apr 1;59(7):1799-806, 1810. PMID: 10208700
Renal fibrosis: insights into pathogenesis and treatment.
el Nahas AM, Muchaneta-Kubara EC, Essawy M, Soylemezoglu O
Int J Biochem Cell Biol 1997 Jan;29(1):55-62. doi: 10.1016/s1357-2725(96)00119-7. PMID: 9076941

Recent clinical studies

Etiology

Acute Kidney Injury and Hair-Straightening Products: A Case Series.
Bnaya A, Abu-Amer N, Beckerman P, Volkov A, Cohen-Hagai K, Greenberg M, Ben-Chetrit S, Ben Tikva Kagan K, Goldman S, Navarro HA, Sneineh MA, Rozen-Zvi B, Borovitz Y, Tobar A, Yanay NB, Biton R, Angel-Korman A, Rappoport V, Leiba A, Bathish Y, Farber E, Kaidar-Ronat M, Schreiber L, Shashar M, Kazarski R, Chernin G, Itzkowitz E, Atrash J, Iaina NL, Efrati S, Nizri E, Lurie Y, Ben Itzhak O, Assady S, Kenig-Kozlovsky Y, Shavit L
Am J Kidney Dis 2023 Jul;82(1):43-52.e1. Epub 2023 Jan 5 doi: 10.1053/j.ajkd.2022.11.016. PMID: 36610611
Nephrotoxicity of Antimicrobials and Antibiotics.
Morales-Alvarez MC
Adv Chronic Kidney Dis 2020 Jan;27(1):31-37. doi: 10.1053/j.ackd.2019.08.001. PMID: 32146999
Idiopathic hypercalciuria and formation of calcium renal stones.
Coe FL, Worcester EM, Evan AP
Nat Rev Nephrol 2016 Sep;12(9):519-33. Epub 2016 Jul 25 doi: 10.1038/nrneph.2016.101. PMID: 27452364Free PMC Article
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
C3 glomerulopathy: clinicopathologic features and predictors of outcome.
Medjeral-Thomas NR, O'Shaughnessy MM, O'Regan JA, Traynor C, Flanagan M, Wong L, Teoh CW, Awan A, Waldron M, Cairns T, O'Kelly P, Dorman AM, Pickering MC, Conlon PJ, Cook HT
Clin J Am Soc Nephrol 2014 Jan;9(1):46-53. Epub 2013 Oct 31 doi: 10.2215/CJN.04700513. PMID: 24178974Free PMC Article

Diagnosis

Snake bite associated with acute kidney injury.
Sarkar S, Sinha R, Chaudhury AR, Maduwage K, Abeyagunawardena A, Bose N, Pradhan S, Bresolin NL, Garcia BA, McCulloch M
Pediatr Nephrol 2021 Dec;36(12):3829-3840. Epub 2021 Feb 9 doi: 10.1007/s00467-020-04911-x. PMID: 33559706
Nephrotoxicity of Antimicrobials and Antibiotics.
Morales-Alvarez MC
Adv Chronic Kidney Dis 2020 Jan;27(1):31-37. doi: 10.1053/j.ackd.2019.08.001. PMID: 32146999
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
C3 glomerulopathy: clinicopathologic features and predictors of outcome.
Medjeral-Thomas NR, O'Shaughnessy MM, O'Regan JA, Traynor C, Flanagan M, Wong L, Teoh CW, Awan A, Waldron M, Cairns T, O'Kelly P, Dorman AM, Pickering MC, Conlon PJ, Cook HT
Clin J Am Soc Nephrol 2014 Jan;9(1):46-53. Epub 2013 Oct 31 doi: 10.2215/CJN.04700513. PMID: 24178974Free PMC Article

Therapy

Renal involvement in IgG4-related disease.
Boffa JJ, Esteve E, Buob D
Presse Med 2020 Apr;49(1):104017. Epub 2020 Mar 29 doi: 10.1016/j.lpm.2020.104017. PMID: 32234380
Nephrotoxicity of Antimicrobials and Antibiotics.
Morales-Alvarez MC
Adv Chronic Kidney Dis 2020 Jan;27(1):31-37. doi: 10.1053/j.ackd.2019.08.001. PMID: 32146999
Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways.
Li R, Guo Y, Zhang Y, Zhang X, Zhu L, Yan T
Int J Mol Sci 2019 Mar 4;20(5) doi: 10.3390/ijms20051103. PMID: 30836660Free PMC Article
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083

Prognosis

Snake bite associated with acute kidney injury.
Sarkar S, Sinha R, Chaudhury AR, Maduwage K, Abeyagunawardena A, Bose N, Pradhan S, Bresolin NL, Garcia BA, McCulloch M
Pediatr Nephrol 2021 Dec;36(12):3829-3840. Epub 2021 Feb 9 doi: 10.1007/s00467-020-04911-x. PMID: 33559706
IgA vasculitis (Henoch-Shönlein purpura) in adults: Diagnostic and therapeutic aspects.
Audemard-Verger A, Pillebout E, Guillevin L, Thervet E, Terrier B
Autoimmun Rev 2015 Jul;14(7):579-85. Epub 2015 Feb 14 doi: 10.1016/j.autrev.2015.02.003. PMID: 25688001
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
C3 glomerulopathy: clinicopathologic features and predictors of outcome.
Medjeral-Thomas NR, O'Shaughnessy MM, O'Regan JA, Traynor C, Flanagan M, Wong L, Teoh CW, Awan A, Waldron M, Cairns T, O'Kelly P, Dorman AM, Pickering MC, Conlon PJ, Cook HT
Clin J Am Soc Nephrol 2014 Jan;9(1):46-53. Epub 2013 Oct 31 doi: 10.2215/CJN.04700513. PMID: 24178974Free PMC Article
Lyme nephritis.
Littman MP
J Vet Emerg Crit Care (San Antonio) 2013 Mar-Apr;23(2):163-73. Epub 2013 Mar 5 doi: 10.1111/vec.12026. PMID: 23461642

Clinical prediction guides

Snake bite associated with acute kidney injury.
Sarkar S, Sinha R, Chaudhury AR, Maduwage K, Abeyagunawardena A, Bose N, Pradhan S, Bresolin NL, Garcia BA, McCulloch M
Pediatr Nephrol 2021 Dec;36(12):3829-3840. Epub 2021 Feb 9 doi: 10.1007/s00467-020-04911-x. PMID: 33559706
C3 glomerulonephritis and dense deposit disease share a similar disease course in a large United States cohort of patients with C3 glomerulopathy.
Bomback AS, Santoriello D, Avasare RS, Regunathan-Shenk R, Canetta PA, Ahn W, Radhakrishnan J, Marasa M, Rosenstiel PE, Herlitz LC, Markowitz GS, D'Agati VD, Appel GB
Kidney Int 2018 Apr;93(4):977-985. Epub 2018 Jan 6 doi: 10.1016/j.kint.2017.10.022. PMID: 29310824
Pathology of IgA nephropathy.
Roberts IS
Nat Rev Nephrol 2014 Aug;10(8):445-54. Epub 2014 May 27 doi: 10.1038/nrneph.2014.92. PMID: 24861083
C3 glomerulopathy: clinicopathologic features and predictors of outcome.
Medjeral-Thomas NR, O'Shaughnessy MM, O'Regan JA, Traynor C, Flanagan M, Wong L, Teoh CW, Awan A, Waldron M, Cairns T, O'Kelly P, Dorman AM, Pickering MC, Conlon PJ, Cook HT
Clin J Am Soc Nephrol 2014 Jan;9(1):46-53. Epub 2013 Oct 31 doi: 10.2215/CJN.04700513. PMID: 24178974Free PMC Article
Lyme nephritis.
Littman MP
J Vet Emerg Crit Care (San Antonio) 2013 Mar-Apr;23(2):163-73. Epub 2013 Mar 5 doi: 10.1111/vec.12026. PMID: 23461642

Recent systematic reviews

Biopsy-proven kidney involvement in hypocomplementemic urticarial vasculitis.
Corthier A, Jachiet M, Bertin D, Servais A, Barbet C, Bigot A, Doutre MS, Bessis D, Bouffandeau A, Moranne O, Jarrot PA, Bardin N, Terrier B, Burtey S, Puéchal X, Daniel L, Jourde-Chiche N
BMC Nephrol 2022 Feb 16;23(1):67. doi: 10.1186/s12882-022-02689-8. PMID: 35172758Free PMC Article
Renal lithiasis and inflammatory bowel diseases, an update on pediatric population.
Bianchi L, Gaiani F, Bizzarri B, Minelli R, Cortegoso Valdivia P, Leandro G, Di Mario F, De' Angelis GL, Ruberto C
Acta Biomed 2018 Dec 17;89(9-S):76-80. doi: 10.23750/abm.v89i9-S.7908. PMID: 30561398Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...