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Malignant neoplasm of thoracic esophagus

MedGen UID:
102268
•Concept ID:
C0153411
•
Neoplastic Process
Synonyms: cancer of thoracic part of esophagus; cancer of thoracic part of oesophagus; Malignant Neoplasm of the Thoracic Esophagus; malignant neoplasm of the thoracic esophagus; malignant neoplasm of the thoracic oesophagus; Malignant Neoplasm of Thoracic Esophagus; malignant neoplasm of thoracic esophagus; malignant neoplasm of thoracic part of esophagus; malignant neoplasm of thoracic part of oesophagus; malignant thoracic part of esophagus neoplasm; malignant thoracic part of oesophagus neoplasm; Malignant tumor of thoracic part of esophagus; thoracic part of esophagus cancer; thoracic part of oesophagus cancer
SNOMED CT: Malignant neoplasm of thoracic esophagus (187723009); Malignant tumor of thoracic part of esophagus (187723009)
 
Monarch Initiative: MONDO:0021325

Definition

A primary or metastatic malignant neoplasm involving the thoracic region of the esophagus. [from NCI]

Professional guidelines

PubMed

Advances in diagnosis and management of cancer of the esophagus.
Deboever N, Jones CM, Yamashita K, Ajani JA, Hofstetter WL
BMJ 2024 Jun 3;385:e074962. doi: 10.1136/bmj-2023-074962. PMID: 38830686
Update on Management of Squamous Cell Esophageal Cancer.
Waters JK, Reznik SI
Curr Oncol Rep 2022 Mar;24(3):375-385. Epub 2022 Feb 10 doi: 10.1007/s11912-021-01153-4. PMID: 35142974
Management of Malignant Tracheoesophageal Fistula.
Shamji FM, Inculet R
Thorac Surg Clin 2018 Aug;28(3):393-402. doi: 10.1016/j.thorsurg.2018.04.007. PMID: 30054077

Recent clinical studies

Etiology

Gastric conduit reconstruction after esophagectomy.
Watanabe M, Takahashi N, Tamura M, Terayama M, Kuriyama K, Okamura A, Kanamori J, Imamura Y
Dis Esophagus 2024 Oct 2;37(10) doi: 10.1093/dote/doae045. PMID: 38762331
Optimal surgery for esophagogastric junctional cancer.
Hayashi T, Yoshikawa T
Langenbecks Arch Surg 2022 Jun;407(4):1399-1407. Epub 2021 Nov 17 doi: 10.1007/s00423-021-02375-7. PMID: 34786603
Esophageal Cancer: Tumor-Node-Metastasis Staging.
Betancourt-Cuellar SL, Benveniste MFK, Palacio DP, Hofstetter WL
Radiol Clin North Am 2021 Mar;59(2):219-229. doi: 10.1016/j.rcl.2020.11.008. PMID: 33551083
Management of Gastroesophageal Junction Tumors.
Okereke IC
Surg Clin North Am 2017 Apr;97(2):265-275. Epub 2017 Feb 14 doi: 10.1016/j.suc.2016.11.004. PMID: 28325186
Omentoplasty for oesophagogastrostomy after oesophagectomy.
Yuan Y, Zeng X, Hu Y, Xie T, Zhao Y
Cochrane Database Syst Rev 2014 Oct 2;2014(10):CD008446. doi: 10.1002/14651858.CD008446.pub3. PMID: 25274134Free PMC Article

Diagnosis

Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Ong JS, An J, Han X, Law MH, Nandakumar P; 23andMe Research team; Esophageal cancer consortium, Schumacher J, Gockel I, Bohmer A, Jankowski J, Palles C, Olsen CM, Neale RE, Fitzgerald R, Thrift AP, Vaughan TL, Buas MF, Hinds DA, Gharahkhani P, Kendall BJ, MacGregor S
Gut 2022 Jun;71(6):1053-1061. Epub 2021 Jun 29 doi: 10.1136/gutjnl-2020-323906. PMID: 34187846Free PMC Article
Esophageal Cancer: Tumor-Node-Metastasis Staging.
Betancourt-Cuellar SL, Benveniste MFK, Palacio DP, Hofstetter WL
Radiol Clin North Am 2021 Mar;59(2):219-229. doi: 10.1016/j.rcl.2020.11.008. PMID: 33551083
Esophageal Neoplasms: Radiologic-Pathologic Correlation.
Lichtenberger JP 3rd, Zeman MN, Dulberger AR, Alqutub S, Carter BW, Manning MA
Radiol Clin North Am 2021 Mar;59(2):205-217. doi: 10.1016/j.rcl.2020.11.002. PMID: 33551082
Management of Gastroesophageal Junction Tumors.
Okereke IC
Surg Clin North Am 2017 Apr;97(2):265-275. Epub 2017 Feb 14 doi: 10.1016/j.suc.2016.11.004. PMID: 28325186
Transhiatal esophagectomy.
Zwischenberger JB, Sankar AB
Chest Surg Clin N Am 1995 Aug;5(3):527-42. PMID: 7583037

Therapy

CROSS Versus FLOT Regimens in Esophageal and Esophagogastric Junction Adenocarcinoma: A Propensity-Matched Comparison.
Donlon NE, Moran B, Kamilli A, Davern M, Sheppard A, King S, Donohoe CL, Lowery M, Cunningham M, Ravi N, Mueller C, Cools-Lartigue J, Ferri L, Reynolds JV
Ann Surg 2022 Nov 1;276(5):792-798. Epub 2022 Jul 25 doi: 10.1097/SLA.0000000000005617. PMID: 35876385
Dissecting the single-cell transcriptome network underlying esophagus non-malignant tissues and esophageal squamous cell carcinoma.
Chen Z, Zhao M, Liang J, Hu Z, Huang Y, Li M, Pang Y, Lu T, Sui Q, Zhan C, Lin M, Guo W, Wang Q, Tan L
EBioMedicine 2021 Jul;69:103459. Epub 2021 Jun 27 doi: 10.1016/j.ebiom.2021.103459. PMID: 34192657Free PMC Article
Preoperative exercise to improve fitness in patients undergoing complex surgery for cancer of the lung or oesophagus (PRE-HIIT): protocol for a randomized controlled trial.
Sheill G, Guinan E, O'Neill L, Normand C, Doyle SL, Moore S, Newell J, McDermott G, Ryan R, Reynolds JV, Hussey J
BMC Cancer 2020 Apr 15;20(1):321. doi: 10.1186/s12885-020-06795-4. PMID: 32293334Free PMC Article
Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations.
Chang J, Tan W, Ling Z, Xi R, Shao M, Chen M, Luo Y, Zhao Y, Liu Y, Huang X, Xia Y, Hu J, Parker JS, Marron D, Cui Q, Peng L, Chu J, Li H, Du Z, Han Y, Tan W, Liu Z, Zhan Q, Li Y, Mao W, Wu C, Lin D
Nat Commun 2017 May 26;8:15290. doi: 10.1038/ncomms15290. PMID: 28548104Free PMC Article
Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus.
Herskovic A, Martz K, al-Sarraf M, Leichman L, Brindle J, Vaitkevicius V, Cooper J, Byhardt R, Davis L, Emami B
N Engl J Med 1992 Jun 11;326(24):1593-8. doi: 10.1056/NEJM199206113262403. PMID: 1584260

Prognosis

Gastric conduit reconstruction after esophagectomy.
Watanabe M, Takahashi N, Tamura M, Terayama M, Kuriyama K, Okamura A, Kanamori J, Imamura Y
Dis Esophagus 2024 Oct 2;37(10) doi: 10.1093/dote/doae045. PMID: 38762331
Management of Gastroesophageal Junction Tumors.
Okereke IC
Surg Clin North Am 2017 Apr;97(2):265-275. Epub 2017 Feb 14 doi: 10.1016/j.suc.2016.11.004. PMID: 28325186
Surgical techniques.
Lerut T, Coosemans W, Decker G, De Leyn P, Moons J, Nafteux P, Van Raemdonck D
J Surg Oncol 2005 Dec 1;92(3):218-29. doi: 10.1002/jso.20363. PMID: 16299783
Treatment of esophagogastric tumors.
Lambert R
Endoscopy 2000 Apr;32(4):322-30. doi: 10.1055/s-2000-8995. PMID: 10774974
Treatment of esophageal carcinoma.
Lerut T, Coosemans W, De Leyn P, Van Raemdonck D, Deneffe G, Decker G
Chest 1999 Dec;116(6 Suppl):463S-465S. doi: 10.1378/chest.116.suppl_3.463s. PMID: 10619509

Clinical prediction guides

Gastric conduit reconstruction after esophagectomy.
Watanabe M, Takahashi N, Tamura M, Terayama M, Kuriyama K, Okamura A, Kanamori J, Imamura Y
Dis Esophagus 2024 Oct 2;37(10) doi: 10.1093/dote/doae045. PMID: 38762331
Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.
Ong JS, An J, Han X, Law MH, Nandakumar P; 23andMe Research team; Esophageal cancer consortium, Schumacher J, Gockel I, Bohmer A, Jankowski J, Palles C, Olsen CM, Neale RE, Fitzgerald R, Thrift AP, Vaughan TL, Buas MF, Hinds DA, Gharahkhani P, Kendall BJ, MacGregor S
Gut 2022 Jun;71(6):1053-1061. Epub 2021 Jun 29 doi: 10.1136/gutjnl-2020-323906. PMID: 34187846Free PMC Article
Risk Prediction Model of 90-Day Mortality After Esophagectomy for Cancer.
D'Journo XB, Boulate D, Fourdrain A, Loundou A, van Berge Henegouwen MI, Gisbertz SS, O'Neill JR, Hoelscher A, Piessen G, van Lanschot J, Wijnhoven B, Jobe B, Davies A, Schneider PM, Pera M, Nilsson M, Nafteux P, Kitagawa Y, Morse CR, Hofstetter W, Molena D, So JB, Immanuel A, Parsons SL, Larsen MH, Dolan JP, Wood SG, Maynard N, Smithers M, Puig S, Law S, Wong I, Kennedy A, KangNing W, Reynolds JV, Pramesh CS, Ferguson M, Darling G, Schröder W, Bludau M, Underwood T, van Hillegersberg R, Chang A, Cecconello I, Ribeiro U Jr, de Manzoni G, Rosati R, Kuppusamy M, Thomas PA, Low DE; International Esodata Study Group
JAMA Surg 2021 Sep 1;156(9):836-845. doi: 10.1001/jamasurg.2021.2376. PMID: 34160587Free PMC Article
Multi-omics profiling of primary small cell carcinoma of the esophagus reveals RB1 disruption and additional molecular subtypes.
Li R, Yang Z, Shao F, Cheng H, Wen Y, Sun S, Guo W, Li Z, Zhang F, Xue L, Bi N, Wang J, Sun Y, Li Y, Tan F, Xue Q, Gao S, Shi S, Gao Y, He J
Nat Commun 2021 Jun 18;12(1):3785. doi: 10.1038/s41467-021-24043-6. PMID: 34145257Free PMC Article
Surgical techniques.
Lerut T, Coosemans W, Decker G, De Leyn P, Moons J, Nafteux P, Van Raemdonck D
J Surg Oncol 2005 Dec 1;92(3):218-29. doi: 10.1002/jso.20363. PMID: 16299783

Recent systematic reviews

Incidence of suicide death in patients with cancer: A systematic review and meta-analysis.
Du L, Shi HY, Yu HR, Liu XM, Jin XH, Yan-Qian, Fu XL, Song YP, Cai JY, Chen HL
J Affect Disord 2020 Nov 1;276:711-719. Epub 2020 Jul 20 doi: 10.1016/j.jad.2020.07.082. PMID: 32794450
Preoperative chemotherapy for resectable thoracic esophageal cancer.
Kidane B, Coughlin S, Vogt K, Malthaner R
Cochrane Database Syst Rev 2015 May 19;2015(5):CD001556. doi: 10.1002/14651858.CD001556.pub3. PMID: 25988291Free PMC Article
Multimodality approaches for the curative treatment of esophageal cancer.
Jang R, Darling G, Wong RK
J Natl Compr Canc Netw 2015 Feb;13(2):229-38. doi: 10.6004/jnccn.2015.0029. PMID: 25691613
Omentoplasty for oesophagogastrostomy after oesophagectomy.
Yuan Y, Zeng X, Hu Y, Xie T, Zhao Y
Cochrane Database Syst Rev 2014 Oct 2;2014(10):CD008446. doi: 10.1002/14651858.CD008446.pub3. PMID: 25274134Free PMC Article
Longitudinal and circumferential resection margin in adenocarcinoma of distal esophagus and cardia.
Migliore M, Rassl D, Criscione A
Future Oncol 2014 Apr;10(5):891-901. doi: 10.2217/fon.13.241. PMID: 24799068

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