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Malignant Neoplasm of the Middle Third of the Esophagus

MedGen UID:
102269
•Concept ID:
C0153414
•
Neoplastic Process
Synonyms: Ca middle third esophagus; Malignant Middle Third of Esophagus Neoplasm; Malignant Middle Third of Esophagus Tumor; Malignant Middle Third of the Esophagus Neoplasm; Malignant Middle Third of the Esophagus Tumor; Malignant neoplasm of middle third of esophagus; Malignant Neoplasm of Middle Third of Esophagus; Malignant tumor of middle third of esophagus; Malignant Tumor of Middle Third of Esophagus; Malignant Tumor of the Middle Third of the Esophagus
SNOMED CT: Ca middle third esophagus (187726001); Malignant tumor of middle third of esophagus (187726001); Malignant neoplasm of middle third of esophagus (187726001)

Definition

A primary or metastatic malignant neoplasm involving the middle third segment of the esophagus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Neoplasm of the Middle Third of the Esophagus

Professional guidelines

PubMed

The management of mid & proximal oesophageal squamous cell carcinoma.
Wong I, Law S
Best Pract Res Clin Gastroenterol 2018 Oct-Dec;36-37:85-90. Epub 2018 Nov 30 doi: 10.1016/j.bpg.2018.11.012. PMID: 30551861
Clinical characteristics and management of gastric tube cancer after esophagectomy.
Shirakawa Y, Noma K, Maeda N, Ninomiya T, Tanabe S, Kikuchi S, Kuroda S, Nishizaki M, Kagawa S, Kawahara Y, Okada H, Fujiwara T
Esophagus 2018 Jul;15(3):180-189. Epub 2018 Mar 27 doi: 10.1007/s10388-018-0611-2. PMID: 29951985
Endoscopic diagnosis and treatment of esophageal verrucous squamous cell cancer.
Sweetser S, Jacobs NL, Wong Kee Song LM
Dis Esophagus 2014 Jul;27(5):452-6. Epub 2012 Oct 15 doi: 10.1111/j.1442-2050.2012.01434.x. PMID: 23067443

Recent clinical studies

Etiology

The Prognostic Role of Expression of Nectin-4 in Esophageal Cancer.
Lin X, Hu H, Pan Y, Gao S
Med Sci Monit 2019 Dec 28;25:10089-10094. doi: 10.12659/MSM.918288. PMID: 31883369Free PMC Article
Safety and efficacy of nivolumab in combination with S-1/capecitabine plus oxaliplatin in patients with previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: interim results of a randomized, phase II trial (ATTRACTION-4).
Boku N, Ryu MH, Kato K, Chung HC, Minashi K, Lee KW, Cho H, Kang WK, Komatsu Y, Tsuda M, Yamaguchi K, Hara H, Fumita S, Azuma M, Chen LT, Kang YK
Ann Oncol 2019 Feb 1;30(2):250-258. doi: 10.1093/annonc/mdy540. PMID: 30566590Free PMC Article
The management of mid & proximal oesophageal squamous cell carcinoma.
Wong I, Law S
Best Pract Res Clin Gastroenterol 2018 Oct-Dec;36-37:85-90. Epub 2018 Nov 30 doi: 10.1016/j.bpg.2018.11.012. PMID: 30551861
Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction.
Li J, Qin S, Xu J, Xiong J, Wu C, Bai Y, Liu W, Tong J, Liu Y, Xu R, Wang Z, Wang Q, Ouyang X, Yang Y, Ba Y, Liang J, Lin X, Luo D, Zheng R, Wang X, Sun G, Wang L, Zheng L, Guo H, Wu J, Xu N, Yang J, Zhang H, Cheng Y, Wang N, Chen L, Fan Z, Sun P, Yu H
J Clin Oncol 2016 May 1;34(13):1448-54. Epub 2016 Feb 16 doi: 10.1200/JCO.2015.63.5995. PMID: 26884585
Adenocarcinoma of the esophagus in the young.
Oezcelik A, Ayazi S, DeMeester SR, Zehetner J, Abate E, Dunn J, Grant KS, Lipham JC, Hagen JA, DeMeester TR
J Gastrointest Surg 2013 Jun;17(6):1032-5. Epub 2013 Apr 6 doi: 10.1007/s11605-013-2177-6. PMID: 23564309

Diagnosis

Cancer Diagnoses After Recent Weight Loss.
Wang QL, Babic A, Rosenthal MH, Lee AA, Zhang Y, Zhang X, Song M, Rezende LFM, Lee DH, Biller L, Ng K, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Eliassen AH, Birmann BM, Stampfer MJ, Giovannucci EL, Kraft P, Nowak JA, Yuan C, Wolpin BM
JAMA 2024 Jan 23;331(4):318-328. doi: 10.1001/jama.2023.25869. PMID: 38261044Free PMC Article
Acute esophageal necrosis.
Rodrigues BD, Dos Santos R, da Luz MM, Chaves E Silva F, Reis IG
Clin J Gastroenterol 2016 Dec;9(6):341-344. Epub 2016 Oct 11 doi: 10.1007/s12328-016-0692-1. PMID: 27730597
Adenocarcinoma of the esophagus in the young.
Oezcelik A, Ayazi S, DeMeester SR, Zehetner J, Abate E, Dunn J, Grant KS, Lipham JC, Hagen JA, DeMeester TR
J Gastrointest Surg 2013 Jun;17(6):1032-5. Epub 2013 Apr 6 doi: 10.1007/s11605-013-2177-6. PMID: 23564309
Tumors of the esophagus.
Hatch GF 3rd, Wertheimer-Hatch L, Hatch KF, Davis GB, Blanchard DK, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):401-11. doi: 10.1007/s002689910065. PMID: 10706912
Esophageal sarcomas.
Perch SJ, Soffen EM, Whittington R, Brooks JJ
J Surg Oncol 1991 Nov;48(3):194-8. doi: 10.1002/jso.2930480311. PMID: 1658495

Therapy

Long-term efficacy and predictors of pembrolizumab-based regimens in patients with advanced esophageal cancer in the real world.
Wang HC, Huang X, Chen J, Li Y, Cong Y, Qu BL, Feng SQ, Liu F
World J Gastroenterol 2023 Nov 7;29(41):5641-5656. doi: 10.3748/wjg.v29.i41.5641. PMID: 38077159Free PMC Article
Esophageal cancer surgery in Greece during the era of the financial crisis.
Schizas D, Mylonas KS, Hasemaki N, Mpaili E, Ntomi V, Michalinos A, Theochari NA, Theochari CA, Mpoura M, Bakopoulos A, Liakakos T
Dis Esophagus 2021 Feb 10;34(2) doi: 10.1093/dote/doaa067. PMID: 32766686
Safety and efficacy of nivolumab in combination with S-1/capecitabine plus oxaliplatin in patients with previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: interim results of a randomized, phase II trial (ATTRACTION-4).
Boku N, Ryu MH, Kato K, Chung HC, Minashi K, Lee KW, Cho H, Kang WK, Komatsu Y, Tsuda M, Yamaguchi K, Hara H, Fumita S, Azuma M, Chen LT, Kang YK
Ann Oncol 2019 Feb 1;30(2):250-258. doi: 10.1093/annonc/mdy540. PMID: 30566590Free PMC Article
Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction.
Li J, Qin S, Xu J, Xiong J, Wu C, Bai Y, Liu W, Tong J, Liu Y, Xu R, Wang Z, Wang Q, Ouyang X, Yang Y, Ba Y, Liang J, Lin X, Luo D, Zheng R, Wang X, Sun G, Wang L, Zheng L, Guo H, Wu J, Xu N, Yang J, Zhang H, Cheng Y, Wang N, Chen L, Fan Z, Sun P, Yu H
J Clin Oncol 2016 May 1;34(13):1448-54. Epub 2016 Feb 16 doi: 10.1200/JCO.2015.63.5995. PMID: 26884585
Radiotherapy.
Jelliffe AM
Postgrad Med J 1974 Apr;50(582):231-2. doi: 10.1136/pgmj.50.582.231. PMID: 4217448Free PMC Article

Prognosis

Cancer Diagnoses After Recent Weight Loss.
Wang QL, Babic A, Rosenthal MH, Lee AA, Zhang Y, Zhang X, Song M, Rezende LFM, Lee DH, Biller L, Ng K, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Eliassen AH, Birmann BM, Stampfer MJ, Giovannucci EL, Kraft P, Nowak JA, Yuan C, Wolpin BM
JAMA 2024 Jan 23;331(4):318-328. doi: 10.1001/jama.2023.25869. PMID: 38261044Free PMC Article
Safety and efficacy of nivolumab in combination with S-1/capecitabine plus oxaliplatin in patients with previously untreated, unresectable, advanced, or recurrent gastric/gastroesophageal junction cancer: interim results of a randomized, phase II trial (ATTRACTION-4).
Boku N, Ryu MH, Kato K, Chung HC, Minashi K, Lee KW, Cho H, Kang WK, Komatsu Y, Tsuda M, Yamaguchi K, Hara H, Fumita S, Azuma M, Chen LT, Kang YK
Ann Oncol 2019 Feb 1;30(2):250-258. doi: 10.1093/annonc/mdy540. PMID: 30566590Free PMC Article
The management of mid & proximal oesophageal squamous cell carcinoma.
Wong I, Law S
Best Pract Res Clin Gastroenterol 2018 Oct-Dec;36-37:85-90. Epub 2018 Nov 30 doi: 10.1016/j.bpg.2018.11.012. PMID: 30551861
Tumors of the esophagus.
Hatch GF 3rd, Wertheimer-Hatch L, Hatch KF, Davis GB, Blanchard DK, Foster RS Jr, Skandalakis JE
World J Surg 2000 Apr;24(4):401-11. doi: 10.1007/s002689910065. PMID: 10706912
Radiotherapy.
Jelliffe AM
Postgrad Med J 1974 Apr;50(582):231-2. doi: 10.1136/pgmj.50.582.231. PMID: 4217448Free PMC Article

Clinical prediction guides

Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition.
Botteri E, Peveri G, Berstad P, Bagnardi V, Hoff G, Heath AK, Cross AJ, Vineis P, Dossus L, Johansson M, Freisling H, Matta K, Huybrechts I, Chen SLF, B Borch K, Sandanger TM, H Nøst T, Dahm CC, Antoniussen CS, Tin Tin S, Fournier A, Marques C, Artaud F, Sánchez MJ, Guevara M, Santiuste C, Agudo A, Bajracharya R, Katzke V, Ricceri F, Agnoli C, Bergmann MM, Schulze MB, Panico S, Masala G, Tjønneland A, Olsen A, Stocks T, Manjer J, Aizpurua-Atxega A, Weiderpass E, Riboli E, Gunter MJ, Ferrari P
Eur J Epidemiol 2024 Feb;39(2):147-159. Epub 2024 Jan 5 doi: 10.1007/s10654-023-01059-4. PMID: 38180593
Long-term efficacy and predictors of pembrolizumab-based regimens in patients with advanced esophageal cancer in the real world.
Wang HC, Huang X, Chen J, Li Y, Cong Y, Qu BL, Feng SQ, Liu F
World J Gastroenterol 2023 Nov 7;29(41):5641-5656. doi: 10.3748/wjg.v29.i41.5641. PMID: 38077159Free PMC Article
Esophageal cancer surgery in Greece during the era of the financial crisis.
Schizas D, Mylonas KS, Hasemaki N, Mpaili E, Ntomi V, Michalinos A, Theochari NA, Theochari CA, Mpoura M, Bakopoulos A, Liakakos T
Dis Esophagus 2021 Feb 10;34(2) doi: 10.1093/dote/doaa067. PMID: 32766686
Silence of FOXD2-AS1 inhibited the proliferation and invasion of esophagus cells by regulating miR-145-5p/CDK6 axis.
Shi W, Gao Z, Song J, Wang W
Histol Histopathol 2020 Sep;35(9):1013-1021. Epub 2020 Jun 11 doi: 10.14670/HH-18-232. PMID: 32524576
Esophageal cancer: pneumo-64-MDCT.
Ulla M, Cavadas D, Muñoz I, Beskow A, Seehaus A, García-Mónaco R
Abdom Imaging 2010 Aug;35(4):383-9. Epub 2009 Jun 30 doi: 10.1007/s00261-009-9554-3. PMID: 19568806

Recent systematic reviews

Effect of different surgical approaches on the survival and safety of Siewert type II esophagogastric junction adenocarcinoma: a systematic review and meta-analysis.
Zheng H, Yin X, Pan T, Tao X, Xu X, Li Z
BMC Cancer 2023 Nov 21;23(1):1130. doi: 10.1186/s12885-023-11640-5. PMID: 37990193Free PMC Article
The relationship between metabolic syndrome and increased risk of Barrett's esophagus: an updated systematic review and meta-analysis.
Karimian M, Salamati M, Azami M
BMC Gastroenterol 2020 May 6;20(1):138. doi: 10.1186/s12876-020-01267-2. PMID: 32375671Free PMC Article
Effectiveness of voice rehabilitation on vocalisation in postlaryngectomy patients: a systematic review.
Xi S
Int J Evid Based Healthc 2010 Dec;8(4):256-8. doi: 10.1111/j.1744-1609.2010.00177.x. PMID: 21091891

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