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Anti-factor XIII antibody positivity

MedGen UID:
1052752
•Concept ID:
CN377329
•
Finding
Synonym: Anti-FXIII antibody positivity
 
HPO: HP:6000498

Definition

The presence of an antibody in the blood circulation that is directed against factor XIII. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-factor XIII antibody positivity

Recent clinical studies

Etiology

Studies on factor XIII antigen in congenital factor XIII deficiency. A tentative classification of the disease in two groups.
Girolami A, Burul A, Fabris F, Cappellato G, Betterle C
Folia Haematol Int Mag Klin Morphol Blutforsch 1978;105(1):131-41. PMID: 77814

Diagnosis

Novel Immunochromatographic Test for Anti-factor XIII B Subunit Autoantibodies to Diagnose Autoimmune Acquired Factor XIII Deficiency.
Osaki T, Yokoyama C, Magari Y, Souri M, Ichinose A
Thromb Haemost 2023 Aug;123(8):793-803. Epub 2023 Mar 23 doi: 10.1055/a-2061-3182. PMID: 36958345
Aggressive fatal case of autoimmune hemorrhaphilia resulting from anti-Factor XIII antibodies.
Sugiyama H, Uesugi H, Suzuki S, Tanaka K, Souri M, Ichinose A
Blood Coagul Fibrinolysis 2013 Jan;24(1):85-9. doi: 10.1097/MBC.0b013e328358e8e7. PMID: 23183237

Therapy

Aggressive fatal case of autoimmune hemorrhaphilia resulting from anti-Factor XIII antibodies.
Sugiyama H, Uesugi H, Suzuki S, Tanaka K, Souri M, Ichinose A
Blood Coagul Fibrinolysis 2013 Jan;24(1):85-9. doi: 10.1097/MBC.0b013e328358e8e7. PMID: 23183237

Prognosis

Aggressive fatal case of autoimmune hemorrhaphilia resulting from anti-Factor XIII antibodies.
Sugiyama H, Uesugi H, Suzuki S, Tanaka K, Souri M, Ichinose A
Blood Coagul Fibrinolysis 2013 Jan;24(1):85-9. doi: 10.1097/MBC.0b013e328358e8e7. PMID: 23183237

Clinical prediction guides

Studies on factor XIII antigen in congenital factor XIII deficiency. A tentative classification of the disease in two groups.
Girolami A, Burul A, Fabris F, Cappellato G, Betterle C
Folia Haematol Int Mag Klin Morphol Blutforsch 1978;105(1):131-41. PMID: 77814

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