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Series GSE92456 Query DataSets for GSE92456
Status Public on Jun 09, 2017
Title Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of BET inhibitor JQ1
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We analyzed anti-proliferative dominant-negative Brd4 mutants that compete with the function of distinct Brd4 domains. We used these Brd4 mutants to compare the Brd4-specific transcriptome with the transcriptome of JQ1 treated cells.
Overall design We performed polyA RNA-seq of Raji cells expressing Brd4 constructs f3 and f9 (dnBrd4_f3/f9) and Raji cell expressing the luciferase control vector treated with JQ1 (luc_JQ1) or DMSO as control (luc_DMSO).
Contributor(s) Decker T, Kluge M, Krebs S, Shah N, Blum H, Friedel CC, Eick D
Citation(s) 28490802
Submission date Dec 15, 2016
Last update date May 15, 2019
Contact name Caroline Friedel
Organization name Ludwig-Maximilians-Universität München
Department Institut für Informatik
Street address Amalienstr. 17
City München
ZIP/Postal code 80333
Country Germany
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (20)
GSM2429917 luc_DMSO_rep1
GSM2429918 luc_DMSO_rep2
GSM2429919 luc_DMSO_rep3
BioProject PRJNA357609
SRA SRP095194

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Supplementary file Size Download File type/resource
GSE92456_raw_feature_counts.txt.gz 800.7 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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