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Metastatic Lung Non-Small Cell Carcinoma

MedGen UID:
1648938
•Concept ID:
C4744562
•
Neoplastic Process

Definition

A non-small cell carcinoma that arises from the lung and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Evolution of ramucirumab in the treatment of cancer - A review of literature.
Vennepureddy A, Singh P, Rastogi R, Atallah JP, Terjanian T
J Oncol Pharm Pract 2017 Oct;23(7):525-539. Epub 2016 Jun 15 doi: 10.1177/1078155216655474. PMID: 27306885
Molecular genetic testing for lung adenocarcinomas: a practical approach to clinically relevant mutations and translocations.
Dacic S
J Clin Pathol 2013 Oct;66(10):870-4. Epub 2013 Jun 25 doi: 10.1136/jclinpath-2012-201336. PMID: 23801495
Efficacy and side effects of cisplatin- and carboplatin-based doublet chemotherapeutic regimens versus non-platinum-based doublet chemotherapeutic regimens as first line treatment of metastatic non-small cell lung carcinoma: a systematic review of randomized controlled trials.
Rajeswaran A, Trojan A, Burnand B, Giannelli M
Lung Cancer 2008 Jan;59(1):1-11. Epub 2007 Aug 27 doi: 10.1016/j.lungcan.2007.07.012. PMID: 17720276

Recent clinical studies

Etiology

Lung resection after initial nonoperative treatment for non-small cell lung cancer.
Dunne EG, Fick CN, Tan KS, Toumbacaris N, Mastrogiacomo B, Adusumilli PS, Rocco G, Molena D, Huang J, Park BJ, Bott MJ, Rusch VR, Sihag S, Isbell JM, Chaft JE, Li BT, Gomez D, Rimner A, Bains MS, Jones DR
J Thorac Cardiovasc Surg 2024 Aug;168(2):364-373.e10. Epub 2023 Nov 30 doi: 10.1016/j.jtcvs.2023.11.040. PMID: 38042400Free PMC Article
Surgery for Locally Advanced and Oligometastatic Non-Small Cell Lung Cancer.
Coster JN, Groth SS
Surg Oncol Clin N Am 2020 Oct;29(4):543-554. doi: 10.1016/j.soc.2020.07.001. PMID: 32883457
Brain metastases from non-small cell lung carcinoma: Changing concepts for improving patients' outcome.
Rancoule C, Vallard A, Guy JB, Espenel S, Diao P, Chargari C, Magné N
Crit Rev Oncol Hematol 2017 Aug;116:32-37. Epub 2017 May 20 doi: 10.1016/j.critrevonc.2017.05.007. PMID: 28693798
Bone metastases and non-small cell lung cancer: from bisphosphonates to targeted therapy.
Rossi A, Gridelli C, Ricciardi S, de Marinis F
Curr Med Chem 2012;19(32):5524-35. doi: 10.2174/092986712803833209. PMID: 22963665
Early palliative care for patients with metastatic non-small-cell lung cancer.
Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ
N Engl J Med 2010 Aug 19;363(8):733-42. doi: 10.1056/NEJMoa1000678. PMID: 20818875

Diagnosis

Non-Small Cell Lung Cancer, Version 4.2024, NCCN Clinical Practice Guidelines in Oncology.
Riely GJ, Wood DE, Ettinger DS, Aisner DL, Akerley W, Bauman JR, Bharat A, Bruno DS, Chang JY, Chirieac LR, DeCamp M, Desai AP, Dilling TJ, Dowell J, Durm GA, Gettinger S, Grotz TE, Gubens MA, Juloori A, Lackner RP, Lanuti M, Lin J, Loo BW, Lovly CM, Maldonado F, Massarelli E, Morgensztern D, Mullikin TC, Ng T, Owen D, Owen DH, Patel SP, Patil T, Polanco PM, Riess J, Shapiro TA, Singh AP, Stevenson J, Tam A, Tanvetyanon T, Yanagawa J, Yang SC, Yau E, Gregory KM, Hang L
J Natl Compr Canc Netw 2024 May;22(4):249-274. doi: 10.6004/jnccn.2204.0023. PMID: 38754467
Non-Small Cell Lung Cancer, Version 3.2022, NCCN Clinical Practice Guidelines in Oncology.
Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman JR, Bharat A, Bruno DS, Chang JY, Chirieac LR, D'Amico TA, DeCamp M, Dilling TJ, Dowell J, Gettinger S, Grotz TE, Gubens MA, Hegde A, Lackner RP, Lanuti M, Lin J, Loo BW, Lovly CM, Maldonado F, Massarelli E, Morgensztern D, Ng T, Otterson GA, Pacheco JM, Patel SP, Riely GJ, Riess J, Schild SE, Shapiro TA, Singh AP, Stevenson J, Tam A, Tanvetyanon T, Yanagawa J, Yang SC, Yau E, Gregory K, Hughes M
J Natl Compr Canc Netw 2022 May;20(5):497-530. doi: 10.6004/jnccn.2022.0025. PMID: 35545176
The evolving role of radiotherapy in non-small cell lung cancer.
Brown S, Banfill K, Aznar MC, Whitehurst P, Faivre Finn C
Br J Radiol 2019 Dec;92(1104):20190524. Epub 2019 Sep 19 doi: 10.1259/bjr.20190524. PMID: 31535580Free PMC Article
Non-Small Cell Lung Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology.
Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman J, Chirieac LR, D'Amico TA, DeCamp MM, Dilling TJ, Dobelbower M, Doebele RC, Govindan R, Gubens MA, Hennon M, Horn L, Komaki R, Lackner RP, Lanuti M, Leal TA, Leisch LJ, Lilenbaum R, Lin J, Loo BW Jr, Martins R, Otterson GA, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Stevenson J, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M
J Natl Compr Canc Netw 2017 Apr;15(4):504-535. doi: 10.6004/jnccn.2017.0050. PMID: 28404761
Early palliative care for patients with metastatic non-small-cell lung cancer.
Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ
N Engl J Med 2010 Aug 19;363(8):733-42. doi: 10.1056/NEJMoa1000678. PMID: 20818875

Therapy

Emerging therapeutic agents for advanced non-small cell lung cancer.
Chen R, Manochakian R, James L, Azzouqa AG, Shi H, Zhang Y, Zhao Y, Zhou K, Lou Y
J Hematol Oncol 2020 May 24;13(1):58. doi: 10.1186/s13045-020-00881-7. PMID: 32448366Free PMC Article
The biology and management of non-small cell lung cancer.
Herbst RS, Morgensztern D, Boshoff C
Nature 2018 Jan 24;553(7689):446-454. doi: 10.1038/nature25183. PMID: 29364287
Non-Small Cell Lung Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology.
Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman J, Chirieac LR, D'Amico TA, DeCamp MM, Dilling TJ, Dobelbower M, Doebele RC, Govindan R, Gubens MA, Hennon M, Horn L, Komaki R, Lackner RP, Lanuti M, Leal TA, Leisch LJ, Lilenbaum R, Lin J, Loo BW Jr, Martins R, Otterson GA, Reckamp K, Riely GJ, Schild SE, Shapiro TA, Stevenson J, Swanson SJ, Tauer K, Yang SC, Gregory K, Hughes M
J Natl Compr Canc Netw 2017 Apr;15(4):504-535. doi: 10.6004/jnccn.2017.0050. PMID: 28404761
Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data.
NSCLC Meta-analysis Collaborative Group
Lancet 2014 May 3;383(9928):1561-71. Epub 2014 Feb 25 doi: 10.1016/S0140-6736(13)62159-5. PMID: 24576776Free PMC Article
Early palliative care for patients with metastatic non-small-cell lung cancer.
Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ
N Engl J Med 2010 Aug 19;363(8):733-42. doi: 10.1056/NEJMoa1000678. PMID: 20818875

Prognosis

Lorlatinib in advanced ROS1-positive non-small-cell lung cancer: a multicentre, open-label, single-arm, phase 1-2 trial.
Shaw AT, Solomon BJ, Chiari R, Riely GJ, Besse B, Soo RA, Kao S, Lin CC, Bauer TM, Clancy JS, Thurm H, Martini JF, Peltz G, Abbattista A, Li S, Ou SI
Lancet Oncol 2019 Dec;20(12):1691-1701. Epub 2019 Oct 25 doi: 10.1016/S1470-2045(19)30655-2. PMID: 31669155
Systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio can predict clinical outcomes in patients with metastatic non-small-cell lung cancer treated with nivolumab.
Liu J, Li S, Zhang S, Liu Y, Ma L, Zhu J, Xin Y, Wang Y, Yang C, Cheng Y
J Clin Lab Anal 2019 Oct;33(8):e22964. Epub 2019 Jul 8 doi: 10.1002/jcla.22964. PMID: 31282096Free PMC Article
The biology and management of non-small cell lung cancer.
Herbst RS, Morgensztern D, Boshoff C
Nature 2018 Jan 24;553(7689):446-454. doi: 10.1038/nature25183. PMID: 29364287
Ablative Therapy for Oligometastatic Non-Small Cell Lung Cancer.
Juan O, Popat S
Clin Lung Cancer 2017 Nov;18(6):595-606. Epub 2017 Mar 14 doi: 10.1016/j.cllc.2017.03.002. PMID: 28377206
Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group.
Ginsberg RJ, Rubinstein LV
Ann Thorac Surg 1995 Sep;60(3):615-22; discussion 622-3. doi: 10.1016/0003-4975(95)00537-u. PMID: 7677489

Clinical prediction guides

Circulating Tumor DNA Minimal Residual Disease Detection of Non-Small-Cell Lung Cancer Treated With Curative Intent.
Pellini B, Chaudhuri AA
J Clin Oncol 2022 Feb 20;40(6):567-575. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01929. PMID: 34985936Free PMC Article
Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review.
Arbour KC, Riely GJ
JAMA 2019 Aug 27;322(8):764-774. doi: 10.1001/jama.2019.11058. PMID: 31454018
Association of Survival and Immune-Related Biomarkers With Immunotherapy in Patients With Non-Small Cell Lung Cancer: A Meta-analysis and Individual Patient-Level Analysis.
Yu Y, Zeng D, Ou Q, Liu S, Li A, Chen Y, Lin D, Gao Q, Zhou H, Liao W, Yao H
JAMA Netw Open 2019 Jul 3;2(7):e196879. doi: 10.1001/jamanetworkopen.2019.6879. PMID: 31290993Free PMC Article
Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non-Small Cell Lung Cancer.
Aggarwal C, Thompson JC, Black TA, Katz SI, Fan R, Yee SS, Chien AL, Evans TL, Bauml JM, Alley EW, Ciunci CA, Berman AT, Cohen RB, Lieberman DB, Majmundar KS, Savitch SL, Morrissette JJD, Hwang WT, Elenitoba-Johnson KSJ, Langer CJ, Carpenter EL
JAMA Oncol 2019 Feb 1;5(2):173-180. doi: 10.1001/jamaoncol.2018.4305. PMID: 30325992Free PMC Article
Early palliative care for patients with metastatic non-small-cell lung cancer.
Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, Dahlin CM, Blinderman CD, Jacobsen J, Pirl WF, Billings JA, Lynch TJ
N Engl J Med 2010 Aug 19;363(8):733-42. doi: 10.1056/NEJMoa1000678. PMID: 20818875

Recent systematic reviews

Cannabis-based medicines and medical cannabis for adults with cancer pain.
Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
Targeted therapy for advanced anaplastic lymphoma kinase (<I>ALK</I>)-rearranged non-small cell lung cancer.
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Uncommon EGFR mutations in non-small-cell lung cancer: A systematic literature review of prevalence and clinical outcomes.
John T, Taylor A, Wang H, Eichinger C, Freeman C, Ahn MJ
Cancer Epidemiol 2022 Feb;76:102080. Epub 2021 Dec 15 doi: 10.1016/j.canep.2021.102080. PMID: 34922050
Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data.
NSCLC Meta-analysis Collaborative Group
Lancet 2014 May 3;383(9928):1561-71. Epub 2014 Feb 25 doi: 10.1016/S0140-6736(13)62159-5. PMID: 24576776Free PMC Article

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