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Anti-coagulation factor antibody positivity

MedGen UID:
1052536
•Concept ID:
CN377159
•
Finding
HPO: HP:6000351

Definition

The presence of an antibody in the blood circulation that is directed against a coagulation factor. [from HPO]

Recent clinical studies

Etiology

Cardiac transplantation and/or mechanical circulatory support device placement using heparin anti-coagulation in the presence of acute heparin-induced thrombocytopenia.
Zucker MJ, Sabnani I, Baran DA, Balasubramanian S, Camacho M
J Heart Lung Transplant 2010 Jan;29(1):53-60. Epub 2009 Oct 9 doi: 10.1016/j.healun.2009.08.016. PMID: 19819167
Livedo racemosa as a marker of increased risk of recurrent thrombosis in patients with negative anti-phospholipid antibodies.
Martínez-Valle F, Ordi-Ros J, Selva-O'Callaghan A, Balada E, Solans-Laque R, Vilardell-Tarres M
Med Clin (Barc) 2009 May 30;132(20):767-71. Epub 2009 Apr 28 doi: 10.1016/j.medcli.2008.09.044. PMID: 19403146
Heparin-induced thrombocytopenia: a common complication in cardiac transplant recipients.
Hourigan LA, Walters DL, Keck SA, Dec GW
J Heart Lung Transplant 2002 Dec;21(12):1283-9. doi: 10.1016/s1053-2498(02)00458-8. PMID: 12490273
The anti-phospholipid antibody syndrome (Hughes syndrome): therapeutic aspects.
Cuadrado MJ, Khamashta MA
Baillieres Best Pract Res Clin Rheumatol 2000 Mar;14(1):151-63. doi: 10.1053/berh.1999.0083. PMID: 10882220

Diagnosis

Treatment of Biopsy-Proven Acute Antibody-Mediated Rejection Using Thymoglobulin (ATG) Monotherapy and a Combination of Rituximab, Intravenous Immunoglobulin, and Plasmapheresis: Lesson Learned from Primary Experience.
Zheng J, Xue W, Qing X, Jing X, Hou J, Tian X, Guo Q, He X, Cai J
Clin Transpl 2014:223-30. PMID: 26281149
Cardiac transplantation and/or mechanical circulatory support device placement using heparin anti-coagulation in the presence of acute heparin-induced thrombocytopenia.
Zucker MJ, Sabnani I, Baran DA, Balasubramanian S, Camacho M
J Heart Lung Transplant 2010 Jan;29(1):53-60. Epub 2009 Oct 9 doi: 10.1016/j.healun.2009.08.016. PMID: 19819167
Livedo racemosa as a marker of increased risk of recurrent thrombosis in patients with negative anti-phospholipid antibodies.
Martínez-Valle F, Ordi-Ros J, Selva-O'Callaghan A, Balada E, Solans-Laque R, Vilardell-Tarres M
Med Clin (Barc) 2009 May 30;132(20):767-71. Epub 2009 Apr 28 doi: 10.1016/j.medcli.2008.09.044. PMID: 19403146
Heparin-induced thrombocytopenia: a common complication in cardiac transplant recipients.
Hourigan LA, Walters DL, Keck SA, Dec GW
J Heart Lung Transplant 2002 Dec;21(12):1283-9. doi: 10.1016/s1053-2498(02)00458-8. PMID: 12490273
The anti-phospholipid antibody syndrome (Hughes syndrome): therapeutic aspects.
Cuadrado MJ, Khamashta MA
Baillieres Best Pract Res Clin Rheumatol 2000 Mar;14(1):151-63. doi: 10.1053/berh.1999.0083. PMID: 10882220

Therapy

Treatment of Biopsy-Proven Acute Antibody-Mediated Rejection Using Thymoglobulin (ATG) Monotherapy and a Combination of Rituximab, Intravenous Immunoglobulin, and Plasmapheresis: Lesson Learned from Primary Experience.
Zheng J, Xue W, Qing X, Jing X, Hou J, Tian X, Guo Q, He X, Cai J
Clin Transpl 2014:223-30. PMID: 26281149
Cardiac transplantation and/or mechanical circulatory support device placement using heparin anti-coagulation in the presence of acute heparin-induced thrombocytopenia.
Zucker MJ, Sabnani I, Baran DA, Balasubramanian S, Camacho M
J Heart Lung Transplant 2010 Jan;29(1):53-60. Epub 2009 Oct 9 doi: 10.1016/j.healun.2009.08.016. PMID: 19819167
Effect of sairei-to combined with aspirin and prednisolone on four recurrent reproductive failure women who are positive for anti-phospholipid antibodies.
Takakuwa K, Ishii K, Takaki Y, Natsume N, Adachi H, Kurata H, Tamura M, Kurabayasi T, Tanaka K
Am J Chin Med 2003;31(4):659-63. doi: 10.1142/S0192415X03001326. PMID: 14587888
Heparin-induced thrombocytopenia: a common complication in cardiac transplant recipients.
Hourigan LA, Walters DL, Keck SA, Dec GW
J Heart Lung Transplant 2002 Dec;21(12):1283-9. doi: 10.1016/s1053-2498(02)00458-8. PMID: 12490273

Prognosis

Treatment of Biopsy-Proven Acute Antibody-Mediated Rejection Using Thymoglobulin (ATG) Monotherapy and a Combination of Rituximab, Intravenous Immunoglobulin, and Plasmapheresis: Lesson Learned from Primary Experience.
Zheng J, Xue W, Qing X, Jing X, Hou J, Tian X, Guo Q, He X, Cai J
Clin Transpl 2014:223-30. PMID: 26281149
Effect of sairei-to combined with aspirin and prednisolone on four recurrent reproductive failure women who are positive for anti-phospholipid antibodies.
Takakuwa K, Ishii K, Takaki Y, Natsume N, Adachi H, Kurata H, Tamura M, Kurabayasi T, Tanaka K
Am J Chin Med 2003;31(4):659-63. doi: 10.1142/S0192415X03001326. PMID: 14587888
Heparin-induced thrombocytopenia: a common complication in cardiac transplant recipients.
Hourigan LA, Walters DL, Keck SA, Dec GW
J Heart Lung Transplant 2002 Dec;21(12):1283-9. doi: 10.1016/s1053-2498(02)00458-8. PMID: 12490273

Clinical prediction guides

Treatment of Biopsy-Proven Acute Antibody-Mediated Rejection Using Thymoglobulin (ATG) Monotherapy and a Combination of Rituximab, Intravenous Immunoglobulin, and Plasmapheresis: Lesson Learned from Primary Experience.
Zheng J, Xue W, Qing X, Jing X, Hou J, Tian X, Guo Q, He X, Cai J
Clin Transpl 2014:223-30. PMID: 26281149
Livedo racemosa as a marker of increased risk of recurrent thrombosis in patients with negative anti-phospholipid antibodies.
Martínez-Valle F, Ordi-Ros J, Selva-O'Callaghan A, Balada E, Solans-Laque R, Vilardell-Tarres M
Med Clin (Barc) 2009 May 30;132(20):767-71. Epub 2009 Apr 28 doi: 10.1016/j.medcli.2008.09.044. PMID: 19403146

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