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Acute Leukemia of Ambiguous Lineage, Not Otherwise Specified

MedGen UID:
1666838
•Concept ID:
C4726591
•
Neoplastic Process
Synonym: Acute Leukemia of Ambiguous Lineage, NOS

Definition

Acute leukemia of ambiguous lineage, expressing combinations of markers that do not allow for its classification as either acute undifferentiated leukemia or mixed phenotype acute leukemia, and definitive classification along a single lineage is difficult. (WHO 2017) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute Leukemia of Ambiguous Lineage, Not Otherwise Specified

Professional guidelines

PubMed

Mixed Phenotype/Lineage Leukemia: Has Anything Changed for 2021 on Diagnosis, Classification, and Treatment?
Béné MC, Porwit A
Curr Oncol Rep 2022 Aug;24(8):1015-1022. Epub 2022 Apr 5 doi: 10.1007/s11912-022-01252-w. PMID: 35380407Free PMC Article
Genetic Testing in the Diagnosis and Biology of Acute Leukemia.
Harris MH, Czuchlewski DR, Arber DA, Czader M
Am J Clin Pathol 2019 Aug 1;152(3):322-346. doi: 10.1093/ajcp/aqz093. PMID: 31367767
Treatment of blastic plasmacytoid dendritic cell neoplasm.
Sullivan JM, Rizzieri DA
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):16-23. doi: 10.1182/asheducation-2016.1.16. PMID: 27913457Free PMC Article

Recent clinical studies

Etiology

Incidence of myeloid neoplasms in Spain (2002-2013): a population-based study of the Spanish network of cancer registries.
Solans M, Sanvisens A, Ameijide A, Merino S, Rojas D, Alemán A, Banqueri E, Chico M, Marcos AI, de Castro V, Gil L, de Munain AL, Puigdemont M, Sánchez MJ, Perucha J, Ruiz-Armengol P, Chirlaque MD, Guevara M, Carulla M, Marcos-Gragera R
Sci Rep 2022 Jan 10;12(1):323. doi: 10.1038/s41598-021-03734-6. PMID: 35013373Free PMC Article
14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia.
Di Giacomo D, La Starza R, Gorello P, Pellanera F, Kalender Atak Z, De Keersmaecker K, Pierini V, Harrison CJ, Arniani S, Moretti M, Testoni N, De Santis G, Roti G, Matteucci C, Bassan R, Vandenberghe P, Aerts S, Cools J, Bornhauser B, Bourquin JP, Piazza R, Mecucci C
Blood 2021 Sep 2;138(9):773-784. doi: 10.1182/blood.2020010510. PMID: 33876209Free PMC Article

Diagnosis

Incidence of myeloid neoplasms in Spain (2002-2013): a population-based study of the Spanish network of cancer registries.
Solans M, Sanvisens A, Ameijide A, Merino S, Rojas D, Alemán A, Banqueri E, Chico M, Marcos AI, de Castro V, Gil L, de Munain AL, Puigdemont M, Sánchez MJ, Perucha J, Ruiz-Armengol P, Chirlaque MD, Guevara M, Carulla M, Marcos-Gragera R
Sci Rep 2022 Jan 10;12(1):323. doi: 10.1038/s41598-021-03734-6. PMID: 35013373Free PMC Article
14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia.
Di Giacomo D, La Starza R, Gorello P, Pellanera F, Kalender Atak Z, De Keersmaecker K, Pierini V, Harrison CJ, Arniani S, Moretti M, Testoni N, De Santis G, Roti G, Matteucci C, Bassan R, Vandenberghe P, Aerts S, Cools J, Bornhauser B, Bourquin JP, Piazza R, Mecucci C
Blood 2021 Sep 2;138(9):773-784. doi: 10.1182/blood.2020010510. PMID: 33876209Free PMC Article

Therapy

14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia.
Di Giacomo D, La Starza R, Gorello P, Pellanera F, Kalender Atak Z, De Keersmaecker K, Pierini V, Harrison CJ, Arniani S, Moretti M, Testoni N, De Santis G, Roti G, Matteucci C, Bassan R, Vandenberghe P, Aerts S, Cools J, Bornhauser B, Bourquin JP, Piazza R, Mecucci C
Blood 2021 Sep 2;138(9):773-784. doi: 10.1182/blood.2020010510. PMID: 33876209Free PMC Article

Prognosis

Incidence of myeloid neoplasms in Spain (2002-2013): a population-based study of the Spanish network of cancer registries.
Solans M, Sanvisens A, Ameijide A, Merino S, Rojas D, Alemán A, Banqueri E, Chico M, Marcos AI, de Castro V, Gil L, de Munain AL, Puigdemont M, Sánchez MJ, Perucha J, Ruiz-Armengol P, Chirlaque MD, Guevara M, Carulla M, Marcos-Gragera R
Sci Rep 2022 Jan 10;12(1):323. doi: 10.1038/s41598-021-03734-6. PMID: 35013373Free PMC Article

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