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Metastatic Oropharyngeal Squamous Cell Carcinoma

MedGen UID:
124732
•Concept ID:
C0280374
•
Neoplastic Process
Synonym: Metastatic Squamous Cell Carcinoma of the Oropharynx

Definition

A squamous cell carcinoma of the oropharynx which has spread from the original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Oropharyngeal Squamous Cell Carcinoma

Professional guidelines

PubMed

2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer.
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Surgical management of lung metastases.
Patrini D, Panagiotopoulos N, Lawrence D, Scarci M
Br J Hosp Med (Lond) 2017 Apr 2;78(4):192-198. doi: 10.12968/hmed.2017.78.4.192. PMID: 28398890
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Primary Site Surgery in Distantly Metastatic Oropharyngeal Squamous Cell Carcinoma.
Carey RM, Prasad A, Wei K, Brant JA, Brody RM, Leibowitz JM, Civantos FJ, Sweeny L
Laryngoscope 2024 May;134(5):2243-2251. Epub 2023 Nov 10 doi: 10.1002/lary.31177. PMID: 37947342
Oncological safety of the Hayes-Martin manoeuvre in neck dissections for node-positive oropharyngeal squamous cell carcinoma.
Riffat F, Buchanan MA, Mahrous AK, Fish BM, Jani P
J Laryngol Otol 2012 Oct;126(10):1045-8. Epub 2012 Aug 21 doi: 10.1017/S0022215112001740. PMID: 22906561

Diagnosis

Metastatic oropharyngeal squamous cell carcinoma to the thyroid: A case report and review of literature.
Walker H, Speers J, Fabry M, Kadakia S
Am J Otolaryngol 2024 Jul-Aug;45(4):104306. Epub 2024 Apr 16 doi: 10.1016/j.amjoto.2024.104306. PMID: 38669814
Multiple Eruptive Keratoacanthomas Secondary to Nivolumab Immunotherapy.
Olsen E, Svoboda SA, Montanez-Wiscovich M, Saikaly SK
J Immunother 2024 Apr 1;47(3):98-100. Epub 2023 Nov 27 doi: 10.1097/CJI.0000000000000498. PMID: 38009069
Primary Site Surgery in Distantly Metastatic Oropharyngeal Squamous Cell Carcinoma.
Carey RM, Prasad A, Wei K, Brant JA, Brody RM, Leibowitz JM, Civantos FJ, Sweeny L
Laryngoscope 2024 May;134(5):2243-2251. Epub 2023 Nov 10 doi: 10.1002/lary.31177. PMID: 37947342
Threshold for interpretation of p16 immunostaining in fine-needle aspirate specimens of metastatic oropharyngeal squamous cell carcinoma.
Manucha V, Patel T, Grunes D, Akhtar I
J Am Soc Cytopathol 2020 May-Jun;9(3):177-184. Epub 2020 Feb 11 doi: 10.1016/j.jasc.2020.01.004. PMID: 32115376

Therapy

Multiple Eruptive Keratoacanthomas Secondary to Nivolumab Immunotherapy.
Olsen E, Svoboda SA, Montanez-Wiscovich M, Saikaly SK
J Immunother 2024 Apr 1;47(3):98-100. Epub 2023 Nov 27 doi: 10.1097/CJI.0000000000000498. PMID: 38009069
Unexpected response to fourth-line paclitaxel in a patient with metastatic oropharyngeal squamous cell carcinoma, immunotherapy-refractory: a case report.
Mosca M, Filippini DM, Tober N, Rojas FL, Rihawi K, Di Fabio F
Anticancer Drugs 2022 Aug 1;33(7):691-695. Epub 2022 Mar 23 doi: 10.1097/CAD.0000000000001302. PMID: 35324531
Personalized Medicine Approach for an Exceptional Response to Multiple-recurrent and Metastatic HER2-positive Oropharyngeal Squamous Cell Carcinoma.
Seim NB, Kang SY, Bhandari M, Jones RG, Teknos TN
Ann Otol Rhinol Laryngol 2017 Apr;126(4):334-339. Epub 2017 Jan 6 doi: 10.1177/0003489416687309. PMID: 28061634
Oncological safety of the Hayes-Martin manoeuvre in neck dissections for node-positive oropharyngeal squamous cell carcinoma.
Riffat F, Buchanan MA, Mahrous AK, Fish BM, Jani P
J Laryngol Otol 2012 Oct;126(10):1045-8. Epub 2012 Aug 21 doi: 10.1017/S0022215112001740. PMID: 22906561

Prognosis

Multiple Eruptive Keratoacanthomas Secondary to Nivolumab Immunotherapy.
Olsen E, Svoboda SA, Montanez-Wiscovich M, Saikaly SK
J Immunother 2024 Apr 1;47(3):98-100. Epub 2023 Nov 27 doi: 10.1097/CJI.0000000000000498. PMID: 38009069
Primary Site Surgery in Distantly Metastatic Oropharyngeal Squamous Cell Carcinoma.
Carey RM, Prasad A, Wei K, Brant JA, Brody RM, Leibowitz JM, Civantos FJ, Sweeny L
Laryngoscope 2024 May;134(5):2243-2251. Epub 2023 Nov 10 doi: 10.1002/lary.31177. PMID: 37947342
Threshold for interpretation of p16 immunostaining in fine-needle aspirate specimens of metastatic oropharyngeal squamous cell carcinoma.
Manucha V, Patel T, Grunes D, Akhtar I
J Am Soc Cytopathol 2020 May-Jun;9(3):177-184. Epub 2020 Feb 11 doi: 10.1016/j.jasc.2020.01.004. PMID: 32115376
Pulmonary artery pseudoaneurysm embolisation to treat massive haemoptysis due to metastatic oropharyngeal squamous cell carcinoma.
Tantrige P, Johnston E, Garzillo G, Huang DY
BMJ Case Rep 2019 Jun 26;12(6) doi: 10.1136/bcr-2019-230283. PMID: 31248889Free PMC Article
Personalized Medicine Approach for an Exceptional Response to Multiple-recurrent and Metastatic HER2-positive Oropharyngeal Squamous Cell Carcinoma.
Seim NB, Kang SY, Bhandari M, Jones RG, Teknos TN
Ann Otol Rhinol Laryngol 2017 Apr;126(4):334-339. Epub 2017 Jan 6 doi: 10.1177/0003489416687309. PMID: 28061634

Clinical prediction guides

Threshold for interpretation of p16 immunostaining in fine-needle aspirate specimens of metastatic oropharyngeal squamous cell carcinoma.
Manucha V, Patel T, Grunes D, Akhtar I
J Am Soc Cytopathol 2020 May-Jun;9(3):177-184. Epub 2020 Feb 11 doi: 10.1016/j.jasc.2020.01.004. PMID: 32115376

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