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Advanced Prostate Carcinoma

MedGen UID:
1662330
•Concept ID:
C4744712
•
Neoplastic Process

Definition

A prostatic carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Prostate Carcinoma

Professional guidelines

PubMed

Functional and mutational analysis after radiation and cetuximab treatment on prostate carcinoma cell line DU145.
Schneider R, Gademann G, Ochel HJ, Neumann K, Jandrig B, Hass P, Walke M, Schostak M, Brunner T, Christoph F
Radiat Oncol 2021 Jul 28;16(1):137. doi: 10.1186/s13014-021-01859-6. PMID: 34321039Free PMC Article
Treatment of locally advanced prostate cancer--the case for radical prostatectomy.
Hakenberg OW, Fröhner M, Wirth MP
Urol Int 2006;77(3):193-9. doi: 10.1159/000094808. PMID: 17033204
Total cystoprostatectomy in the treatment of locally advanced prostate carcinoma.
Sato K, Tsuchiya N, Habuchi T, Satoh S, Shimoda N, Kato T
Aktuelle Urol 2003 Jul;34(4):259-61. doi: 10.1055/s-2003-41611. PMID: 14566679

Recent clinical studies

Etiology

Histologic patterns in prostatic adenocarcinoma are not predictive of mutations in the homologous recombination repair pathway.
Mahlow J, Barry M, Albertson DJ, Jo YJ, Balatico M, Seasor T, Gebrael G, Kumar SA, Sayegh N, Tripathi N, Agarwal N, Swami U, Sirohi D
Hum Pathol 2024 Feb;144:28-33. Epub 2024 Jan 24 doi: 10.1016/j.humpath.2024.01.005. PMID: 38278448
Effect of Bicalutamide Combined with Docetaxel on Serum PSA and VEGF Levels in Patients with Advanced Prostate Carcinoma.
Guo Z, Hu X, Lv R, Zhang Y, Meng L, Liu Z, Yan L
Dis Markers 2022;2022:4506350. Epub 2022 Aug 17 doi: 10.1155/2022/4506350. PMID: 36033830Free PMC Article
Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma.
Vidal Crespo N, Enguita Arnal L, Gómez-Ferrer Á, Collado Serra A, Mascarós JM, Calatrava Fons A, Casanova Ramón-Borja J, Rubio Briones J, Ramírez-Backhaus M
Medicina (Kaunas) 2022 Aug 5;58(8) doi: 10.3390/medicina58081057. PMID: 36013525Free PMC Article
Metabolic Alterations, Aggressive Hormone-Naïve Prostate Cancer and Cardiovascular Disease: A Complex Relationship.
Di Francesco S, Robuffo I, Caruso M, Giambuzzi G, Ferri D, Militello A, Toniato E
Medicina (Kaunas) 2019 Mar 7;55(3) doi: 10.3390/medicina55030062. PMID: 30866568Free PMC Article
The Role of the Microenvironment in Prostate Cancer-Associated Bone Disease.
Turner CJ, Edwards CM
Curr Osteoporos Rep 2016 Oct;14(5):170-7. doi: 10.1007/s11914-016-0323-2. PMID: 27566487

Diagnosis

Inhibition of the Cyclin K-CDK12 complex induces DNA damage and increases the effect of androgen deprivation therapy in prostate cancer.
Frei K, Schecher S, Daher T, Hörner N, Richter J, Hildebrand U, Schindeldecker M, Witzel HR, Tsaur I, Porubsky S, Gaida MM, Roth W, Tagscherer KE
Int J Cancer 2024 Mar 15;154(6):1082-1096. Epub 2023 Nov 2 doi: 10.1002/ijc.34778. PMID: 37916780
Metabolic Alterations, Aggressive Hormone-Naïve Prostate Cancer and Cardiovascular Disease: A Complex Relationship.
Di Francesco S, Robuffo I, Caruso M, Giambuzzi G, Ferri D, Militello A, Toniato E
Medicina (Kaunas) 2019 Mar 7;55(3) doi: 10.3390/medicina55030062. PMID: 30866568Free PMC Article
CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma.
Kibel AS, Suarez BK, Belani J, Oh J, Webster R, Brophy-Ebbers M, Guo C, Catalona WJ, Picus J, Goodfellow PJ
Cancer Res 2003 May 1;63(9):2033-6. PMID: 12727815
Hormone therapy for patients with prostate carcinoma.
Klotz L
Cancer 2000 Jun 15;88(12 Suppl):3009-14. doi: 10.1002/1097-0142(20000615)88:12+<3009::aid-cncr17>3.3.co;2-5. PMID: 10898345
Gammopathy associated with advanced prostate carcinoma.
Abdul M, Hoosein NM
Urol Res 1995;23(3):185-8. doi: 10.1007/BF00389571. PMID: 7483145

Therapy

Inhibition of the Cyclin K-CDK12 complex induces DNA damage and increases the effect of androgen deprivation therapy in prostate cancer.
Frei K, Schecher S, Daher T, Hörner N, Richter J, Hildebrand U, Schindeldecker M, Witzel HR, Tsaur I, Porubsky S, Gaida MM, Roth W, Tagscherer KE
Int J Cancer 2024 Mar 15;154(6):1082-1096. Epub 2023 Nov 2 doi: 10.1002/ijc.34778. PMID: 37916780
The Role of the Microenvironment in Prostate Cancer-Associated Bone Disease.
Turner CJ, Edwards CM
Curr Osteoporos Rep 2016 Oct;14(5):170-7. doi: 10.1007/s11914-016-0323-2. PMID: 27566487
Adjuvant hormone therapy for localised and locally advanced prostate carcinoma: a systematic review and meta-analysis of randomised trials.
Shelley MD, Kumar S, Coles B, Wilt T, Staffurth J, Mason MD
Cancer Treat Rev 2009 Nov;35(7):540-6. Epub 2009 Jun 2 doi: 10.1016/j.ctrv.2009.05.001. PMID: 19493624
Hormone therapy for patients with prostate carcinoma.
Klotz L
Cancer 2000 Jun 15;88(12 Suppl):3009-14. doi: 10.1002/1097-0142(20000615)88:12+<3009::aid-cncr17>3.3.co;2-5. PMID: 10898345
Bisphosphonates in prostate carcinoma.
Adami S
Cancer 1997 Oct 15;80(8 Suppl):1674-9. doi: 10.1002/(sici)1097-0142(19971015)80:8+<1674::aid-cncr18>3.3.co;2-d. PMID: 9362435

Prognosis

Histologic patterns in prostatic adenocarcinoma are not predictive of mutations in the homologous recombination repair pathway.
Mahlow J, Barry M, Albertson DJ, Jo YJ, Balatico M, Seasor T, Gebrael G, Kumar SA, Sayegh N, Tripathi N, Agarwal N, Swami U, Sirohi D
Hum Pathol 2024 Feb;144:28-33. Epub 2024 Jan 24 doi: 10.1016/j.humpath.2024.01.005. PMID: 38278448
Inhibition of the Cyclin K-CDK12 complex induces DNA damage and increases the effect of androgen deprivation therapy in prostate cancer.
Frei K, Schecher S, Daher T, Hörner N, Richter J, Hildebrand U, Schindeldecker M, Witzel HR, Tsaur I, Porubsky S, Gaida MM, Roth W, Tagscherer KE
Int J Cancer 2024 Mar 15;154(6):1082-1096. Epub 2023 Nov 2 doi: 10.1002/ijc.34778. PMID: 37916780
Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma.
Vidal Crespo N, Enguita Arnal L, Gómez-Ferrer Á, Collado Serra A, Mascarós JM, Calatrava Fons A, Casanova Ramón-Borja J, Rubio Briones J, Ramírez-Backhaus M
Medicina (Kaunas) 2022 Aug 5;58(8) doi: 10.3390/medicina58081057. PMID: 36013525Free PMC Article
Assessment of bone scans in advanced prostate carcinoma using fully automated and semi-automated bone scan index methods.
Takahashi Y, Yoshimura M, Suzuki K, Hashimoto T, Hirose H, Uchida K, Inoue S, Koizumi K, Tokuuye K
Ann Nucl Med 2012 Aug;26(7):586-93. Epub 2012 Jun 29 doi: 10.1007/s12149-012-0617-0. PMID: 22744807
Bisphosphonates in prostate carcinoma.
Adami S
Cancer 1997 Oct 15;80(8 Suppl):1674-9. doi: 10.1002/(sici)1097-0142(19971015)80:8+<1674::aid-cncr18>3.3.co;2-d. PMID: 9362435

Clinical prediction guides

Histologic patterns in prostatic adenocarcinoma are not predictive of mutations in the homologous recombination repair pathway.
Mahlow J, Barry M, Albertson DJ, Jo YJ, Balatico M, Seasor T, Gebrael G, Kumar SA, Sayegh N, Tripathi N, Agarwal N, Swami U, Sirohi D
Hum Pathol 2024 Feb;144:28-33. Epub 2024 Jan 24 doi: 10.1016/j.humpath.2024.01.005. PMID: 38278448
Effect of Bicalutamide Combined with Docetaxel on Serum PSA and VEGF Levels in Patients with Advanced Prostate Carcinoma.
Guo Z, Hu X, Lv R, Zhang Y, Meng L, Liu Z, Yan L
Dis Markers 2022;2022:4506350. Epub 2022 Aug 17 doi: 10.1155/2022/4506350. PMID: 36033830Free PMC Article
Bilateral Seminal Vesicle Invasion Is Not Associated with Worse Outcomes in Locally Advanced Prostate Carcinoma.
Vidal Crespo N, Enguita Arnal L, Gómez-Ferrer Á, Collado Serra A, Mascarós JM, Calatrava Fons A, Casanova Ramón-Borja J, Rubio Briones J, Ramírez-Backhaus M
Medicina (Kaunas) 2022 Aug 5;58(8) doi: 10.3390/medicina58081057. PMID: 36013525Free PMC Article
Review of clinical manifestations of biochemically-advanced prostate cancer cases.
Chiong E, Wong AF, Chan YH, Chin CM
Asian J Surg 2005 Jul;28(3):202-6. doi: 10.1016/S1015-9584(09)60344-4. PMID: 16024317
Chemotherapy for patients with advanced prostate carcinoma: a new option for therapy.
Oh WK
Cancer 2000 Jun 15;88(12 Suppl):3015-21. doi: 10.1002/1097-0142(20000615)88:12+<3015::aid-cncr18>3.0.co;2-m. PMID: 10898346

Recent systematic reviews

Adjuvant hormone therapy for localised and locally advanced prostate carcinoma: a systematic review and meta-analysis of randomised trials.
Shelley MD, Kumar S, Coles B, Wilt T, Staffurth J, Mason MD
Cancer Treat Rev 2009 Nov;35(7):540-6. Epub 2009 Jun 2 doi: 10.1016/j.ctrv.2009.05.001. PMID: 19493624
A systematic review and meta-analysis of randomised trials of neo-adjuvant hormone therapy for localised and locally advanced prostate carcinoma.
Shelley MD, Kumar S, Wilt T, Staffurth J, Coles B, Mason MD
Cancer Treat Rev 2009 Feb;35(1):9-17. Epub 2008 Oct 15 doi: 10.1016/j.ctrv.2008.08.002. PMID: 18926640
Systematic review and meta-analysis of monotherapy compared with combined androgen blockade for patients with advanced prostate carcinoma.
Samson DJ, Seidenfeld J, Schmitt B, Hasselblad V, Albertsen PC, Bennett CL, Wilt TJ, Aronson N
Cancer 2002 Jul 15;95(2):361-76. doi: 10.1002/cncr.10647. PMID: 12124837

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