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| Status |
Public on Apr 29, 2008 |
| Title |
Profiling Gene Expression in Human Placentae of Different Gestational Ages: an OPRU Network and UW SCOR Study |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We used a whole genome approach to identify major functional gene categories (including xenobiotic transporters and metabolizing enzymes) whose expression depends on gestational age. STUDY DESIGN: We compared gene expression profiles of 1st (45-59 days) and 2nd trimester (109-115 days), and C-section term placentae. RESULTS: In 1st trimester placentae, genes related to cell cycle, DNA, aminoacids and carbohydrate metabolism were significantly overrepresented, while genes related to signal transduction were downregulated. In the organism defense category, we identified genes involved in chemical response, metabolism, and transport. Analysis of signal transduction pathways suggested, and subsequently confirmed independently, that the Wnt pathway was regulated by gestational age. CONCLUSIONS: Our study will serve as a reference database to gain insight into the regulation of gene expression in the developing placentae and, thus, allow comparisons with placentae from complicated pregnancies such as those in women experiencing gestational diabetes, pre-eclampsia and teratogenic sequelae.
Keywords: time series
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| Overall design |
Comparison of plaental gene expression profiles of three gestational stages (1st trimester (45-59 days), 2nd trimester (109-115 days), and C-section term placentae), with four replicates each,
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| Contributor(s) |
Beyer RP |
| Citation(s) |
19050320 |
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| Submission date |
Dec 19, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
James William MacDonald |
| E-mail(s) |
jmacdon@uw.edu
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| Organization name |
University of Washington
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| Department |
Environmental and Occupational Health Sciences
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| Street address |
4225 Roosevelt Way NE
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| City |
Seattle |
| State/province |
WA |
| ZIP/Postal code |
98105-6099 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (12)
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| GSM252349 |
First trimester placenta Grp1H17634 |
| GSM252350 |
First trimester placenta Grp1H17790 |
| GSM252351 |
First trimester placenta Grp1H18035 |
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| Relations |
| BioProject |
PRJNA104003 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE9984_RAW.tar |
50.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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