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Unresectable Synovial Sarcoma

MedGen UID:
1660219
•Concept ID:
C4727008
•
Neoplastic Process

Definition

Synovial sarcoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Synovial Sarcoma

Professional guidelines

PubMed

Poor Treatment Outcomes with Second-Line Chemotherapy in Advanced Synovial Sarcoma.
Kojima Y, Shimoi T, Seo T, Yazaki S, Okuya T, Ohtake Y, Okuma HS, Shimomura A, Nishikawa T, Tanioka M, Sudo K, Noguchi E, Tamura K, Yoshida A, Iwata S, Kobayashi E, Kawai A, Fujiwara Y, Yonemori K
Oncology 2022;100(7):370-375. Epub 2022 Apr 11 doi: 10.1159/000524500. PMID: 35405680
Poor treatment outcomes with palliative gemcitabine and docetaxel chemotherapy in advanced and metastatic synovial sarcoma.
Pender A, Davis EJ, Chauhan D, Messiou C, Al-Muderis O, Thway K, Fisher C, Zaidi S, Miah A, Judson I, van der Graaf W, Keedy VL, Benson C, Jones RL
Med Oncol 2018 Aug 20;35(10):131. doi: 10.1007/s12032-018-1193-5. PMID: 30128716Free PMC Article
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis.
Ravi V, Wang WL, Lewis VO
Curr Opin Oncol 2011 Jul;23(4):361-6. doi: 10.1097/CCO.0b013e328347e1e3. PMID: 21577109

Recent clinical studies

Etiology

A phase II study of gemcitabine and docetaxel combination in relapsed metastatic or unresectable locally advanced synovial sarcoma.
Tansir G, Rastogi S, Kumar A, Barwad A, Mridha AR, Dhamija E, Shamim SA, Bhatnagar S, Bhoriwal S
BMC Cancer 2023 Jul 8;23(1):639. doi: 10.1186/s12885-023-11099-4. PMID: 37422615Free PMC Article
Poor Treatment Outcomes with Second-Line Chemotherapy in Advanced Synovial Sarcoma.
Kojima Y, Shimoi T, Seo T, Yazaki S, Okuya T, Ohtake Y, Okuma HS, Shimomura A, Nishikawa T, Tanioka M, Sudo K, Noguchi E, Tamura K, Yoshida A, Iwata S, Kobayashi E, Kawai A, Fujiwara Y, Yonemori K
Oncology 2022;100(7):370-375. Epub 2022 Apr 11 doi: 10.1159/000524500. PMID: 35405680
Synovial Sarcoma in Children, Adolescents, and Young Adults: A Report From the Children's Oncology Group ARST0332 Study.
Venkatramani R, Xue W, Randall RL, Wolden S, Anderson J, Lopez-Terrada D, Black J, Kao SC, Shulkin B, Ostrenga A, Pappo A, Spunt SL
J Clin Oncol 2021 Dec 10;39(35):3927-3937. Epub 2021 Oct 8 doi: 10.1200/JCO.21.01628. PMID: 34623899Free PMC Article
Surgical excision and not chemotherapy is the most powerful modality in treating synovial sarcoma: the UK's North East experience.
Khan M, Rankin KS, Todd R, Lethbridge E, Gerrand C
Arch Orthop Trauma Surg 2019 Apr;139(4):443-449. Epub 2018 Nov 8 doi: 10.1007/s00402-018-3059-x. PMID: 30406818
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article

Diagnosis

Afamitresgene Autoleucel: First Approval.
Keam SJ
Mol Diagn Ther 2024 Nov;28(6):861-866. Epub 2024 Oct 15 doi: 10.1007/s40291-024-00749-3. PMID: 39404764
Synovial Sarcoma in Children, Adolescents, and Young Adults: A Report From the Children's Oncology Group ARST0332 Study.
Venkatramani R, Xue W, Randall RL, Wolden S, Anderson J, Lopez-Terrada D, Black J, Kao SC, Shulkin B, Ostrenga A, Pappo A, Spunt SL
J Clin Oncol 2021 Dec 10;39(35):3927-3937. Epub 2021 Oct 8 doi: 10.1200/JCO.21.01628. PMID: 34623899Free PMC Article
Synovial sarcoma presenting with huge mediastinal mass: a case report and review of literature.
Salah S, Al-Ibraheem A, Daboor A, Al-Hussaini M
BMC Res Notes 2013 Jun 25;6:240. doi: 10.1186/1756-0500-6-240. PMID: 23800262Free PMC Article
Unusual primary tumors of the heart.
Vander Salm TJ
Semin Thorac Cardiovasc Surg 2000 Apr;12(2):89-100. doi: 10.1053/ct.2000.5080. PMID: 10807431
Esophageal sarcomas.
Perch SJ, Soffen EM, Whittington R, Brooks JJ
J Surg Oncol 1991 Nov;48(3):194-8. doi: 10.1002/jso.2930480311. PMID: 1658495

Therapy

Afamitresgene Autoleucel: First Approval.
Keam SJ
Mol Diagn Ther 2024 Nov;28(6):861-866. Epub 2024 Oct 15 doi: 10.1007/s40291-024-00749-3. PMID: 39404764
Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): an international, open-label, phase 2 trial.
D'Angelo SP, Araujo DM, Abdul Razak AR, Agulnik M, Attia S, Blay JY, Carrasco Garcia I, Charlson JA, Choy E, Demetri GD, Druta M, Forcade E, Ganjoo KN, Glod J, Keedy VL, Le Cesne A, Liebner DA, Moreno V, Pollack SM, Schuetze SM, Schwartz GK, Strauss SJ, Tap WD, Thistlethwaite F, Valverde Morales CM, Wagner MJ, Wilky BA, McAlpine C, Hudson L, Navenot JM, Wang T, Bai J, Rafail S, Wang R, Sun A, Fernandes L, Van Winkle E, Elefant E, Lunt C, Norry E, Williams D, Biswas S, Van Tine BA
Lancet 2024 Apr 13;403(10435):1460-1471. Epub 2024 Mar 27 doi: 10.1016/S0140-6736(24)00319-2. PMID: 38554725Free PMC Article
A phase II study of gemcitabine and docetaxel combination in relapsed metastatic or unresectable locally advanced synovial sarcoma.
Tansir G, Rastogi S, Kumar A, Barwad A, Mridha AR, Dhamija E, Shamim SA, Bhatnagar S, Bhoriwal S
BMC Cancer 2023 Jul 8;23(1):639. doi: 10.1186/s12885-023-11099-4. PMID: 37422615Free PMC Article
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Pericardial synovial sarcoma.
Anand AK, Khanna A, Sinha SK, Mukherjee U, Walia JS, Singh AN
Clin Oncol (R Coll Radiol) 2003 Jun;15(4):186-8. doi: 10.1016/s0936-6555(02)00215-7. PMID: 12846496

Prognosis

Synovial Sarcoma in Children, Adolescents, and Young Adults: A Report From the Children's Oncology Group ARST0332 Study.
Venkatramani R, Xue W, Randall RL, Wolden S, Anderson J, Lopez-Terrada D, Black J, Kao SC, Shulkin B, Ostrenga A, Pappo A, Spunt SL
J Clin Oncol 2021 Dec 10;39(35):3927-3937. Epub 2021 Oct 8 doi: 10.1200/JCO.21.01628. PMID: 34623899Free PMC Article
Surgical excision and not chemotherapy is the most powerful modality in treating synovial sarcoma: the UK's North East experience.
Khan M, Rankin KS, Todd R, Lethbridge E, Gerrand C
Arch Orthop Trauma Surg 2019 Apr;139(4):443-449. Epub 2018 Nov 8 doi: 10.1007/s00402-018-3059-x. PMID: 30406818
Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.
Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S
Lancet Oncol 2017 Nov;18(11):1493-1501. Epub 2017 Oct 4 doi: 10.1016/S1470-2045(17)30624-1. PMID: 28988646Free PMC Article
Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis.
Ravi V, Wang WL, Lewis VO
Curr Opin Oncol 2011 Jul;23(4):361-6. doi: 10.1097/CCO.0b013e328347e1e3. PMID: 21577109
Unusual primary tumors of the heart.
Vander Salm TJ
Semin Thorac Cardiovasc Surg 2000 Apr;12(2):89-100. doi: 10.1053/ct.2000.5080. PMID: 10807431

Clinical prediction guides

Epirubicin, cisplatin plus ifosfamide versus standard chemotherapeutic regimens for advanced/unresectable primary thoracic sarcomas.
Rodriguez-Cid JR, Juarez-Vignon Whaley JJ, Sánchez-Domínguez G, Guzmán-Casta J, Carrasco-CaraChards S, Guzmán-Huesca J, Riera-Sala R, Sánchez-Ríos CP, Cruz-Zermeño M, Seidman-Sorsby A, de Jesús Rodríguez-Zea I, Alatorre-Alexander JA, Martínez-Barrera LM, Santillán-Doherty PJ, Godina-Flores A, Imaz-Olguin V, Sosa-Sánchez R, Green-Renner D
J Cancer Res Clin Oncol 2023 Aug;149(9):5479-5491. Epub 2022 Dec 4 doi: 10.1007/s00432-022-04454-8. PMID: 36463530
Surgical excision and not chemotherapy is the most powerful modality in treating synovial sarcoma: the UK's North East experience.
Khan M, Rankin KS, Todd R, Lethbridge E, Gerrand C
Arch Orthop Trauma Surg 2019 Apr;139(4):443-449. Epub 2018 Nov 8 doi: 10.1007/s00402-018-3059-x. PMID: 30406818
Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas.
Maekawa A, Kohashi K, Kuda M, Iura K, Ishii T, Endo M, Nakatsura T, Iwamoto Y, Oda Y
BMC Cancer 2016 Jul 20;16:511. doi: 10.1186/s12885-016-2542-4. PMID: 27439614Free PMC Article
Unusual primary tumors of the heart.
Vander Salm TJ
Semin Thorac Cardiovasc Surg 2000 Apr;12(2):89-100. doi: 10.1053/ct.2000.5080. PMID: 10807431
Synovial sarcoma in children and adolescents: the St Jude Children's Research Hospital experience.
Pappo AS, Fontanesi J, Luo X, Rao BN, Parham DM, Hurwitz C, Avery L, Pratt CB
J Clin Oncol 1994 Nov;12(11):2360-6. doi: 10.1200/JCO.1994.12.11.2360. PMID: 7964951

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