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Diagonal earlobe crease

MedGen UID:
1621631
•Concept ID:
C4531074
•
Anatomical Abnormality
HPO: HP:0031511

Definition

Diagonal earlobe creases run from the lower pole of the external meatus, diagonally backwards to the edge of the lobe at approximately 45 degrees. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiagonal earlobe crease

Recent clinical studies

Etiology

The relationship of diagonal earlobe crease (Frank's sign) and obstructive coronary artery disease in patients undergoing coronary angiography.
Gakovic B, Neskovic SA, Vranic I, Grujicic K, Mijatovic S, Ljubojevic A, Stankovic I
Wien Klin Wochenschr 2023 Dec;135(23-24):667-673. Epub 2023 Oct 30 doi: 10.1007/s00508-023-02297-y. PMID: 37902857
The prognostic value of the Frank sign.
Prangenberg J, Doberentz E, Johann L, Madea B
Forensic Sci Med Pathol 2022 Jun;18(2):149-155. Epub 2022 Feb 18 doi: 10.1007/s12024-022-00463-8. PMID: 35179701Free PMC Article
Diagonal earlobe crease and long-term survival after myocardial infarction.
Thilo C, Meisinger C, Heier M, von Scheidt W, Kirchberger I
BMC Cardiovasc Disord 2021 Dec 16;21(1):597. doi: 10.1186/s12872-021-02425-4. PMID: 34915852Free PMC Article
Anterior Tragal Crease Is Associated With Atherosclerosis: A Study Evaluating Carotid Artery Intima-Media Thickness.
Rerknimitr P, Pongpairoj K, Kumtornrat C, Panchaprateep R, Hurst CP, Chutinet A, Asawanonda P, Suwanwela NC
Angiology 2017 Sep;68(8):683-687. Epub 2017 Jan 5 doi: 10.1177/0003319716685481. PMID: 28056529
Diagonal earlobe crease and coronary artery disease in a Chinese population.
Wu XL, Yang DY, Zhao YS, Chai WH, Jin ML
BMC Cardiovasc Disord 2014 Apr 4;14:43. doi: 10.1186/1471-2261-14-43. PMID: 24708687Free PMC Article

Diagnosis

The relationship of diagonal earlobe crease (Frank's sign) and obstructive coronary artery disease in patients undergoing coronary angiography.
Gakovic B, Neskovic SA, Vranic I, Grujicic K, Mijatovic S, Ljubojevic A, Stankovic I
Wien Klin Wochenschr 2023 Dec;135(23-24):667-673. Epub 2023 Oct 30 doi: 10.1007/s00508-023-02297-y. PMID: 37902857
The prognostic value of the Frank sign.
Prangenberg J, Doberentz E, Johann L, Madea B
Forensic Sci Med Pathol 2022 Jun;18(2):149-155. Epub 2022 Feb 18 doi: 10.1007/s12024-022-00463-8. PMID: 35179701Free PMC Article
Frank's sign - A dermatological link to coronary artery disease?
Lee KG
Med J Malaysia 2017 Jun;72(3):195-196. PMID: 28733570
Anterior Tragal Crease Is Associated With Atherosclerosis: A Study Evaluating Carotid Artery Intima-Media Thickness.
Rerknimitr P, Pongpairoj K, Kumtornrat C, Panchaprateep R, Hurst CP, Chutinet A, Asawanonda P, Suwanwela NC
Angiology 2017 Sep;68(8):683-687. Epub 2017 Jan 5 doi: 10.1177/0003319716685481. PMID: 28056529
Diagonal earlobe crease and coronary artery disease in a Chinese population.
Wu XL, Yang DY, Zhao YS, Chai WH, Jin ML
BMC Cardiovasc Disord 2014 Apr 4;14:43. doi: 10.1186/1471-2261-14-43. PMID: 24708687Free PMC Article

Prognosis

The relationship of diagonal earlobe crease (Frank's sign) and obstructive coronary artery disease in patients undergoing coronary angiography.
Gakovic B, Neskovic SA, Vranic I, Grujicic K, Mijatovic S, Ljubojevic A, Stankovic I
Wien Klin Wochenschr 2023 Dec;135(23-24):667-673. Epub 2023 Oct 30 doi: 10.1007/s00508-023-02297-y. PMID: 37902857
The prognostic value of the Frank sign.
Prangenberg J, Doberentz E, Johann L, Madea B
Forensic Sci Med Pathol 2022 Jun;18(2):149-155. Epub 2022 Feb 18 doi: 10.1007/s12024-022-00463-8. PMID: 35179701Free PMC Article
Diagonal earlobe crease and long-term survival after myocardial infarction.
Thilo C, Meisinger C, Heier M, von Scheidt W, Kirchberger I
BMC Cardiovasc Disord 2021 Dec 16;21(1):597. doi: 10.1186/s12872-021-02425-4. PMID: 34915852Free PMC Article
Anterior Tragal Crease Is Associated With Atherosclerosis: A Study Evaluating Carotid Artery Intima-Media Thickness.
Rerknimitr P, Pongpairoj K, Kumtornrat C, Panchaprateep R, Hurst CP, Chutinet A, Asawanonda P, Suwanwela NC
Angiology 2017 Sep;68(8):683-687. Epub 2017 Jan 5 doi: 10.1177/0003319716685481. PMID: 28056529
Diagonal earlobe crease and coronary artery disease in a Chinese population.
Wu XL, Yang DY, Zhao YS, Chai WH, Jin ML
BMC Cardiovasc Disord 2014 Apr 4;14:43. doi: 10.1186/1471-2261-14-43. PMID: 24708687Free PMC Article

Clinical prediction guides

Frank's Sign: A Link Between Dermatovenerology, Cardiac Pathology, and Neurology.
Čerimagić D
Acta Dermatovenerol Croat 2023 Nov;31(2):101-102. PMID: 38006371
The relationship of diagonal earlobe crease (Frank's sign) and obstructive coronary artery disease in patients undergoing coronary angiography.
Gakovic B, Neskovic SA, Vranic I, Grujicic K, Mijatovic S, Ljubojevic A, Stankovic I
Wien Klin Wochenschr 2023 Dec;135(23-24):667-673. Epub 2023 Oct 30 doi: 10.1007/s00508-023-02297-y. PMID: 37902857
Diagonal earlobe crease and long-term survival after myocardial infarction.
Thilo C, Meisinger C, Heier M, von Scheidt W, Kirchberger I
BMC Cardiovasc Disord 2021 Dec 16;21(1):597. doi: 10.1186/s12872-021-02425-4. PMID: 34915852Free PMC Article
Frank's sign - A dermatological link to coronary artery disease?
Lee KG
Med J Malaysia 2017 Jun;72(3):195-196. PMID: 28733570
Diagonal earlobe crease and coronary artery disease in a Chinese population.
Wu XL, Yang DY, Zhao YS, Chai WH, Jin ML
BMC Cardiovasc Disord 2014 Apr 4;14:43. doi: 10.1186/1471-2261-14-43. PMID: 24708687Free PMC Article

Recent systematic reviews

Diagonal earlobe crease (Frank's sign) and increased risk of cerebrovascular diseases: review of the literature and implications for clinical practice.
Pacei F, Bersano A, Brigo F, Reggiani S, Nardone R
Neurol Sci 2020 Feb;41(2):257-262. Epub 2019 Oct 23 doi: 10.1007/s10072-019-04080-2. PMID: 31641899

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