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Conserved domains on  [gi|2099395616|ref|NP_001258821|]
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telomeric repeat-binding factor 2 [Gallus gallus]

Protein Classification

TRFH and SANT_TRF domain-containing protein( domain architecture ID 10832506)

protein containing domains TRFH, TRF2_RBM, and SANT_TRF

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRFH cd00280
Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain ...
 20-219 1.44e-103

Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, protecting the chromosome ends from degradation and end-to-end fusion. Proteins TRF1, TRF2 and Taz1 bind telomeric DNA and are also involved in recruiting interacting proteins, TIN2, and Rap1, to the telomeres. It has also been demonstrated that PARP1 associates with TRF2 and is capable of poly(ADP-ribosyl)ation of TRF2, which affects binding of TRF2 to telomeric DNA. TRF1, TRF2 and Taz1 proteins contain three functional domains: an N-terminal acidic domain, a central TRF-specific/dimerization domain, and a C-terminal DNA binding domain with a single Myb-like repeat. Homodimerization, a prerequisite to DNA binding, results in the juxtaposition of two Myb DNA binding domains.


:

Pssm-ID: 238174  Cd Length: 200  Bit Score: 314.77  E-value: 1.44e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  20 SDDREQAVNRWVLQFYFHQAVAAYRAGRNRDFRQLRDVMQALLVRPLEREPAVAQMLRVMQFLSRIEEGENLDCTFDKET 99
Cdd:cd00280     1 EADAEAVANRWVLDFYFHSACRAFREGRYEDFRRTRDIAEALLVGPLKLTATQLKTLRIMQFLSRIAEGKNLDCQFENDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 100 ELTPLESAIGILQLIAKEFSVPEKKIELIHKVLKEAAVIVCIKNKEFSKALAVLKRHMeKDTGNQKKRTELQTIIREKNR 179
Cdd:cd00280    81 ELTPLESALMVLESIEKEFSLPETLHEEIRKLIKEQAVAVCMENGEFKKAEEVLKRLF-SDPESQKLRMKLLMIIREKDP 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2099395616 180 AHPIIRDFSYVNFQQYMFQFLKTYVDTSE-PLLVTMMKSLN 219
Cdd:cd00280   160 AHPVLQNFSYSHFMQKMKSYVELVLDEKEsPFLLKAAAKVV 200
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 666-714 5.79e-20

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


:

Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 83.39  E-value: 5.79e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2099395616 666 QKWTVQESEWIKDGVRKYGEGRWKTISEKYPF-QNRTSVQIKDRYRTMKK 714
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVGNWAKILKDYFFvNNRTSVDLKDKWRNLKK 50
TERF2_RBM pfam16772
Telomeric repeat-binding factor 2 Rap1-binding motif; This domain, found in telomeric ...
 495-535 1.36e-16

Telomeric repeat-binding factor 2 Rap1-binding motif; This domain, found in telomeric repeat-binding factor 2, binds to the C-terminus of repressor activator protein 1 (RAP1) (telomeric repeat-binding factor 2-interacting protein 1).


:

Pssm-ID: 435576  Cd Length: 41  Bit Score: 73.60  E-value: 1.36e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2099395616 495 PFRTVTTYGISVLREAFKMLSNSPDSDALFNKLDETDLPSP 535
Cdd:pfam16772   1 PPETPTTYGISVLKAAFKSLSDSQDPDAAFTKLDETDLTLP 41
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 220-566 2.42e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 2.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  220 SEHAEEPKRSSVTPESPSRTEDQEEAyepLRRVKHSvgtlRRAETAGGVAGAPSCPEMAKdPTGAPEHVGTVKDAVRAPC 299
Cdd:PHA03247  2632 SPAANEPDPHPPPTVPPPERPRDDPA---PGRVSRP----RRARRLGRAAQASSPPQRPR-RRAARPTVGSLTSLADPPP 2703

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  300 PAESTEDsqgAPRCAetardVMGAPSPsemtkdlLGAPKCTETARDVVRAPSPAESTKDPVGTPGHAETARDVARAPSPA 379
Cdd:PHA03247  2704 PPPTPEP---APHAL-----VSATPLP-------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA 2768

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  380 ETTknlPGAPECADTVKNTVRAPSPAERRKDLVRAPKRAETARDVVRAPSPAERVKDTVGASEPMKSASYPTASQPRiaa 459
Cdd:PHA03247  2769 PAP---PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP--- 2842

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  460 vksskvfSVPVEISEQPAAAAPVHAGVSSRDLERTPFRTVTTYG-ISVLREAFKMLSNSPDSDALfNKLDETDLPSPQQM 538
Cdd:PHA03247  2843 -------PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPArPPVRRLARPAVSRSTESFAL-PPDQPERPPQPQAP 2914

                          330       340
                   ....*....|....*....|....*...
gi 2099395616  539 SPSVSHRTKRRKEEKNQGSETLDSPEIP 566
Cdd:PHA03247  2915 PPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
 
Name Accession Description Interval E-value
TRFH cd00280
Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain ...
 20-219 1.44e-103

Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, protecting the chromosome ends from degradation and end-to-end fusion. Proteins TRF1, TRF2 and Taz1 bind telomeric DNA and are also involved in recruiting interacting proteins, TIN2, and Rap1, to the telomeres. It has also been demonstrated that PARP1 associates with TRF2 and is capable of poly(ADP-ribosyl)ation of TRF2, which affects binding of TRF2 to telomeric DNA. TRF1, TRF2 and Taz1 proteins contain three functional domains: an N-terminal acidic domain, a central TRF-specific/dimerization domain, and a C-terminal DNA binding domain with a single Myb-like repeat. Homodimerization, a prerequisite to DNA binding, results in the juxtaposition of two Myb DNA binding domains.


Pssm-ID: 238174  Cd Length: 200  Bit Score: 314.77  E-value: 1.44e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  20 SDDREQAVNRWVLQFYFHQAVAAYRAGRNRDFRQLRDVMQALLVRPLEREPAVAQMLRVMQFLSRIEEGENLDCTFDKET 99
Cdd:cd00280     1 EADAEAVANRWVLDFYFHSACRAFREGRYEDFRRTRDIAEALLVGPLKLTATQLKTLRIMQFLSRIAEGKNLDCQFENDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 100 ELTPLESAIGILQLIAKEFSVPEKKIELIHKVLKEAAVIVCIKNKEFSKALAVLKRHMeKDTGNQKKRTELQTIIREKNR 179
Cdd:cd00280    81 ELTPLESALMVLESIEKEFSLPETLHEEIRKLIKEQAVAVCMENGEFKKAEEVLKRLF-SDPESQKLRMKLLMIIREKDP 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2099395616 180 AHPIIRDFSYVNFQQYMFQFLKTYVDTSE-PLLVTMMKSLN 219
Cdd:cd00280   160 AHPVLQNFSYSHFMQKMKSYVELVLDEKEsPFLLKAAAKVV 200
TRF pfam08558
Telomere repeat binding factor (TRF); Telomere repeat binding factor (TRF) family proteins are ...
 30-198 2.56e-42

Telomere repeat binding factor (TRF); Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain pfam00249 at the carboxy terminus. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres. This domain is composed of multiple alpha helices arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors.


Pssm-ID: 400735  Cd Length: 212  Bit Score: 152.56  E-value: 2.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  30 WVLQFYFHQAVAAYRAGRNR-----------DFRQLRDVMQALLVRPLEREPAVAQMLR----------VMQFLSRIEEG 88
Cdd:pfam08558   3 WVLDNLSTQLLRALREGPYTdvlaivsepdsEFRESFDILESLFERTKKLYSTRSPLLSpsilkiresyIMQTLRRINLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  89 ENLDCTFDkETELTPLESAIGILQLIAKEFSVPEKKIELIHKVLKEAAVIVCIKNKEFSKALAVLKRHMEKDTGN----- 163
Cdd:pfam08558  83 TFLDSVFG-NLEVGFLELAENFLDIFCPEDGKLLKPQGVLYLDLKTQAYIVALKEGPFKSASEILDKLFPDDLADilkqr 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2099395616 164 ----------------QKKRTELQTIIREKNRAHPIIRDFSYVNFQQYMFQ 198
Cdd:pfam08558 162 ndklltpsetdfvercKKRREKLLNIINEKDPYHPLLQNFSWESFLKELLS 212
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 666-714 5.79e-20

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 83.39  E-value: 5.79e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2099395616 666 QKWTVQESEWIKDGVRKYGEGRWKTISEKYPF-QNRTSVQIKDRYRTMKK 714
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVGNWAKILKDYFFvNNRTSVDLKDKWRNLKK 50
TERF2_RBM pfam16772
Telomeric repeat-binding factor 2 Rap1-binding motif; This domain, found in telomeric ...
 495-535 1.36e-16

Telomeric repeat-binding factor 2 Rap1-binding motif; This domain, found in telomeric repeat-binding factor 2, binds to the C-terminus of repressor activator protein 1 (RAP1) (telomeric repeat-binding factor 2-interacting protein 1).


Pssm-ID: 435576  Cd Length: 41  Bit Score: 73.60  E-value: 1.36e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2099395616 495 PFRTVTTYGISVLREAFKMLSNSPDSDALFNKLDETDLPSP 535
Cdd:pfam16772   1 PPETPTTYGISVLKAAFKSLSDSQDPDAAFTKLDETDLTLP 41
TRF2_RBM cd11654
RAP1 binding motif of telomere repeat binding factor; TRF2 (Telomere repeat binding factor 2) ...
 494-535 1.07e-12

RAP1 binding motif of telomere repeat binding factor; TRF2 (Telomere repeat binding factor 2) functions as part of the 6-component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminus (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA-binding proteins (TRF2, TRF1 and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM) described by this model, the TIN2 binding motif (TBM), and a myb-like DNA binding domain.


Pssm-ID: 212553  Cd Length: 42  Bit Score: 62.78  E-value: 1.07e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2099395616 494 TPFRTVTTYGISVLREAFKMLSNSPDSDALFNKLDETDLPSP 535
Cdd:cd11654     1 QPVSTPTTIGISTLKAAFKSLSQAEDSDAAFAKLDQKDLVRP 42
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
665-714 1.99e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 59.16  E-value: 1.99e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2099395616  665 KQKWTVQESEWIKDGVRKYGEGRWKTISEKYPfqNRTSVQIKDRYRTMKK 714
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP--GRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 665-713 5.45e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 57.90  E-value: 5.45e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2099395616 665 KQKWTVQESEWIKDGVRKYGeGRWKTISEKYPfqNRTSVQIKDRYRTMK 713
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLP--GRTDNQCKNRWQNYL 46
PHA03247 PHA03247
large tegument protein UL36; Provisional
 220-566 2.42e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 2.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  220 SEHAEEPKRSSVTPESPSRTEDQEEAyepLRRVKHSvgtlRRAETAGGVAGAPSCPEMAKdPTGAPEHVGTVKDAVRAPC 299
Cdd:PHA03247  2632 SPAANEPDPHPPPTVPPPERPRDDPA---PGRVSRP----RRARRLGRAAQASSPPQRPR-RRAARPTVGSLTSLADPPP 2703

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  300 PAESTEDsqgAPRCAetardVMGAPSPsemtkdlLGAPKCTETARDVVRAPSPAESTKDPVGTPGHAETARDVARAPSPA 379
Cdd:PHA03247  2704 PPPTPEP---APHAL-----VSATPLP-------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA 2768

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  380 ETTknlPGAPECADTVKNTVRAPSPAERRKDLVRAPKRAETARDVVRAPSPAERVKDTVGASEPMKSASYPTASQPRiaa 459
Cdd:PHA03247  2769 PAP---PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP--- 2842

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  460 vksskvfSVPVEISEQPAAAAPVHAGVSSRDLERTPFRTVTTYG-ISVLREAFKMLSNSPDSDALfNKLDETDLPSPQQM 538
Cdd:PHA03247  2843 -------PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPArPPVRRLARPAVSRSTESFAL-PPDQPERPPQPQAP 2914

                          330       340
                   ....*....|....*....|....*...
gi 2099395616  539 SPSVSHRTKRRKEEKNQGSETLDSPEIP 566
Cdd:PHA03247  2915 PPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
 
Name Accession Description Interval E-value
TRFH cd00280
Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain ...
 20-219 1.44e-103

Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, protecting the chromosome ends from degradation and end-to-end fusion. Proteins TRF1, TRF2 and Taz1 bind telomeric DNA and are also involved in recruiting interacting proteins, TIN2, and Rap1, to the telomeres. It has also been demonstrated that PARP1 associates with TRF2 and is capable of poly(ADP-ribosyl)ation of TRF2, which affects binding of TRF2 to telomeric DNA. TRF1, TRF2 and Taz1 proteins contain three functional domains: an N-terminal acidic domain, a central TRF-specific/dimerization domain, and a C-terminal DNA binding domain with a single Myb-like repeat. Homodimerization, a prerequisite to DNA binding, results in the juxtaposition of two Myb DNA binding domains.


Pssm-ID: 238174  Cd Length: 200  Bit Score: 314.77  E-value: 1.44e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  20 SDDREQAVNRWVLQFYFHQAVAAYRAGRNRDFRQLRDVMQALLVRPLEREPAVAQMLRVMQFLSRIEEGENLDCTFDKET 99
Cdd:cd00280     1 EADAEAVANRWVLDFYFHSACRAFREGRYEDFRRTRDIAEALLVGPLKLTATQLKTLRIMQFLSRIAEGKNLDCQFENDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 100 ELTPLESAIGILQLIAKEFSVPEKKIELIHKVLKEAAVIVCIKNKEFSKALAVLKRHMeKDTGNQKKRTELQTIIREKNR 179
Cdd:cd00280    81 ELTPLESALMVLESIEKEFSLPETLHEEIRKLIKEQAVAVCMENGEFKKAEEVLKRLF-SDPESQKLRMKLLMIIREKDP 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2099395616 180 AHPIIRDFSYVNFQQYMFQFLKTYVDTSE-PLLVTMMKSLN 219
Cdd:cd00280   160 AHPVLQNFSYSHFMQKMKSYVELVLDEKEsPFLLKAAAKVV 200
TRF pfam08558
Telomere repeat binding factor (TRF); Telomere repeat binding factor (TRF) family proteins are ...
 30-198 2.56e-42

Telomere repeat binding factor (TRF); Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain pfam00249 at the carboxy terminus. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres. This domain is composed of multiple alpha helices arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors.


Pssm-ID: 400735  Cd Length: 212  Bit Score: 152.56  E-value: 2.56e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  30 WVLQFYFHQAVAAYRAGRNR-----------DFRQLRDVMQALLVRPLEREPAVAQMLR----------VMQFLSRIEEG 88
Cdd:pfam08558   3 WVLDNLSTQLLRALREGPYTdvlaivsepdsEFRESFDILESLFERTKKLYSTRSPLLSpsilkiresyIMQTLRRINLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  89 ENLDCTFDkETELTPLESAIGILQLIAKEFSVPEKKIELIHKVLKEAAVIVCIKNKEFSKALAVLKRHMEKDTGN----- 163
Cdd:pfam08558  83 TFLDSVFG-NLEVGFLELAENFLDIFCPEDGKLLKPQGVLYLDLKTQAYIVALKEGPFKSASEILDKLFPDDLADilkqr 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2099395616 164 ----------------QKKRTELQTIIREKNRAHPIIRDFSYVNFQQYMFQ 198
Cdd:pfam08558 162 ndklltpsetdfvercKKRREKLLNIINEKDPYHPLLQNFSWESFLKELLS 212
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 666-714 5.79e-20

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 83.39  E-value: 5.79e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 2099395616 666 QKWTVQESEWIKDGVRKYGEGRWKTISEKYPF-QNRTSVQIKDRYRTMKK 714
Cdd:cd11660     1 RKWTDEEDEALVEGVEKYGVGNWAKILKDYFFvNNRTSVDLKDKWRNLKK 50
TERF2_RBM pfam16772
Telomeric repeat-binding factor 2 Rap1-binding motif; This domain, found in telomeric ...
 495-535 1.36e-16

Telomeric repeat-binding factor 2 Rap1-binding motif; This domain, found in telomeric repeat-binding factor 2, binds to the C-terminus of repressor activator protein 1 (RAP1) (telomeric repeat-binding factor 2-interacting protein 1).


Pssm-ID: 435576  Cd Length: 41  Bit Score: 73.60  E-value: 1.36e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 2099395616 495 PFRTVTTYGISVLREAFKMLSNSPDSDALFNKLDETDLPSP 535
Cdd:pfam16772   1 PPETPTTYGISVLKAAFKSLSDSQDPDAAFTKLDETDLTLP 41
TRF2_RBM cd11654
RAP1 binding motif of telomere repeat binding factor; TRF2 (Telomere repeat binding factor 2) ...
 494-535 1.07e-12

RAP1 binding motif of telomere repeat binding factor; TRF2 (Telomere repeat binding factor 2) functions as part of the 6-component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminus (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA-binding proteins (TRF2, TRF1 and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM) described by this model, the TIN2 binding motif (TBM), and a myb-like DNA binding domain.


Pssm-ID: 212553  Cd Length: 42  Bit Score: 62.78  E-value: 1.07e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2099395616 494 TPFRTVTTYGISVLREAFKMLSNSPDSDALFNKLDETDLPSP 535
Cdd:cd11654     1 QPVSTPTTIGISTLKAAFKSLSQAEDSDAAFAKLDQKDLVRP 42
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 667-713 1.96e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 59.13  E-value: 1.96e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2099395616 667 KWTVQESEWIKDGVRKYGEGRWKTISEKYPfqNRTSVQIKDRYRTMK 713
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKELP--GRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
665-714 1.99e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 59.16  E-value: 1.99e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2099395616  665 KQKWTVQESEWIKDGVRKYGEGRWKTISEKYPfqNRTSVQIKDRYRTMKK 714
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP--GRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 665-713 5.45e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 57.90  E-value: 5.45e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2099395616 665 KQKWTVQESEWIKDGVRKYGeGRWKTISEKYPfqNRTSVQIKDRYRTMK 713
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLP--GRTDNQCKNRWQNYL 46
SANT_DMAP1_like cd11658
SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These ...
 668-712 4.46e-07

SANT/myb-like domain of Human Dna Methyltransferase 1 Associated Protein 1-like; These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212556  Cd Length: 46  Bit Score: 47.02  E-value: 4.46e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2099395616 668 WTVQESEWIKDGVRKYGEgRWKTISEKYPFQN-RTSVQIKDRYRTM 712
Cdd:cd11658     1 WTKEETDYLFDLVKRFDL-RWNVILDRYPFQKgRSVEDLKEKYYHL 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
 220-566 2.42e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 2.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  220 SEHAEEPKRSSVTPESPSRTEDQEEAyepLRRVKHSvgtlRRAETAGGVAGAPSCPEMAKdPTGAPEHVGTVKDAVRAPC 299
Cdd:PHA03247  2632 SPAANEPDPHPPPTVPPPERPRDDPA---PGRVSRP----RRARRLGRAAQASSPPQRPR-RRAARPTVGSLTSLADPPP 2703

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  300 PAESTEDsqgAPRCAetardVMGAPSPsemtkdlLGAPKCTETARDVVRAPSPAESTKDPVGTPGHAETARDVARAPSPA 379
Cdd:PHA03247  2704 PPPTPEP---APHAL-----VSATPLP-------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA 2768

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  380 ETTknlPGAPECADTVKNTVRAPSPAERRKDLVRAPKRAETARDVVRAPSPAERVKDTVGASEPMKSASYPTASQPRiaa 459
Cdd:PHA03247  2769 PAP---PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP--- 2842

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  460 vksskvfSVPVEISEQPAAAAPVHAGVSSRDLERTPFRTVTTYG-ISVLREAFKMLSNSPDSDALfNKLDETDLPSPQQM 538
Cdd:PHA03247  2843 -------PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPArPPVRRLARPAVSRSTESFAL-PPDQPERPPQPQAP 2914

                          330       340
                   ....*....|....*....|....*...
gi 2099395616  539 SPSVSHRTKRRKEEKNQGSETLDSPEIP 566
Cdd:PHA03247  2915 PPPQPQPQPPPPPQPQPPPPPPPRPQPP 2942
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 198-630 2.43e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.76  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 198 QFLKTYVDTSEPLLVTMMKSLNSEHAEEPK---RSSVTPESPSRTEDQEEAYEPLRRVKHSvgtlrraeTAGGVAGAPSC 274
Cdd:PTZ00449  483 QEIKKLIKKSKKKLAPIEEEDSDKHDEPPEgpeASGLPPKAPGDKEGEEGEHEDSKESDEP--------KEGGKPGETKE 554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 275 PEMAKDPTGAPEHvgtvkdavrAPCPAESTEDSQGAPRCAETARDvmgapsPSEMTKdllgaPKCTETARDVVRAPSPA- 353
Cdd:PTZ00449  555 GEVGKKPGPAKEH---------KPSKIPTLSKKPEFPKDPKHPKD------PEEPKK-----PKRPRSAQRPTRPKSPKl 614

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 354 -ESTKDPvGTPGHAETARDVARAPSPAETTKnlPGAPECADTVKNTVRAPSPA--------ERRKD--LVRAPKRAETAR 422
Cdd:PTZ00449  615 pELLDIP-KSPKRPESPKSPKRPPPPQRPSS--PERPEGPKIIKSPKPPKSPKppfdpkfkEKFYDdyLDAAAKSKETKT 691

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 423 DVVRAPSPAERVKDTVGASePMKSASYPTASQPRIAAVKSSKVFSVPVEISEQPAAAAPVHAGVSSRD-LERTPFRTVTT 501
Cdd:PTZ00449  692 TVVLDESFESILKETLPET-PGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIEFFTPPEEERTfFHETPADTPLP 770

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 502 ygiSVLREAFKmlsnSPDSDALFNKLDET----DLPSPQQMSPSVSHRT---KRRKE----------EKNQGSETLDSPE 564
Cdd:PTZ00449  771 ---DILAEEFK----EEDIHAETGEPDEAmkrpDSPSEHEDKPPGDHPSlpkKRHRLdglalsttdlESDAGRIAKDASG 843

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 565 IPHKSKR------LFT----------ISKMIMD-QGSQCSKSSESPDSSQERVVSSAYRPVQELPDQPVSTKRSSQQRWN 627
Cdd:PTZ00449  844 KIVKLKRsksfddLTTveeaeemgaeARKIVVDdDGTEADDEDTHPPEEKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPD 923


                  ...
gi 2099395616 628 SSY 630
Cdd:PTZ00449  924 SAF 926
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
260-481 3.89e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.15  E-value: 3.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 260 RRAETAGGVAGAPScpEMAKDPTGAPEHVGTVKDAVRAPCPAESTEDSQGAPRCAETARDVMGAPSPSEMTKDLLGAPKC 339
Cdd:PRK07003  394 SAVPAVTAVTGAAG--AALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPP 471

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 340 TETARDVVRAPS-PAESTKDPVGTPGHAETARDVARAPSPAETTKNLPGAPECADTVKNTVRAPSPAERrkdlvRAPKR- 417
Cdd:PRK07003  472 ADSGSASAPASDaPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAA-----APAARa 546

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2099395616 418 --AETARDVVRAPS---PAERVKDTVGASEP-MKSASYPTASQPRIAA-VKSSKVFSVPVEISEQPAAAAP 481
Cdd:PRK07003  547 ggAAAALDVLRNAGmrvSSDRGARAAAAAKPaAAPAAAPKPAAPRVAVqVPTPRARAATGDAPPNGAARAE 617
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 363-495 4.56e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 46.63  E-value: 4.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 363 PGHAETARDVARAPSPAETTKNLPGAPECADTVKNTVRAPSPAerrkdlvrAPKRAETARDVVRAPSPAERVKDTVGASE 442
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPA--------AAASAPAAPPAAAPPAPVAAPAAAAPAAA 437

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2099395616 443 PMKSASyPTASQPRIAAVKSSKVFSVPVEISEQP----AAAAPVHAGVSSRdLERTP 495
Cdd:PRK14951  438 PAAAPA-AVALAPAPPAQAAPETVAIPVRVAPEPavasAAPAPAAAPAAAR-LTPTE 492
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
267-480 1.69e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 267 GVAGAPSCPEMAKDPTGAPEHVGTVKDAVRAPCPAESTEDSQGAPRCAETARDVMGAPSPSEMTKDLLGAPKCTETARDV 346
Cdd:PRK12323  366 GQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPG 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 347 VR-------APSPAESTKDPVGTP-GHAETARDVARAPSPAETTKNLPGAPECADTVKNTVRAPSPAERRKDLVRAPKrA 418
Cdd:PRK12323  446 GApapapapAAAPAAAARPAAAGPrPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVA-E 524

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2099395616 419 ETARDVVRAPSPAERVKDTVGASEPMKSASYPTASQPRIAAVKSSKVFSVPVEISEQPAAAA 480
Cdd:PRK12323  525 SIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAA 586
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 668-712 3.89e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.83  E-value: 3.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2099395616 668 WTVQESEWIKDGVRKYGeGRWKTISEKYPFqnRTSVQIKDRYRTM 712
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGR--RTPKQCFDRWRRK 42
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
282-386 4.97e-04

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 43.69  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 282 TGAPEHVGTVKDAVRAPcPAESTEDSQGAPrcaetardvmgAPSPSEMTKDLLGAPKCTETArdvVRAPSPAESTKDPVG 361
Cdd:PRK11907   19 TASNPKLAQAEEIVTTT-PATSTEAEQTTP-----------VESDATEEADNTETPVAATTA---AEAPSSSETAETSDP 83

                          90       100
                  ....*....|....*....|....*
gi 2099395616 362 TPGHAETARDVARAPSPAETTKNLP 386
Cdd:PRK11907   84 TSEATDTTTSEARTVTPAATETSKP 108
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
335-480 9.33e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 9.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 335 GAPKCTETARDVVRAPSPAESTKDPVGTPGHAETARDVARAPSPAETTKNLPGAPECADTVKNTVRAPSPaerrkdlVRA 414
Cdd:PRK07003  379 AVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAP-------VPA 451

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2099395616 415 PKRAETARDVVRAPSPAERVKDTVGASEPMKSASYPTASQPRIAAVKSSKVFSVPVEISEQPAAAA 480
Cdd:PRK07003  452 KANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAS 517
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
297-497 2.06e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 297 APCPAESTEDSQGAPRCAETARDVMGAPSPSEMTKDLLGAPKCTETARDVVRAPSPAESTKDPVGTPGHAETARDVARAP 376
Cdd:PRK12323  373 GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAP 452

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 377 SPAETTKNLPgAPECADTVKNTVRAPSPAERrkdlvRAPKRAETARDvvRAPSPAERVKDTVGASEPMKSASYP----TA 452
Cdd:PRK12323  453 APAAAPAAAA-RPAAAGPRPVAAAAAAAPAR-----AAPAAAPAPAD--DDPPPWEELPPEFASPAPAQPDAAPagwvAE 524

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 2099395616 453 SQPRIAAVKSSKVFSVPVEisEQPAAAAPVHAGVSSRDLERTPFR 497
Cdd:PRK12323  525 SIPDPATADPDDAFETLAP--APAAAPAPRAAAATEPVVAPRPPR 567
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
235-489 2.49e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 2.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 235 SPSRTEDQEEAYEPLRRVKHSVGTLRRAETAGGVAGAPSCPEMAKDPTGAPehvgTVKDAVRAPCPAESTEDSQGAPRCA 314
Cdd:PRK12323  373 GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAP----ARRSPAPEALAAARQASARGPGGAP 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 315 ETARDVMGAPSPSEMTKDLLGAPKCTETARDVVRAPSPAESTKDPVGTPGHAETARDVArAPSPAETTKNLPGApECADT 394
Cdd:PRK12323  449 APAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFA-SPAPAQPDAAPAGW-VAESI 526

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 395 VKNTVRAPSPAERRKDLVRAPKRAETARDVVRAPSPAERVKDTVGASEPMKSASYPT--------------ASQPRIAAV 460
Cdd:PRK12323  527 PDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPAlaarlpvrglaqqlARQSELAGV 606

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 2099395616 461 KSSKV-FSVPV------EISEQPAAAAPVHAGVSSR 489
Cdd:PRK12323  607 EGDTVrLRVPVpalaeaEVVERLQAALTEHFGQPVR 642
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
263-459 2.76e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.99  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 263 ETAGGVAGAPSCPEMAKDPTGAPehvgtVKDAVRAPCPAESTEDSQGAPRCAETArdvmgAPSPSEmtkdllGAPKCTET 342
Cdd:PRK07003  359 EPAVTGGGAPGGGVPARVAGAVP-----APGARAAAAVGASAVPAVTAVTGAAGA-----ALAPKA------AAAAAATR 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 343 ARDVVRAPSPAESTKDPVGTPGHAETARDVARAPSPAETTKNLPGAPECADTVKNTVRAPS--PAERRKDLVRAPKRAET 420
Cdd:PRK07003  423 AEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDapPDAAFEPAPRAAAPSAA 502

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 2099395616 421 ARDVVR---APSPAERVKDTVGASEPMKSASYPTASQPRIAA 459
Cdd:PRK07003  503 TPAAVPdarAPAAASREDAPAAAAPPAPEARPPTPAAAAPAA 544
PHA03247 PHA03247
large tegument protein UL36; Provisional
 269-503 4.09e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 4.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  269 AGAPSCPEMAKDPTGAPEHVGTVKDAVRAPCPAESTEDSQGA---PR-------CAETARDVMGAPSPSEMTKDLLGAP- 337
Cdd:PHA03247  2486 ARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEpvhPRmltwirgLEELASDDAGDPPPPLPPAAPPAAPd 2565

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  338 KCTETARDVVRAPSPAESTKD--------------PVGTPGhaETARDVARAPSPAETTK------------NLPGAPEC 391
Cdd:PHA03247  2566 RSVPPPRPAPRPSEPAVTSRArrpdappqsarpraPVDDRG--DPRGPAPPSPLPPDTHApdppppspspaaNEPDPHPP 2643

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616  392 ADTVKNTVRAPSPAERRkdlVRAPKRAETARDVVRAPSPAER-----VKDTVGA-------------SEPMKSASYPTAS 453
Cdd:PHA03247  2644 PTVPPPERPRDDPAPGR---VSRPRRARRLGRAAQASSPPQRprrraARPTVGSltsladpppppptPEPAPHALVSATP 2720

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 2099395616  454 QPRIAAVKSSKVFSVPVEISEQPAAAAPVHAGVssrdlERTPFRTVTTYG 503
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGG-----PARPARPPTTAG 2765
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
223-443 4.37e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 223 AEEPKRSSVTPESPSRTEDQEEAYEPLRRVKHSVGTLRRAETAGGVAGAPSCPEMAKDPTGAPEHVGTVKDAVRAPcPAE 302
Cdd:PRK07003  407 GAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPAS-DAP 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2099395616 303 STEDSQGAPRCAETARDVMGAPSPSEmtkDLLGAPKCTETARDVVRAP---SPAESTKDPVGTPGHAETARDV------- 372
Cdd:PRK07003  486 PDAAFEPAPRAAAPSAATPAAVPDAR---APAAASREDAPAAAAPPAPearPPTPAAAAPAARAGGAAAALDVlrnagmr 562

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2099395616 373 -----ARAPSPAETTKNLPGAPECADTVKNTVRAPSPaerrkdlvRAPKRAETARDVVRAPSPaeRVKDTVGASEP 443
Cdd:PRK07003  563 vssdrGARAAAAAKPAAAPAAAPKPAAPRVAVQVPTP--------RARAATGDAPPNGAARAE--QAAESRGAPPP 628
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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