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    TERF2 telomeric repeat binding factor 2 [ Gallus gallus (chicken) ]

    Gene ID: 395598, updated on 10-Oct-2024

    Summary

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    Symbol
    TERF2provided by CGNC
    Full Name
    telomeric repeat binding factor 2provided by CGNC
    Primary source
    CGNC:415
    See related
    Ensembl:ENSGALG00010008246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    TRF2
    Orthologs
    human mouse all
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    Genomic context

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    See TERF2 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 11 NC_052542.1 (18585718..18593531, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 11 NC_052583.1 (18933676..18941488, complement)

    Chromosome 11 - NC_052542.1Genomic Context describing neighboring genes Neighboring gene component of oligomeric golgi complex 8 Neighboring gene NIP7, nucleolar pre-rRNA processing protein Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene cytochrome b5 type B Neighboring gene nuclear factor of activated T-cells 5 Neighboring gene uncharacterized LOC124417145

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterisation of the chicken gene encoding the telomeric protein TRF2. Konrad JP, et al. Gene, 1999 Oct 18. PMID 10571037
    2. The telomeric protein Rap1 is conserved in vertebrates and is expressed from a bidirectional promoter positioned between the Rap1 and KARS genes. Tan M, et al. Gene, 2003 Dec 24. PMID 14659874
    3. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables double-stranded telomeric DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables telomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance via recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of telomeric D-loop disassembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protection from non-homologous end joining at telomere IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomeric D-loop disassembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in telomeric loop formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of shelterin complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    telomeric repeat-binding factor 2
    Names
    TTAGGG-repeat binding factor 2 TRF2
    telomeric DNA-binding protein
    telomeric repeat binding factor a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271892.2 → NP_001258821.2  telomeric repeat-binding factor 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000248
      UniProtKB/Swiss-Prot
      Q9PU53
      UniProtKB/TrEMBL
      A0A8V0XZ26
      Related
      ENSGALP00010011279.1, ENSGALT00010019731.1
      Conserved Domains (4) summary
      cd11654
      Location:494 → 535
      TRF2_RBM; RAP1 binding motif of telomere repeat binding factor
      cd11660
      Location:666 → 714
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      PHA03247
      Location:220 → 566
      PHA03247; large tegument protein UL36; Provisional
      cd00280
      Location:20 → 219
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052542.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      18585718..18593531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040707005.2 → XP_040562939.1  telomeric repeat-binding factor 2 isoform X3

      UniProtKB/Swiss-Prot
      Q9PU53
      Conserved Domains (3) summary
      PTZ00449
      Location:169 → 491
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd11660
      Location:585 → 633
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      cl02779
      Location:20 → 190
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

    2. XM_015292545.4 → XP_015148031.2  telomeric repeat-binding factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9PU53
      Conserved Domains (4) summary
      cd11654
      Location:465 → 506
      TRF2_RBM; RAP1 binding motif of telomere repeat binding factor
      cd11660
      Location:637 → 685
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      PHA03247
      Location:191 → 537
      PHA03247; large tegument protein UL36; Provisional
      cl02779
      Location:20 → 190
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

    3. XM_015292546.4 → XP_015148032.2  telomeric repeat-binding factor 2 isoform X2

      UniProtKB/Swiss-Prot
      Q9PU53
      Conserved Domains (3) summary
      PTZ00449
      Location:198 → 520
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd11660
      Location:614 → 662
      SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family
      cd00280
      Location:20 → 219
      TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052583.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      18933676..18941488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046925358.1 → XP_046781314.1  telomeric repeat-binding factor 2 isoform X3

    2. XM_046925356.1 → XP_046781312.1  telomeric repeat-binding factor 2 isoform X1

    3. XM_046925357.1 → XP_046781313.1  telomeric repeat-binding factor 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9PU53.2 GenPept UniProtKB/Swiss-Prot:Q9PU53

    Gene LinkOut

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