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| Status |
Public on Mar 09, 2017 |
| Title |
Transcriptional profiling of diabetic peripheral neuropathy patients, diabetic patients, and healthy participants |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). It is not diagnosed or managed properly in the majority of patients, because its pathogenesis remains controversial. In this study, using microarray-based genome-wide expression analyses, we sought to identify both common and distinct mechanisms underlying the pathogenesis of DM and DPN. The results demonstrated that down-regulation of the neurotrophin-MAPK signaling pathway may be the major mechanism of DPN pathogenesis, thus providing a potential approach for DPN treatment.
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| Overall design |
6 DPN, 6 DM, and 6 CN
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| Contributor(s) |
Luo L, Xu J |
| Citation(s) |
28900628 |
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| Submission date |
Mar 08, 2017 |
| Last update date |
Aug 07, 2018 |
| Contact name |
Jin Xu |
| E-mail(s) |
nbusykes@163.com
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| Organization name |
Ningbo University
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| Street address |
818 Fenghua Road
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| City |
Ningbo |
| ZIP/Postal code |
315211 |
| Country |
China |
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| Platforms (1) |
| GPL22448 |
Phalanx Human lncRNA OneArray v1_mRNA |
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| Samples (18)
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| Relations |
| BioProject |
PRJNA378558 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE95849_RAW.tar |
46.8 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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