U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Indolent T-Lymphoblastic Proliferation

MedGen UID:
1383416
•Concept ID:
C4330484
•
Disease or Syndrome

Definition

A non-neoplastic T-cell lymphoproliferation that may mimic T-lymphoblastic lymphoma. It usually involves the lymphoid tissues of the upper aerodigestive tract. It recurs locally, but systemic dissemination is rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIndolent T-Lymphoblastic Proliferation

Professional guidelines

PubMed

Flow Cytometric Evaluation of Surface and Cytoplasmic TRBC1 Expression in the Differential Diagnosis of Immature T-Cell Proliferations.
Horna P, Otteson GE, Shi M, Jevremovic D, Yuan J, Olteanu H
Am J Clin Pathol 2022 Jan 6;157(1):64-72. doi: 10.1093/ajcp/aqab098. PMID: 34302330

Recent clinical studies

Etiology

Indolent T-lymphoblastic proliferation: A systematic review of the literature analyzing the epidemiologic, clinical, and pathologic features of 45 cases.
Saglam A, Singh K, Gollapudi S, Kumar J, Brar N, Butzmann A, Warnke R, Ohgami RS
Int J Lab Hematol 2022 Aug;44(4):700-711. Epub 2022 May 16 doi: 10.1111/ijlh.13873. PMID: 35577551
LIM domain only 2 (LMO2) expression distinguishes T-lymphoblastic leukemia/lymphoma from indolent T-lymphoblastic proliferations.
Brar N, Butzmann A, Kumar J, Peerani R, Morgan EA, Grigoriadis G, Kumar B, Tatarczuch RM, Warnke RA, Ohgami RS
Histopathology 2020 Dec;77(6):984-988. Epub 2020 Sep 24 doi: 10.1111/his.14176. PMID: 32526041
Follicular Dendritic Cell Sarcoma With Indolent T-Lymphoblastic Proliferation Is Associated With Paraneoplastic Autoimmune Multiorgan Syndrome.
Walters M, Pittelkow MR, Hasserjian RP, Harris NL, Macon WR, Kurtin PJ, Rech KLG
Am J Surg Pathol 2018 Dec;42(12):1647-1652. doi: 10.1097/PAS.0000000000001158. PMID: 30222603
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
Pizzi M, Brignola S, Righi S, Agostinelli C, Bertuzzi C, Pillon M, Semenzato G, Rugge M, Sabattini E
Hum Pathol 2018 Nov;81:131-137. Epub 2018 Jun 30 doi: 10.1016/j.humpath.2018.06.027. PMID: 29969607
Indolent T-lymphoblastic proliferation (iT-LBP): a review of clinical and pathologic features and distinction from malignant T-lymphoblastic lymphoma.
Ohgami RS, Arber DA, Zehnder JL, Natkunam Y, Warnke RA
Adv Anat Pathol 2013 May;20(3):137-40. doi: 10.1097/PAP.0b013e31828d17ec. PMID: 23574769

Diagnosis

Indolent T-lymphoblastic proliferation involving hepatocellular carcinoma-presentation in novel settings and comprehensive review of literature.
Ghezavati A, Liang CA, Mais D, Nazarullah A
J Hematop 2023 Sep;16(3):167-175. Epub 2023 Jul 16 doi: 10.1007/s12308-023-00554-7. PMID: 38175402
Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report.
Han W, Wang B, Yong X, Zhang Y, Shao M, Wang C
Pathol Oncol Res 2023;29:1611151. Epub 2023 May 12 doi: 10.3389/pore.2023.1611151. PMID: 37252318Free PMC Article
Indolent T-lymphoblastic proliferation: A systematic review of the literature analyzing the epidemiologic, clinical, and pathologic features of 45 cases.
Saglam A, Singh K, Gollapudi S, Kumar J, Brar N, Butzmann A, Warnke R, Ohgami RS
Int J Lab Hematol 2022 Aug;44(4):700-711. Epub 2022 May 16 doi: 10.1111/ijlh.13873. PMID: 35577551
Indolent T-Lymphoblastic Proliferation in Idiopathic Multicentric Castleman Disease.
Karki NR, Arfa AS, Savage N, Kutlar A
Acta Haematol 2022;145(2):214-220. Epub 2021 Nov 24 doi: 10.1159/000520240. PMID: 34818661
Indolent T-lymphoblastic proliferation (iT-LBP): a review of clinical and pathologic features and distinction from malignant T-lymphoblastic lymphoma.
Ohgami RS, Arber DA, Zehnder JL, Natkunam Y, Warnke RA
Adv Anat Pathol 2013 May;20(3):137-40. doi: 10.1097/PAP.0b013e31828d17ec. PMID: 23574769

Prognosis

Indolent T-lymphoblastic proliferation involving hepatocellular carcinoma-presentation in novel settings and comprehensive review of literature.
Ghezavati A, Liang CA, Mais D, Nazarullah A
J Hematop 2023 Sep;16(3):167-175. Epub 2023 Jul 16 doi: 10.1007/s12308-023-00554-7. PMID: 38175402
Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report.
Han W, Wang B, Yong X, Zhang Y, Shao M, Wang C
Pathol Oncol Res 2023;29:1611151. Epub 2023 May 12 doi: 10.3389/pore.2023.1611151. PMID: 37252318Free PMC Article
Follicular Dendritic Cell Sarcoma With Indolent T-Lymphoblastic Proliferation Is Associated With Paraneoplastic Autoimmune Multiorgan Syndrome.
Walters M, Pittelkow MR, Hasserjian RP, Harris NL, Macon WR, Kurtin PJ, Rech KLG
Am J Surg Pathol 2018 Dec;42(12):1647-1652. doi: 10.1097/PAS.0000000000001158. PMID: 30222603
Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review.
Yasuda H, Tsutsui M, Ota Y, Tanaka M, Komatsu N
Histopathology 2018 Apr;72(5):862-866. Epub 2018 Jan 19 doi: 10.1111/his.13433. PMID: 29143359
Indolent T-lymphoblastic proliferation (iT-LBP): a review of clinical and pathologic features and distinction from malignant T-lymphoblastic lymphoma.
Ohgami RS, Arber DA, Zehnder JL, Natkunam Y, Warnke RA
Adv Anat Pathol 2013 May;20(3):137-40. doi: 10.1097/PAP.0b013e31828d17ec. PMID: 23574769

Clinical prediction guides

Indolent T-lymphoblastic proliferation with fibrolamellar hepatocellular carcinoma developed after colorectal adenocarcinoma: a case report.
Han W, Wang B, Yong X, Zhang Y, Shao M, Wang C
Pathol Oncol Res 2023;29:1611151. Epub 2023 May 12 doi: 10.3389/pore.2023.1611151. PMID: 37252318Free PMC Article
Follicular Dendritic Cell Sarcoma With Indolent T-Lymphoblastic Proliferation Is Associated With Paraneoplastic Autoimmune Multiorgan Syndrome.
Walters M, Pittelkow MR, Hasserjian RP, Harris NL, Macon WR, Kurtin PJ, Rech KLG
Am J Surg Pathol 2018 Dec;42(12):1647-1652. doi: 10.1097/PAS.0000000000001158. PMID: 30222603
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall.
Pizzi M, Brignola S, Righi S, Agostinelli C, Bertuzzi C, Pillon M, Semenzato G, Rugge M, Sabattini E
Hum Pathol 2018 Nov;81:131-137. Epub 2018 Jun 30 doi: 10.1016/j.humpath.2018.06.027. PMID: 29969607
Indolent T-lymphoblastic proliferation concomitant with acinic cell carcinoma mimicking T-lymphoblastic lymphoma: case report and literature review.
Yasuda H, Tsutsui M, Ota Y, Tanaka M, Komatsu N
Histopathology 2018 Apr;72(5):862-866. Epub 2018 Jan 19 doi: 10.1111/his.13433. PMID: 29143359
Indolent T-lymphoblastic proliferation with disseminated multinodal involvement and partial CD33 expression.
Ohgami RS, Sendamarai AK, Atwater SK, Liedtke M, Fleming MD, Natkunam Y, Warnke RA
Am J Surg Pathol 2014 Sep;38(9):1298-304. doi: 10.1097/PAS.0000000000000197. PMID: 24618611

Recent systematic reviews

Indolent T-lymphoblastic proliferation: A systematic review of the literature analyzing the epidemiologic, clinical, and pathologic features of 45 cases.
Saglam A, Singh K, Gollapudi S, Kumar J, Brar N, Butzmann A, Warnke R, Ohgami RS
Int J Lab Hematol 2022 Aug;44(4):700-711. Epub 2022 May 16 doi: 10.1111/ijlh.13873. PMID: 35577551

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...