U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Parotid Gland Adenoid Cystic Carcinoma

MedGen UID:
1656047
•Concept ID:
C4727411
•
Neoplastic Process

Definition

The reemergence of parotid gland adenoid cystic carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Parotid Gland Adenoid Cystic Carcinoma

Professional guidelines

PubMed

Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker.
Mayer M, Nachtsheim L, Prinz J, Shabli S, Suchan M, Klußmann JP, Quaas A, Arolt C, Wolber P
Clin Exp Metastasis 2023 Oct;40(5):395-405. Epub 2023 Jul 22 doi: 10.1007/s10585-023-10222-w. PMID: 37480387Free PMC Article
Management and outcome of adenoid cystic carcinoma of the major salivary glands: the 22-year experience of a single institution.
Ozaki A, Kawata R, Kinoshita I, Higashino M, Terada T, Haginomori SI, Kurisu Y, Hirose Y
Acta Otolaryngol 2023 May-Jun;143(6):536-542. Epub 2023 Jun 16 doi: 10.1080/00016489.2023.2220371. PMID: 37326148
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116

Recent clinical studies

Etiology

Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.
Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome.
Westergaard-Nielsen M, Godballe C, Eriksen JG, Larsen SR, Kiss K, Agander T, Ulhøi BP, Charabi B, Klug TE, Jacobsen H, Johansen J, Kristensen CA, Andersen E, Andersen M, Andreasen S, Bjørndal K
Eur Arch Otorhinolaryngol 2021 Apr;278(4):1179-1188. Epub 2020 Jul 20 doi: 10.1007/s00405-020-06205-2. PMID: 32691231
Parotid adenoid cystic carcinoma: Retrospective single institute analysis.
Mannelli G, Cecconi L, Fasolati M, Santoro R, Franchi A, Gallo O
Am J Otolaryngol 2017 Jul-Aug;38(4):394-400. Epub 2017 Mar 31 doi: 10.1016/j.amjoto.2017.03.008. PMID: 28478090
Brachytherapy for recurrent malignant tumours of the parotid gland.
Zhang J, Zheng L, Liu SM, Huang MW, Shi Y, Wang W, Zhang JG
Br J Oral Maxillofac Surg 2015 Jan;53(1):58-62. Epub 2014 Oct 19 doi: 10.1016/j.bjoms.2014.09.016. PMID: 25445387
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116

Diagnosis

Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.
Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome.
Westergaard-Nielsen M, Godballe C, Eriksen JG, Larsen SR, Kiss K, Agander T, Ulhøi BP, Charabi B, Klug TE, Jacobsen H, Johansen J, Kristensen CA, Andersen E, Andersen M, Andreasen S, Bjørndal K
Eur Arch Otorhinolaryngol 2021 Apr;278(4):1179-1188. Epub 2020 Jul 20 doi: 10.1007/s00405-020-06205-2. PMID: 32691231
Pediatric sialoblastoma: Evaluation and management.
Irace AL, Adil EA, Archer NM, Silvera VM, Perez-Atayde A, Rahbar R
Int J Pediatr Otorhinolaryngol 2016 Aug;87:44-9. Epub 2016 Apr 29 doi: 10.1016/j.ijporl.2016.04.037. PMID: 27368441
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Curative high-dose reirradiation for patients with recurrent head and neck adenoid cystic carcinomas: outcomes and analysis of patterns of failure.
Mahé M, Beddok A, Goudjil F, Ala Eddine C, Bolle S, Champion L, Feuvret L, Herman P, Zefkili S, Choussy O, Le Tourneau C, Dendale R, Buvat I, Sauvaget E, Créhange G, Calugaru V
Int J Radiat Biol 2024;100(1):79-86. Epub 2023 Aug 21 doi: 10.1080/09553002.2023.2242934. PMID: 37526368
The efficacy of neutron radiation therapy in treating salivary gland malignancies.
Timoshchuk MA, Dekker P, Hippe DS, Parvathaneni U, Liao JJ, Laramore GE, Dillon JK
Oral Oncol 2019 Jan;88:51-57. Epub 2018 Nov 21 doi: 10.1016/j.oraloncology.2018.11.006. PMID: 30616797
Prognostic Factors and Clinical Outcome in Parotid Gland Tumors: a Single Institution Experience from the Eastern Black Sea Region of Turkey.
Kandaz M, Soydemir G, Bahat Z, Canyilmaz E, Yoney A
Asian Pac J Cancer Prev 2016;17(3):1169-74. doi: 10.7314/apjcp.2016.17.3.1169. PMID: 27039743
Brachytherapy for recurrent malignant tumours of the parotid gland.
Zhang J, Zheng L, Liu SM, Huang MW, Shi Y, Wang W, Zhang JG
Br J Oral Maxillofac Surg 2015 Jan;53(1):58-62. Epub 2014 Oct 19 doi: 10.1016/j.bjoms.2014.09.016. PMID: 25445387
Management of salivary gland tumors.
Andry G, Hamoir M, Locati LD, Licitra L, Langendijk JA
Expert Rev Anticancer Ther 2012 Sep;12(9):1161-8. doi: 10.1586/era.12.92. PMID: 23098116

Prognosis

Clinicopathological characteristics of four major histological types of high-grade parotid carcinoma.
Kawata R, Kinoshita I, Jinnin T, Higashino M, Terada T, Kurisu Y, Hirose Y, Tochizawa T
Int J Clin Oncol 2023 Dec;28(12):1597-1606. Epub 2023 Oct 13 doi: 10.1007/s10147-023-02416-9. PMID: 37831230
Management and outcome of adenoid cystic carcinoma of the major salivary glands: the 22-year experience of a single institution.
Ozaki A, Kawata R, Kinoshita I, Higashino M, Terada T, Haginomori SI, Kurisu Y, Hirose Y
Acta Otolaryngol 2023 May-Jun;143(6):536-542. Epub 2023 Jun 16 doi: 10.1080/00016489.2023.2220371. PMID: 37326148
Salivary gland carcinoma in Denmark: a national update and follow-up on incidence, histology, and outcome.
Westergaard-Nielsen M, Godballe C, Eriksen JG, Larsen SR, Kiss K, Agander T, Ulhøi BP, Charabi B, Klug TE, Jacobsen H, Johansen J, Kristensen CA, Andersen E, Andersen M, Andreasen S, Bjørndal K
Eur Arch Otorhinolaryngol 2021 Apr;278(4):1179-1188. Epub 2020 Jul 20 doi: 10.1007/s00405-020-06205-2. PMID: 32691231
Parotid adenoid cystic carcinoma: Retrospective single institute analysis.
Mannelli G, Cecconi L, Fasolati M, Santoro R, Franchi A, Gallo O
Am J Otolaryngol 2017 Jul-Aug;38(4):394-400. Epub 2017 Mar 31 doi: 10.1016/j.amjoto.2017.03.008. PMID: 28478090
Brachytherapy for recurrent malignant tumours of the parotid gland.
Zhang J, Zheng L, Liu SM, Huang MW, Shi Y, Wang W, Zhang JG
Br J Oral Maxillofac Surg 2015 Jan;53(1):58-62. Epub 2014 Oct 19 doi: 10.1016/j.bjoms.2014.09.016. PMID: 25445387

Clinical prediction guides

Nectin-4 is frequently expressed in primary salivary gland cancer and corresponding lymph node metastases and represents an important treatment-related biomarker.
Mayer M, Nachtsheim L, Prinz J, Shabli S, Suchan M, Klußmann JP, Quaas A, Arolt C, Wolber P
Clin Exp Metastasis 2023 Oct;40(5):395-405. Epub 2023 Jul 22 doi: 10.1007/s10585-023-10222-w. PMID: 37480387Free PMC Article
HMTH1 induces the metastasis and recurrence of the parotid adenoma by repairing DNA damage.
Xu J, Yang ZY, Chen X, Liu X
Eur Rev Med Pharmacol Sci 2018 Jul;22(13):4363-4370. doi: 10.26355/eurrev_201807_15435. PMID: 30024628
Survival Outcome of Intermediate-Grade Salivary Gland Carcinoma.
Park GC, Roh JL, Cho KJ, Jung YG, Lee HW, Kim TG, Choi SH, Nam SY, Kim SY
Oncology 2018;94(2):125-132. Epub 2017 Nov 18 doi: 10.1159/000484411. PMID: 29151106
Parotid adenoid cystic carcinoma: Retrospective single institute analysis.
Mannelli G, Cecconi L, Fasolati M, Santoro R, Franchi A, Gallo O
Am J Otolaryngol 2017 Jul-Aug;38(4):394-400. Epub 2017 Mar 31 doi: 10.1016/j.amjoto.2017.03.008. PMID: 28478090
Re-irradiation of adenoid cystic carcinoma: analysis and evaluation of outcome in 52 consecutive patients treated with raster-scanned carbon ion therapy.
Jensen AD, Poulakis M, Nikoghosyan AV, Chaudhri N, Uhl M, Münter MW, Herfarth KK, Debus J
Radiother Oncol 2015 Feb;114(2):182-8. Epub 2015 Jan 29 doi: 10.1016/j.radonc.2015.01.002. PMID: 25640299

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...