GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE90708 Query DataSets for GSE90708
Status Public on Dec 01, 2016
Title Expression data of multi regional colorectal carcinoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Understanding intratumor heterogeneity is clinically important because it could cause therapeutic failure by fostering evolutionary adaptation. To this end, we profiled the genome and epigenome in multiple regions within each of nine colorectal tumors. Extensive intertumor heterogeneity is observed, from which we inferred the evolutionary history of the tumors. First, clonally shared alterations appeared, in which C>T transitions at CpG site and CpG island hypermethylation were relatively enriched. Correlation between mutation counts and patients’ ages suggests that the early-acquired alterations resulted from aging. In the late phase, a parental clone was branched into numerous subclones. Known driver alterations were observed frequently in the early-acquired alterations, but rarely in the late-acquired alterations. Consistently, our computational simulation of the branching evolution suggests that extensive intratumor heterogeneity could be generated by neutral evolution. Collectively, we propose a new model of colorectal cancer evolution, which is useful for understanding and confronting this heterogeneous disease.
Overall design We isolated total RNA from geographically separated samples of one of eight series (case3) of colorectal carcinoma and matched normal mucosa and hybridised to the Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray
Contributor(s) Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, Sawada G, Iwaya T, Kurashige J, Shinden Y
Citation(s) 28542232
Submission date Nov 30, 2016
Last update date Sep 02, 2019
Contact name RYUTARO UCHI
Organization name KYUSHUUNIVERSItY
Street address MAIDASHI3-1-1
State/province FUKUOKA
ZIP/Postal code 812-8582
Country Japan
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (22)
GSM2410995 case3_S_RNA
GSM2410996 case3_I_RNA
GSM2410997 case3_B_RNA
This SubSeries is part of SuperSeries:
GSE90709 Methylation, expression, and SNP data of multi regional colorectal carcinoma
BioProject PRJNA355559

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE90708_RAW.tar 67.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap