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Impairment in personality functioning

MedGen UID:
1613001
Concept ID:
C4531101
Mental or Behavioral Dysfunction
HPO: HP:0031466

Definition

A maladaptive personality trait characterized by moderate or greater impairment in personality (self /interpersonal) functioning. [from HPO]

Professional guidelines

PubMed

Nysaeter TE, Hummelen B, Christensen TB, Eikenaes IU, Selvik SG, Pedersen G, Bender DS, Skodol AE, Paap MCS
J Pers Assess 2023 Jan-Feb;105(1):111-120. Epub 2022 Mar 14 doi: 10.1080/00223891.2022.2039166. PMID: 35285763

Recent clinical studies

Etiology

Sidpra J, Sudhakar S, Biswas A, Massey F, Turchetti V, Lau T, Cook E, Alvi JR, Elbendary HM, Jewell JL, Riva A, Orsini A, Vignoli A, Federico Z, Rosenblum J, Schoonjans AS, de Wachter M, Delgado Alvarez I, Felipe-Rucián A, Haridy NA, Haider S, Zaman M, Banu S, Anwaar N, Rahman F, Maqbool S, Yadav R, Salpietro V, Maroofian R, Patel R, Radhakrishnan R, Prabhu SP, Lichtenbelt K, Stewart H, Murakami Y, Löbel U, D'Arco F, Wakeling E, Jones W, Hay E, Bhate S, Jacques TS, Mirsky DM, Whitehead MT, Zaki MS, Sultan T, Striano P, Jansen AC, Lequin M, de Vries LS, Severino M, Edmondson AC, Menzies L, Campeau PM, Houlden H, McTague A, Efthymiou S, Mankad K
Brain 2024 Aug 1;147(8):2775-2790. doi: 10.1093/brain/awae056. PMID: 38456468Free PMC Article
Miao Y, Zhang S, Liang Z, Wang Y, Tian D, Jin S, Guo Q, Xue H, Teng X, Xiao L, Wu Y
Nitric Oxide 2023 Nov 1;140-141:77-90. Epub 2023 Oct 22 doi: 10.1016/j.niox.2023.10.002. PMID: 37875241
Frampton JE
Target Oncol 2023 Nov;18(6):973-980. Epub 2023 Oct 19 doi: 10.1007/s11523-023-01002-3. PMID: 37855990Free PMC Article
Bingaman N, Ferguson L, Thompson N, Reyes A, McDonald CR, Hermann BP, Arrotta K, Busch RM
Epilepsia 2023 Dec;64(12):3331-3341. Epub 2023 Oct 24 doi: 10.1111/epi.17795. PMID: 37814399Free PMC Article
Dienel SJ, Dowling KF, Barile Z, Bazmi HH, Liu A, Vespoli JC, Fish KN, Lewis DA
JAMA Psychiatry 2023 Dec 1;80(12):1235-1245. doi: 10.1001/jamapsychiatry.2023.2972. PMID: 37647039Free PMC Article

Diagnosis

Njøten KL, Espehaug B, Magnussen LH, Jürgensen M, Kvale G, Søfteland E, Aarli BB, Frisk B
Physiol Rep 2023 Nov;11(22):e15850. doi: 10.14814/phy2.15850. PMID: 37984816Free PMC Article
Frampton JE
Target Oncol 2023 Nov;18(6):973-980. Epub 2023 Oct 19 doi: 10.1007/s11523-023-01002-3. PMID: 37855990Free PMC Article
Bingaman N, Ferguson L, Thompson N, Reyes A, McDonald CR, Hermann BP, Arrotta K, Busch RM
Epilepsia 2023 Dec;64(12):3331-3341. Epub 2023 Oct 24 doi: 10.1111/epi.17795. PMID: 37814399Free PMC Article
Greyslak KT, Hetrick B, Bergman BC, Dean TA, Wesolowski SR, Gannon M, Schenk S, Sullivan EL, Aagaard KM, Kievit P, Chicco AJ, Friedman JE, McCurdy CE
Diabetes 2023 Dec 1;72(12):1766-1780. doi: 10.2337/db23-0289. PMID: 37725952Free PMC Article
Dienel SJ, Dowling KF, Barile Z, Bazmi HH, Liu A, Vespoli JC, Fish KN, Lewis DA
JAMA Psychiatry 2023 Dec 1;80(12):1235-1245. doi: 10.1001/jamapsychiatry.2023.2972. PMID: 37647039Free PMC Article

Therapy

Gibson E, Koh CL, Eames S, Bennett S, Scott AM, Hoffmann TC
Cochrane Database Syst Rev 2022 Mar 29;3(3):CD006430. doi: 10.1002/14651858.CD006430.pub3. PMID: 35349186Free PMC Article
Clare L, Kudlicka A, Oyebode JR, Jones RW, Bayer A, Leroi I, Kopelman M, James IA, Culverwell A, Pool J, Brand A, Henderson C, Hoare Z, Knapp M, Morgan-Trimmer S, Burns A, Corbett A, Whitaker R, Woods B
Health Technol Assess 2019 Mar;23(10):1-242. doi: 10.3310/hta23100. PMID: 30879470Free PMC Article
Buchheim A, Diamond D
Psychiatr Clin North Am 2018 Dec;41(4):651-668. doi: 10.1016/j.psc.2018.07.010. PMID: 30447730
Vuralli D, Ayata C, Bolay H
J Headache Pain 2018 Nov 15;19(1):109. doi: 10.1186/s10194-018-0933-4. PMID: 30442090Free PMC Article
Thieme H, Morkisch N, Mehrholz J, Pohl M, Behrens J, Borgetto B, Dohle C
Cochrane Database Syst Rev 2018 Jul 11;7(7):CD008449. doi: 10.1002/14651858.CD008449.pub3. PMID: 29993119Free PMC Article

Prognosis

Clougher D, Forte MF, Mezquida G, Sánchez-Torres AM, Serra-Navarro M, Penadés R, Lobo A, Pinto AG, Panadero R, Roldán A, Vieta E, de la Serna E, Trabsa A, Martínez-Aran A, Torrent C, Tortorella A, Menculini G, Ramos-Quiroga JA, Cuesta MJ, Bernardo M, Amoretti S; PEPs group
Eur Neuropsychopharmacol 2024 Aug;85:66-77. Epub 2024 Jul 15 doi: 10.1016/j.euroneuro.2024.05.006. PMID: 39013243
Kerber A, Gewehr E, Zimmermann J, Sachser C, M Fegert J, Knaevelsrud C, Spitzer C
Personal Ment Health 2023 Aug;17(3):246-258. Epub 2023 Feb 5 doi: 10.1002/pmh.1578. PMID: 36740219
Fowler JC, Lamkin J, Allen JG, Madan A, Oldham JM, Petersen NJ, Frueh BC
Psychotherapy (Chic) 2022 Mar;59(1):38-47. Epub 2021 Dec 23 doi: 10.1037/pst0000421. PMID: 34941338
Konstantakopoulos G
Psychiatriki 2019 Jan-Mar;30(1):13-16. doi: 10.22365/jpsych.2019.301.13. PMID: 31115349
Sanvicente-Vieira B, Romani-Sponchiado A, Kluwe-Schiavon B, Brietzke E, Araujo RB, Grassi-Oliveira R
Subst Use Misuse 2017 Jan 2;52(1):127-133. Epub 2016 Sep 12 doi: 10.1080/10826084.2016.1212890. PMID: 27617349

Clinical prediction guides

Luo J, Zhang B, Estabrook R, Graham EK, Driver CC, Schalet BD, Turiano NA, Spiro A, Mroczek DK
J Pers Soc Psychol 2022 Mar;122(3):493-522. doi: 10.1037/pspp0000399. PMID: 35157486Free PMC Article
Fowler JC, Lamkin J, Allen JG, Madan A, Oldham JM, Petersen NJ, Frueh BC
Psychotherapy (Chic) 2022 Mar;59(1):38-47. Epub 2021 Dec 23 doi: 10.1037/pst0000421. PMID: 34941338
Nador JD, Zoia M, Pachai MV, Ramon M
Sci Rep 2021 Jun 23;11(1):13184. doi: 10.1038/s41598-021-92549-6. PMID: 34162959Free PMC Article
Konstantakopoulos G
Psychiatriki 2019 Jan-Mar;30(1):13-16. doi: 10.22365/jpsych.2019.301.13. PMID: 31115349
Doering S, Blüml V, Parth K, Feichtinger K, Gruber M, Aigner M, Rössler-Schülein H, Freidl M, Wininger A
BMC Psychiatry 2018 Sep 14;18(1):294. doi: 10.1186/s12888-018-1870-0. PMID: 30223818Free PMC Article

Recent systematic reviews

Gómez-Soria I, Iguacel I, Aguilar-Latorre A, Peralta-Marrupe P, Latorre E, Zaldívar JNC, Calatayud E
Arch Gerontol Geriatr 2023 Jan;104:104807. Epub 2022 Sep 6 doi: 10.1016/j.archger.2022.104807. PMID: 36116285
Gibson E, Koh CL, Eames S, Bennett S, Scott AM, Hoffmann TC
Cochrane Database Syst Rev 2022 Mar 29;3(3):CD006430. doi: 10.1002/14651858.CD006430.pub3. PMID: 35349186Free PMC Article
Crivelli L, Palmer K, Calandri I, Guekht A, Beghi E, Carroll W, Frontera J, García-Azorín D, Westenberg E, Winkler AS, Mangialasche F, Allegri RF, Kivipelto M
Alzheimers Dement 2022 May;18(5):1047-1066. Epub 2022 Mar 17 doi: 10.1002/alz.12644. PMID: 35297561Free PMC Article
Thieme H, Morkisch N, Mehrholz J, Pohl M, Behrens J, Borgetto B, Dohle C
Cochrane Database Syst Rev 2018 Jul 11;7(7):CD008449. doi: 10.1002/14651858.CD008449.pub3. PMID: 29993119Free PMC Article
Oosterwijk AM, Nieuwenhuis MK, van der Schans CP, Mouton LJ
Physiother Theory Pract 2018 Jul;34(7):505-528. Epub 2018 Jan 29 doi: 10.1080/09593985.2017.1422206. PMID: 29377745

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