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Advanced Lung Carcinoma

MedGen UID:
1656952
•Concept ID:
C4727088
•
Neoplastic Process

Definition

A lung carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Appraisal of Basic-Hemostatic Markers in Lung Cancer Patients During Follow-Up Care After Radiotherapy Treatment.
Wolny-Rokicka EI, Wydmański J, Tukiendorf A, Mróz P, Zembroń-Łacny A
Med Sci Monit 2018 Nov 27;24:8577-8582. doi: 10.12659/MSM.910280. PMID: 30479323Free PMC Article
Surgical treatment of locally far-advanced lung carcinoma.
Takita H, Edgerton F, Conway D, Marabella PC, Vincent RG
J Surg Oncol 1981;17(3):283-6. doi: 10.1002/jso.2930170311. PMID: 7253663

Recent clinical studies

Etiology

High risk of thrombosis in patients with advanced lung cancer harboring rearrangements in ROS1.
Muñoz-Unceta N, Zugazagoitia J, Manzano A, Jiménez-Aguilar E, Olmedo ME, Cacho JD, Oliveira J, Dómine M, Ortega-Morán L, Aguado C, Luna AM, Fernández L, Pérez J, Font C, Salvador C, Corral J, Benítez G, Ros S, Biosca M, Calvo V, Martínez J, Sánchez-Cánovas M, López R, Sereno M, Mielgo X, Aparisi F, Carmona M, Carrión R, Ponce-Aix S, Soares M, Martínez-Salas I, García-Morillo M, Juan-Vidal O, Blasco A, Muñoz AJ, Paz-Ares L; Grupo de trombosis y cáncer SEOM
Eur J Cancer 2020 Dec;141:193-198. Epub 2020 Nov 7 doi: 10.1016/j.ejca.2020.10.002. PMID: 33166862
The value of serum Bcl-2 levels in advanced lung cancer patients.
Tas F, Duranyildiz D, Oguz H, Camlica H, Oral EN, Yasasever V, Topuz E
Med Oncol 2005;22(2):139-43. doi: 10.1385/MO:22:2:139. PMID: 15965276
The correlation between fatigue, physical function, the systemic inflammatory response, and psychological distress in patients with advanced lung cancer.
Brown DJ, McMillan DC, Milroy R
Cancer 2005 Jan 15;103(2):377-82. doi: 10.1002/cncr.20777. PMID: 15558809
Weekly, high-dose paclitaxel in advanced lung carcinoma: a phase II study with pharmacokinetics by the Cancer and Leukemia Group B.
Akerley W, Herndon JE, Egorin MJ, Lyss AP, Kindler HL, Savarese DM, Sherman CA, Rosen DM, Hollis D, Ratain MJ, Green MR
Cancer 2003 May 15;97(10):2480-6. doi: 10.1002/cncr.11375. PMID: 12733147
Mental state as a possible independent prognostic variable for survival in patients with advanced lung carcinoma.
Nakahara Y, Mochizuki Y, Miyamoto Y, Tanaka A, Kawamura T, Sasaki S, Nakahara Y, Katsura Y
Cancer 2002 Jun 1;94(11):3006-15. doi: 10.1002/cncr.10608. PMID: 12115391

Diagnosis

A 79-Year-Old Woman With Advanced Lung Carcinoma and Bilateral Infiltrates.
Jager EC, de Boer WS, van Schaik ML, Tomlow B
Chest 2022 Jun;161(6):e355-e358. doi: 10.1016/j.chest.2022.01.043. PMID: 35680315
Pulmonary sequestration with Aspergillus infection presenting as massive hemoptysis and hemothorax with highly elevated carcinoembryonic antigen in pleural effusion that mimics advanced lung malignancy.
Luo W, Hu TC, Luo L, Li YL
Eur J Med Res 2021 May 25;26(1):48. doi: 10.1186/s40001-021-00519-5. PMID: 34034813Free PMC Article
High risk of thrombosis in patients with advanced lung cancer harboring rearrangements in ROS1.
Muñoz-Unceta N, Zugazagoitia J, Manzano A, Jiménez-Aguilar E, Olmedo ME, Cacho JD, Oliveira J, Dómine M, Ortega-Morán L, Aguado C, Luna AM, Fernández L, Pérez J, Font C, Salvador C, Corral J, Benítez G, Ros S, Biosca M, Calvo V, Martínez J, Sánchez-Cánovas M, López R, Sereno M, Mielgo X, Aparisi F, Carmona M, Carrión R, Ponce-Aix S, Soares M, Martínez-Salas I, García-Morillo M, Juan-Vidal O, Blasco A, Muñoz AJ, Paz-Ares L; Grupo de trombosis y cáncer SEOM
Eur J Cancer 2020 Dec;141:193-198. Epub 2020 Nov 7 doi: 10.1016/j.ejca.2020.10.002. PMID: 33166862
Association of locally produced IL10 and TGFb1 with tumor size, histological type and presence of metastases in patients with lung carcinoma.
Karlicic V, Vukovic J, Stanojevic I, Sotirovic J, Peric A, Jovic M, Cvijanovic V, Djukic M, Banovic T, Vojvodic D
J BUON 2016 Sept-Oct;21(5):1210-1218. PMID: 27837625
Mental state as a possible independent prognostic variable for survival in patients with advanced lung carcinoma.
Nakahara Y, Mochizuki Y, Miyamoto Y, Tanaka A, Kawamura T, Sasaki S, Nakahara Y, Katsura Y
Cancer 2002 Jun 1;94(11):3006-15. doi: 10.1002/cncr.10608. PMID: 12115391

Therapy

Nivolumab increases pulmonary artery pressure in patients treated for non-small cell lung cancer.
Fournel L, Boudou-Rouquette P, Prieto M, Hervochon R, Guinet C, Arrondeau J, Alexandre J, Damotte D, Wislez M, Batteux F, Icard P, Goldwasser F, Alifano M
Cancer Chemother Pharmacol 2020 Oct;86(4):497-505. Epub 2020 Sep 16 doi: 10.1007/s00280-020-04142-9. PMID: 32936316
Appraisal of Basic-Hemostatic Markers in Lung Cancer Patients During Follow-Up Care After Radiotherapy Treatment.
Wolny-Rokicka EI, Wydmański J, Tukiendorf A, Mróz P, Zembroń-Łacny A
Med Sci Monit 2018 Nov 27;24:8577-8582. doi: 10.12659/MSM.910280. PMID: 30479323Free PMC Article
The value of serum Bcl-2 levels in advanced lung cancer patients.
Tas F, Duranyildiz D, Oguz H, Camlica H, Oral EN, Yasasever V, Topuz E
Med Oncol 2005;22(2):139-43. doi: 10.1385/MO:22:2:139. PMID: 15965276
Weekly, high-dose paclitaxel in advanced lung carcinoma: a phase II study with pharmacokinetics by the Cancer and Leukemia Group B.
Akerley W, Herndon JE, Egorin MJ, Lyss AP, Kindler HL, Savarese DM, Sherman CA, Rosen DM, Hollis D, Ratain MJ, Green MR
Cancer 2003 May 15;97(10):2480-6. doi: 10.1002/cncr.11375. PMID: 12733147
Study of pretreatment serum levels of HER-2/neu oncoprotein as a prognostic and predictive factor in patients with advanced nonsmall cell lung carcinoma.
Ardizzoni A, Cafferata MA, Paganuzzi M, Filiberti R, Marroni P, Neri M, Fontana V, Nicoló G, Perdelli L, Stampino CG, Rosso R, Puntoni R
Cancer 2001 Oct 1;92(7):1896-904. PMID: 11745263

Prognosis

High risk of thrombosis in patients with advanced lung cancer harboring rearrangements in ROS1.
Muñoz-Unceta N, Zugazagoitia J, Manzano A, Jiménez-Aguilar E, Olmedo ME, Cacho JD, Oliveira J, Dómine M, Ortega-Morán L, Aguado C, Luna AM, Fernández L, Pérez J, Font C, Salvador C, Corral J, Benítez G, Ros S, Biosca M, Calvo V, Martínez J, Sánchez-Cánovas M, López R, Sereno M, Mielgo X, Aparisi F, Carmona M, Carrión R, Ponce-Aix S, Soares M, Martínez-Salas I, García-Morillo M, Juan-Vidal O, Blasco A, Muñoz AJ, Paz-Ares L; Grupo de trombosis y cáncer SEOM
Eur J Cancer 2020 Dec;141:193-198. Epub 2020 Nov 7 doi: 10.1016/j.ejca.2020.10.002. PMID: 33166862
Association of locally produced IL10 and TGFb1 with tumor size, histological type and presence of metastases in patients with lung carcinoma.
Karlicic V, Vukovic J, Stanojevic I, Sotirovic J, Peric A, Jovic M, Cvijanovic V, Djukic M, Banovic T, Vojvodic D
J BUON 2016 Sept-Oct;21(5):1210-1218. PMID: 27837625
Radiotherapy.
Adamietz IA
Front Radiat Ther Oncol 2010;42:164-172. Epub 2009 Nov 24 doi: 10.1159/000262472. PMID: 19955803
The value of serum Bcl-2 levels in advanced lung cancer patients.
Tas F, Duranyildiz D, Oguz H, Camlica H, Oral EN, Yasasever V, Topuz E
Med Oncol 2005;22(2):139-43. doi: 10.1385/MO:22:2:139. PMID: 15965276
Mental state as a possible independent prognostic variable for survival in patients with advanced lung carcinoma.
Nakahara Y, Mochizuki Y, Miyamoto Y, Tanaka A, Kawamura T, Sasaki S, Nakahara Y, Katsura Y
Cancer 2002 Jun 1;94(11):3006-15. doi: 10.1002/cncr.10608. PMID: 12115391

Clinical prediction guides

High risk of thrombosis in patients with advanced lung cancer harboring rearrangements in ROS1.
Muñoz-Unceta N, Zugazagoitia J, Manzano A, Jiménez-Aguilar E, Olmedo ME, Cacho JD, Oliveira J, Dómine M, Ortega-Morán L, Aguado C, Luna AM, Fernández L, Pérez J, Font C, Salvador C, Corral J, Benítez G, Ros S, Biosca M, Calvo V, Martínez J, Sánchez-Cánovas M, López R, Sereno M, Mielgo X, Aparisi F, Carmona M, Carrión R, Ponce-Aix S, Soares M, Martínez-Salas I, García-Morillo M, Juan-Vidal O, Blasco A, Muñoz AJ, Paz-Ares L; Grupo de trombosis y cáncer SEOM
Eur J Cancer 2020 Dec;141:193-198. Epub 2020 Nov 7 doi: 10.1016/j.ejca.2020.10.002. PMID: 33166862
Nivolumab increases pulmonary artery pressure in patients treated for non-small cell lung cancer.
Fournel L, Boudou-Rouquette P, Prieto M, Hervochon R, Guinet C, Arrondeau J, Alexandre J, Damotte D, Wislez M, Batteux F, Icard P, Goldwasser F, Alifano M
Cancer Chemother Pharmacol 2020 Oct;86(4):497-505. Epub 2020 Sep 16 doi: 10.1007/s00280-020-04142-9. PMID: 32936316
Association of locally produced IL10 and TGFb1 with tumor size, histological type and presence of metastases in patients with lung carcinoma.
Karlicic V, Vukovic J, Stanojevic I, Sotirovic J, Peric A, Jovic M, Cvijanovic V, Djukic M, Banovic T, Vojvodic D
J BUON 2016 Sept-Oct;21(5):1210-1218. PMID: 27837625
Weekly, high-dose paclitaxel in advanced lung carcinoma: a phase II study with pharmacokinetics by the Cancer and Leukemia Group B.
Akerley W, Herndon JE, Egorin MJ, Lyss AP, Kindler HL, Savarese DM, Sherman CA, Rosen DM, Hollis D, Ratain MJ, Green MR
Cancer 2003 May 15;97(10):2480-6. doi: 10.1002/cncr.11375. PMID: 12733147
Mental state as a possible independent prognostic variable for survival in patients with advanced lung carcinoma.
Nakahara Y, Mochizuki Y, Miyamoto Y, Tanaka A, Kawamura T, Sasaki S, Nakahara Y, Katsura Y
Cancer 2002 Jun 1;94(11):3006-15. doi: 10.1002/cncr.10608. PMID: 12115391

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