Somatostatin Analogs in Clinical Practice: a Review

Mariana Gomes-Porras; Jersy Cárdenas-Salas; Cristina Álvarez-Escolá

doi:10.3390/ijms21051682

Somatostatin Analogs in Clinical Practice: a Review

Int J Mol Sci. 2020 Feb 29;21(5):1682. doi: 10.3390/ijms21051682.

Authors

Mariana Gomes-Porras¹, Jersy Cárdenas-Salas², Cristina Álvarez-Escolá¹

Affiliations

¹ Department of Endocrinology, "La Paz" University Hospital. Paseo de la Castellana, 261, 28046 Madrid, Spain.
² Department of Endocrinology, "Fundación Jiménez-Diaz" University Hospital. Av. de los Reyes Católicos, 2, 28040 Madrid, Spain.

Abstract

Somatostatin analogs are an invaluable therapeutic option in the diagnosis and treatment of somatotropinomas, thyrotropinomas, and functioning and non-functioning gastroenteropancreatic neuroendocrine tumors. They should also be considered an effective and safe therapeutic alternative to corticotropinomas, gonadotropinomas, and prolactinomas resistant to dopamine agonists. Somatostatin analogs have also shown to be useful in the treatment of other endocrine diseases (congenital hyperinsulinism, Graves' orbitopathy, diabetic retinopathy, diabetic macular edema), non-endocrine tumors (breast, colon, prostate, lung, and hepatocellular), and digestive diseases (chronic refractory diarrhea, hepatorenal polycystosis, gastrointestinal hemorrhage, dumping syndrome, and intestinal fistula).

Keywords: Somatostatin analog; cancer; carcinoid; lanreotide; neuroendocrine tumor; octreotide; pasireotide; pituitary adenoma.

Publication types

Review

MeSH terms

Antineoplastic Agents, Hormonal / therapeutic use*
Diabetic Retinopathy / drug therapy
Diabetic Retinopathy / pathology
Graves Ophthalmopathy / drug therapy
Graves Ophthalmopathy / pathology
Growth Hormone-Secreting Pituitary Adenoma / drug therapy*
Growth Hormone-Secreting Pituitary Adenoma / genetics
Growth Hormone-Secreting Pituitary Adenoma / pathology
Humans
Intestinal Neoplasms / drug therapy*
Intestinal Neoplasms / genetics
Intestinal Neoplasms / pathology
Macular Edema / drug therapy
Macular Edema / pathology
Neuroendocrine Tumors / drug therapy*
Neuroendocrine Tumors / genetics
Neuroendocrine Tumors / pathology
Pancreatic Neoplasms / drug therapy*
Pancreatic Neoplasms / genetics
Pancreatic Neoplasms / pathology
Pituitary Neoplasms / drug therapy
Pituitary Neoplasms / pathology
Somatostatin / analogs & derivatives
Somatostatin / genetics
Somatostatin / therapeutic use*
Stomach Neoplasms / drug therapy*
Stomach Neoplasms / genetics
Stomach Neoplasms / pathology

Substances

Antineoplastic Agents, Hormonal
Somatostatin

Supplementary concepts

Gastro-enteropancreatic neuroendocrine tumor