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Reactive hypoglycemia

MedGen UID:
124409
•Concept ID:
C0271710
•
Disease or Syndrome
Synonyms: Hypoglycemia, Postprandial; Hypoglycemia, Reactive; Postprandial Hypoglycemia; Reactive Hypoglycemia
SNOMED CT: Reactive hypoglycemia (317006); Hypoglycemic reaction (317006); Post-prandial hypoglycemia (237638000)
 
HPO: HP:0012051

Definition

Hypoglycermia following a meal (or more generally, after intake of glucose). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReactive hypoglycemia

Conditions with this feature

Obesity due to prohormone convertase I deficiency
MedGen UID:
318777
•Concept ID:
C1833053
•
Disease or Syndrome
Proprotein convertase-1/3 deficiency is an autosomal recessive disorder characterized by neonatal severe generalized malabsorptive diarrhea and failure to thrive. As the disease progresses, additional endocrine abnormalities develop, including diabetes insipidus, growth hormone deficiency, primary hypogonadism, adrenal insufficiency, and hypothyroidism (summary by Wilschanski et al., 2014).
See: Condition Record
Obesity due to prohormone convertase I deficiency

Professional guidelines

PubMed

Nutritional guidelines for the management of insulin resistance.
Muscogiuri G, Barrea L, Caprio M, Ceriani F, Chavez AO, El Ghoch M, Frias-Toral E, Mehta RJ, Mendez V, Paschou SA, Pazderska A, Savastano S, Colao A
Crit Rev Food Sci Nutr 2022;62(25):6947-6960. Epub 2021 Apr 2 doi: 10.1080/10408398.2021.1908223. PMID: 33797999
Hypoglycemia in cystic fibrosis: Prevalence, impact and treatment.
Moheet A, Chan CL, Granados A, Ode KL, Moran A, Battezzati A
J Cyst Fibros 2019 Oct;18 Suppl 2:S19-S24. doi: 10.1016/j.jcf.2019.08.004. PMID: 31679723
Pathophysiology, diagnosis and management of postoperative dumping syndrome.
Tack J, Arts J, Caenepeel P, De Wulf D, Bisschops R
Nat Rev Gastroenterol Hepatol 2009 Oct;6(10):583-90. Epub 2009 Sep 1 doi: 10.1038/nrgastro.2009.148. PMID: 19724252

Recent clinical studies

Etiology

Combination of alcohol and glucose consumption as a risk to induce reactive hypoglycemia.
Oba-Yamamoto C, Takeuchi J, Nakamura A, Takikawa R, Ozaki A, Nomoto H, Kameda H, Cho KY, Atsumi T, Miyoshi H
J Diabetes Investig 2021 Apr;12(4):651-657. Epub 2020 Sep 7 doi: 10.1111/jdi.13375. PMID: 33448697Free PMC Article
Hypoglycemia in cystic fibrosis: Prevalence, impact and treatment.
Moheet A, Chan CL, Granados A, Ode KL, Moran A, Battezzati A
J Cyst Fibros 2019 Oct;18 Suppl 2:S19-S24. doi: 10.1016/j.jcf.2019.08.004. PMID: 31679723
Possible relation between partial small bowel obstruction and severe postprandial reactive hypoglycemia after Roux-en-Y gastric bypass.
Laurenius A, Hedberg S, Olbers T
Surg Obes Relat Dis 2019 Jun;15(6):1024-1028. Epub 2019 Mar 22 doi: 10.1016/j.soard.2019.03.031. PMID: 31101561
The future of the Roux-en-Y gastric bypass.
Lim CH, Jahansouz C, Abraham AA, Leslie DB, Ikramuddin S
Expert Rev Gastroenterol Hepatol 2016 Jul;10(7):777-84. Epub 2016 Apr 6 doi: 10.1586/17474124.2016.1169921. PMID: 27027414
Reactive hypoglycemia.
Hofeldt FD
Endocrinol Metab Clin North Am 1989 Mar;18(1):185-201. PMID: 2645126

Diagnosis

The future of the Roux-en-Y gastric bypass.
Lim CH, Jahansouz C, Abraham AA, Leslie DB, Ikramuddin S
Expert Rev Gastroenterol Hepatol 2016 Jul;10(7):777-84. Epub 2016 Apr 6 doi: 10.1586/17474124.2016.1169921. PMID: 27027414
Postprandial reactive hypoglycemia.
Brun JF, Fedou C, Mercier J
Diabetes Metab 2000 Nov;26(5):337-51. PMID: 11119013
Hypoglycemia in adults.
Virally ML, Guillausseau PJ
Diabetes Metab 1999 Dec;25(6):477-90. PMID: 10633872
Reactive hypoglycemia.
Hofeldt FD
Endocrinol Metab Clin North Am 1989 Mar;18(1):185-201. PMID: 2645126
Reactive hypoglycemia.
Hofeldt FD
Metabolism 1975 Oct;24(10):1193-208. doi: 10.1016/0026-0495(75)90156-0. PMID: 1165734

Therapy

The future of the Roux-en-Y gastric bypass.
Lim CH, Jahansouz C, Abraham AA, Leslie DB, Ikramuddin S
Expert Rev Gastroenterol Hepatol 2016 Jul;10(7):777-84. Epub 2016 Apr 6 doi: 10.1586/17474124.2016.1169921. PMID: 27027414
Approach to the patient with postprandial hypoglycemia.
Galati SJ, Rayfield EJ
Endocr Pract 2014 Apr;20(4):331-40. doi: 10.4158/EP13132.RA. PMID: 24246338
Reactive hypoglycemia.
Hofeldt FD
Endocrinol Metab Clin North Am 1989 Mar;18(1):185-201. PMID: 2645126
Reactive hypoglycemia.
Johnson DD, Dorr KE, Swenson WM, Service FJ
JAMA 1980 Mar 21;243(11):1151-5. PMID: 7359666
Classification of reactive hypoglycemia.
Anderson JW, Herman RH
Am J Clin Nutr 1969 May;22(5):646-50. doi: 10.1093/ajcn/22.5.646. PMID: 4894611

Prognosis

Association between pre-exercise food ingestion timing and reactive hypoglycemia: Insights from a large database of continuous glucose monitoring data.
Zignoli A, Fontana FY, Lipman DJ, Skroce K, Maturana FM, Zisser HC
Eur J Sport Sci 2023 Dec;23(12):2340-2348. Epub 2023 Jul 30 doi: 10.1080/17461391.2023.2233468. PMID: 37424300
Nutritional guidelines for the management of insulin resistance.
Muscogiuri G, Barrea L, Caprio M, Ceriani F, Chavez AO, El Ghoch M, Frias-Toral E, Mehta RJ, Mendez V, Paschou SA, Pazderska A, Savastano S, Colao A
Crit Rev Food Sci Nutr 2022;62(25):6947-6960. Epub 2021 Apr 2 doi: 10.1080/10408398.2021.1908223. PMID: 33797999
Incidence of Hypoglycemia After Gastric Bypass vs Sleeve Gastrectomy: A Randomized Trial.
Capristo E, Panunzi S, De Gaetano A, Spuntarelli V, Bellantone R, Giustacchini P, Birkenfeld AL, Amiel S, Bornstein SR, Raffaelli M, Mingrone G
J Clin Endocrinol Metab 2018 Jun 1;103(6):2136-2146. doi: 10.1210/jc.2017-01695. PMID: 29590421
Psychobiological effects of carbohydrates.
Spring B, Chiodo J, Harden M, Bourgeois MJ, Mason JD, Lutherer L
J Clin Psychiatry 1989 May;50 Suppl:27-33; discussion 34. PMID: 2565898
Transient insulin increase in reactive hypoglycemia in obese and non-obese subjects.
McCool C, Luqman W, Schmitt T, Raymundo R, Nolan S, Stephan T, Ahmad U, Danowski TS
Int J Obes 1977;1(2):179-83. PMID: 617330

Clinical prediction guides

Nutritional guidelines for the management of insulin resistance.
Muscogiuri G, Barrea L, Caprio M, Ceriani F, Chavez AO, El Ghoch M, Frias-Toral E, Mehta RJ, Mendez V, Paschou SA, Pazderska A, Savastano S, Colao A
Crit Rev Food Sci Nutr 2022;62(25):6947-6960. Epub 2021 Apr 2 doi: 10.1080/10408398.2021.1908223. PMID: 33797999
Possible relation between partial small bowel obstruction and severe postprandial reactive hypoglycemia after Roux-en-Y gastric bypass.
Laurenius A, Hedberg S, Olbers T
Surg Obes Relat Dis 2019 Jun;15(6):1024-1028. Epub 2019 Mar 22 doi: 10.1016/j.soard.2019.03.031. PMID: 31101561
Mechanisms of surgical control of type 2 diabetes: GLP-1 is key factor.
Holst JJ, Madsbad S
Surg Obes Relat Dis 2016 Jul;12(6):1236-42. Epub 2016 Mar 3 doi: 10.1016/j.soard.2016.02.033. PMID: 27313194
Hypoglycemia in adults.
Virally ML, Guillausseau PJ
Diabetes Metab 1999 Dec;25(6):477-90. PMID: 10633872
Reactive hypoglycemia.
Johnson DD, Dorr KE, Swenson WM, Service FJ
JAMA 1980 Mar 21;243(11):1151-5. PMID: 7359666

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