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Grade 4 Generalized Edema, CTCAE

MedGen UID:
1642431
•Concept ID:
C4686744
•
Finding

Definition

Life-threatening consequences [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 4 Generalized Edema, CTCAE

Recent clinical studies

Etiology

Toxicities associated with immune checkpoint inhibitors: a systematic study.
Kong X, Chen L, Su Z, Sullivan RJ, Blum SM, Qi Z, Liu Y, Huo Y, Fang Y, Zhang L, Gao J, Wang J
Int J Surg 2023 Jun 1;109(6):1753-1768. doi: 10.1097/JS9.0000000000000368. PMID: 37132038Free PMC Article
Hand-foot syndrome induced by chemotherapy drug: Case series study and literature review.
Zaiem A, Hammamia SB, Aouinti I, Charfi O, Ladhari W, Kastalli S, Aidli SE, Lakhoua G
Indian J Pharmacol 2022 May-Jun;54(3):208-215. doi: 10.4103/ijp.ijp_175_21. PMID: 35848692Free PMC Article
Early vascular toxicity after pediatric allogeneic hematopoietic stem cell transplantation.
Leimi L, Jahnukainen K, Olkinuora H, Meri S, Vettenranta K
Bone Marrow Transplant 2022 May;57(5):705-711. Epub 2022 Feb 17 doi: 10.1038/s41409-022-01607-8. PMID: 35177827Free PMC Article
Complications of Percutaneous Radiofrequency Ablation of Spinal Osseous Metastases: An 8-Year Single-Center Experience.
Tomasian A, Marlow J, Hillen TJ, Jennings JW
AJR Am J Roentgenol 2021 Jun;216(6):1607-1613. Epub 2021 Mar 31 doi: 10.2214/AJR.20.23494. PMID: 33787296
Chronic toxicity and long-term outcome in intraoperative electron radiotherapy as boost followed by whole-breast irradiation.
Oses G, Cases C, Valduvieco I, Farrús B, Alonso I, Caparrós X, Mases J, Muñoz-Guglielmetti D, Biete A, Castro C, Escudero E, Molina M, Herreros A, Saez J, Mollà M
Clin Transl Oncol 2021 Aug;23(8):1593-1600. Epub 2021 Feb 3 doi: 10.1007/s12094-021-02555-3. PMID: 33534078

Diagnosis

Life-threatening Autoimmune Cardiomyopathy Reproducibly Induced in a Patient by Checkpoint Inhibitor Therapy.
Tajmir-Riahi A, Bergmann T, Schmid M, Agaimy A, Schuler G, Heinzerling L
J Immunother 2018 Jan;41(1):35-38. doi: 10.1097/CJI.0000000000000190. PMID: 29077601

Therapy

Toxicities associated with immune checkpoint inhibitors: a systematic study.
Kong X, Chen L, Su Z, Sullivan RJ, Blum SM, Qi Z, Liu Y, Huo Y, Fang Y, Zhang L, Gao J, Wang J
Int J Surg 2023 Jun 1;109(6):1753-1768. doi: 10.1097/JS9.0000000000000368. PMID: 37132038Free PMC Article
Early vascular toxicity after pediatric allogeneic hematopoietic stem cell transplantation.
Leimi L, Jahnukainen K, Olkinuora H, Meri S, Vettenranta K
Bone Marrow Transplant 2022 May;57(5):705-711. Epub 2022 Feb 17 doi: 10.1038/s41409-022-01607-8. PMID: 35177827Free PMC Article
Complications of Percutaneous Radiofrequency Ablation of Spinal Osseous Metastases: An 8-Year Single-Center Experience.
Tomasian A, Marlow J, Hillen TJ, Jennings JW
AJR Am J Roentgenol 2021 Jun;216(6):1607-1613. Epub 2021 Mar 31 doi: 10.2214/AJR.20.23494. PMID: 33787296
Chronic toxicity and long-term outcome in intraoperative electron radiotherapy as boost followed by whole-breast irradiation.
Oses G, Cases C, Valduvieco I, Farrús B, Alonso I, Caparrós X, Mases J, Muñoz-Guglielmetti D, Biete A, Castro C, Escudero E, Molina M, Herreros A, Saez J, Mollà M
Clin Transl Oncol 2021 Aug;23(8):1593-1600. Epub 2021 Feb 3 doi: 10.1007/s12094-021-02555-3. PMID: 33534078
Assessment of toxicities and outcomes in patients with breast cancer treated with hypofractionated radiotherapy.
Sindhu M, Malik M, Ahmed SF, Valiyaveettil D
Indian J Cancer 2020 Oct-Dec;57(4):423-427. doi: 10.4103/ijc.IJC_670_18. PMID: 33078749

Prognosis

Toxicities associated with immune checkpoint inhibitors: a systematic study.
Kong X, Chen L, Su Z, Sullivan RJ, Blum SM, Qi Z, Liu Y, Huo Y, Fang Y, Zhang L, Gao J, Wang J
Int J Surg 2023 Jun 1;109(6):1753-1768. doi: 10.1097/JS9.0000000000000368. PMID: 37132038Free PMC Article
Hand-foot syndrome induced by chemotherapy drug: Case series study and literature review.
Zaiem A, Hammamia SB, Aouinti I, Charfi O, Ladhari W, Kastalli S, Aidli SE, Lakhoua G
Indian J Pharmacol 2022 May-Jun;54(3):208-215. doi: 10.4103/ijp.ijp_175_21. PMID: 35848692Free PMC Article
Early vascular toxicity after pediatric allogeneic hematopoietic stem cell transplantation.
Leimi L, Jahnukainen K, Olkinuora H, Meri S, Vettenranta K
Bone Marrow Transplant 2022 May;57(5):705-711. Epub 2022 Feb 17 doi: 10.1038/s41409-022-01607-8. PMID: 35177827Free PMC Article
Assessment of toxicities and outcomes in patients with breast cancer treated with hypofractionated radiotherapy.
Sindhu M, Malik M, Ahmed SF, Valiyaveettil D
Indian J Cancer 2020 Oct-Dec;57(4):423-427. doi: 10.4103/ijc.IJC_670_18. PMID: 33078749
Low-dose prednisolone in first-line docetaxel for patients with metastatic castration-resistant prostate cancer: is there a clinical benefit?
Kongsted P, Svane IM, Lindberg H, Daugaard G, Sengeløv L
Urol Oncol 2015 Nov;33(11):494.e15-20. Epub 2015 Aug 5 doi: 10.1016/j.urolonc.2015.06.022. PMID: 26254696

Clinical prediction guides

Efficacy, tolerance and acceptability of pulsed dye laser on facial and neckline telangiectasias in systemic scleroderma: a prospective open-label monocentric study in 21 patients.
Kottler D, Dupechez L, Martin Silva N, Boutemy J, Dumont A, Maigné G, Aouba A, Dompmartin A
J Cosmet Laser Ther 2023 Nov 17;25(5-8):77-85. Epub 2024 Feb 19 doi: 10.1080/14764172.2024.2313472. PMID: 38373440
Ultrasound-Based Grading System for Radiation-Induced Acute Breast Toxicity.
Wang J, Zhou B, Yang X, Tridandapani S, Lin J, Torres MA, Liu T
J Ultrasound Med 2023 Jun;42(6):1307-1317. Epub 2022 Dec 30 doi: 10.1002/jum.16144. PMID: 36583524
Early vascular toxicity after pediatric allogeneic hematopoietic stem cell transplantation.
Leimi L, Jahnukainen K, Olkinuora H, Meri S, Vettenranta K
Bone Marrow Transplant 2022 May;57(5):705-711. Epub 2022 Feb 17 doi: 10.1038/s41409-022-01607-8. PMID: 35177827Free PMC Article
Complications of Percutaneous Radiofrequency Ablation of Spinal Osseous Metastases: An 8-Year Single-Center Experience.
Tomasian A, Marlow J, Hillen TJ, Jennings JW
AJR Am J Roentgenol 2021 Jun;216(6):1607-1613. Epub 2021 Mar 31 doi: 10.2214/AJR.20.23494. PMID: 33787296
Chronic toxicity and long-term outcome in intraoperative electron radiotherapy as boost followed by whole-breast irradiation.
Oses G, Cases C, Valduvieco I, Farrús B, Alonso I, Caparrós X, Mases J, Muñoz-Guglielmetti D, Biete A, Castro C, Escudero E, Molina M, Herreros A, Saez J, Mollà M
Clin Transl Oncol 2021 Aug;23(8):1593-1600. Epub 2021 Feb 3 doi: 10.1007/s12094-021-02555-3. PMID: 33534078

Recent systematic reviews

Toxicities associated with immune checkpoint inhibitors: a systematic study.
Kong X, Chen L, Su Z, Sullivan RJ, Blum SM, Qi Z, Liu Y, Huo Y, Fang Y, Zhang L, Gao J, Wang J
Int J Surg 2023 Jun 1;109(6):1753-1768. doi: 10.1097/JS9.0000000000000368. PMID: 37132038Free PMC Article

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