U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Advanced Prostate Adenocarcinoma

MedGen UID:
1659392
•Concept ID:
C4744714
•
Neoplastic Process

Definition

A prostatic adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Prostate Adenocarcinoma

Professional guidelines

PubMed

PEG10 is associated with treatment-induced neuroendocrine prostate cancer.
Kim S, Thaper D, Bidnur S, Toren P, Akamatsu S, Bishop JL, Colins C, Vahid S, Zoubeidi A
J Mol Endocrinol 2019 Jul 1;63(1):39-49. doi: 10.1530/JME-18-0226. PMID: 31013476

Recent clinical studies

Etiology

Influence of Humoral Response Against GnRH, Generated by Immunization with a Therapeutic Vaccine Candidate on the Evolution of Patients with Castration-Sensitive Prostate Adenocarcinoma.
Campal-Espinosa AC, Junco-Barranco JA, Fuentes-Aguilar F, Calzada-Aguilera L, Rivacoba-Betancourt A, Rodríguez-Bueno RH, Bover-Campal AC, Bover-Fuentes EE, González L, de Quesada L, Alvarez A, Garay-Pérez HE
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231207318. doi: 10.1177/15330338231207318. PMID: 37828833Free PMC Article
Dose-escalated radiotherapy for clinically localized and locally advanced prostate cancer.
Kim S, Kong JH, Lee Y, Lee JY, Kang TW, Kong TH, Kim MH, You SH
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD012817. doi: 10.1002/14651858.CD012817.pub2. PMID: 36884035Free PMC Article
Targeting the androgen receptor signaling pathway in advanced prostate cancer.
Chung C, Abboud K
Am J Health Syst Pharm 2022 Jul 22;79(15):1224-1235. doi: 10.1093/ajhp/zxac105. PMID: 35390118
Strategies to Circumvent Testosterone Surge and Disease Flare in Advanced Prostate Cancer: Emerging Treatment Paradigms.
Pokuri VK, Nourkeyhani H, Betsy B, Herbst L, Sikorski M, Spangenthal E, Fabiano A, George S
J Natl Compr Canc Netw 2015 Jul;13(7):e49-55. doi: 10.6004/jnccn.2015.0109. PMID: 26150586
Acute myeloid leukemia incidence following radiation therapy for localized or locally advanced prostate adenocarcinoma.
Ojha RP, Fischbach LA, Zhou Y, Felini MJ, Singh KP, Thertulien R
Cancer Epidemiol 2010 Jun;34(3):274-8. Epub 2010 Apr 27 doi: 10.1016/j.canep.2010.04.003. PMID: 20427255

Diagnosis

Granulomatous prostatitis: mimicking locally advanced prostate adenocarcinoma.
Mannatrizio D, Eusebi L, Yehia M, Filosa A, Guglielmi G
Acta Biomed 2023 Oct 17;94(5):e2023245. doi: 10.23750/abm.v94i5.13751. PMID: 37850783Free PMC Article
Influence of Humoral Response Against GnRH, Generated by Immunization with a Therapeutic Vaccine Candidate on the Evolution of Patients with Castration-Sensitive Prostate Adenocarcinoma.
Campal-Espinosa AC, Junco-Barranco JA, Fuentes-Aguilar F, Calzada-Aguilera L, Rivacoba-Betancourt A, Rodríguez-Bueno RH, Bover-Campal AC, Bover-Fuentes EE, González L, de Quesada L, Alvarez A, Garay-Pérez HE
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231207318. doi: 10.1177/15330338231207318. PMID: 37828833Free PMC Article
Acute myeloid leukemia incidence following radiation therapy for localized or locally advanced prostate adenocarcinoma.
Ojha RP, Fischbach LA, Zhou Y, Felini MJ, Singh KP, Thertulien R
Cancer Epidemiol 2010 Jun;34(3):274-8. Epub 2010 Apr 27 doi: 10.1016/j.canep.2010.04.003. PMID: 20427255
Quality of life in men with locally advanced adenocarcinoma of the prostate: an exploratory analysis using data from the CaPSURE database.
White WM, Sadetsky N, Waters WB, Carroll PR, Litwin MS
J Urol 2008 Dec;180(6):2409-13; discussion 2414. Epub 2008 Oct 18 doi: 10.1016/j.juro.2008.08.079. PMID: 18930270
Apoptosis and nuclear shapes in benign prostate hyperplasia and prostate adenocarcinoma: comparison with and relation to Gleason score.
Choi NG, Sohn JH, Park HW, Jung TY
Int J Urol 1999 Jan;6(1):13-8. doi: 10.1046/j.1442-2042.1999.06116.x. PMID: 10221859

Therapy

Dose-escalated radiotherapy for clinically localized and locally advanced prostate cancer.
Kim S, Kong JH, Lee Y, Lee JY, Kang TW, Kong TH, Kim MH, You SH
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD012817. doi: 10.1002/14651858.CD012817.pub2. PMID: 36884035Free PMC Article
Targeting the androgen receptor signaling pathway in advanced prostate cancer.
Chung C, Abboud K
Am J Health Syst Pharm 2022 Jul 22;79(15):1224-1235. doi: 10.1093/ajhp/zxac105. PMID: 35390118
PEG10 is associated with treatment-induced neuroendocrine prostate cancer.
Kim S, Thaper D, Bidnur S, Toren P, Akamatsu S, Bishop JL, Colins C, Vahid S, Zoubeidi A
J Mol Endocrinol 2019 Jul 1;63(1):39-49. doi: 10.1530/JME-18-0226. PMID: 31013476
Pembrolizumab for advanced prostate adenocarcinoma: findings of the KEYNOTE-028 study.
Hansen AR, Massard C, Ott PA, Haas NB, Lopez JS, Ejadi S, Wallmark JM, Keam B, Delord JP, Aggarwal R, Gould M, Yang P, Keefe SM, Piha-Paul SA
Ann Oncol 2018 Aug 1;29(8):1807-1813. doi: 10.1093/annonc/mdy232. PMID: 29992241
Changing perspectives of the role of chemotherapy in advanced prostate cancer.
Burgess EF, Roth BJ
Urol Clin North Am 2006 May;33(2):227-36, vii. doi: 10.1016/j.ucl.2005.12.006. PMID: 16631461

Prognosis

Extracorporeal hemoadsorption therapy as a potential therapeutic option for rapid removal of Apixaban in high risk-surgical patients: a case report.
Dalmastri V, Angelini A, Minerva V, Ballarini M, Grammatico F, Todeschini P, Pizzini AM, Silingardi M, La Manna G
J Med Case Rep 2023 Jul 7;17(1):283. doi: 10.1186/s13256-023-03949-3. PMID: 37415195Free PMC Article
Acute myeloid leukemia incidence following radiation therapy for localized or locally advanced prostate adenocarcinoma.
Ojha RP, Fischbach LA, Zhou Y, Felini MJ, Singh KP, Thertulien R
Cancer Epidemiol 2010 Jun;34(3):274-8. Epub 2010 Apr 27 doi: 10.1016/j.canep.2010.04.003. PMID: 20427255
Late urinary morbidity with high dose prostate brachytherapy as a boost to conventional external beam radiation therapy for local and locally advanced prostate cancer.
Pellizzon AC, Salvajoli JV, Maia MA, Ferrigno R, Novaes PE, Fogarolli RC, Pellizzon RJ
J Urol 2004 Mar;171(3):1105-8. doi: 10.1097/01.ju.0000113260.07979.d3. PMID: 14767280
Apoptosis and nuclear shapes in benign prostate hyperplasia and prostate adenocarcinoma: comparison with and relation to Gleason score.
Choi NG, Sohn JH, Park HW, Jung TY
Int J Urol 1999 Jan;6(1):13-8. doi: 10.1046/j.1442-2042.1999.06116.x. PMID: 10221859
Advanced prostate cancer follow-up with prostate-specific antigen, prostatic acid phosphatase, osteocalcin and bone isoenzyme of alkaline phosphatase.
Curatolo C, Ludovico GM, Correale M, Pagliarulo A, Abbate I, Cirrillo Marucco E, Barletta A
Eur Urol 1992;21 Suppl 1:105-7. doi: 10.1159/000474904. PMID: 1385127

Clinical prediction guides

Influence of Humoral Response Against GnRH, Generated by Immunization with a Therapeutic Vaccine Candidate on the Evolution of Patients with Castration-Sensitive Prostate Adenocarcinoma.
Campal-Espinosa AC, Junco-Barranco JA, Fuentes-Aguilar F, Calzada-Aguilera L, Rivacoba-Betancourt A, Rodríguez-Bueno RH, Bover-Campal AC, Bover-Fuentes EE, González L, de Quesada L, Alvarez A, Garay-Pérez HE
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231207318. doi: 10.1177/15330338231207318. PMID: 37828833Free PMC Article
Peritoneal Carcinomatosis From Metastatic Prostate Cancer Identified on 68 Ga-Prostate-Specific Membrane Antigen PET/CT.
Lau KS, Le K, Bui C, Wong VCK, Mansberg R
Clin Nucl Med 2023 Aug 1;48(8):704-706. Epub 2023 Jun 8 doi: 10.1097/RLU.0000000000004734. PMID: 37290423
PEG10 is associated with treatment-induced neuroendocrine prostate cancer.
Kim S, Thaper D, Bidnur S, Toren P, Akamatsu S, Bishop JL, Colins C, Vahid S, Zoubeidi A
J Mol Endocrinol 2019 Jul 1;63(1):39-49. doi: 10.1530/JME-18-0226. PMID: 31013476
Predictive clinical indicators of biochemical progression in advanced prostate cancer patients receiving Leuplin depot as androgen deprivation therapy.
Chen CH, Hsieh JT, Huang KH, Pu YS, Chang HC
PLoS One 2014;9(8):e105091. Epub 2014 Aug 14 doi: 10.1371/journal.pone.0105091. PMID: 25121948Free PMC Article
Quality of life in men with locally advanced adenocarcinoma of the prostate: an exploratory analysis using data from the CaPSURE database.
White WM, Sadetsky N, Waters WB, Carroll PR, Litwin MS
J Urol 2008 Dec;180(6):2409-13; discussion 2414. Epub 2008 Oct 18 doi: 10.1016/j.juro.2008.08.079. PMID: 18930270

Recent systematic reviews

Dose-escalated radiotherapy for clinically localized and locally advanced prostate cancer.
Kim S, Kong JH, Lee Y, Lee JY, Kang TW, Kong TH, Kim MH, You SH
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD012817. doi: 10.1002/14651858.CD012817.pub2. PMID: 36884035Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...